gene regulation and information flow

... points (DPs) and other priority information requirements (PIRs) have been reached, and this often involves working closely with recon and surveillance (R&S) elements Information flow also occurs ... because of the high level of human decision-making (i.e command and control), and the coordination and exchange of information within and between battle staffs Fortunately, intelligent agent technology ... allows for basic message passing and information exchange between agents Messages are stored in queues local to each agent and can be retrieved and handled through tasks and methods within the agent's

Ngày tải lên: 18/10/2022, 10:36

... PPARγ ligands in different cancer cells, which in turn is linked to mitochondrial damage and subsequent cell death (Ichihara and Pelliniemi, 2007; Ito et al., 2007; Julie et al., 2008; Wang and Mak, ... demonstrated that PPARγ activation leads to down-regulation of NHE1 expression, and PPARγ ligands significantly inhibited the short-term cell viability and long-term colony forming ability in various ... formation and loss in colony-forming ability brought about by 15d-PGJ2, we concluded that repression of NHE1 expression by PPARγ ligand is involved in the anti-tumor effects of PPARγ ligands REGULATION

Ngày tải lên: 09/09/2015, 10:19

... To this end, MCF-7, MDA-MB-231 and T47D cells were treated with different doses of synthetic ligands as well as natural ligand of PPARγ, and the protein expression and mRNA transcript level of ... varied from ligand to ligand, this could be explained by the different binding affinities of these ligands to PPARγ receptor Taken together, we surmise that PPARγ ligands induced down-regulation ... Jeong and Yoon, 2011) Having established NHE1 gene as a bona fide PPARγ target gene and an important therapeutic target, we next examined whether ERα interferes with PPARγ-dependent down-regulation

Ngày tải lên: 09/09/2015, 10:19

... dimerization and transcriptionally inactive by disabling both AF1 and AF2 domains of ERα (Fawell et al., 1990) Raloxifene acts as an estrogen antagonist in both breast and uterus (Mitlak and Cohen, ... (Thiebaud and Secrest, 2001) To ascertain that both fulvestrant and raloxifene acted as ERα antagonist in our system, the protein expression of two ERα target genes, progesterone receptor and Trang ... inhibit ERα transcriptional activity and facilitate down-regulation of NHE1 expression by PPARγ ligand Trang 12Figure 23: ERα antagonists enhance PPARγ-mediated down-regulation of NHE1 in regular serum

Ngày tải lên: 09/09/2015, 10:19

... ROLE OF NF-κB AND HISTONE DEACETYLASE IN GENE REGULATION CHEW SOO FEN NATIONAL UNIVERSITY OF SINGAPORE 2008 Trang 2 THE ROLE OF NF-κB AND HISTONE DEACETYLASE IN GENE REGULATION ... of genes encoding cytokines (IL-1 and TNFα) and growth factors (VEGF and CSF) These secreted cytokines and growth factors bind to the receptors expressed on adjacent tumour cell surface, and ... and metastasis (Karin and Greten, 2005) In the first phase of tumourigenesis, the DNA of a normal cell becomes mutated by physical and chemical carcinogens, leading to the activation of oncogenes

Ngày tải lên: 14/09/2015, 08:45

... (1979) and Lane and Crawford (1979) first detected p53 in complexes with SV40 T antigen Since then numerous research has been done on this gene p53 gene is approximately 20 kb long with 11 exons and ... apoptosis and genomic integrity Upon DNA damage, p53 is activated and the regulation of p53 is controlled both transcriptionally and through posttranslational modifications including phosphorylation and ... 1997; Kapoor and Lozano, 1998; Blaydes and Hupp, 1998; Siliciano et al., 1997) Once activated, p53 forms a tetramer and binds to the p53 responsive element on the target genes and stimulates

Ngày tải lên: 15/09/2015, 17:10

... gratitude for his support and encouragement, for his enlightening teachings and guidance, and for his invaluable mentorship and friendship He has created a unique and yet conducive environment ... Molecular Nephrology and Gene Regulation, who made the lab such an enjoyable place to work and learn Special thanks to fellow colleagues Sharon Thio, Christopher Yang, Shahidah, Jit Kong and Chui Sun ... their moral and technical supports, for reviewing my manuscripts and for many constructive and insightful discussions I also wish to acknowledge Olivia Chao, for her generous friendship and help

Ngày tải lên: 16/09/2015, 17:12

... regulatory GTPases and transcription factors 2.5 Epigenetic Gene Regulation Epigenetic gene regulation alters the transcriptional activity of genes without changing the DNA sequence Epigenetic control ... the third pathway of inactivation of genes besides loss of heterogeneity and gene mutation (Jones and Laird, 1999; Baylin and Herman, 2000) Epigenetic gene regulation can be imposed by many mechanisms ... modification, local nucleosome remodelling, and long-range epigenetic regulations (Lund and van Lohuizen, 2004) Epigenetic gene regulation collaborates with genetic alterations in cancer development

Ngày tải lên: 16/10/2015, 15:37

... to increase our understanding of the gene function, genetic regulation and compensatory processes This integrative approach provided new insights into the molecular basis and regulatory processes ... of candidate genes involved in secondary metabolic pathways and core metabolic processes responded to Psy1 down-regulation The aspartate rich domain (DXXXD) was important for PSY1 function, and ... to investigate gene function and regulation in wheat ultimately depends on robust, flexible, high-throughput reverse genetics tools RNA interference (RNAi) is a sequence-specific gene suppression

Ngày tải lên: 22/05/2020, 04:56

... was followed for gene regulation by Bax and Bcl2 gene with β-Actin as housekeeping gene The study concludes that Bcl2 gene showed more fold up regulation when compared with Bax gene on the pooled ... samples on Hep G2 cell line And to analyze the gene regulation with Bax and Bcl2 gene for the samples Materials and Methods Collection of samples Homemade curd and commercial curd were collected ... Lactobacillus acidophilus on Hep G2 Cell Line and its Effects on Gene Regulation with Bax and Bcl2 N G Ramesh Babu 1 , K A Simrah Fathima 2 *, V Nandhini 3 and V Nandhini 4 Department of Biotechnology,

Ngày tải lên: 06/08/2020, 00:41

... for Semantic Information Theories) concerning semantic information and information flow including Dreske (1981), Devlin (1991), and in particular, Barwise and Seligman’s (1991) information channel ... tackle information flow, IF insists on analyzing relations between tokens and types According to the second principle of information flow, i.e., ‘information flow crucially involves both types and ... applicable and adoptable both theoretically and practically with IF 3.1 Channel-Theoretical Information Flow The Channel-theoretical Information Flow theory (IF) is a mathematical model of semantic information

Ngày tải lên: 18/10/2022, 10:45

... to increase our understanding of the gene function, genetic regulation and compensatory processes This integrative approach provided new insights into the molecular basis and regulatory processes ... of candidate genes involved in secondary metabolic pathways and core metabolic processes responded to Psy1 down-regulation The aspartate rich domain (DXXXD) was important for PSY1 function, and ... to investigate gene function and regulation in wheat ultimately depends on robust, flexible, high-throughput reverse genetics tools RNA interference (RNAi) is a sequence-specific gene suppression

Ngày tải lên: 04/12/2022, 10:36

... investigates regulation of HLA-DR gene transcription, post transcriptional events and shedding of surface HLA-DR, as well as the regulation of HLA-DR by GM-CSF and an immunomodulatory cytokine Plasma and ... that an up-regulation of HLA-DR mRNA was observed from 2 hours culture and at time points 4, 6 and 8 hours Transcriptional regulation of HLA-DR by IFN-γ has previously been reported [10] and the ... the regulation of HLA-DR at the level of gene transcription has been investigated in patients with sepsis, this correlated with high cortisol levels and was thought to be acting on the down regulation

Ngày tải lên: 03/11/2012, 09:57

... Environment Standard), (2) Effluent Standards; and (3) Supporting Standards (testing, sampling standards etc) Most of supporting standards are adapted from those of International Organization for Standardization ... environmental regulations, like the US and EU markets, have to meet and anticipate these high standards But once satisfying these standards, they are more likely to have higher penetration rate and the ... economic and environmental state; (2) perceptions and barriers to their improvement of their environmental performance; and (3) their responses to the current environmental standards and policies and

Ngày tải lên: 24/08/2013, 18:48

... Relation to Sea Urchin Grazing and Water Flow Conditions, and Their Restoration Effort in Ogatsu Bay, Japan Hitoshi TAMAKI*, Keisaku KUSAKA**, Minji FUKUDA***, Shogo ARAI**** and Daisuke MURAOKA***** ... comparative study on the distribution of U pinnatifida and other macrophytes, bottom sediments, flow regime and density of sea urchin between the inner and outer areas of the Bay We also performed a ... surveys of the water velocities at randomly selected ten U pinnatifida habitats and twenty unvegetated areas in Line 1 and Line 2 were conducted in September 2004 and August 2005 Each area for the

Ngày tải lên: 05/09/2013, 09:38

... Schabacker, J., and Boles, A., “Experimental and numerical study of developed flow and heat transfer in coolants with channels with 45 degree ribs”, Int Journal of Heat and fluid flow, 20, 311-319, ... belonging to the secondary flow and partly belonging to the main flow through the gap As a result of the presence of gap, the secondary flow along the rib joins the main flow to accelerate it which ... function of roughness and flow parameters in the form of repeated ribs In order to understand the mechanism of heat transfer through a roughened duct having inclined rib with and without gap, the

Ngày tải lên: 05/09/2013, 16:10

... Evgenia V Kriventseva, and Nicola Mulder vii 17 19 Information Fusion and Metabolic Network Control ¨ Andreas Freier, Ralf Hofestadt, Matthias Lange, and Uwe Scholz 49 II Gene Regulation: From Sequence ... questions of gene regulation and metabolism without explicit mention of the connection between networks and the phenotype One of the challenges, computationally, in understanding gene regulation ... approaches to metabolism and gene regulation This is an area of computational biology that welcomes new methods, ideas, and approaches with the goal of generating a better understanding of the complex...

Ngày tải lên: 08/04/2014, 12:45

... retinoblastoma gene family and added to the complexity of cell cycle regulation This chapter will elaborate on the role of the retinoblastoma gene family in cell cycle regulation and tumor suppression ... Retinoblastoma Gene Family 4.1 Rb Gene Family Members The retinoblastoma gene family comprises, besides Rb, the structurally and functionally related Rb-like genes p107 (RBL1) and p130 (RBL2) ... hypothesis The Retinoblastoma Gene Family in Differentiation and Tumorigenesis Regulation of the E2F transcription factors is a key role of the retinoblastoma gene family and disruption of that function...

Ngày tải lên: 25/10/2013, 21:20

... anisomycin and FBS on actin stress fibers in SMCs and their modulation by toxin B and latrunculin B Cells were first stimulated with either S1P, anisomycin or FBS for 30 and then fixed, permeabilized and ... RhoA GTPase and p38 in transcriptional and post-transcriptional regulation of the CTGF/CCN2 gene In order to determine whether CTGF/CCN2 expression occurs via increased transcription and/ or by ... transcripts and the role of RhoA GTPase and p38 signaling in such a regulation, nuclear run-on assays and message stability analyses were carried out The transcription rate of the CTGF/CCN2 gene was...

Ngày tải lên: 19/02/2014, 16:20

... two-hybrid EcR gene switch with high ligand sensitivity and low background expression levels when compared to the earlier versions of EcR gene switches [14] The chemical-inducible gene regulation ... LmRXR and HsRXR LBDs as a partner of CfEcR, we were able to combine these two important aspects of the gene switch together and develop a tight EcR gene regulation system with improved ligand sensitivity ... VCH9, and GCfEVY + VCH9) and VGCfEQ454E, and monopartite (VGCfEH436E, VGCfEVY) switch formats and compared to the data obtained from the gene switches containing wild-type CfEcR (GCfEWt + VCH9 and...

Ngày tải lên: 16/03/2014, 06:20