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... task (button) Further from Fig 2, mean DTC was higher in elderly than in younger subjects for some but not for other task combinations, thus reflecting agerelated deficits of dual-task performance ... summarized in the top part of Tab DTC was small for both constituent tasks of walko+memo (i.e., for walking as well as for memorizing), but was large for both constituent tasks of walko+checkgw Elderly ... Engelhard and P Guardiera for help in the re-analysis of data from our previous study References It should be noted, however, that visual demand may not be the only critical factor for falls in healthy...

Ngày tải lên: 19/06/2014, 08:20

... Staining of leaf sections with MitoTracker was not successful, therefore double labelling was performed on protoplasts Page of 14 (page number not for citation purposes) BMC Plant Biology 2008, ... http://www.biomedcentral.com/1471-2229/8/40 Ornithine-δ-aminotransferase does not contribute to stress-induced proline accumulation The mitochondrial localisation of δOAT indicated that it is not involved in the formation of Pro, since ... homozygous for the oat3 T-DNA insertion but heterozygous for the δOAT-GFP construct In bacteria and mammals, transamination of Orn constitutes an alternative route for GSA/P5C and subsequently Pro formation...

Ngày tải lên: 12/08/2014, 05:20

... Glycosylation of BST-2 is not required for inhibition of virus release and for sensitivity to Vpu Glycosylation of BST-2 is not required for inhibition of virus release and for sensitivity to Vpu ... as wt BST-2 and did not inhibit release of wt NL4-3 (Fig 4B) We therefore conclude that glycosylation of BST-2 is not critical for the inhibition of virus release and does not affect sensitivity ... only the post-ER form of BST-2 can efficiently homo-dimerize while the high mannose form remains largely, if not exclusively, in monomeric form BST-2 dimerization is important for inhibition of...

Ngày tải lên: 12/08/2014, 23:22

... that only values us for what we’ve done lately, not for what we once did That’s the worst, and best, thing about it But not for a few, and Crick clearly was one of those It helped that he was ... contributions for granted, and they should Their focus is not on our past, it’s on their present and future, their ideas, their problems The Francis Cricks of the world are pretty rare - not because ... beat the “what-have-you-done -for- melately” syndrome that consigns so many senior investigators to the dustbin of history Winning a Nobel Prize helps, to be sure, but how many of you who are chemists...

Ngày tải lên: 14/08/2014, 14:21

... benefits of helping Focusing on breeder age may help isolate variation in the benefits of helping, rather than the costs, since contributing a constant effort can have larger effects for some breeders ... possible that the reduced performance of yearlings in pairs is due to a reduced optimal reproductive effort for these birds These hypotheses are not mutually exclusive, but each is considered in ... of the male was years (range 1–10) for yearling-female pairs, years (2 –11) for yearling-female groups, years (2–11) for older-female pairs and years (1–11) for older-female groups; Kruskal–Wallis,...

Ngày tải lên: 14/03/2014, 16:20

... set, is therefore another important parameter of data quality The above numerical criteria are usually quoted for all data and for the highest resolution shell Unfortunately, it is not customary ... the users as a text-formatted file For a structure with the accession code 9xyz, the corresponding file would be 9xyz.pdb (For easier handling by computer programs, the same information is also stored ... the contents of PDB file headers is not easy for non-crystallographers, yet we must stress that any user of such information should look at the header first, before spending too much time looking...

Ngày tải lên: 16/03/2014, 06:20

... these AtxA-binding proteins, but were not toxic Our results show that F24 and the last 26 amino acid residues of potently neurotoxic AtxA are not enough to transform a nontoxic sPLA2 into a neurotoxic ... molecule also contribute to produce the neurotoxic effect ACKNOWLEDGEMENTS The authors would like to thank Dr Tadej Malovrh for help in lethality measurements and Dr Roger H Pain for critical reading ... residues differing from the corresponding AtnI2 region distributed mainly on the molecular surface (Fig 2), did not induce any substantial conformational changes in the protein fold In contrast to...

Ngày tải lên: 31/03/2014, 08:20

... used for Agrobacterium-mediated transformation of the potato line K41 We obtained 65 and 58 independent transgenic lines for the Rar1 and Sgt1 genes, respectively Page of (page number not for ... (PT29), non-transformed K41 lines and K41 lines that were transformed with the construct containing either Rar1 or Sgt1, but not silenced The inoculation and resistance evaluation were performed as ... resistance phenotype http://www.biomedcentral.com/1471-2229/8/8 as the RB gene In addition, the role the Rar1 and Sgt1 genes are not universal and these genes are not essential for resistance...

Ngày tải lên: 12/08/2014, 05:20

... shown that Vpu is phosphorylated by CK-II [12], but the importance of an active CK-II for the ability of Vpu to degrade tetherin is not known Therefore, we measured Vpu-mediated tetherin degradation ... and HLT ex vivo, but not in macrophages that express higher levels of tetherin In sum, our data suggest that the ability of Vpu to counteract tetherin is an important determinant for HIV-1 cell ... of p24 (1 ng p24) [25] showed that only changes in nef, but not in vpu, impaired viral infectivity (Fig 3C) Most Figure Vpu S52A does not impair HIV-1 release from P4-CCR5 cells (A) Western blot...

Ngày tải lên: 12/08/2014, 23:22

... podoplanin-specific antibody 18H5, but not antibodies with other specificities recognize non-viable cells (A) CEM×174 cells were analyzed for their distribution in the forward and sideward scatter, ... for 30 minutes at 4°C before staining of apoptotic cells for subsequent FACS analysis Statistical analyses Statistical significance was determined by employing a two-tailed student's t-test for ... interaction was not inhibited by mannan and was not enhanced by expression of the viral Env protein In agreement with these results, soluble HIV-1 Env protein bound specifically to DC-SIGN but not to...

Ngày tải lên: 12/08/2014, 23:23

... the distributions of two polymorphism’s genotypes in the controls were both consistent with Hardy-Weinberg equilibrium except for one study [26 ]for p53 Arg72Pro, and one studies [21] for GSTP1 ... controls) for p53 Arg72Pro and studies (1885 cases and 2194 controls) for GSTP1 Ile105Val were available for this meta-analysis The minor Pro allele (for p53 Arg72Pro) and Val allele (for GSTP1 ... Arg75Pro for the Pro/Arg+Pro/Pro genotypes, compared with the Arg/Arg genotype Figure ORs (log scale) of esophageal cancer associated with GSTP1 Ile106Val for the Ile/Val+Val/Val genotypes, compared...

Ngày tải lên: 25/10/2012, 11:40

... difference for the platelet counts for those achieving CR and those who did not (982 x 109/L for both groups) The drop of the platelet count over the months was 50.3 % for all 45 MPD patients, 56.6 % for ... with PR+F (not shown) Reliable methods for the measurement of anagrelide metabolites were not available at the time of study Effects on TPO and sIL-6R levels TPO PV and ET patients did not differ ... significant changes were observed for this variable over the studied months, neither for all patients, nor for those entering CR or PR+F (Figure 1) The mean ± 2SD values for our patients at start were...

Ngày tải lên: 03/11/2012, 10:52

... am not overambitious I am happy with my work I am not famous but I have independence I cannot create some of the more daring clothes that I would perhaps have been able to create in Europe but ... mistress He even wanted to buy me jewelry but I did not accept That's why I am not wearing any.” “They would add nothing to your appearance Nobody would notice them,” I said “That's sweet Don't ... business There was no other viable option for me in Egypt I had a few days‟ grace before starting work I went for a long stroll in the city I was away from Cairo for only a few months and yet it was...

Ngày tải lên: 06/11/2012, 17:33

... which have not been investigated, and we therefore cannot exclude the possibility that other prolines in tau may be important for its binding to Fyn-SH3 Here, we have demonstrated, for the first ... Prescott ED, Fuhrer C & Burden SJ (2001) Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors ... interact, but to differing extents, with Fyn-SH3 This suggests that the results shown here are not artefactual, owing to incorrect folding of the tau mutants, at least not in the regions responsible for...

Ngày tải lên: 14/02/2014, 14:20

... results not only show that the regulatory role for PI3-K in P2Y12 signaling is conserved in mouse and human platelets, but also highlight the importance of the PI3-Kb isoform PI3-Kb and not PI3-Kc ... together, these results suggest that, in both mouse and human platelets, the PI3-Kb but not the PI3-Kc isoform contributes to platelet procoagulant activity following P2Y12 stimulation Discussion ... platelets Knowing that the PI3-Kß isoform is responsible for a considerable amount of the PIP3 formed in platelets [21], this may suggest that the PIP3 produced by this isoform leads to plasma membrane...

Ngày tải lên: 18/02/2014, 16:20

... it is apparently not used for ubiquitin addition Therefore, the reason why Lys147 rather than Lys5 is the main acceptor site for ubiquitin in Rac1 remains to be elucidated Of note, however, is ... which may not be fulfilled by Rac1b pull-down C Lys147 The main target site for Rac1 ubiquitination is Lys147, a surface residue not hampered in Rac1b We first reasoned that the site(s) for ubiquitin ... not involved in contacts with any of the interacting proteins described so far, and is not affected by the 19-residue insertion in Rac1b Therefore, the impairment of Rac1b ubiquitination is not...

Ngày tải lên: 18/02/2014, 16:20

... and not- for- profit governance.) The 20 Questions for Not- for- Profits Series 20 Questions Directors of Not- for- profit Organizations Should Ask about Governance 20 Questions Directors of Not- for- profit ... should perform in consultation with other board members TT The board has processes for assessing its own performance and that of committees TT The board has processes for assessing the performance ... differences between for- profit and not- for- profit organizations is their view of costs Success for a business is defined as making a profit by maximizing revenues and minimizing costs Not- for- profits...

Ngày tải lên: 21/02/2014, 17:20

... focimatrix (for focal intra-epithelial matrix) [7] These observations indicate that ECM components contribute to the microenvironment of GC, but their specific roles in follicular development have not ... isolation of GC), or prepared for western immunoblotting For studies of ERK1/2 phosporylation, GC were cultured on LN or plastic, with and without inhibitors, for 24 h before western immunoblotting ... for autoradiography from Integra Bioscience (Cergy-Pontoise, France) For protein assay, the BC Assay protein kit was obtained from Uptima Interchim (Montluçon, France) Immobilon P membranes for...

Ngày tải lên: 05/03/2014, 17:20

... essential information throughout the text on treatment Bar Association Charity and Not- for- Profit Law Section, of not- for- profit corporations and their directors under for their input and help in ... also usually different for not- for- profit corporations, although this What is a not- for- profit corporation? varies from jurisdiction to jurisdiction Incorporating a Not- for- profit corporations ... organization Corporations & Directors Ⅵ |1| The not- for- profit board of directors For- profit and not- for- profit directors share a legal The not- for- profit corporation is governed by a board responsibility...

Ngày tải lên: 08/03/2014, 16:20

... different from for- profit accounting The primary area which is different for not- for- profit organizations is accounting for contributions For- profit corporations make gifts, but they not receive ... information on taxes for not- for- profit organizations Relevant information from former Chapter 29, “Principal Federal Tax Forms Filed,” has now been included in new Chapter 28 The actual tax forms ... POINTS TO CONSIDER IN NOT- FOR- PROFIT FISCAL MANAGEMENT (a) Accounting Principles (i) Not- for- Profit Accounting Is Not Very Different from For- Profit Accounting Most of not- for- profit accounting...

Ngày tải lên: 13/03/2014, 23:41