heliannanes a structure activity relationship sar study
Design, optimization and structure activity relationship study of CD2 derived peptides for immunomodulation
... interaction FDA approval for chronic plaque psoriasis Efalizumab (Raptiva®) anti-CD11a humanized mAb LFA-1/ICAM-1 interaction FDA approval for plaque psoriasis and progressive psoriatic arthritis ... truncation and alanine scanning for optimization Finally, the biological activity and secondary structure of the peptides were investigated to elucidate the Structure-Activity Relationship (SAR) A ... lecturers and technical staffs for their assistance, in particular, Ms Ng Sek Eng and Mr Mayandi Venkatesh I also greatly appreciate Dr Swarup Sanjay and his lab staffs, Ms Chai Feng from the Department...
Ngày tải lên: 04/10/2015, 15:46
Quantitative structure-activity relationship and molecular docking studies of a series of quinazolinonyl analogues as inhibitors of gamma amino butyric acid aminotransferase
... experiences [3] Gamma aminobutyric acid aminotransferase (GABAAT) is a validated target for anti-epileptic drugs because its selective inhibition raises GABA concentration in brain which has an antiepileptic ... the developed QSAR models were evaluated by internal and external validation parameters Internal and external validations The internal and external validation parameters were com-pared with the ... with approved therapeutic properties is an important challenge for medicinal chemists Quantitative Structure-Activity Relationships (QSAR) are mathematical frameworks which interface molecular structures...
Ngày tải lên: 15/01/2020, 00:58
Quantitative structure–activity relationship study on potent anticancer compounds against MOLT-4 and P388 leukemia cell lines
... Accepted 31 March 2016 Available online 8 April 2016 A B S T R A C T A quantitative structure–activity relationship (QSAR) study was carried out on 112 anticancer compounds to develop a robust model ... experimental activity, respectively Also, the accuracy of the prediction of the QSAR equation was vali-dated by F-value, R2 and R2adj A large F-value demonstrates the possibility of a chance correlation ... distinctive organic moiety acting as anticancer The nature of models in a QSAR study is expressed by its fitting and forecast capacity QSAR on P388 and MOLT-4 cell line dataset In order to assemble a decent...
Ngày tải lên: 15/01/2020, 05:25
Multi target selection and high throughput quantitative structure activity relationship model development
... OOPL Object-oriented programming language PCD Pathway Cross-talk Database QSAR Quantitative structure-activity relationship SA-PLS Simulated annealing-partial least squares SVR Support vector regression ... antagonists.135 Validated QSAR models were used to mine 3 publicly available chemical databases: the National Cancer Institute (NCI) database, the Maybridge database and the ChemDiv database and resulted ... consensus QSAR models were then used to virtual screen 3 million compounds from 4 chemical databases: National Cancer Institute (NCI) database, Maybridge database, ChemDiv database and ZINC database...
Ngày tải lên: 09/09/2015, 10:09
Multi faceted structure activity relationship analysis using graphical representations
... Hernandez-Campos A., Giulianotti M A.,Castillo R., Medina-Franco J L Structure-activity relationships of benzim-idazole derivatives as antiparasitic agents: Dual-activity dierence (DAD)maps ... interactive and lively work-ing atmosphere I am especially thankful to Dr Anne Mai Wassermann, Dr.Dagmar Stumpfe, Dr Lisa Peltason, Dr Martin Vogt, Dr Mathias Wawer, Dr Vigneshwaran Namasivayam and Dr ... small steps in chemical space are ac-companied by large changes in activity. Numerical analysis functions including the SAR index (SARI)4or the structure-activity landscape index (SALI)5have...
Ngày tải lên: 19/11/2015, 15:56
Computational methods for structure activity relationship analysis and activity prediction
... provides a basis for the explorationof SARs. The activity landscape concept is an approach that has become popular.4 , 30 An activity landscape can be defined as any graphical representation that grates ... poten-Predictive Approaches Activity landscapes are used to analyze SAR data sets for which activity values have already been obtained from experiments The numerical and graphical SAR analysis schemes, ... oped by Hansch et al.26 and has been invaluable for understanding SARs In QSAR, a mathematical model is derived that relates structural features and/or molecular properties to bioactivity QSAR models...
Ngày tải lên: 26/11/2015, 09:53
Structure activity relationship studies on the factor XIIIa inhibitor tridegin
... conveniently mea-sured in vitro by different assays The earliest assays available were an amine-incorporation assay137as well as different ammonia-release assays.138,139Later on, the isopeptidase activity ... transglutaminase activity, it has been shown to act as a GTPase,protein disulfide isomerase and kinase Tgase 2 plays a role in cell death and differentiation,matrix stabilization, adhesion and migration.6,13It ... for example subcutaneoushematomas, intramuscular and joint hemorrhage, and intracranial hemorrhage.75The latter is also the most frequent cause of fatality and disability in FXIII deficient patients.75,94...
Ngày tải lên: 26/11/2015, 10:18
Mechanistic studies of anti malarial spiroindolones and synthesis and structure activity relationship studies of an inhibitor of dengue proliferation
... four Plasmodium species, namely falciparum, vivax, ovale and malariae, that cause malaria in humans, Plasmodium falciparum is the most virulent and is responsible for the majority of deaths from ... Trang 1I MECHANISTIC STUDIES OF ANTI-MALARIAL SPIROINDOLONES AND II SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF AN INHIBITOR OF Trang 2I MECHANISTIC STUDIES OF ANTI-MALARIAL ... weakness for uncomplicated cases and coma, pernicious anemia and pulmonary edema for complicated cases (3) In 2006, there were approximately 247 million malaria cases among 3.3 billion people at...
Ngày tải lên: 26/11/2015, 10:48
Inhibitory effects against α-glucosidase and α-amylase of the flavonoids-rich extract from Scutellaria baicalensis shoots and interpretation of structure–activity relationship of its eight
... enzymes as glucoamylase, dextrinase, maltase and sucrase as well as the pancreatic α-amylase [9] Due to the presence of an intramolecular nitrogen, acarbose attaches to the carbohydrate binding ... 2 diabetes via scavenging various free radicals caused by increased oxidative stresses Keywords: Scutellaria baicalensis shoots, Flavonoids, α-Glucosidase, α-Amylase, Structure–activity relationship, ... chinensis on alpha-glucosidase activities and postprandial blood glucose J Enthopharmacol 85:283–287 7 Nair SS, Kavrekar V, Mishra A (2013) In vitro studies on alpha amylase and alpha glucosidase inhibitory...
Ngày tải lên: 29/05/2020, 13:53
Synthesis fungicidal activity and structure activity relationship of acylaminocycloalkylsulfonamides against botrytis cinerea
... The fungicidal activity of the title compounds against various B cinerea strains was evaluated According to their fungicidal activities, structure-activity relationship (SAR) was also discussed ... compounds against the two strains For example, the activity of the title compounds against Dd-15 was generally high, and average inhibition rate was about 76.0% While the activity was relatively low against ... Trang 1Synthesis, Fungicidal Activity, and Structure Activity Relationship of β-Acylaminocycloalkylsulfonamides against Botrytis cinerea Chun-Hui Liu1,*, Xiao-Yuan Chen1,*, Pei-Wen...
Ngày tải lên: 19/03/2023, 15:24
Tài liệu Oracle - Building A Banking Customer Relationship Data Warehouse - A Case Study - White Paper (pdf) pptx
... Logical Data Model Finalize MIS data mart logical data model Define data warehouse Implementation Road map and schedules I.T Hardware Vendor End Users Operations Trang 75-8 Detail design Architecture ... layer accessed the Data Warehouse, as well as, Data Marts • The Hub component (Extraction Layer) fed data to the ODS, as well as, the Data Warehouse Extraction and Transformation processes extracted ... staff and head office departmental staff • The power user is the sophisticated user, such as marketing and brand coordinators and financial officers, who have a range of PC skills and are capable...
Ngày tải lên: 24/01/2014, 06:20
Báo cáo y học: " Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions" pps
... Nosema ceranae 100 Nosema ceranae 100 Encephalitozoon cuniculi Antonospora locustae 99 100 97 100 Paranosema grylli ATP transporters Clade I Antonospora locustae Antonospora locustae Ancestral ATP ... of the ATP transporter family based on available amino acid sequences from a range of microsporidian parasites 1, Putative ancestral duplication of ATP transporters within the microsporidia following ... Thymidylate Peptide protea- (ECU02_ kinase chain nucleoside gamma some beta release diphoschain 0310) subunit factor phate subunit reductase small chain Gamma glutamyl transpeptidase DNAdirected RNA...
Ngày tải lên: 09/08/2014, 20:20
Báo cáo sinh học: " Genetic variability of host-parasite relationship traits: utilization of isofemale lines in a Drosophila simulans parasitic wasp" pptx
... L boulardi used in this study were caught in the oasis of Nasrallah (near Kairouan, Tunisia) in 1985 and have been reared on a strain of D melanogaster collected from the same location At this ... generations As shown by the data on extreme values, the distributions of some parameters are asymmetrical Results of the 2-way analysis of variance are given in Table II The total variance has ... containing a dead, melanized and encapsulated parasite in the abdomen (B); the number of adult wasps (C); the number of dead Drosophila larvae or pupae (D) This parameter, D, is - - - - equal to 100- (A+ B+C)...
Ngày tải lên: 14/08/2014, 20:20
Báo cáo y học: " First Dominique Dormont international conference on "Host-pathogen interactions in chronic infections – viral and host determinants of HCV, HCMV, and HIV infections" pdf
... post-integration into the human genome A large body of data has accumulated to indicate that the cells of HIV-1- infected patients may contain proviral DNA but produce only a small amount of viral RNA ... He also demonstrated an absence of liver damage in vaccinated animals, whereas ALT and GGT levels were high in control animals He concluded that this vaccine can prevent hepatitis and protect animals ... cells by antiviral antibodies in acute and chronic hepatitis C J Virol 2004, 78:9030-9040 Kamal SM, Ismail A, Graham CS, He Q, Rasenack JW, Peters T, Tawil AA, Fehr JJ, Khalifa Kel S, Madwar MM,...
Ngày tải lên: 13/08/2014, 09:21
Host viral interactions host factors in coronavirus replication and coronaviral strategies of immune evasion
... Alphacoronavirus Coronavirinae Betacoronavirus Torovirinae Gammacoronavirus Coronaviridae Nidovirales Arteriviridae Roniviridae Figure 1.1: Taxonomical classification of coronaviruses Alphacoronaviruses ... gastroenteritis virus APN Human Human coronavirus-229E APN Cattle Bovine coronavirus 9-O-acetylated sialic acid Human Human coronavirus-OC43 9-O-acetylated sialic acid SARS coronavirus Angiotensin converting ... terminal ectodomain, followed by a transmembrane domain and finally a short C terminal endodomain Post-translational cleavage of the ectodomain by cellular proteases [18,19,20] yields two fragments:...
Ngày tải lên: 09/09/2015, 10:07
Computational studies of host pathogen protein protein interactions a case study of the h sapiens m tuberclulosis H37RV system
... (2011) have also obtained similar results from analyzing the same pathway data: human signal transduction pathways derived from Pathway Interaction Database (PID)(Schaefer et al., 2009) and Reactome(Joshi-Tope ... interaction data are intra-species PPIs, but also contains some host-pathogen PPI data 1.5.3 Host-pathogen interaction integration and analysis databases Host-pathogen interaction integration and analysis ... experimental data, (v) biological explanation of selected examples, etc 1.4.1 Assessment based on gold standard Known truly interacting host-pathogen PPI data (gold standard) are available for a few pathogens...
Ngày tải lên: 10/09/2015, 09:08
Chemistry of nanostructured materials
... and Centre for Catalysis Research and Innovation University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada abdel.sayari@science.uottawa.ca The area of periodic mesoporous materials has grown tremendously ... microporous and has a high adsorption capacity for methane Metal-organic frameworks can also be created by a combined use of amines and carboxylates For example, in [Zn4(OH)2(fa)3(4,4’-bpy)2] (fa = fumarate), ... expand applications of porous materials beyond traditional areas such as adsorption and catalysis, metal-organic frameworks based on semiconducting chalcogenide nanoclusters are highly desirable...
Ngày tải lên: 23/04/2013, 14:23
Gián án Chapter 22 Chemistry of the Nonmetals
... Chemistry: A Molecular Approach 28 Nanotubes Tro, Chemistry: A Molecular Approach 29 Nanocars Tro, Chemistry: A Molecular Approach 30 Carbides • carbides are binary compounds of C with a less electronegative ... Julia Burdge, 2nd e., McGraw Hill 14 Mica: a Phyllosilicate Tro, Chemistry: A Molecular Approach 15 Silicate Structures Tro, Chemistry: A Molecular Approach 16 Boron • metalloid • at least allotropes, ... Chemistry: A Molecular Approach 21 Carbon • exhibits the most versatile bonding of all the elements • diamond structure consists of tetrahedral sp3 carbons in a 3-dimensional array • graphite structures...
Ngày tải lên: 28/11/2013, 01:12
Tài liệu Báo cáo khoa học: Coordination chemistry of iron(III)±porphyrin±antibody complexes In¯uence on the peroxidase activity of the axial coordination of an imidazole on the iron atom ppt
... to Brault & Rougee [48], it could then be analyzed by means of the standard equation 1aDA 1aDAI Kd aDAI Â 1a Ln 2 where DA A ) A0 , DAI A ) AI and A0 , AI, and A are the absorbances ... 28 Takagi, M., Khoda, K., Hamuro, T., Harada, A. , Yamaguchi, H., Harada, A. , Kamachi, M & Imanaka, T (1995) Thermostable peroxidase activity with a recombinant antibody L chainporphyrin Fe (III) ... opposite face of the porphyrin (Fig 7D) An optimal catalytic effect can then be obtained as the COOH residue can act as a general acid±base catalyst and the imidazole ligand can modulate the redox...
Ngày tải lên: 21/02/2014, 03:20
Visualization of Host Behavior for Network Security pdf
... Rheingans, P., and Komlodi, A (2006) Focusing on context in network traffic analysis IEEE Computer Graphics and Applications, 26(2):72–80 [Kamada and Kawai, 1989] Kamada, T and Kawai, S (1989) An algorithm ... lines and that only correlations between neighboring axes can be identified 2.1 Analysis of application ports An important subarea is visualization of application port activity as an indication ... their sheer amount causes scalability issues in both manual and visual analysis Since traditional statistical graphics are familiar to analysts, their design often forms the basic metaphor of newly...
Ngày tải lên: 05/03/2014, 23:20
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