external validation of haq progression

... Fulfillment of the Requirements for the Degree of Doctor of Medicine By Anya Golkowski Barron 2020 Trang 31 Department of Pediatrics, Yale University, School of Medicine, New Haven, CT 2 Department of ... altered algorithm yielded a sensitivity of 94.0% and a specificity of 79.2% for predicting “no attention”, compared to a sensitivity of 97.9% and a specificity of 94.8% in the original study Our findings ... being the salt and light of my world To my parents for being the giants whose shoulders I stand on To Dr Mona Sharifi the office of student research and the department of Pediatrics without whom...

Ngày tải lên: 27/02/2022, 06:33

... of external validation studies The aim of this article is therefore to report a review of the methodological conduct and reporting of pub-lished articles describing the external validation of ... Journal of Cardiology, Annals of Surgery, Annals of Internals Medicine, Journal of the American College of Cardiology (4 articles) American Journal of Surgery, Blood, Circulation, Journal of Urology, ... 40% of external validation studies were reported in the same article that described the development of the prediction model Of the 60% of articles that were solely evaluating the performance of...

Ngày tải lên: 02/11/2022, 10:41

... independent of RA disease activity As part of a sensitivity analysis, we restricted the cohort to patients without any of these ICD-9 codes as part of a sensitivity analysis As part of two additional ... characteristics of the eligible cohort remained similar (right-most column of Table 2) The primary results of the study are shown in Table 3 Among biologic users (Table 3), a total of 28% of treatment ... effective Because of similarities in both the descriptive characteristics of the study populations of biologic and non-biologic DMARD users and the performance characteristics of the effectiveness...

Ngày tải lên: 25/10/2012, 10:45

... promoterProf dr.ir A.Y Hoekstra University of Twente Prof dr.ir H.G Wind University of Twente Prof dr.ir A.E Mynett UNESCO-IHE / WL | Delft Hydraulics Prof dr S.M de Jong University of Utrecht ... five different types of integration within the framework of Integrated Assessment Modelling (IAM) These are integrations of disciplines, of models, of scales, of issues, and of stakeholders Scrase ... University of Twente, chairman/secretary Prof dr P.G.E.F Augustinus University of Utrecht, promoter Prof dr S.J.M.H Hulscher University of Twente, promoter Dr J.L de Kok University of Twente,...

Ngày tải lên: 06/11/2012, 10:35

... provision, unfair actions/decisions of the administrators, abuse of power, misconduct of the officials, and failure to enforce rules Even though the number of complaints has dropped slightly from ... excellent performance of the public officials (Morrison, 2000) Taken together, Kim (2006) and Lee, Nam, Park, and Lee (2006) strongly suggested that research on job performance of public officials is ... also served as a preliminary investigation of the psychometric properties of the Malay language version of the job performance instrument with a sample of respondents from the Malaysian Public...

Ngày tải lên: 11/09/2013, 11:44

... that the external cost of 1 tonne of SO2 released in a city of 100,000 people is €6,000 The default results then provide a set of factors for cities of different sizes To scale up to a city of 500,000 ... measurement of the length of each country's coastline bordering the sea area in question The weighted average was then calculated as the sum of: {[externality of country_a] * [length of coast for ... the future External costs of air pollution vary according to a variety of environmental factors, including overall levels of pollution, geographic location of emission sources, height of emission...

Ngày tải lên: 17/02/2014, 22:20

... valuation of an accident of type j happening to an oc- cupant of a passenger car ej: monetary valuation of an accident of type j happening to a truck wj: monetary valuation of an accident of type ... the monetary valuation of these different catego- ries of marginal external costs for the case of Belgium 111 T H E MONETARY VALUATION O F THE EXTERNAL The external costs of an additional passenger ... state of the road which is defined as a function of the number of trucks and of a number of other factors f The environmental costs per km are defined as where piis): pollution costs per km of...

Ngày tải lên: 07/03/2014, 11:20

... Quackenbush delineated three components of validation: techni-cal validation, biologic validation, and regulatory validation (see Box 2).6 Because of the broad nature of the topic, the workshop was designed ... achievements of engineers Dr Wm A Wulf is president of the National Academy of Engineering The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of ... development of microarray technologies) have expanded those evaluations to permit the simultaneous detection of the expression of tens of thousands of genes and to support holistic evaluations of the...

Ngày tải lên: 07/03/2014, 13:20

... apoptotic TA isoform(s) and the antiapoptotic DM isoforms In gen-eral, TAp73 isoforms regulate the transcription of DMp73 isoforms, which, in turn, act as dominant nega-tive regulators of both TAp73 ... ultimate effect of p73 isoforms in cancer progres-sion is attributed to the TA⁄ DM ratio, rather than the overexpression of a specific p73 isoform or a specific class of p73 isoforms per se [20,21] ... Cancer Research Centre, University of Liverpool, UK 5 Laboratory of Clinical Virology, Faculty of Medicine, University of Crete, Heraklion, Greece 6 Department of Oncological and Experimental Pathology,...

Ngày tải lên: 29/03/2014, 09:20

... therefore use features to indicate the sequences of part-of-speech for a pair of candidate paraphrases We used the preterminal symbols of the syntactic trees of the parser used for SYNT Character-based ... right part of Table 2 provides the results for our validation experiments of the union set for all pre-vious techniques We obtain our best results for this study using the output of our validation ... acquisition of local paraphras-ing patterns in Zhao et al (2008) The work of Callison-Burch (2008) has shown how the mono-lingual context of a sentence to paraphrase can be used to improve the quality of...

Ngày tải lên: 31/03/2014, 21:20

... assessment) Precision The precision of an analytical method describes the ness of agreement (degree of scatter) between a series ofmeasurements obtained from multiple sampling of thesame homogenous sample ... provide guidance on validation of analytical meth-ods and immunogenicity methmeth-ods to monitor anti-pro-tein drug antibody response Less information is available for validation of flow cytometry ... initiation of thevalidation study (data not shown) Tetramer (0.1 μg/mL)titration (2.5, 5, 10, and 20 μL) was performed and theuse of 10 μL was found to be optimal Long term perform-ance of the tetramer...

Ngày tải lên: 18/06/2014, 15:20

... examine the effect of overnight shipping on inhibition of internalization of AF488-MCP-1 by the receptor antago-nist a direct comparison of the effect of overnight storage on the IC50 of the CCR2 inhibitor ... addition of AF488-MCP-1 as a control An example of the staining is in Figure 1 For most purposes the internalization assay was performed within 2 hours of blood draw However, as part of the validation ... pharmacodynamic effect of new drug entities However, to date, the analytical validation of cytometry based assays is limited and there is no suitable guidance for method validation of flow cytometry-based...

Ngày tải lên: 18/06/2014, 15:20

... in prevention of blood clots A2 – Expectations of symptom relief A3 – Expectations of side effects A4 – Importance of ease of use A5 – Worries about making mistakes A6 – Importance of independency ... the items ofPACT-Q1 cannot be thought of as one single concept Scoring and psychometric validation of the PACT-Q The last series of PCA and MA led to the conclusion that the 7 items of the "Treatment ... initial validation and for the psychometric validation The good quality of completion and returns of both PACT-Q1 and PACT-Q2 in all of the countries reflected the good acceptability of the questionnaire...

Ngày tải lên: 18/06/2014, 18:20

... limitation of this study is the use of a 7-item modified Morisky scale for the validation of TSQM-9 An item from the original Morisky scale related to stop-ping medication because of feeling ... conceptual framework of TS-M, patients' per-ception of side effects with their medication is an impor-tant component of satisfaction with their medication However, the use of the TSQM with the ... adverse event reporting and their own professional discretion Thus, in a naturalistic study of the usual care of hypertension man-agement, the administration of a questionnaire, such as the TSQM,...

Ngày tải lên: 18/06/2014, 18:20

... of seven) of u-PA-/- mice developed arthritis with an average maximum clinical score of 0.6 ± 0.2, compared with 80% (eight out of 10) of C57BL/6 mice with an average maximum clinical score of ... of nine (56%) of the sham chimeras developed disease with a low severity of 1.2 ± 0.4 The u-PA-/- ® C57 chimeras developed disease similar to u-PA-/- mice (Figure 1b); 56% (seven out of 11) of ... an incidence of 80% (eight out of 10 mice) and average maximum clinical severity of 4.1 ± 1.2 C57BL/6 sham chimeras (C57 ® C57) developed disease of a similar incidence (92%, 11 out of 12 mice)...

Ngày tải lên: 12/08/2014, 11:23

... case of complex biological systems, the spectrum derived is a composite of the individual spectra of the components of that tissue, and analysis of chemical changes depends on knowledge of the ... The number of cells per mm2 was calculated by counting the number of cells within an area measured by the MCID software Preparation of purified type II collagen and crude extract of proteoglycan ... M2139 (dark grey) over the course of 21 days (b) The number of empty chondrons expressed as a percentage of the total number of chondrons, indicating the loss of chondrocyte from the extracellular...

Ngày tải lên: 09/08/2014, 06:23

... Page of 11 (page number not for citation purposes) Figure by ALP Inhibition of IL-1β-induced upregulation of E-selectin in glEND.2 cells by ALP (a) Inhibition of IL-1β-induced upregulation of E-selectin ... reorganization of stimulated granulocytes and the accompanying suppression of conformational changes of the β2 chain of the integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) [5], because the activation of ... inhibition of the cytoplasmic degradation of IκBα However, ALP did not suppress the phosphorylation or ubiquitination of IκBα and did not exhibit activities of a broad-spectrum inhibitor of the proteasomal...

Ngày tải lên: 09/08/2014, 08:22

... onset of fibrogenesis [3,4,32], we employed indirect immunofluorescence analysis with an anti-MOMA-2 antibody (a marker of macrophages) to examine the effect of loss of mPGES-1 on the ability of ... a-SMA-expressing myofibroblasts are a hallmark of both SSc and bleomycin-induced skin fibrosis [23,24], we then continued our studies by determining the effect of loss of mPGES-1 on the induction of a-SMA-expressing ... expression and role of mPGES-1 in fibrogenesis are unknown There is no perfect mouse model that recapitulates every facet of SSc; however, the bleomycin-induced model of skin scleroderma is often used...

Ngày tải lên: 12/08/2014, 15:22

... of adverse events of CCII was lower than that of methotrexate (MTX) [19] These results demonstrate clinical efficacy of an oral tolerance approach for RA To evaluate the efficacy and safety of ... administration of CII prevents and reduces the severity of autoimmune diseases [11] Work from these animal models has recently been extended into human clinical trials of RA with differing degrees of success ... Admission criteria also included patients of either gender with RA with a duration of to 24 months Active RA was defined as the presence of at least three of the following criteria: six or more...

Ngày tải lên: 12/08/2014, 11:22

... capacity of DCs The effect of amiloride in vivo Our data show that pretreatment of professional APCs with amiloride prevents activation of CII-specific T cells in vitro We also confirmed the effect of ... blockade of macropinocytosis prevented intracellular accumulation of CII and resulted in profound blockade of antigen presentation to T cells The involvement of macropinocytosis in uptake of autoantigens, ... Page of 11 (page number not for citation purposes) We addressed the route of CII uptake into late endosomes in pulse-chase experiments in the presence of inhibitors of uptake Pretreatment of macrophages...

Ngày tải lên: 09/08/2014, 08:22