genetic studies in experimental cancer

... Terrain online tool with precise instruction could be found at http://terrainatlas.medeolinx.cn/user/login 3 Estimating the gene expression with the treatment Since the repurposing drugs in section ... In the prior study [8], by modeling the gene expression dynamic in breast cancer and applying system control theory, we suggested 10 drugs promising for breast cancer repurposing For breast cancer ... synthesizing new compounds Prominent successful examples for drug repurposing include viagra, avastin, and rituxan [6] 1 Informatics Institute, School of Medicine, the University of Alabama at Birmingham

Ngày tải lên: 20/01/2020, 05:25

... human geneticists interested in inferring the complex mapping of traits and diseases The rela-tively homogeneous genetic composition reported for Sardinian population has shown to be useful in depicting ... (phosphothreonine in position 198), and it is located in the linker region between the NH2-terminal domain and the BRCT1 (BRCA1 C-terminus) domain (positions 315–403); the Arg399Gln polymorphism oc-curs in ... contains 17 exons that encodes a 70 kDa protein consisting of 633 amino acids Shen et al [12] have iden-tified two polymorphisms resulting in nonconservative amino acid substitution variants in

Ngày tải lên: 17/06/2020, 11:31

... the dynamic interplay between environmental factors and other co-factors, including genetic predisposition, in the pathogenesis of bladder cancer [9] Protecting against carcinogen-induced and ... changes in carcinogens biotransformation leading to increased cancer susceptibility [2] In our investigation we examined the frequency of GSTP1 and GSTM1 variants in a cohort of 93 bladder cancer ... metab-olizing enzymes involved in catalyzing and detoxifying a variety of carcinogens including reactive electrophilic compounds [11] Members of the GST family play an important role in cellular

Ngày tải lên: 17/06/2020, 18:52

... determined using the following formula (ISTA, 1985) Seed vigour = Germination percentage × Seedling length (cm) Root length stress tolerance index (RLSI) and plant height stress tolerance index ... coefficients of variability akin to fresh weight of groundnut seedlings in the present investigation Further, it also showed similar tendency to that of fresh weight of seedlings in having high heritability ... considered in the in vitro screening have recorded high heritability with moderate to high genetic advance indicating the reliability of selection for these traits in identifying the drought tolerant

Ngày tải lên: 14/01/2020, 13:09

... grown in tropical regions of the world as a major protein rich crop bringing considerable improvement in human diet Average protein content in the seed is around 24 per cent The protein is comparatively ... analysis Accepted: 10 March 2019 Available Online: 10 April 2019 Article Info Trang 2in the amino acid lysine but predominantly deficient in cereal grains (Baskaran et al., 2009) Presently, the ... effects on seed yield indicating that there is always scope for enhancement of grain yield by selecting this trait The present results are in agreement with findings of Mishra and Singh (2012) and

Ngày tải lên: 14/01/2020, 13:45

... alarming increase in the population throughout the world, the demand for rice will continue to increase in near future Therefore, rice breeders across the world aim at increasing the grain yield ... Online: 10 September 2019 Article Info Trang 2Understanding of nature and magnitude of genetic variation governing the inheritance of relatively quantitative traits like yield and attributing ... fertility, are in contrast with present findings Since the estimates of heritability are in broad sense selection based on heritability alone is misleading hence another estimate called genetic advance

Ngày tải lên: 11/03/2020, 11:15

... growing of wheat is middle of November In order to meet increasing demands of food due to rising population and income, food production in India and other south Asian countries need to be increased ... rainfed About 70% of the world’s staple food continues and will continue to be harvested from rainfed areas In India rainfed agriculture occupies 67 percent net sown area (94 M ha), contributing ... percent of food grains and supporting 40 percent of the population In view of the growing demand for food grains in the country, there is a need to increase the productivity of rainfed areas from

Ngày tải lên: 11/03/2020, 11:40

... Aurora kinases are members of serine-threonine kinases family essential for cell cycle control [5] Aurora kinase A (AURKA) is in-volved in regulation of a several oncogenic signaling pro-cesses, including ... cytokinesis and plays a significant role in establishment of the correct kinetochore/microtubule binding [6] Aurora kinase C (AURKC) acts as a chromosomal passenger pro-tein, participating in the ... polymorphisms (SNPs) in genes encoding mitotic kinases could influence development and progression of gastric cancer (GC) Methods: Case-control study of nine SNPs in mitotic genes was conducted using qPCR

Ngày tải lên: 17/06/2020, 18:10

... confounders in-cluding smoking [9, 12] Genetically, recent genome-wide association studies (GWAS) or sequencing studies of lung cancer unveiled a role of inherited susceptibility component overriding ... largest sample size was included Studies with limited or incomplete data Trang 3including case studies, studies with only EGFR mutantcases or incomplete information associating with both EGFR mutation ... (rs7216064, BPTF) in Asians [62–64] These findings suggest underlying genetic modifiers responsible for a predisposition to somatic EGFR mutation in lung cancer Thus, it will be interesting to investigate

Ngày tải lên: 17/06/2020, 19:20

... predisposing breast cancer susceptibility variant in populations in Belarus, Russia, Ukraine and Poland [29] In another study, two protein-truncating mutations in the ATM gene were found in two ... of the kinase domain in the ATM gene in a series of women with breast cancer There are a few studies regarding associations between breast cancer development and the ATM gene mutation in the Polish ... hypothesize a role of variants in theATM, H2AFX and MRE11 genes in determining breast cancer (BC) susceptibility Methods: We examined the whole sequence of the ATM kinase domain and estimated the frequency

Ngày tải lên: 23/07/2020, 02:43

... of FATS as an E2-independent E3 toward p53, in addition to pinpointing a genetic marker with potential value in predicting breast cancer risk in women with parity ≥3 Once this genetic variant ... ubiquitination and activation a Purified GST protein or GST-tagged FATS protein was incubated with purified E1 and ubiquitin protein in ubiquitination buffer at 30 C for 90 min The polyubiquitination ... FATS protein was incubated with purified E1, ubiquitin and p53 protein in ubiquitination buffer at 30 °C for 90 min The non-proteolytic polyubiquitination was examined by Western blot using a p53-specific

Ngày tải lên: 28/09/2020, 01:25

... vigour, fruit bearing ability, reduction in size of apple fruit and increasing attacks of pests resulting in low production and poor crop quality (Sen et al., 2015) Keeping in view, the present ... correlation coefficients were used in finding out their direct and indirect contribution towards yield per tree To have a deeper insight into, the direct and indirect effects of variables) on ... date of opening of first flower to the date of opening of last flower was taken as the duration of flowering Fruits retained in all the cultivars were recorded one week before harvesting of fruits

Ngày tải lên: 28/09/2020, 17:14

... care should be taken in comparing differ-ent thrombin assays [35], our CAT assay results are in line with previous studies in breast cancer reporting in-creased levels of thrombin formation [2], ... variant in breast cancer risk Correspondingly, other studies across cancer types did not succeed in finding an association with prothrombin G20210A [3,19,21,22,33] Pihuschet al found an increased ... Supporting our observations, the two latter studies also found that neither protein S nor protein C levels in patients deviated from healthy controls In a study of gastrointestinal cancer, Lindahlet

Ngày tải lên: 30/09/2020, 15:04

... plant in cross-2 but negative association in cross-1 A sound genetic information has been an indispensable prelude for modifying the vast array of gene frequencies to enable genetic enrichment in ... useful in determining suitable selection scheme for maximum genetic gain This information can also be used for locating the most important yield components Trang 6The purpose of the present investigation ... basic information regarding the genetic variability, heritability and inter-relationship at phenotypic levels for grain yield and its components in field pea Three parents used in the present investigation

Ngày tải lên: 14/10/2020, 17:57

... binding protein heterodimer in damage recognition, because the complex binds damaged DNA with high affinity [43] and can dramatically increase the repair rate of certain DNA adducts, including ... in lung cancer cases and in concurrent controls using a molecular method for genotyping Using the MEDLINE database, we identified genetic epidemiological studies [9-13] that provided information ... activated carcinogens can bind to DNA and form DNA adducts that are capable of inducing mutations and initiating carcinogenesis The capacity to repair DNA damage induced by activated carcinogens 61...

Ngày tải lên: 31/10/2012, 14:59

... Noninvasive imaging of αvβ3 integrin expression using 18F-labeled RGD-containing glycopeptide and β positron emission tomography Cancer Res 2001; 61: 1781–1785 46 Haubner R: αvβ3-Integrin imaging: ... Figure Experimental setting Our experimental setting demonstrating two rats prior to positioning in the PET-CT scanner and homemade injector (two animals can be examined in parallel per scanning) ... imaging of many human cancers overexpressing the GRP receptor such as breast cancer and prostate carcinoma [6–13, 40–41] Integrins play a key role in angiogenesis and tumor metastasis by mediating...

Ngày tải lên: 18/06/2014, 18:20

... FCS-containing media during genistein incubation and the incubation with higher genistein doses Mechanisms of interaction To search for mechanisms of interaction we investigated protein expression ... Genistein, a tyrosine kinase inhibitor, enhanced radiosensitivity in human esophageal cancer cell lines in vitro: possible involvement of inhibition of survival signal transduction pathways Int ... activity by genistein pretreatment could be shown Furthermore, a significant increase in cleaved PARP protein was measured following combined genistein and radiation treatment, indicating increased apoptosis...

Ngày tải lên: 09/08/2014, 09:22

... polymorphism interacts with heavy cigarette smoking in a multiplicative manner These findings contribute to the growing understanding of how genetic and environmental factors interact in RA pathogenesis, ... the indices of additive interactions between binary smoking variable and binary PTPN22 genotype fPmulti is the P value for multiplicative interaction term between binary smoking variable and binary ... not included in the final models As is evident comparing the results of a model taking only the matching factors into account, adjustment for potential confounders did not significantly influence...

Ngày tải lên: 09/08/2014, 10:23

... viz., minimum length of repeat-core, the size of the genomic library screened, screening stringency, oligos used for screening and SSR mining tools, notwithstanding the innate differences in genomic ... CS, Singh L: Fingerprinting of Indian coffee selections and development of reference DNA polymorphism panels for creating molecular IDs for variety identification In Proceedings of 20th international ... affinities within/between cultivated and wild coffee germplasm The diploid microsatellite data were examined for their potential in genetic diversity studies by studying the variation and interrelationship...

Ngày tải lên: 12/08/2014, 05:20

... eIF4E binding protein beclin-1-regulated autophagy AMP activated protein kinase artesunate bafilomycin A1 Bax-interacting factor big mitogen-activated protein kinase bovine serum albumin cycloheximide ... regulatory-associated protein of mTOR rapamycin-insensitive companion of mTOR reactive oxygen species Beclin-1 interacting and cystein-rich containing S6 kinase Small interfering RNA soluble N-ethylmaleimide-sensitive ... assembly site phosphate buffer saline phosphoinositide-dependent kinase phosphatidylethanolamine paraformaldehyde phosphoinositide 3- kinase protein kinase B protein kinase C proximity ligation assay...

Ngày tải lên: 09/09/2015, 08:16