from in silico data to the laboratory experiment

... other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material If material is not included in the ... were added to the reference database facilitating step by step the analysis since the coverage of the allelic spectrum by the database improved Alleles that matched those from IPD or from the NCBI ... from the initial (top: alignment of the RNA-Seq reads to the reference allele N*06:01, the range from nt 256 to 264, which is different from all known sheep alleles, is indicated by a red line)

Ngày tải lên: 30/01/2023, 21:04

... was thevariation in the positioning of the side chain of Phe330 The divergence in the orienta- tion of the aromatic ring of Phe330 must clearly be taken into account in designing anti-cholinesterse ... [42] After docking of compound A into the binding pocket, the selected flexible side chains were minimized with respect to the predicted pose After repositioning of the side chains, the ligand was ... all heavy atoms in the ligand and all heavy atoms in the tein, including any cofactor atoms and water molecule atoms that might be present Thepro-second term describes the electrostatic interactions

Ngày tải lên: 13/08/2014, 16:20

... 35 to 50% of them die The enormous case-fatality had led to an intense research effort to understand the complex pathogenesis of sepsis and to apply the acquired knowl-edge in therapeutic interventions ... participating in the Hellenic Sepsis Study Group [7] The aim of the study was to identify if the early statuses of the innate and adaptive immune systems of septic patients differ in relation to the ... collected into ethyldiamine tetracetic acid (EDTA)-coated tubes (Vacutainer, Becton Dickinson, Cockeysville, MD, USA) and transported to the central laboratory within less than eight hours at the fourth

Ngày tải lên: 13/08/2014, 20:22

... into the topic, brainstorming: making a list; comparing ideas; sharing experiences, activating language: eliciting and providing vocabulary In the second stage, the learners are expected to raise ... highlighted by the teacher In the task cycle, learners perform the task in pairs or small groups; rehearse their reports before presenting findings in front of the audience The final stage is the language ... English When they took the entrance exam to this university, they just took the test in math, physics and chemistry; therefore, they only paid attention to these subjects to pass the exam English

Ngày tải lên: 19/03/2015, 10:32

... before the intervention The students were told that the result of the test was counted in their final learning result; therefore, all the students did the test to the best of their ability The survey ... researcher was in charge of teaching reading As a result, effects from other factors on students‘ reading were limited to the minimum 2.3.2 Data collection instruments The data to be analyzed principally ... in reading comprehension The improvement in reading performance was strikingly illustrated through the difference in their reading results in the pre-test and post-test In order to examine the

Ngày tải lên: 28/03/2015, 09:05

... proliferating cells was shown to inactivate the protein, leading to cell cycle progression Inflammatory cytokines such as pro-interleukin-1-beta, pro-interleukin-16 and pro-interleukin-18 are ... and extrinsic (Figure 1-3) The extrinsic pathway is initiated when the CD95 ligand binds to the CD95 death receptor, leading to receptor oligomerization and the formation of the death inducing signaling ... led to the exposure of previously hidden pro-apoptotic domains on the native protein, converting these proteins into cell death effectors Caspase cleavage of MEKK1 leads to the exposure of a kinase

Ngày tải lên: 11/09/2015, 09:05

... help them to improve the pronunciation ability Trang 145 The scope of the studyAs could be seen from the title of the study, this paper investigates the use ofphonics instruction in teaching English ... which the thought is actualized orgiven audible shape: the nature of these noises, their combinations, and theirfunctions in relation to the meaning Phonetics is subdivided into practical andtheoretical ... passes fromthe larynx to the lips” According to English phonetics and phonology, vowel was defined asbelow:“Vowel is a speech sound in which the air stream from the lung is notblocked in any way in

Ngày tải lên: 14/09/2015, 09:29

... a) to find out the reality of applying TBL in teaching English speaking at high schools in Ha Tinh province b) to investigate student’s attitudes towards applying TBL in teaching English speaking ... s in Ha Tinh province The study tried to find out how TBL can fit into English speaking classes to promote the students’ communicative competence The methods for empirical investigation in the ... 4.2.1 The Reality of Teaching Speaking at High Schools in Ha Tinh province 42 4.2.2 The Reality of Applying TBL in Teaching Speaking Skills 54 4.2.3 The Teachers’ Difficulties in Applying TBL to

Ngày tải lên: 08/11/2015, 19:33

... According to the Internet Advertising Report (IAB) (2012), the Internet Advertising Revenues hit a historic high in the 3rd Quarter of 2012, with an 18% increase since the same period in 2011 ... possible to minimize the marketing waste and advertise as effectively as possible  Computing power vs storage costs  the increase in computing power has led to a significant decrease in storage ... individualistic behavior of the person, to one that tends towards being involved in a “community”, to interaction and involvement Trang 29According to Fill (2009), the traditional marketing mix has evolved

Ngày tải lên: 19/12/2016, 12:12

... rate, and the abstracts of the oral presentations in two international conferences Bibliography: All the references in the thesis, including those in the individual manuscripts Trang 21in the eastern ... defined as the earliest unit of the Galilee Basin It consists of mainly fine to medium grained sandstone with minor mudstone, which were deposited in the east part of the northern Galilee Basin by ... sandstones The grain size of sandstones dominating in the formation fines upwards, with a greater prevalence of siltstone before a conformable transition into shale, siltstone and minor sandstone

Ngày tải lên: 07/08/2017, 15:33

... Trang 3 Surveying and constructing the theoretical basis of speaking skill andlanguage games. Investigating and inquiring the reality, collecting data of teachingspeaking to the 10th students ... Thewinner is the one that gets the highest point Finally, the teacher can call the representatives from four groups to talk about theirfavorite teams, using the information they have gained via the quiz ... the situation of teaching and learning speaking to the 10th formstudents at Thong Nhat high school  Investigating the effectiveness of using games in teaching speaking to the 10th form students

Ngày tải lên: 17/10/2017, 10:41

... is stored together in memory is likely to beaccessed together These principles are leveraged by using caches, combining thebest of both worlds by leveraging the fast access to SRAM chips and the ... ComputingTrang 27• Data from various sources have to be combined in a single database ment system, andmanage-• This data has to be analyzed in real-time to support interactive decision taking.The ... for marketing campaigns or even to control the manu-facturing rate Another example for extracting business relevant information from the Web ismonitoring search terms The search engine Google

Ngày tải lên: 04/03/2019, 08:47

... 3.1.2 Being free from/minimizing barriers (to learning) Being free from or minimizing barriers refers to the removal of difficulties preventing one from engaging in the courses The barriers to learning, ... role, from being a transmitter of Trang 9information to being the support for students The corresponding changes in the teaching tasks include counselling, motivating the learners, and individualizing ... dominant technology at each stage The five stages cover the period from correspondence learning in the 19th century to the present era of interactive online learning It then examines how the

Ngày tải lên: 10/01/2020, 07:41

... mind ascription In the USA people find the state of UWS the more adverse the less mind they ascribe to the patients, whereas in Germany, the oppos-ite is true This could result from the general value ... variance explained by the regression model The final model was highly significant (F (7/210) = 5.39; p < 0.001) Together, the factors are able to explain 15.2% of the variance in mind ascription ... aversive situation To explain the generally low mind ascription to a UWS patient and the astonishingly high mind ascription to a dead person within the US sample, Gray argued that the ‘apparent reasons

Ngày tải lên: 10/01/2020, 14:07

... Honors Thesis in partial fulfillment of the requirements for the degree of Bachelor of Science in Business Administration in Accounting and Finance and for the degree of Bachelor of Science in International ... accounting information can compare the financial performance of a business in one country with that of a similar business in another country The financial statements for two businesses prepared using ... versions Other studies employ interview and survey techniques to gather information about specific problems that IFRS translators face Through interviews with the translators involved in the Finnish

Ngày tải lên: 11/01/2020, 17:06

... Honors Thesis in partial fulfillment of the requirements for the degree of Bachelor of Science in Business Administration in Accounting and Finance and for the degree of Bachelor of Science in International ... accounting information can compare the financial performance of a business in one country with that of a similar business in another country The financial statements for two businesses prepared using ... versions Other studies employ interview and survey techniques to gather information about specific problems that IFRS translators face Through interviews with the translators involved in the Finnish

Ngày tải lên: 13/01/2020, 03:17

... cofactor binding site for either pyrroloquinoline quinone (PQQ) or NADPH In particular, AASDH, containing a PQQ binding domain, is supposed to be involved in lysine degradation and to convert the ... domain of the ACV synthetase from Penicillium chrysogenum [7] The results of the docking experiments indicated (Fig 4) that the possible binding modes cluster into two solutions According to the first ... site of the phosphopantetheine attachment The resulting alignment was finally utilized to train the HMM The resulting HMM was used to align a subset of the A-T domains listed in Table The alignment...

Ngày tải lên: 23/03/2014, 13:20

... step in steroid synthesis [159] The PBR also binds some porphyrins, including protoporphyrin IX, a potent inducer of the PTP [160], and is thought to be involved in transport of porphyrins into the ... devoted to identifying the signaling pathways linking myocardial protection to PTP inhibition, which may involve protein kinase Ce [217] and mitogen-activated protein kinase kinase [218] An integrated ... of interest in the PT as an effector mechanism of cell death, however, only followed the demonstration that in the course of apoptosis, cytochrome c is released into the cytosol [72], together...

Ngày tải lên: 30/03/2014, 11:20

... if the shRNA were allowed to inhibit infection and act as a Class gene therapy, then the viral productivity of each infected neighbour was modified by the inhibition by the shRNA in the uninfected ... reduction in efficacy of each shRNA from 80% to 60% and kept all other parameters unchanged The reduction in efficacy from 80% (S1) to 60% (S4) led to a slight increase in the number of infected ... HSC from 20% to an apparently more biologically relevant 1% A reduction in the proportion of HSC containing shRNAs from 20% (S1) to 1% (S5) increased the number of infected cells from 35 to 42%...

Ngày tải lên: 13/08/2014, 01:20

... biotechnologists to develop new crops involving the tools of gene and metabolic engineering For example, scientists have been working on tomatoes that can be vine-ripened and shipped without bruising Others ... biotechnology Using established cell cultures, it is now possible to define the rate-limiting step in biosynthesis by determining accumulation of presumed intermediates, characterizing the limiting enzyme ... reduce the need for costly and highly toxic pesticides This applies also to nutritionally important constituents in crops The new techniques from the gene and metabolic engineering toolbox will bring...

Ngày tải lên: 25/10/2013, 05:20