gene expression changes and metabolic model

... habit and feeds on other snakes, reptiles and rodents (Lim and Ibrahim, 1970), and is widespread in Southeast Asia extending from Thailand to Trang 38Malaysia, Indonesian islands of Bali and Java ... blot and Chapter 5: GENERAL CONCLUSION AND FUTURE DIRECTIONS 5.1 General Conclusion and Future Directions 202 Trang 11SUMMARY OBJECTIVE: This study aims to explore the mechanism(s) of neuro-degeneration ... of Bungarus candidus Venom and Candoxin 108 3.7 Densitometric tracing curves of Bungarus candidus Venom and CDX 109 3.10 Brain wet-to-dry Weight Analysis after Injection of Candoxin 113 3.13...

Ngày tải lên: 15/09/2015, 17:11

... examine gene expression and miRNA changes in the brainstem and prefrontal cortex in a mouse facial carrageenan injection model of orofacial pain At the brainstem level, increased expression of genes ...       GENE EXPRESSION CHANGES IN THE BRAINSTEM AND PREFRONTAL CORTEX IN A MOUSE MODEL OF OROFACIAL PAIN POH KAY WEE (B.Sc.(Hons.), NUS) SUPERVISOR: ... expressed genes by real-time RT-PCR 60   3.4 Western blot analysis of P-selectin and ICAM-1 61   3.5 Immunohistochemistry of P-selectin and ICAM-1 62   3.6 Localization of P-selectin and ICAM-1...

Ngày tải lên: 10/09/2015, 08:34

... of new genes, to infer the role that individual genes or group of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression The quality of gene expression ... Trang 1GENE EXPRESSION CHANGES IN THE BRAINSTEM IN A MOUSE MODEL OF OROFACIAL PAIN DR LUTFUN NAHAR NATIONAL UNIVERSITY OF SINGAPORE 2009 Trang 2GENE EXPRESSION CHANGES IN THE BRAINSTEM ... hyperalgesia and secondary hyperalgesia, respectively (Urban and Gebhart, 1999) Increased release of SP from primary afferents (Otsuka and Yanagisawa, 1987, McCarson and Krause 1996) and increased expression...

Ngày tải lên: 07/10/2015, 09:55

... would reflect gene expressions shared between T2Bo and L17 and exclude L17-specific transcripts as gene family member variations are known to exist between different B bovis strains [15] Expression ... smORFs but 16 ves genes in T2Bo_V, and 13 smORFs but five ves genes in T2Bo_A, were upregulated, and none of the smORF gene locations were associated with those of ves, smORF gene transcriptional ... seven and eight ves α and β genes, respectively, were upregulated in T2Bo_V and among them, three α and β are paired in divergently oriented manner as described previously [16] Al-Khedery and Allred...

Ngày tải lên: 02/11/2022, 08:56

... prognostic genes including 19 genes (PC and NC) in stage I, four genes (PC) in stage II, 15 genes (PC and NC) in stage III, and 12 genes (PC and NC) in stage IV The Kaplan-Meier curves and Log-rank ... predisposing and triggering factors are involved in cancer progression, including genetics, epi-genetics, and environmental driver events [7 8] Such hidden events adversely affect gene expression or gene ... ‘Differentiation/Growth’, and ‘Cancer-Related’ pathways for stage II, ‘Filipodum’, ‘SMAD/ Bone’, and ‘Hormone’ pathways for stage III, and ‘Morpho-genesis’, ‘Angio‘Morpho-genesis’, and ‘PH-Regulation’...

Ngày tải lên: 30/01/2023, 20:32

... lead to changes in expression of thousands of genes [9,12,13] Another challenge is that the specificity and sensitivity of a given RNA profiling platform are affected by the abundance and variability ... copy number variation analysis and genome-wide gene expression Even though peripheral whole blood is one of the most easily accessed tissues for whole genome gene expression profiling, there are ... for gene expression profiling employing cDNA targets effectively mitigates the negative impact on data of abundant globin transcripts and greatly improves the ability to identify relevant gene expression...

Ngày tải lên: 18/06/2014, 16:20

... involve analysis of gene expression and the Figure 4 Changes in gene expression after storage in liquid nitro- gen. The changes in gene expression after thawing the cells and cul- turing for ... (passage 1) and higher passages, the graphs for compari- sons between higher passages are also presented. Of note, Figure 2 Changes in gene expression during passaging. (a) The changes in gene expression ... gene expression of the second passage is comparable to gene expression prior to freezing. Conclusions: The results of this study show, that experiments, which examine gene expression of RASF and...

Ngày tải lên: 12/08/2014, 12:20

... to study the pathogenesis at an early disease stage Knowledge of the gene expression pattern and the events that contribute to the genesis and progression of ANFH in this rat model could provide ... bound target was detected using the GeneChip Hybridization, Wash and Stain kit, and the GeneChip Fluidics Station 450 (Affymetrix) The arrays were scanned using the GeneChip Scanner 3000 7G (Affymetrix) ... G1 and G3, separately, and G3 replicates were compared with G1 to generate a list of differentially expressed genes The results were analyzed by a defined set of criteria in which the altered expression...

Ngày tải lên: 12/08/2014, 14:22

... identified through the use of gene profiling, but little is known about gene expression changes that occur with IT [11] Liu et al con-ducted a study to evaluate gene expression changes in patients undergoing ... up-regulated and 16 were down-regulated genes From these datasets, we have identified changes in immunologically relevant genes from both the innate and adaptive response with upregulation of expressed genes ... the authors found only modest differences in the gene expressions of the 32 genes More recently, Zhang et al analyzed gene expression of chemokines and their receptors in the nasal mucosa AR patients...

Ngày tải lên: 13/08/2014, 13:22

... observed expression signature. We present a strategy for identifying such signaling pathways and evaluate the strategy using six human and mouse gene expression signatures. Background Genetic ... procedure Gene expression signature Identification of putative transcription factor binding sites MotifScanner Pathways deregulated in the gene expression signature Expected: Randomly selected gene ... methods that relate gene expression signaturesor profiles to gene annotations. Two widely used methods for such analysisare EASE [7] and GSEA [10]. EASE uses a gene signature and can, among other...

Ngày tải lên: 14/08/2014, 07:21

... The changes in the expression of glucone- ogenesis and stress genes reflect the shift to glucose metabolism and the release from stress. Similarly, genes that are related to the TCA cycle and ... of genes [46]. The correlations between changes in gene expression of all approximately 6,000 genes are indicated for pairs of experiments. Change in gene expression is the average change in expression ... the most notable changes in gene expression were the early induction of genes associated with protein translation (rRNA process- ing and ribosomal proteins) and the repression of genes asso- ciated...

Ngày tải lên: 14/08/2014, 08:20

... lipogenesis and adipogenesis ADD1/SREBP1c can activate a broad pro-gram of genes that are involved in fatty acid and triglyceride metabolism in both fat and liver, and can also accelerate adi-pogenesis ... cluster 8]), is involved in G1/S progression and cyclin E expression [55] Correspondence between phenotypic changes and gene expression In addition to the metabolic networks, the molecular atlas ... with distinct expression profiles Relative expression levels (log2 ratios) for EST gene at different time points are shown and color coded according to the legend at the top (left) and expression...

Ngày tải lên: 14/08/2014, 16:20

... controlling unbiased gene expression Compari-son of sex-specific genes to unbiased genes will determine if the relationship between expression and genetic variation at sexually dimorphic genes is different ... in the various gene features and expression variation are still strong for average and highly expressed genes and weak for lowly expressed genes (data not shown) Highly expressed genes also show ... sex-biased expression, and trans factors might contribute more to male-specific gene expression than cis effects Our analysis of sex-specific gene expression also shows that female-sex-specific genes...

Ngày tải lên: 14/08/2014, 20:22

... UGT1A1 Region 23 VI Gene Expression Analysis 26 DISCUSSION I Gene Expression in Paired Normal and Tumor Samples 29 II Gene Expression in Baseline and Surgical Samples ... both tumor and normal surgical samples and expression in surgical samples was significantly upregulated, overall III Correlation of Gene Expression and Therapeutic Response Seven genes were analyzed ... normal and tumor samples to determine if there was a difference in their expression levels and found there to be greater expression in tumor samples than in normal samples 31 II Gene Expression...

Ngày tải lên: 24/08/2014, 10:58

... the 19 GENE TARGET PROPERTIES Codon Adaptation Index Codon Bias Connector Disorder Essentiality 5125 GENES Essentiality Expression 5125 GENES Expression Gene Duplication # of Interactors Gene Duplication ... transcription factors and their associated targets in the yeast regulatory network, relationships between gene properties such as expression and binding status and breast cancer type, and finally using ... extensive downstream remodeling of transcriptional programs, and the genes and molecular mechanisms affected by this dichotomy are of particular interest Identification of gene signatures of specific...

Ngày tải lên: 09/08/2014, 22:24

... NRE(A+B)); and in both Box A and B, NRE(A–B–) (C) Qualitative analysis of LacZ reporter activation in the interaction of APUM-2 and APUM-7 with NRE WT and NRE mutants The iron responsive element RNA and ... human and mouse possess two; and Drosophila and Dyctiostelium have only one member [5] Recently, new studies have revealed the presence of ten, two and one homologs in Trypanosome, Plasmodium and ... Francischini and R B Quaggio 14 Parisi M & Lin H (1999) The Drosophila pumilio gene encodes two functional protein isoforms that play multiple roles in germline development, gonadogenesis, oogenesis and...

Ngày tải lên: 18/02/2014, 06:20

... existence of SMO5 in human normal and tumor cell lines SMO5 cDNA was subcloned and sequenced, and active protein was produced, purified and assayed for kinetic properties and substrate specificities NCI-H157 ... decreases in intracellular spermine pools and increased spermidine levels in SMO1 and SMO5 cells These changes in spermine and spermidine levels in both SMO1 and SMO5 overexpressing cell lines were ... was novel and unexpected SMO activity assays of SMO ⁄ PAOh1 and SMO5 overexpressing nuclear and cytoplasmic extracts corroborate these data, showing spermine oxidase activity and H2O2 generation...

Ngày tải lên: 07/03/2014, 05:20

... language models: one on the combined English halves of the bitexts, and one on two billion words of English These were smoothed using modified Kneser-Ney (Chen and Goodman, 1998) and stored using randomized ... DeNeefe, Wei Wang, and Ignacio Thayer 2006 Scalable inference and training of context-rich syntactic translation models In Proc COLING-ACL 2006, pages 961–968 Mary Hearne and Andy Way 2003 Seeing ... David Talbot and Thorsten Brants 2008 Randomized language models via perfect hash functions In Proc ACL-08: HLT, pages 505–513 Ashish Venugopal, Andreas Zollmann, Noah A Smith, and Stephan Vogel...

Ngày tải lên: 07/03/2014, 22:20

... iron and steel and motor vehicles (2.8 per cent and 5.3 per cent respectively) and approximately the same size as the international trade in textiles (7.5 per cent), oil and gas (8.6 per cent) and ... Europe: Belgium, Denmark, Finland, France, Germany, Italy, Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom of Great Britain and Northern Ireland Sources: UNDCP country ... Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom); National price and purity data have...

Ngày tải lên: 08/03/2014, 06:20