gene therapy approaches for rheumatoid arthritis

... Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis Noriyuki Fujikado, Shinobu Saijo and Yoichiro Iwakura Center for Experimental ... the gene was present in both arthritic mice and normal mice Fold changes for gene expression were calculated, and genes with more than a threefold change in gene expression were selected for ... Distribution of arthritis-related genes on the mouse genome Distribution of arthritis-related genes on the mouse genome The num-bers of significantly changed genes are indicated for each chromosome...

Ngày tải lên: 09/08/2014, 08:22

... assessed the risk for RA in dominant, additive, and recessive models Gene-environment and gene-gene interactions We conducted assessments for gene-environment tions by testing for both additive ... allele and heavy smoking for both seropositive and seronegative RA We did not observe similar gene-smoking interactions for CTLA-4 or PADI-4, for the overall risk for RA, or for RF-posi-tive or ... susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study Proc Natl Acad Sci USA 1998, 95:10746-50. 3. Jawaheer D, Gregersen PK: Rheumatoid arthritis The genetic components...

Ngày tải lên: 09/08/2014, 10:23

... Articles in Arthritis Research & Therapy are listed in PubMed and archived at PubMed Central For information about publishing your research in Arthritis Research & Therapy go to http://arthritis-research.com/authors/instructions/ ... validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis Arthritis Research & Therapy 2011, 13:R155 doi:10.1186/ar3471 Jeffrey R Curtis ... activity indices for rheumatoid arthritis: validation of a clinical activity score Arthritis Res Ther 2005, 7:R796-806 van Gestel AM, Haagsma CJ, van Riel PL: Validation of rheumatoid arthritis improvement...

Ngày tải lên: 25/10/2012, 10:45

... Receptors 157 Molecular Chemotherapy 157 Antiangiogenic Gene Therapy 157 Virotherapy 158 Gene Therapy for Other Gynecological Cancers 159 Gene Therapy for Other Gynecological Disorders ... developmental gene transfer applications for gynecological diseases Key Words: gene transfer, gene therapy, ovarian cancer, cervical cancer, gynecological disease Contents Introduction 154 Gene Therapy ... rationalized gene transfer as an approach for the treatment of diseases resistant to more conventional therapies Gene therapy aims at transfer of genes for correction of either genetic or somatic...

Ngày tải lên: 22/03/2014, 11:20

... kinase A; PKC = protein kinase C; PMA = phorbol 12-myristate 13-acetate; RA = rheumatoid arthritis; RA-SMC = rheumatoid arthritis synovial membrane cell; RPMI = Roswell Park Memorial Institute [medium]; ... demonstrated for collagen-induced arthritis The aim of this study was to characterise its potential anti-arthritic effect on human monocytes, macrophages, T cells, and rheumatoid arthritis synovial ... pretreated for 1 hour with 10µMrolipram and then stimu-lated for 30 min with 10µM VIP before harvesting of cell lysates The stimulation time was previously defined in our laboratory as optimal for activation...

Ngày tải lên: 09/08/2014, 01:23

... core set of disease activity measures for rheumatoid arthritis clinical tri-als The Committee on Outcome Measures in Rheumatoid Arthritis Clinical Trials Arthritis Rheum 1993, 36:729-740. 14 Smolen ... Benefit of very early referral and very early therapy with dis-ease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis Rheumatology (Oxford) 2004, 43:906-914. 10 Ward MM, Lubeck ... 11 Smolen JS, Sokka T, Pincus T, Breedveld FC: A proposed treat-ment algorithm for rheumatoid arthritis: aggressive therapy, methotrexate, and quantitative measures Clin Exp Rheumatol 2003:S209-S210....

Ngày tải lên: 09/08/2014, 06:22

... Core Set for rheumatoid arthritis are shown in bold typeface. Table 4 (Continued) Body Functions (b): patients' reporting of ICF categories (2 nd level) Trang 9egories Both approaches performed ... Core Set for RA with respect to previous focus groups Saturation was checked separately for the two approaches Confirmation of the ICF categories contained in the Comprehensive ICF Core Set for RA ... Health; RA = rheumatoid arthritis; WHA = World Health Assembly; WHO = World Health Organization. Trang 2Arthritis Impact Measurement Scales (AIMS2 [4]), which canbe considered a generic instrument...

Ngày tải lên: 09/08/2014, 08:22

... M, Foxwell BM: Heterogeneous requirement of I κB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy Arthritis Rheum 2003, ... helper cells in rheumatoid arthritis Arthritis Rheum 1993, 36:603-607. 12 Firestein GS, Alvaro-Gracia JM, Maki R: Quantitative analysis of cytokine gene expression in rheumatoid arthritis J Immunol ... chemotactic cytokine for macro-phages in rheumatoid arthritis J Clin Invest 1994, 93:921-928. 7. Robinson E, Keystone EC, Schall TJ, Gillett N, Fish EN: Chemok-ine expression in rheumatoid arthritis (RA):...

Ngày tải lên: 09/08/2014, 08:23

... surface receptor for vascular endothelial growth factor (VEGF) – a key regulator of angiogenesis in rheumatoid arthritis Bioinformatics analyses predict that the majority of human genes undergo ... cycles of 95°C for 45 seconds, 60°C for 50 sec-onds, and 72°C for 1 minute The reaction was terminated with an elongation step of 72°C for 10 minutes For quantitative RT-PCR, gene-specific primers ... collagen-induced arthritis (CIA), which is in widespread use as a tool for developing new therapeutics Work in the acute CIA model formed the basis for the widespread clinical use of TNFα inhib-itors for...

Ngày tải lên: 09/08/2014, 10:23

... in combination with “switch*” or “sequential therapy” or “therapy inter-change,” and “rheumatoid arthritis.” Brand names of biologics were also used for each of the drugs cited above The search ... the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis Regina Rendas-Baum1, Gene V Wallenstein2*, Tamas Koncz3, Mark Kosinski1, ... years of age for the RCTs, and between 47 and 58 years of age for the observational studies), disease duration (between 10 and 13 years for the RCTs, and between 9 and 17 years for the observational...

Ngày tải lên: 12/08/2014, 15:22

... Thresholds for Additional QCA 140 Truth Table for 12 Strongly Supported Approaches to COIN and Case Outcome, with Higher Thresholds 141 Prime Implicants for 12 Strongly Supported Approaches ... COIN force was perceived as worse than the insurgents The COIN force avoided excessive collateral damage, disproportionate use of force, or other illegitimate applications of force The COIN force ... supported or favored the COIN force The COIN force or its allies relied on looting for sustainment The COIN force established and then expanded secure areas The COIN force and government had different...

Ngày tải lên: 06/03/2014, 09:21

... Relationships and Implications for the United States Air Force. RAND Project AIR FORCE RAND Project AIR FORCE (PAF), a division of the RAND Corporation, is the U.S Air Forces federally funded research ... Approved for public release; distribution unlimited PROJECT AIR FORCE The research described in this report was sponsored by the United States Air Force under Contract FA7014-06-C-0001 Further information ... prompted Turkey to begin to diversify its foreign policy and reduce its dependence on the United States for its security However, this effort to diversify its foreign policy was mitigated by the constraints...

Ngày tải lên: 22/03/2014, 21:20

... Center for Chemical Process Safety TP149.G8356 1996 680' 068'4—dc20 96-31457 CIP This book is available at a special discount when ordered in bulk quantities For information, contact the Center for ... publication Guidelines for Implementing Process Safety Management Systems, 1993, for guidance on obtaining buy-in The principles described for obtaining support and commitment for PSM are equally ... have established a schedule for project meetings, this can provide a tickler for updating internal communications Otherwise, establish a timetable (for example, monthly) for providing your internal...

Ngày tải lên: 02/04/2014, 16:31

... Required for Shock-Absorbing Surfacing Materials for Use Under Play Equipment 472 Appendix AA: Medication Administration Packet 474 Appendix BB: Emergency Information Form for ... need for these standards For example, while the work to prepare Caring for Our Children was underway, the National Research Council’s report, Who Cares for America’s Children? Child Care Policy for ... teachers in securing community resources for soy-based formula Standard 3.6.1.2: Staff Exclusion for Illness Provides updated information on those conditions for which staff should or should not...

Ngày tải lên: 12/02/2014, 11:20

... health, and the environment, and empowers them to use that information to advance the well-being of current and future generations For more information, visit www.prb.org GROWING UP IN NORTH AMERICA: ... Statistics – Birth Database — 3231 19 For 1999, SSA Boletín de Información Estadística No 19 Vol II, Daños a la salud, 1999 México, D.F 2000 For 2000, SSA Boletín de Información Estadística No 20 Vol ... Mexican civil organizations dedicated to children For more information, visit www.derechosinfancia.org.mx The Population Reference Bureau informs people around the world about population, health,...

Ngày tải lên: 12/02/2014, 12:20

... relevant information is fragmented and only available for fewer countries than for other RPGs For example, data on exposure to chemical hazards in food are only available for the general population ... Publications WHO Regional Office for Europe Scherfigsvej DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote ... other countries, an effort was made to obtain information from non-EU countries Future efforts will concentrate on increasing the geographical coverage of the system The information provided by...

Ngày tải lên: 12/02/2014, 12:20

... 18 LOOK - for signs LISTEN - for complaints FEEL - for fever SMELL - for unusual odor California Child Care Health Program Section Universal Precautions Rationale: Germs responsible for common ... everyone Don’t forget to have fun California Child Care Health Program Introduction Important Topics to Cover (for trainers with a limited amount of time) For the participants to qualify for certificates, ... Immunization Policy for Children • Health History and Immunization Policy for Providers • Preventive Health Needs of Staff • Keeping Health Records • Exclusion for Illness Policy • Caring for Children...

Ngày tải lên: 12/02/2014, 12:20

... to the furnace gas system for recovery into fuel gas or to flare; • Adopting closed loop systems for sampling; The normally accepted material loss for good operating performance is around 0.3 - ... carbon (only for methanol storage vents), absorption in water recycled to the process, or connection Formaldehyde to the suction of the process air blower (only for Primary sources of formaldehyde ... Very carefully handle phosgene, as follows: o Contain all phosgene operations in closed buildings; o Install phosgene sensors to monitor indoor concentrations; o If phosgene traces are detected,...

Ngày tải lên: 14/02/2014, 03:20

... California State Water Resources Control Board, October 27, 1998 • Ratcheting down EPA enforcement efforts The Bush administration’s budget proposals for 2004 would have eliminated 270 EPA enforcement ... extraordinary capacity for generating genetic variations and growing to immense population sizes at incredible rates; for microbes, minutes are tantamount to years.”85 Hospitals that care for the sick, ... advocate for more effective enforcement of environmental laws The organization was founded by Eric Schaeffer, former director of the U.S Environmental Protection Agency’s Office of Regulatory Enforcement,...

Ngày tải lên: 17/02/2014, 10:20

... guidelines for this sector for Total suspended solids mg/l 50 concentrated livestock feeding operations generating point Temperature increase °C

Ngày tải lên: 21/02/2014, 01:20