gene set and pathway based analysis for cancer omics

... nanocarriers and encompassed methods of fabricating nanocarrier-based drug delivery systems for controlled and targeted therapeutic application Chapter 1 provides general information of cancer and cancer ... systems for cancer therapy .13 5.1 Passive targeting strategies and recent developments 15 5.2 Active targeting strategies and stimuli-triggered ligand presentation 16 6 Stimuli-response for ... and damages healthy cells, tissues, and organs Initial treatment with chemotherapy and radiation will often reduce tumor size Radiation can cause cancer cells to mutate and become resistant and

Ngày tải lên: 21/05/2016, 23:06

... promising candidates for biomedical applications, iron oxide-based nanoconjugates are most widely investigated for using in MRI diagnosis [4, 10–13] and hyperthermia treatment [4,10,11,14–17] of cancer ... capped particles become enlarged, however, the mass analysis performed via thermogravimetric analysis (TGA) and magnetization for the case of chitosan and dextran materials showed that the weight contribution ... as indicated by DLS curves, leads to formation of larger clusters The preference of the cluster formation for the OL and CS ferrofluids is that, for the former case the clusters are clearly of

Ngày tải lên: 16/12/2017, 08:55

... process, and requires highly skilled analyst to carry out the chemical analysis of coal and ash On the other hand, determination of moisture and ash is relatively easy using moisture oven and muf-fle ... Bokaro, Talcher and from CCL command area in Jharkhand and Orissa All samples were crushed to pass 212 micron sieve The size of the samples was reduced by coning and quartering method and representa-tive ... Dr M Kumar, A Chakravorty and Dr M Jha, of CIMFR unit Ranchi for their cooperation in sample preparation and chemical analysis References [1] Ward, C.R (2002) Analysis and Significance of Mineral

Ngày tải lên: 13/01/2020, 16:55

... I and I and cluster I and II was (247.31) Cluster mean analysis was calculated using Tocher’s method for nine yield and its attributing traits and presented in Table 4 Higher cluster mean for ... inter and intra cluster distances were estimated as per the procedure outlined by Singh and Choudhary (1977) The analysis of variance for the individual character and analysis of covariance for ... to flowering, and maturity were the most important traits for genetic variability in landrace sorghums On the other hand, head width, head weight, grain yield per plant, and fresh and dry shoot

Ngày tải lên: 11/03/2020, 11:10

... Here, the values of % RSD and CV% of precision study for NIR method for protein, oil and fiber analysis were within the acceptable limits (<10% for RSD and <5% for CV % in majority of cases) ... superiority for rapidity and cost effectiveness over traditional method for protein, oil and fiber analysis from soy bean, pigeon pea and rice genotypes Economic efficiency and speed of analysis Routine ... 1990) NIR analysis For NIR analysis sample were grounded and passed through 0.5 mm sieve to prepare fine powder Powder was dried in oven at 50 C for 6 hrs to remove moisture Protein, fiber and oil

Ngày tải lên: 15/05/2020, 11:12

... options being employed for the improvement of crop Study of heterosis provides information about gene action and helps in identifying desirable gene action Combining ability analysis involved in ... suggested by Fonseca and Patterson (1968) respectively Where F1 = mean hybrid performance, BP = mean performance of better parents and MP = mean performance of mid parent Results and Discussion Combining ... Combining ability analysis The analysis of variance for combining ability manifest the significance of mean squares due to gca and sca for all the traits, except gca mean square for number of primary

Ngày tải lên: 15/05/2020, 12:26

... model for cancer genesis Arguments in favor of the protein-based model de-scribed above can be summarized in four major points: (i) the protein-based model for cancer genesis redefines cancer ... up AA proteins and there-fore unable to generate A1 and A2 entities vital for cancer existence (Fig.1) In summary cancer may begin with the pathological breakup of a functional and normal protein ... exploited by cancer cells is the secretion of high levels of MMPs and cancer cells emerging from a Fig 1 Simplified AA protein-based model for cancer genesis: In a normal cell AA protein forms one

Ngày tải lên: 03/07/2020, 00:48

... Figure 1 and 2 Seeds of the eight wheat genotypes were procured from Indian Institute of Wheat and Barley Research (IIWBR), Karnal and Wheat and Barley Section of Department of Genetics and Plant ... (Gauch and Zobel, 1997) and (2) GGE Biplot or Site Regression model (Yan and Kang, 2003) In GGE biplot analysis both genotypic effect (G) and its interaction with environment (GEI) are used for ... E5 and E6 were included in group 2 On the basis of the angle between two environmental vectors, the environments E4 and E2 formed one group while E3, E5, E5 and E6 formed another group E1 and

Ngày tải lên: 06/08/2020, 00:25

... pathways for cancer survivors-a role for patient-reported outcome measures and health informatics Acta Oncol 2015;54:1 –9. 4 Accreditation Canada Omentum program 2009 standards: cancer care and ... in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. Availability of data and materials The datasets during and/or analysed during the ... and work and social security related aspects For each theme, participants are asked whether they wish to receive information or support, how they prefer to receive in-formation and support, and

Ngày tải lên: 20/09/2020, 17:52

... of orthologous genes to generate the datasets, including DE genes, non-DE genes and unmapped genes for two species to mimic the real sce-nario The unmapped genes represent those genes that exist ... genes and the hypothesis testing framework Notations and model Let G = {g1, g2, , g n} be the complete set of genes from two different species, and G0 be the set of one-to-one orthologous genes ... DE genes at the 1.2-fold level; of those DE genes, 90% are up-regulated in the second species, and we set the number of unique genes as 1000 and 2000 for two species, respectively Besides, we set

Ngày tải lên: 25/11/2020, 12:07

... time-series genes of non-heterogeneity versus het-erogeneity We performed DTWscore analysis on various synthetic datasets and repeated the analysis times, and the results suggest that the DTWscore performs ... DTWscore for each gene was calculated using our pipeline By combin-ing the method to set thresholds, quantitative analysis has enabled the direct separation of heterogeneous and non-heterogeneous genes ... specific set of genes for het-erogeneity analysis Based on the DTW distance index, we normalized the DTW index values to reduce the bias toward extreme values After normalization, the gene with

Ngày tải lên: 25/11/2020, 17:41

... on Genetic Variability, Correlation and Path Coefficient Analysis for Morphological and Yield Traits in Different Arachis spp Kalyani Kumari * and N Sasidharan Department of Seed Science and ... flowering and days to emergence which were recorded on plot basis The data were subjected to statistical analysis and analysis of variance was calculated (Panse and Sukhatme, 1976) and following genetic ... valencia, peruviana and aequatoriana were evaluated for 28 quantitative characters to study the genetic variability parameters, correlation coefficient and path analysis Analysis of variance

Ngày tải lên: 28/04/2021, 02:07

... Boulevard, Langford Lane London SW19 4EU Kidlington, Oxford, OX5 1GB Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, ... #sd2 [, options2] This command thus expects the count, the mean and the standard deviation for thefirst sample and the same information for the second sample The options(options2) correspond to the ... areessentially forms of manipulating, or even literally transforming digital datarepresenting statistical data It is therefore paramount to fully understand howstatistical data are represented and how

Ngày tải lên: 26/08/2021, 16:30

... Gene- expression and network -based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in Glioblastoma Multiforme progression Rotem Ben-Hamo1 and Sol Efroni1,* ... molecular and clinical data sets with a set of computational algorithms we were able to identify a gene- gene and gene- microRNA network that significantly stratifies patient prognosis By combining gene- expression ... Database [12] Gene- expression analysis Pathway Consistency and Pathway Activity metrics were calculated according to [11] and [20] These measures treat the pathway as a network of interactions and give...

Ngày tải lên: 11/08/2014, 12:21

... changes in a large number of genes and pathways, we wondered whether pathway analysis may help us identify “dominant” pathways for each drug resistance phenotype Using pathway analysis, we were indeed ... 3C) Pathway enrichment analysis of these genes revealed that the most significantly enriched pathway was “fatty acid metabolism and oxidation” (4 genes were part of this pathway) Certain genes ... ovarian cancer cell lines To identify genes and pathways important in the development of drug resistance, we performed gene expression profiling analysis on the OV90 drug sensitive cell line and...

Ngày tải lên: 20/06/2014, 08:20

... of gene set sizes and probabilities: For example, there were 260 sets containing between 20 and 30 genes, 124 sets containing between 75 and 125 genes, and 23 sets containing between 225 and ... the genes in a specific gene set to get a binary gene set statistic, which is one if the gene set is altered in the patient and zero if it is not We then obtain a statistic for each gene set ... these gene sets using hypothetical genes To generate realistic genes we sampled nucleotide compositions and sequencing coverage from the real genes in [4] For each of the spiked-in sets and each...

Ngày tải lên: 09/08/2014, 22:23

... of gene set sizes and probabilities: For example, there were 260 sets containing between 20 and 30 genes, 124 sets containing between 75 and 125 genes, and 23 sets containing between 225 and ... the genes in a specific gene set to get a binary gene set statistic, which is one if the gene set is altered in the patient and zero if it is not We then obtain a statistic for each gene set ... these gene sets using hypothetical genes To generate realistic genes we sampled nucleotide compositions and sequencing coverage from the real genes in [4] For each of the spiked-in sets and each...

Ngày tải lên: 09/08/2014, 22:23

... target genes encoding regulators of immune and inammatory responses and also genes involved in apoptosis and cell proliferation [36] In this paper, we report the results of cell -based, in vitro and ... this NF-jB signaling pathway should be tested not just in vitro and cell based but also simulated in silico Combining this method of analysis (in vitro, cell -based and in silico analysis) will facilitate ... performed using the same protocol as that described for the Tris HCl MgCl2 and Hepes MgCl2 MnCl2 assay Kinetic analysis For two substrate prole analysis, initial velocity studies were performed...

Ngày tải lên: 16/03/2014, 11:20

... Software for Genetic Data Analysis Genetics and Biometry Laboratory, University of Geneva, Geneva 2000 41 Slatkin M: A measure of population subdivision based on microsatellite allele frequencies Genetics ... Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 2005, 21:263-265 43 Raymond M, Rousset F: Genepop (version1.2): population genetics software for exact tests and ecumenicism ... starting assumptions For each pair of populations (i, j), and for all loci, we calculated F i and Fj (Fi and F j are the populationspecific divergence; for details see [7,49]) and generated the expected...

Ngày tải lên: 14/08/2014, 13:21

... dissertation I am grateful to him for instilling in me a deep respect for the data, for sharing his wisdom, and for making me realize the attractiveness of studying languages and linguistics I also owe ... the grammatical and semantic characteristics of onomatopoeia The former includes Kloe (1977), Kaida et al (1985) and Taylor (2006), and the latter Schourup (1993) and Tamori and Schourup (1999) ... (documents, reports, etc.) / Learned and scientific writings / General fiction / Mystery and detective fiction / Science fiction / Adventure and Western fiction / Romance and love story / Humor) This...

Ngày tải lên: 24/02/2014, 18:20