finding sentences with biomolecular interactions

... I don"t have enough money with me now; otherwise I would buy that coat A If I didn"t have enough money with me now, I would buy that coat B If I had enough money with me now, I would buy that ... be harmful with our health => B 50 The scientists succeeded in finding a vaccine for that disease A The scientists were able to find a vaccine for that disease B The scientists were finding a ... money B They agreed with his wishes because they were glad to have his money C They didn’t know his plans and never took money from him D They took the money he offered them without realizing his...

Ngày tải lên: 23/05/2015, 15:31

Ngày tải lên: 11/07/2015, 09:20

... Kd of molecular interactions FCCS has been applied to study enzyme activities [44-46], polymerase chain reaction [47], DNA or RNA-protein interactions [48, 49], protein-protein interactions [50-56] ... particles tagged with fluorophores emitting at two different wavelengths are cross-correlated (Fig 2.3) For example, protein X is tagged with a green label while protein Y is tagged with a red label ... different dyes with different emission spectra and cross-correlating their signals Since then, FCCS became a powerful tool with the ability for the determination of molecular interactions 23...

Ngày tải lên: 10/09/2015, 08:38

... start with finding dense bipartite network structure and then mine motifs from the proteins within the structure) Methods finding SLiMs which are found within a statistically significant number of interactions ... instances of A IQ WR are listed along with their position in their respective protein sequences Among the 13 proteins with A IQ WR, of them (the IQ motif sites are marked with asterisks (⋆)) are annotated ... 0.05 The p-values of 17 of SLiMDIet’s Gapped PSSM are also ≤ 0.05 with 16 of them overlap with the 23 SLiMs from ELM and MnM with p-value ≤ 0.05 6.6 113 Domain-SLiM interface between...

Ngày tải lên: 10/09/2015, 15:52

... living organisms Biomolecular interactions between proteins, nucleic acids and small molecules are responsible for complex biological processes By studying these biomolecular interactions, life ... network of interactions in a cell But to resolve the underlying interactions involved in complex biological processes, it requires more than the identification with biochemical methods With recent ... The prism-based FCSpectrometer was first calibrated with fluorescein and AXSA with a single optic fiber and then tested for cross-correlations with biotinylated rhodamine green nanocontainers and...

Ngày tải lên: 14/09/2015, 10:36

... and has a piece of paper with the sentence in the correct order, with one extra space included, representing the 'mine' The other players play with a piece of paper with numbered blanks and the ... not thought of a sentence but work with the students' answers until you get a correct sentence of the required length Encourage students to play around with sentences until they hit the required ... married since October 2000.' The point is to make students think they are reading your mind, by finding the sentences so quickly, so pretend to be surprised when they are successful Sentence Fan Make...

Ngày tải lên: 06/09/2013, 10:10

... Having barricaded the windows, we assembled Becoming tired of my complaints, she turned it off Finding/ having found no one at home, he left Hoping to find the will, she searched Having removed ... Believing that she could trust him, she gave 32 Slates, ripped off by the gale, fell 33 The lion, finding his cage door open and seeing no sign of his keeper, left 34 The government, trying to tax...

Ngày tải lên: 13/09/2013, 21:10

... mediating interactions between tau and Fyn-SH3, and this further suggests that different, and possibly independent, mechanisms are involved in these interactions of tau with the same protein Interactions ... agreement with the findings of our previous study with synthetic tau peptides [21] Fig Pro216 in tau is important for its interaction with Fyn-SH3 CHO cells were transiently cotransfected with Fyn ... the association of tau with Fyn-SH2, but not with Fyn-SH3 This demonstrates that different molecular mechanisms exist for these two distinct interactions of Fyn and tau, with probably disparate...

Ngày tải lên: 14/02/2014, 14:20

... point of contact within the pharmaceutical firm coordinates all interactions with FDA for a specific product What options does DoD have in addressing the management of its relations with FDA? Three ... development or acquisition of drugs and biologics for CBW defense and interactions with FDA Acquisition involves three major interactions between DoD and FDA related to CBW defense: (1) licensing ... context, DoD interactions with FDA are a critical and oftenoverlooked issue DoD responsibility for CBW drug and biologics development is distributed across several organizations within the department...

Ngày tải lên: 17/02/2014, 11:20

... concluded to interact with bacterial membranes and UQs and also with thylakoid membranes and PQs Although NDH-2s are membrane-bound enzymes, the nature of membrane ⁄ protein interactions has not ... common features with already described NDH-2 genes (NCBI accession number AI2824) The putative A tumefaciens NDH-2 protein sequence (AtuNDH-2) showed relatively poor identity with E coli (NDH), ... fold and a GxGxxG motif [28] Based on a comparison with the lipoamide dehydrogenase sequence (an enzyme which shares significant similarity with NDH-2s and the structure of which has been resolved),...

Ngày tải lên: 19/02/2014, 06:20

... assessed intrinsically To so, we compare translation probabilities with concept vector based semantic relatedness measures with respect to human relatedness rankings for reference word pairs ... Wiktionary (Zesch et al., 2008), with good results While classical measures of semantic relatedness have been extensively studied and compared, based on comparisons with human relatedness judgements ... probabilities In this study, we use the correlation with human rankings for reference word pairs to investigate how word translation probabilities compare with traditional semantic relatedness measures...

Ngày tải lên: 20/02/2014, 07:20

... interactions with other proteins that comprise the multi-synthetase complex [16] Based on the finding that VLPs composed only of HIV Gag protein package human LysRS, it was hypothesized that interactions ... change with a functional consequence on viral infectivity Overall, the ability of CyPA to bind both Gag and CA presents the possibility of two such populations within virions Consistent with this ... and TRIM5a interactions with CA remain incomplete and additional biochemical and biophysical studies will be necessary before the full structural and functional consequences of these interactions...

Ngày tải lên: 07/03/2014, 00:20

... of the I2BS at 0.1 lm There was also no activation of MAO-A by any ligand, either with kynuramine (Fig 1) or with 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine (MPTP) (not shown) as a substrate, ... reversibly inhibit MAO, but with IC50 or Ki values in the micromolar range [5,6,17–20] Examples of the literature values for MAO inhibition measured in membranous samples with the ligands used in ... that the inhibition was competitive with the amine substrate The Ki values are given in Table There are only small differences between the values obtained with the two substrates, despite the...

Ngày tải lên: 07/03/2014, 10:20

... shown earlier that the interaction of HIP1 with normal Htt (a protein with fewer than 36 Gln) is stronger than that observed with the mutated Htt (a protein with more than 36 Gln residues) [10] On ... tested whether HIPPI could interact with the 5¢-AAAGACATG-3¢ () 101 to ) 93) motif present in the putative promoter of the caspase-1 gene Interactions of HIPPI with AAAGACATG and various mutants ... determined from the plateau region, obtained with AAAGACATG was calculated to be 1.2 nm (Fig 1C, panel I) A similar result was obtained with AAAGAGATG, with a dissociation constant of 0.3 nm (Fig...

Ngày tải lên: 07/03/2014, 10:20

... the responses obtained with immobilized albumin were subtracted from Ó FEBS 2004 Decorin interacting with type I and VI collagen (Eur J Biochem 271) 3391 those obtained with bound collagen The ... applied for h or h at 37 °C After extensive washing with blocking solution, bound proteoglycans were solubilized with 0.1 M NaOH and neutralized with 0.1 M HCl prior to scintillation counting KD ... fibroblasts 293 cells transfected with human wild-type decorin cDNA and human skin fibroblasts were metabolically labelled with [35S]methionine After immunoprecipitation with a monospecific antibody,...

Ngày tải lên: 07/03/2014, 16:20

... KD1 (blue) with an atom within 4.0 A of the other protein (= binding region) are indicated KD1 makes contact with all substrate ⁄ inhibitor specificity-determining loops on HGFA (compare with Fig ... incompetent and competent conformations is probably quite low, well within the energy provided by substrate interactions, and consistent with the notion of ‘induced fit’ This is probably the case for ... HGFA protease domain with HAI-1-derived KD1 (PDB 1YC0) (A) KD1 (magenta) interacts with HGFA (beige) in a substrate-like manner by occupying subsites S4, S2 and S1 (in orange) with Arg258, Cys259–Cys283,...

Ngày tải lên: 15/03/2014, 11:20

... described above, they found that vents with highly focused outflow of 10 cm s–1 support dense clams, whereas seepages, with low, diffuse flow were associated with dispersed clams and bacterial mats ... even microbial mat sites with net outflow were observed to have periods of LISA A LEVIN several months with little or no flow (Levin et al 2003) Pulsed expulsion events with short-term flow up to ... FISH with Secondary Ion Mass Spectrometry (SIMS) (Orphan et al 2001b, 2004) Microbial metabolic rates also vary with meso-scale habitat features; bacterial mats and different types of clam beds within...

Ngày tải lên: 15/03/2014, 19:20

... based on homology with radixin F1 in complex with IP3 and ´ S Beraud-Dufour et al with talin F2 to F3 (Fig 1B) These models displayed very stable secondary structures and energies with respect to ... full-length protein interact with Rap1, as shown by pull-down and asolectin vesicle sedimentation experiments Moreover, HypoKrit1 interacts with a higher affinity with Rap1GTPcS than with Rap1GDP, indicating ... transfected with Fugene6 transfection reagent (Roche Diagnostics) according to the manufacturer’s instructions BHK cells were cotransfected with pEYFP-Krit1 and pECFP-tubulin with or without pMT2-HA-Rap1V12...

Ngày tải lên: 16/03/2014, 05:20

... molecule’s interactions occur at the aminoacyl-tRNAs (A-site) Indeed, one set of bases protected by interactions of EF-P with the 70S ribosome occurs near the A-loop of the peptidyl- Ribosome interactions ... ribosome Bases protected against chemical modification by interactions with EF-P are shown in red; bases enhanced by the interactions with EF-P are shown in yellow The positions of the exit (E) ... filled with tRNA [33], but closes upon contact with the EF-Tu ternary complex [33] It is possible that EF-P binds to the T-site in order to maintain a closed A-site Ribosome interactions with elongation...

Ngày tải lên: 16/03/2014, 06:20