head and neck cancer treatment in india

... 3-year survival These findings should be taken into account when counselling patients in whom nonstandard treatment is considered Keywords: Head and neck cancer, Nonstandard treatment, Patient compliance, ... Predictive factors for nonstandard treatment decisions in head and neck cancer treatment differed between the treating physician and the patient Patients who received nonstandard treatment had a lower ... physicians decline standard, curative treatment modalities Our objective is to determine factors associated with noncompliance in head and neck cancer treatment for both patients and physicians and to

Ngày tải lên: 28/09/2020, 10:03

... studied using a 10 item containing questionnaire Patients filled in this questionnaire before and every fourth week during treatment The questionnaire in-cluded self-evaluation of pain, breathing, ... than non-responders Inter-estingly, in the EXTREME trial the greatest benefits were also found in swallowing, pain and speech [7] These findings are of high relevance for clinical treat-ment algorithms ... 74% in the phase III trial (“Bonner trial”) in treatment-naive patients and was used in a sub-cohort in the current SOCCER trial (20% of included patients) A further finding of this non-interventional

Ngày tải lên: 05/11/2020, 08:21

... for performing IMRT were parotid gland sparing (n ~100), and/or mandible bone sparing (n = 76) and/or anterior visual pathway and/or brain sparing (n = 10) 34 patients (30 %, 30 following an R1 ... christoph.glanzmann@usz.ch * Corresponding author Abstract Background: Preliminary very encouraging clinical results of intensity modulated radiation therapy (IMRT) in Head Neck Cancer (HNC) are available ... Research IMRT using simultaneously integrated boost (SIB) in head and neck cancer patients Address: 1 Department of Radiation Oncology, University Hospital, Zurich, Switzerland and 2 Department

Ngày tải lên: 09/08/2014, 10:20

... inhibitor-kappaB kinase (IKK)α/β/γ and casein kinase 2 complexes modulating NFκB1, RELA and cREL, and alternative pathways involving NF-κB inducing kinase and IKKα modulating NFκB2 and RELB [1,2,11,24-26] ... 1pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status Addresses: * Head and Neck Surgery Branch, NIDCD, National Institutes ... direct and indirect physical and functionalinteractions from peer-reviewed publications The relation-ships in the network include protein-protein interactions, protein binding to DNA or RNA, protein

Ngày tải lên: 14/08/2014, 08:20

... for head-and-neck cancer, with an emphasis on the description of targeting points, including future perspectives Key words: Nanoparticles, targeted therapeutics, head-and-neck cancer, RNA interference, ... extracellular ligand-binding domain, a hydrophobic transmembrane segment, and an intracellular tyrosine kinase (TK) domain The extracellular domain pro-vides a binding site for the endogenous ligand, epi-dermal ... Drug Administration (FDA) for treatment of colorectal and lung cancers, and HNSCC TK inhibi-tors target the intracellular domain of EGFR, com-peting with adenosine triphosphate (ATP) for binding

Ngày tải lên: 15/01/2020, 16:59

... cell head and neck cancer J Clin Oncol 2003;21:92 –8. 3 Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, et al Defining risk levels in locally advanced head and neck cancers: ... chemotherapy-induced nausea and vomiting (CINV) was prescribed according to international guidelines [13,14], containing a three-drug regimen, which included dexa-methasone, the serotonin receptor ... weekly during CRT, every 1 or 2 days during hospitalizations, and 3 and 12 months after CRT in patients with LA-SCCHN AKI was defined as increase in serum creatinine (sCr) of≥1.5 times baseline or

Ngày tải lên: 17/06/2020, 18:48

... mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer Sandhya Yadav1, Somnath D Bhagat2, Amit Gupta1, Atul Samaiya3, Aasheesh Srivastava2and Sanjeev Shukla1* ... splicing switch in head and neck cancer (HNC) cells Considering the reversible nature of epigenetic marks, we have also examined the utility of dietary-phytochemical in reverting the splicing switch ... expression of PKM2 in various cancers including HNC is correlated with epigenetic mechanism leading to the splicing switch of PKM1 to PKM2 remains to be established in HNC Interestingly, the epigenetic

Ngày tải lên: 17/06/2020, 18:58

... life, and swallowing function in head and neck cancer patients 1 year after definitive therapy Laryngoscope 2012;122(7):1518 –25. 5 Patterson JM, McColl E, Wilson J, Carding P, Rapley T Head and neck ... below and were administered pre-, immediately following CB-EST, and at three months using a five-point scale and summarised using a total ii The European Organization for Research and Treatment ... benefit on recovery and well being Patients liked the combination of talking, visualising issues using a whiteboard and other applied techniques, and concrete goal setting Timing Most participants

Ngày tải lên: 23/07/2020, 23:44

... weeks) treatment of severe sto-matitis in patients undergoing head-and-neck cancer CRT and using oral appliances (dentures and PAP) Short-term use of the admixture paste for head and neck cancer ... adhesives and was developed with the intention of using it in denture-wearing patients In pa-tients with head and neck cancer, severe stomatitis may occur in both the oral cavity and in the pharynx ... (hereinafter re-ferred to as “CRT”) for cancer in the head and neck region with severe oral stomatitis Radiotherapy for head and neck cancer has a nearly 100% risk of caus-ing oral stomatitis in

Ngày tải lên: 24/07/2020, 01:55

... is integrated with extensive biological sampling and exploration into cytokines and mechanisms involved The current paper discusses decisions and methods behind exercise in head and neck cancer ... pa-tient wellbeing and rehabilitation after cancer therapy, and very interestingly a tumor-inhibiting effect of exer-cise is being unraveled [27, 42–47] In particular head and neck cancer patients ... points blood samples are drawn both before and after a training session in the training group Regarding week 13/14: Due to public holidays training can extend beyond 12 weeks, training continues

Ngày tải lên: 06/08/2020, 07:25

... these strategies and intervention effects Randomised and quasi-randomised studies of head and neck cancer patients were included Behavioural interventions to improve swallowing were eligible ... Assessing the robustness of the synthesis We reflect on the number and quality of the studies included, and the methods used in synthesizing the findings Results Synthesis of study and intervention ... reviews focus on understanding how and why inter-ventions work in some situations and not others, rather than simply investigating whether they do or do not work [11] Sutcliffe and colleagues [12]

Ngày tải lên: 20/09/2020, 01:02

... efficacy in conjunc-tion with existing CCRT being the most likely route to clinical development [1, 2] HSP90 is a molecular chaperone involved in the initial folding and continued conformational maintenance ... this increased p53mt signalling may play is not known The early HSP90 inhibitor 17-AAG has been shown to stabilise wild type p53 in head and neck cell lines through a reduction in MDMX increasing ... shRNA indicated a possible rationale for the combination of AUY922 and CCRT in cells lacking ATM function Conclusions: This study supports future clinical studies combining AUY922 and CCRT in p53

Ngày tải lên: 20/09/2020, 01:18

... cellular migration in head and neck cancer and reveal the biological relationship between miR-363, myosin 1b, and HPV-positive SCCHN Keywords: Squamous cell carcinoma of the head and neck, Human papillomavirus, ... polymerase chain reaction; RISC: RNA-induced silencing complex; SCCHN: squamous cell carcinoma of the head and neck; siRNA: small interfering RNA; TCGA: The Cancer Genome Atlas. Trang 9Competing interestsNone. ... against virally infected squamous cell carcinoma of the head and neck. Cancer Res 2005;65(23):11146 –55. 10 Ragin CC, Taioli E Survival of squamous cell carcinoma of the head and neck in relation

Ngày tải lên: 22/09/2020, 23:35

... diagnosis of head and neck cancer –a longitudinal study Head Neck 2001;23(2):113 –25. 6 Langius A, Bjorvell H, Lind MG Oral- and pharyngeal-cancer patients ’ perceived symptoms and health Cancer Nurs ... outpatients with head and neck cancer 6 months after diagnosis Head Neck 2009;31(9):1207 –14. 26 Rogers SN Quality of life for head and neck cancer patients –has treatment planning altered? Oral ... treat-ment In accordance with previous research, patients exhibiting no impairments or in only one domain within CGA were defined as ‘fit’ whilst patients exhibiting im-pairments in two or more domains

Ngày tải lên: 23/09/2020, 00:08

... PG has been proposed to influence migration and invasion of oral squamous cell carcinoma cells in vitro by interacting with the β1 integrin subunit and the lamininβ1 chain [48] NG2/CSPG4 has been ... Figure 3) and was particularly enriched in lesions containing desmoplastic stroma Intriguing was the fact that in 100% of the lesions, SDC2 could be observed in the wall of both nor-mal and intra-lesional ... the average staining intensity within the examined lesion, according to the arbitrary scoring: “-” = absent; “+”, faint; “++”, weak; “+++”, moderate; “++++”, strong; 3 Immunostaining was prevalently

Ngày tải lên: 29/09/2020, 16:16

... (chemo)radiotherapy with curative intent following discussion in a multi-disciplinary meeting, measurable primary cancer on routine pre-treatment im-aging (CT and/or MRI), and provision of fully informed consent ... timepoints ✶= median data point at each imaging timepoint Coloured lines represent individual patients. Trang 7reductions in tumour size during treatment in a range ofhead and neck tumour sites emphasizes ... AccessAlterations in anatomic and functional imaging parameters with repeated FDG PET-CT and MRI during radiotherapy for head and neck cancer: a pilot study Manil Subesinghe1,2, Andrew F Scarsbrook1,2,

Ngày tải lên: 30/09/2020, 13:07

... imaging, PET-MRI fusion, Retrospective image fusion, Side-by-side analysis, Head-and-neck cancer, Staging Background Clinical examination and imaging is routinely performed for the staging of head-and-neck ... data; drafting and revising the manuscript JD: analysis and interpretation of data; drafting and revising the manuscript LMR: analysis and interpretation of data; drafting and revising the manuscript ... analysis and interpretation of data; drafting and revising the manuscript AP: analysis and interpretation of data; drafting and revising the manuscript ME: analysis and interpretation of data; drafting

Ngày tải lên: 30/09/2020, 15:04

... Experimental and clinical data suggest that solid cancers contain treatment-resistant cancer stem cells that will impair treatment efficacy The objective of this study was to investigate if head and neck ... [33] and pancreatic cancer [34] Interest-ingly, in prostate cancer [35], breast cancer [16,36], and glioma [21,25] cells with low proteasome activity are radioresistant and patients with breast cancers ... of the developmental Notch signaling pathway links the CSC phenotype with the proteasome Musashi, a RNA binding protein crucial for maintaining Notch signaling, binds to the 3’-UTR of NF-YA mRNA,

Ngày tải lên: 05/11/2020, 01:29

... up-regulated in many cancer types, includ-ing lung cancer and lymphoma [27,28] Accordinclud-ingly, miR-17-92 cluster members have been shown to take part in feedback loops determining the role ... pathways and were shown to be broadly involved in cancer development (Additional file 2) Figure 3 Expression of miR-10b in the cell lines SCC25, SCC9 and FaDu, and of miR-196a in normal keratinocytes ... catalog number CCL-92), which were irradiated (60 Gy), and maintained in an incubator at 37°C, in a humidified atmosphere containing 5% CO2and grown as previously described [22] Transfection of

Ngày tải lên: 05/11/2020, 05:32

... Feline HNSCC serves as a clinically relevant model for the investigation of intratumoral hypoxia including its measurement, modulation and targeting Keywords: Hypoxia, Head and neck cancer, Feline,64Cu-ATSM ... apart with treatment administered in the intervening interval Similar location of the probe was attempted as outlined in the materials and methods After one week, there was minimal change in tumor ... VEGFR2 inhibitor 64Cu-ATSM PET/CT and intratumoural fluorescent O2 measurements were performed 7 days apart, with treatment occurring in the intervening interval Lower case letter a and b indicates

Ngày tải lên: 05/11/2020, 06:22