hematologic disorders in the elderly

... anticoagulation is the key point when decisions are made about introducing and/or continuing such treatments in the individual elderly patient In order to maximise the safety of anticoagulation in the elderly, ... associated with the likelihood of not receiving VKAs in the multivariate analysis was increasing age No other single factor, including the presence of contraindications to oral anticoagulation influenced ... possibly increase the safety of anticoagulation in the elderly in the near future Keywords: anticoagulation; elderly patient; vitamin K antagonist; hemorrhagic risk; factor-Xa inhibitor; thrombin inhibitors

Ngày tải lên: 14/03/2014, 20:20

... of the prevalence estimates To gain insight into the effect of the differences in the criteria on the prevalence data, both definitions are applied to the LPZ data The LASA result for the independently-living ... and protein intake in the elderly are better than the usual nutritional policy in institutions and primary health care These initiatives have indeed caused more attention to the problem The Committee ... chosen of course affects the results of the study This is also the case in the Dutch investigations into the prevalence of undernutrition Dutch figures In the Netherlands, the prevalence of undernutrition

Ngày tải lên: 22/03/2014, 13:20

... rankings to become 3 of the 4 leading causes of disease and injury burden by 2030 (1) ▪ In a study of individuals aged 65 and older in 7 low- and middle- income countries (including China, India, ... thrombolytic therapy in the elderly 20 2.5 Current recommendations for the elderly 25 3.1 Fundamentals of long-term post-stroke care 31 3.3 Challenges of rehabilitation and the elderly 41 Stroke in the Elderly ... Defining the elderly population ▪ Studies vary widely in the age ranges used to designate older or elderly patients; from 60 to 65 years of age, to 75, 80, or 85 years of age ▪ Even within these

Ngày tải lên: 22/03/2014, 13:20

... are involved in falls among the elderly Many of these factors can be modified Figure 1 shows how intrinsic and extrinsic factors can combine to change the likelihood of falling in the elderly ... intervention to reduce the risk of falling among elderly people living in the community N Engl J Med 1994;331:821-7 TABLE 8 Critical Steps in Reducing the Risk of Falls in the Elderly Eliminate ... programs can reduce the rate of falls in the elderly In one study,34 the interactive group had a relative risk of falling of 0.39 compared with the control group Interventions included the modification

Ngày tải lên: 22/03/2014, 14:20

... daily living  Feeding, Bathing, Dressing, Transferring, Toileting ‹Instrumental activities of daily living  Finances, Telephone, Medications, Shopping, Cooking  Housework, Ambulating, Laundry ... Assessment  ADLs • mobility, dressing, hygiene, feeding and toileting  IADLs • independent living, shopping, cooking, telephone, housekeeping (light), medications, finances, transportation „ Evaluation ... comorbidity„ Must be addressed „ Benzodiazapines may cause confusion „ Antidepressants may precipitate mania „ Psychotherapy, individual or CBT Sleep Disorders in the Elderly related to BPI „ Evaluate

Ngày tải lên: 22/03/2014, 14:20

... minimize the injuries sustained from falls was recommended Williams-Johnson, Wilks, and McDonald further illuminate the situation regarding falls among the elderly in Jamaica [15] In examining ... preceding 1 year period, the expert provided further opinions, insights and data, based on experience at the University Hospital of the West Indies, the leading tertiary care and medical teaching institution ... of the West Indies Mona, Jamaica Trang 2Abstract Falls among the elderly is increasingly being recognized as an issue of concern in both developed and developing countries Falls in the elderly

Ngày tải lên: 28/03/2014, 16:20

... independently in the community Dichotomous; omitting ‘mixed’ residence Institutional living: elderly live in an institution and are dependent on care Mixed living: elderly live in either an institution ... onwards that evaluated the antibody response to the influenza vaccine in the elderly were identified through a MEDLINE search using the terms “influenza”, “vaccine”, “vaccination”, “elderly”, “antibody ... *Percent of elderly having received influenza vaccination in the previous year; **percent of elderly having ever received influenza vaccination. h Community living elderly; I: institutionalized elderly;

Ngày tải lên: 28/03/2014, 20:20

... Increased fall risk in elderly individuals According to the World Health Organization, a fall is defined as the action of finding oneself involuntarily on the ground The prevalence of falls in ... vitamin D in the elderly: an overview of the key role of the non-bone effects Abstract Preventing falls and fall-related fractures in the elderly is an objective yet to be reached There is increasing ... Trang 2death in the elderly [1-3,24] The severity of the fall isdetermined by its consequences including non-vertebral fractures, which essentially depend on the fall mechan-ism resulting in a variable

Ngày tải lên: 19/06/2014, 08:20

... varia-bility in the healthy elderly is lower than that in the falls risk elderly Higher mean MFC in the falls risk elderly group supports our previous findings [4] which showed that increasing the MFC ... problem, and compare the results with those obtained using Poincaré plot indexes analysis Minimum foot clearance (MFC) during walking Figure 1 Minimum foot clearance (MFC) during walking Verti-cal ... than the preceding MFC data point, and points below the line of identity indicate a shorter MFC distance than the previous The MFC Poincaré plot typi-cally appears as an elongated cloud of points

Ngày tải lên: 19/06/2014, 10:20

... of the interviews was then analyzed The second step Trang 3involved holding four focus groups with the same partici-pants to refine the findings and to define the expected key features of the intervention ... complement the data obtained through interviews and focus groups Indeed, the defining characteristics of the intervention were identified on the Table 1: Description of the participants in the interviews ... specific findings into the design of the intervention itself [12,20] Several key research questions about the intervention development process remain, including how to develop strategies for gathering

Ngày tải lên: 11/08/2014, 05:21

... for their diagnosis just before the patient was leaving the emergency room for either the observation unit of our ED or another ward, including the ICU According to the final diagnosis made by the ... appropriate At the time of the study, non-invasive ventilation or continuous positive airway pressure was not performed in the elderly in the ED, but they were performed in the ICU when the patients ... [10,11] The objectives of this study were therefore to determine the causes of ARF in elderly patients, the accuracy of the initial diagnosis suspected by the emergency physician, the impact of initial

Ngày tải lên: 12/08/2014, 23:23

... regulated in skin Again, this novel finding may be important in light of the role of arginase in modulating the balance between inflammation and matrix deposition during healing, and in the progression ... provide novel insight into the relative contribution of hormones and intrinsic aging, including gerontogenes, to delayed wound healing There exists a substantial body of research addressing the tis-sue, ... repair occurs in the elderly [2] Insulin deg-radation in diabetic wounds has been associated with delayed healing [19] and insulin-degrading enzyme (IDE) is down-regulated 20-fold in the aged and

Ngày tải lên: 14/08/2014, 08:21

... Urinary incontinence Urinary incontinence (UI) is defined as the involuntary loss of urine, of sufficient severity to be a health Cancer in the older person Complete the screen by filling in the ... at baseline, anemia incidence was 63% in those undergoing chemotherapy alone, 42% in those receiving a combination of chemotherapy and radiotherapy, and 20% in those treated with radiotherapy ... hypoferremia of in ammation by inducing the synthesis of the iron regulatory hormone hepcidin J Clin Invest 2004; 113: 1271–6 Laftah AH, Ramesh B, Simpson RJ, et al Effect of hepcidin on intestinal iron...

Ngày tải lên: 10/08/2014, 16:22

... point the HSC numbers dramatically fell in D2 mice while they continued to rise in the B6 mice Thus, we surmised that the aging of the stem cells in these two strains differed according to their ... answers For instance, does aging begin at birth, at which point development has culminated in an independently functioning individual, or does it begin at puberty, when the individual has attained reproductive ... lifespan determination in these two strains Congenic mice were then generated where we crossed the QTLcontaining interval from the D2 strain onto a B6 background (B6.D2 Chr 2) to test the mapping data...

Ngày tải lên: 10/08/2014, 16:22

... further increase the response in the elderly participants In one of the studies where vaccine adjuvants were evaluated, thymosin alpha one or placebo was given twice weekly, beginning with vaccination, ... competing schools of thought on the dominant mechanism leading to the age-related decline in antibody production in response to foreign antigens These lines of thinking have attributed the age-related ... explaining the underlying mechanism of the age-related increase in autoantibody, which are related to the age-related decline in the antibody response to foreign antigens: (1) the shift in number...

Ngày tải lên: 10/08/2014, 16:22

... is destined for the hemoglobin in developing erythrocytes in the bone marrow In the absence of bleeding, iron losses from desquamation of intestinal epithelia and skin are relatively minor See ... Experiments in mice lacking IL-6 show that other cytokines, including IL-1, may contribute to hepcidin induction during in ammation, but it is not certain whether the specific hepcidin-stimulatory cytokines ... utilization Iron is excreted by shedding of intestinal and skin cells, and through minor blood loss in the intestine In principle, the iron content of shed epithelial cells could be subject to regulation...

Ngày tải lên: 10/08/2014, 16:22

... erythropoietin insufficiency in older individuals [20] (Fig 15.2) When the circulating levels of erythropoietin were plotted against the levels of hemoglobin and the levels of in ammatory cytokines one ... ferroportin, a protein responsible for carrying the iron from the gastrointestinal tract into the circulation Incidence and prevalence of cobalamin deficiency increase with age [23,24], due to inability ... epidemiologic study initiated by the National Institute of Aging involving elderly people living in several different areas of the USA As with other studies, IL-6 levels were higher in an elderly population...

Ngày tải lên: 10/08/2014, 16:22

... Pgp overexpression in the elderly supports the finding that conventional induction therapy in the elderly is less efficacious than in younger adults Therapeutic strategies to inhibit Pgp cellular ... remains investigational However, because of the high prevalence of the MDR1 phenotype in the elderly population, there is continued investigation into the use of more potent and specific inhibitors ... MDS in the first-line setting [103,104] Fludarabine with cytarabine in the relapsed/refractory setting has a reported CR rate of 36% [105] Non-cytarabine regimens have also been investigated in the...

Ngày tải lên: 10/08/2014, 16:22

... telangiectasia Retinoic acid derivatives, including isotretinoin, etretinate, and acitretin, have demonstrated marginal potency against CTCL as monotherapy; however, they have been used mostly in combination ... Franchini M, Krampera M, Pizzolo G Low-dose epirubicin in combination with cyclophosphamide, vinblastine and prednisone (miniCEOP) for the treatment of aggressive non-Hodgkin’s lymphoma in elderly ... completed a trial involving 96 patients treated with three alternating combination regimens consisting of vincristine, cyclophosphamide, doxorubicin, prednisone, ranimustine, vindesine, etoposide,...

Ngày tải lên: 10/08/2014, 16:22

... for maintenance therapy with fludarabine? Is there an optimal combination – and sequencing – for administering fludarabine and an alkylating agent as combined therapy? The National Cancer Institute ... for the increase in circulating CD34ϩ cells in idiopathic myelofibrosis [28] Interestingly, there is also an increase in circulating endothelial precursor cells that appears to precede the increase ... fusion protein that has been produced by recombinant DNA technology, in which the receptor-binding domain of diphtheria toxin is replaced by the sequences of human interleukin [113] These compounds...

Ngày tải lên: 10/08/2014, 16:22