head and neck cancer prognosis stage 4

... papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer: a systematic review and meta-analysis of trends by time and region Head Neck 2013;35:747 –55. 10 Fakhry C, Westra WH, ... E6/E7 oncogene and p53 function within tumours were associated with the widely reported improved patient survival and prognosis in head and neck cancer Methods: HPV16 DNA, mRNA and p53 mRNA presence ... papillomavirus and p16 overexpression in oropharyngeal tumours: a systematic review Br J Cancer 2014;110(6):1587 –94. 36 Chung CH, Gillison ML Human papillomavirus in head and neck cancer: its role

Ngày tải lên: 21/09/2020, 01:35

... proliferation, and differentiation in endochondral bone formation process13,14 and is an important transcription factor in breast and prostate cancer development and progression15 In breast cancer cells and ... 1Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation Wei-Min Chang1,2,3,*, Yuan-Feng Lin4,*, Chia-Yi Su3, Hsuan-Yu Peng2, Yu-Chan ... study, we investigated the role of PTHLH in head and neck cancer by Figure 4 RUNX2 controls HNSCC cell growth (A and B) The in vitro proliferation (A) and in vivo tumor growth (B) abilities in

Ngày tải lên: 04/12/2022, 15:59

... Oropharynx Hypopharynx ALL HEAD AND NECK CANCERS Trang 5DIAGRAM OF THE LYMPH NODES LEVELS IN THE NECKIII IV V VI ALL HEAD AND NECK CANCERS Comprehensive neck dissection Radical neck dissection All ipsilateral ... structures (most suprahyoid tumours). D ALL HEAD AND NECK CANCERS Trang 3Histopathology reporting of specimens from the primary site of head and neck cancer should include:  tumour site  tumour ... Fine needle aspiration cytology should be used in the investigation of head and neck masses D The risk of having head and neck cancer can be reduced by:  not smoking or chewing tobacco  limiting

Ngày tải lên: 15/03/2014, 01:20

... ± 9.8 [max 40.8] V 40Gy [%] <50% 20.0 ± 15.7 [max 43.2] Larynx Mean [Gy] 34.9 ± 6.4 [max 44.3] V 40Gy [%] <50% 26.6 ± 14.6 [max 42.8] Eyes Mean [Gy] 23.5 ± 8.8 [max 43.6] V 40Gy [%] <50% ... <50Gy 46.7 ± 6.8 [max 56.3] Chiasm D 1% [Gy] <50Gy 40.7 ± 9.0 [max 47.4] Healthy tissue Volume [dm3] 12.57 ± 4.56 11.40 ± 6.42 Mean [Gy] 6.4 ± 2.9 4.4 ± 2.2 V 5Gy [dm3] 3.21 ± 1.42 2.36 ... therapy for head and neck carcinoma The Oncologist 2007, 12:555-564. 2 Lee N, Puri D, Blanco AI, Chao KS: Intensity modulated radiathion therapy in head and neck cancers: an update Head and Neck 2007,

Ngày tải lên: 09/08/2014, 09:20

... Radiotherapy for Locally Recurrent Head-and-Neck Tumors Int J Radiat Oncol Biol Phys 14 Langlois D, Eschwege F, Kramar A, Richard JM: Reirradiation of the head and neck cancers Radiother Oncol 1985, ... head and neck cancer with curative intent Int J Radiat Oncol Biol Phys 1994, 29:687-698. 16 Ohizumi Y, Tamai Y, Imamiya S, Akiba T: Prognostic factors ofreirradiation for recurrent head and neck ... asreirradiation for locally recurrent head and neck cancer Int J Radiat Oncol Biol Phys 2009, 74:1348-1455. 30 Ogita M: Iamge guided radiotherapy (IGRT): Advancement and New technology of CyberKnife

Ngày tải lên: 09/08/2014, 09:21

... with head and neck cancer Head Neck 2000, 22:474-82. 37 Stenson KM, MacCracken E, List M, Haraf DJ, Brockstein B, Weich-selbaum R, Vokes EE: Swallowing function in patients with head and neck cancer ... food", (grade 3); and "I cannot swallow", (grade 4) Grade 3 and grade 4 defined high grade dysphagia Mucositis and xerostomia was evaluated weekly during treatment, and at follow-up, ... Rosenthal DI, Lewin JS, Eisbruch A: Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer J Clin Oncol 2006, 24:2636-43. 6 Garden AS, Harris J, Vokes EE, Forastiere

Ngày tải lên: 09/08/2014, 10:20

... 2.4 82 50 7 10 oro T4N2b LR distant AD 13 100 2 255 8 4 11 oro T4N2c NR distant DOD 3 34 15 179 8 4 12 oro T4N0 Persistence DOD 0 57 0 188 5 2 13 oro T3N2b Persistence distant AD 0 97 5 393 14 ... patients, and 6 % grade 3 skin reactions; 62 % devel-oped grade 3 acute reactions [17] Chao et al [4] found 37 % grade 3/4 skin toxicity, 40 % grade 3/4 mucositis in 74 oropharyngeal cancer patients ... IMRT of head and neck tumors (Table 5) Most of these results are superior to historic results following 3DCRT series with disease free survival rates ranging between about 40 and 88 % [4,7] Actuarial

Ngày tải lên: 09/08/2014, 10:20

... angiogenesis, immune and proinflammatory responses, and therapeutic resistance in head and neck squa- mous cell carcinoma (HNSCC) and other cancers [3-5]. How- ever, nuclear activation of hetero- and homodimers ... differentially expressed by head and neck cancer cell lines differing in p53 status. There were 748 NF- κ B targets predicted and individually annotated for RELA, NF κ B1 or cREL regulation, and a prevalence ... identified and associated with a higher risk for HNSCC recurrence and metastasis by independent groups [43,44]. However, the individual genes and proteins identified from the molecular and clinical

Ngày tải lên: 14/08/2014, 08:20

... targeted therapeutics, head-and-neck cancer, RNA interference, drug delivery, ra-diosensitization, photothermal therapy Introduction Head-and-neck cancer is the sixth most common cancer worldwide, ... locoregionally advanced head-and-neck cancer reported significantly increased survival [147] Table 2 An outline of targeted nanodevices as radiosensitizers in head and neck cancer therapy Carbon ... metabolism and increased FDG uptake, and predict the hypoxic status of cancer [137-140] Over-expression of GLUT-1 may be a metabolic marker of radioresistance and an adverse prognosis [141, 142] This

Ngày tải lên: 15/01/2020, 16:59

... patients with head and neck cancer receiving outpatient treatment with concurrent high-dose cisplatin and radiotherapy Am J Clin Oncol 2018;41: 432 –40. 23 Prasaja Y, Sutandyo N, Andrajati R Incidence ... EORTC (#22931) and RTOG (# 9501) Head Neck 2005;27:843 –50. 4 Pignon JP, le Maître A, Maillard E, Bourhis J, MACH-NC Collaborative Group Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): ... cell head and neck cancer J Clin Oncol 2003;21:92 –8. 3 Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, et al Defining risk levels in locally advanced head and neck cancers:

Ngày tải lên: 17/06/2020, 18:48

... head-and-neck cancer (HNC) Though both epigenetic alterations [40,41] and aberrant alternative splicing [42,43] are in-dividually associated with the development and pro-gression of various cancers ... mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer Sandhya Yadav1, Somnath D Bhagat2, Amit Gupta1, Atul Samaiya3, Aasheesh Srivastava2and Sanjeev Shukla1* ... approach can provide an effective way to modulate cancer-specific-splicing and thereby aid in the treatment of HNC Keywords: Curcumin, Head and neck cancer, PKM, Warburg effect, Alternative splicing

Ngày tải lên: 17/06/2020, 18:58

... Research and Treatment of Cancer – Head and Neck module; EORTC-QLQ: European Organization for Research and Treatment of Cancer- Quality of Life Questionnaire; HADS: Hospital Anxiety and Depression ... Persistence of psychological distress and correlated factors among patients with head and neck cancer Palliative & Supportive Care 2016;14(1):42 –51. 4 Lin BM, Starmer HM, Gourin CG The relationship ... life, and swallowing function in head and neck cancer patients 1 year after definitive therapy Laryngoscope 2012;122(7):1518 –25. 5 Patterson JM, McColl E, Wilson J, Carding P, Rapley T Head and neck

Ngày tải lên: 23/07/2020, 23:44

... 2014;39:25 –9. 6 Katou K Nutrition support and oral Care for Head and Neck Cancer Patients Undergoing Chemoradiotherapy Head and Neck Cancer Frontier 2014;2: 48 –51. 7 Valente VB, Takamiya AS, Ferreira ... treatment by radiotherapy and/or chemotherapy (hereinafter re-ferred to as “CRT”) for cancer in the head and neck region with severe oral stomatitis Radiotherapy for head and neck cancer has a nearly ... Genomic insights into head and neck cancer Cancers of the Head & Neck 2016;1(1) 2 Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, et al. Perspectives on cancer therapy-induced

Ngày tải lên: 24/07/2020, 01:55

... pa-tient wellbeing and rehabilitation after cancer therapy, and very interestingly a tumor-inhibiting effect of exer-cise is being unraveled [27, 42–47] In particular head and neck cancer patients ... Sport and cancer CAMI Crit Rev Oncol Hematol 2015;94(1):74 –86. 45 Brown JC, Winters-Stone K, Lee A, Schmitz KH Cancer, physical activity, and exercise Compr Physiol 2012;2(4):2775 –809. 46 Ibrahim ... Der Laan BFaM V, Pruim J, et al Changes in nutritional status and dietary intake during and after head and neck cancer treatment Head Neck 2011;33(6):863 –70. 15 Van Den Berg MG, Rasmussen-Conrad

Ngày tải lên: 06/08/2020, 07:25

... swallowing interventions, and to explore any relationships between these strategies and intervention effects Randomised and quasi-randomised studies of head and neck cancer patients were included ... 374 Average age across studies was 59.4 years Both the gender and age demographics are broadly reflective of the epidemiology of HNC [48, 49] Patients’ HNC diagnosis ranged from stage II to stage ... [27] and Performance Status Scale (PSS) [28], patient-reported and QOL measures such as the MD Anderson Dysphagia Inventory (MDADI) [29] and European Organisation for Research and Treatment of Cancer

Ngày tải lên: 20/09/2020, 01:02

... included multiple primary HNC, esophageal cancer, gastric cancer, prostate cancer, lung cancer, and renal cancer All of these cancers were found at an early stage by routine endoscopic or computed ... Center, Sunto-gun, Shizuoka, Japan 4 Division of Head and Neck Surgery, Shizuoka Cancer Center, Sunto-gun, Shizuoka, Japan.5Division of Dental and Oral Surgery, Shizuoka Cancer Center, Sunto-gun, Shizuoka, ... HNC: Head and neck cancer; IMRT: Intensity-modulated radiation therapy; OS: Overall survival; PPIs: Proton pump inhibitors; RND: Radical neck dissection; RT: Radiotherapy; SND: Selective neck

Ngày tải lên: 20/09/2020, 01:10

... p53 mutant head and neck cell lines CAL27, FaDu and HN5 a Clonogenic drug scheduling 5 nM AUY922 was added 16 h before addition of 5 μM cisplatin and/or immediate irradiation Cisplatin and AUY922 ... nucleus at 4 h and for CCRT and CCRT + AUY922 conditions at 24 h also Values shown are means ± SEM of a minimum of three independent experiments c Western blot analysis of pS1524 BRCA1 and pS15 ... Ser1981 [40] FANCA mutation and ATR loss have both been shown to increase phos-phorylation of S1981 ATM and S15 p53 [41, 42] with ATM known to phosphorylate S15 of p53 in response to DNA damage [43]

Ngày tải lên: 20/09/2020, 01:18

... targets in head and neck squamous cell carcinoma Curr Opin Oncol 2012;24(3):235 –42. 5 Marur S, D'Souza G, Westra WH, Forastiere AA HPV-associated head and neck cancer: a virus-related cancer epidemic ... between HPV-related head and neck cancer and cervical cancer Br J Cancer 2012;106(9):1526 –34. 24 Kaczkowski B, Morevati M, Rossing M, Cilius F, Norrild B A Decade of Global mRNA and miRNA Profiling ... papilloma virus and p53 in head and neck cancer: clinical correlates and survival Clin cancer res : an official journal of the American Association for Cancer Research 1996;2(4):755 –62. 74 Lajer CB,

Ngày tải lên: 22/09/2020, 23:35

... head and neck cancer 6 months after diagnosis Head Neck 2009;31(9):1207 –14. 26 Rogers SN Quality of life for head and neck cancer patients –has treatment planning altered? Oral Oncol 2009;45(4 ... diagnosis of head and neck cancer –a longitudinal study Head Neck 2001;23(2):113 –25. 6 Langius A, Bjorvell H, Lind MG Oral- and pharyngeal-cancer patients ’ perceived symptoms and health Cancer Nurs ... 2009;10(3 –4):195–204. 10 Pignon JP, le Maitre A, Maillard E, Bourhis J Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients

Ngày tải lên: 23/09/2020, 00:08

... making in head and neck cancer care Laryngoscope 2010;120:2434 –45. 6 McNeil BJ, Weichselbaum R, Pauker SG Speech and survival: tradeoffs between quality and quantity of life in laryngeal cancer ... prognostic modeling in head and neck squamous cell carcinoma Head Neck 2012;34:34 –41. 19 Hagerty RG, Butow PN, Ellis PM, Dimitry S, Tattersall MH Communicating prognosis in cancer care: a systematic ... –5.7 3.40* 1.8 –6.4 1.73 0.8 –3.6 7.22* 2.4 –22.1≥65 years -Female Comorbidity score (ACE-27) Low (0 –1) a High (2 –3) Advanced (III-IV) Prior head and neck cancer yet treated 0.93 0.4 –2.4 0.99

Ngày tải lên: 28/09/2020, 10:03