enzyme immobilization in biodegradable polymers for biomedical applications

... currently receiving a great deal of interest for medical and pharmaceutical applications The main reasons for this increasing attention are certainly its interesting intrinsic properties Indeed, chitosan ... hydrogels formed by chitosan crosslinked with itself that exhibit pH-sensitive swelling Indeed, the numerous inter-chain interactions formed by crosslinking inhibit swelling, since most of the amino ... the conditions of the crosslinking reaction, since they determine and allow the modulation of the crosslinking density, which is the main parameter influencing interesting properties of hydrogels

Ngày tải lên: 30/08/2017, 16:30

... Hoechst 33342 staining in nanocomposite-treated cells, but not in the control These changes might include chromatin condensation, membrane bleb-bing and cell shrinkage 7-AAD staining indicates com-promised ... rat myoblast cell lines (L6) were maintained in DMEM and human colon cancer cell line (HCT116) was maintained in RPMI1640, containing 10% FBS and 5% antibiotic in a activity ofι-car, γ-Fe2O3andι-car-γ-Fe2O3nanocomposite ... induced protein 3 (tnfaip3), a gene encoding A20 protein, regulates NF-κB activation by interacting with various components in the upstream signaling pathway However, both A20 and NF-κB are interrelated,

Ngày tải lên: 02/11/2022, 09:02

... to transfer textual information It consists of six pins arranged in pattern of a 3u2 matrix (a 4u2 matrix for Chinese characters) Information is delivered by stimulating fingertips by vertical ... nonpresetrained actutor Figure 3.35 An inchworm robot 3.3.3 A Braille Display Using Nonpestrained Actuators Although visual graphical display devices have been the dominant method for information interchange, ... Voltage Input Force responce (b) force Figure 3.33 Actuator output with square wave inputs 3.3.2 Inchworm microrobot Using a Nonprestrained Actuator An inchworm robot made with the nonprestrained

Ngày tải lên: 10/08/2014, 02:20

... reference for the selection of materials for applications or a guideline for developing new ferroelectric and piezoelectric polymeric materials 4.5 Remarks Electroactive polymers including ferroelectric ... after being poled Three primary factors are important for poling the materials to achieve high remanent polarization: poling temperature, poling field, and poling time Generally, a higher poling ... polar crystal demains Thermal annealing is the most popular method to increase crystallinity However, for odd-numbered nylons, the melt-quench and cold-stretching process is critical for the parallel

Ngày tải lên: 10/08/2014, 02:20

... complex In such cases, the capacitance is determined by dividing the charge transferred by the voltage excursion Before considering rate-limiting mechanisms, some considerations in choosing maximum ... assist in determining the appropriate upper bounds in actuator stresses 0 50 100 150 200 250 300 0 0.5 1 1.5 2 2.5 Time (minutes) Figure 5.11 Creep in a polypyrrole film in response step in stress ... Proceedings of SPIE, reprinted with permission [18] Work per unit volume is the integral of stress times incremental strain The maximum stress against which mammalian skeletal muscle can maintain

Ngày tải lên: 10/08/2014, 02:20

... transduction and actuation principles inherent in the IPMC by defining it in the linear regime and in static conditions They introduce the linear irreversible thermodynamic relationship for charge transport ... Finite-element model (b) Deformed shape Figure 6.11 Flapping simulation for flapping wing #1 ([27]) (a) Finite-element model (b) Deformed shape Figure 6.12 Flapping simulation for flapping ... #2 The deformed shapes are shown in Figure 6.11b and Figure 6.12b for Wing #1 and #2, respectively Wing #2 is the better design for the flapping wing in terms of a twisting angle Noted that our

Ngày tải lên: 10/08/2014, 02:20

... online calculation using Eq. (7.7) are shown in Figure 7.14. The reconstructed bending motion of the IPMC using the curvature data and the proposed kinematic model is shown in Figure 7.15. In ... underwater propulsion robots using the IPMC. For example, Mojarrad and Shahinpoor developed a propulsion robot using the IPMC as a fin to generate a forward impelling force [11]. Guo et al. developed ... environment, including carps and gibels. A wavy motion is better at reducing an angular recoil from water than a simple bending motion [8]. 7.8 Patterning of IPMC for a Swimming Robot 7.8.1 Comparing

Ngày tải lên: 10/08/2014, 02:20

... with a change in average propelling speed V x, as shown in Figure 7.42 Figure 7.42 Moment of force vs propelling speed By fixing V x as zero, the moments of force M = 1.2 × 10í4Nm for the left ... IPMC, and these waves induce an impelling force We also proposed an analytical model for the robot propulsion considering the drag and resistance forces induced by the bending motion of the IPMC ... images of the bending motion in our experiments and extracted the bending curve, as shown in Figure 7.39 We sampled 15 points with equal spaces on the extracted curved line, as shown in Figure 7.39(d)

Ngày tải lên: 10/08/2014, 02:20

... sequencing chip was demonstrated experimentally Another bonding method, CO2 assisted bonding, was also demonstrated for bonding a 5-inch CD platform By applying a thin PLGA interlayer, the CD platform ... 1998 - June 2001 M.S Mechanical Engineering The Institute of Plastics Machiner and Engineering (IPME) in Beijing University of Chemical Tech Beijing, P.R China September 2001 – August 2002 ... rapid heating and cooling systems for injection molding applications, Polymer Engineering and Science, 42, pp.2471-2481 (2002) Yao, D., and Virupaksha, V L., Study on squeezing flow during nonisothermal

Ngày tải lên: 14/11/2014, 13:26

... chains The integrity of hydrogels in water is maintained mainly due to the molecular interactions, including covalent and non-covalent forces between individual polymeric components present in ... for tissue engineering For antimicrobial therapeutics, we hypothesized that hydrogels with cationic polymers incorporated provide an excellent formulation for clinical use in eliminating various ... application Shear thinning is another important property of hydrogel for biomedical applications For example, injectability is a major requirement for minimal invasive surgery Injectable hydrogel

Ngày tải lên: 08/09/2015, 19:48

... of material failure in which voids, either already existing within the material or nucleated during formation, grow until they link together, or coalesce, to form a continuous fracture path... ... on strain hardening  Load-line displacement (LLD) crack  no M Displacement resulting from the deformation of the beam without the crack  crack M Displacement resulting from the deformation ... vector. Engineering Fracture Mechanics, 68(12): 1385-1402. Qian, X. (2011). An out-of-plane length scale for ductile crack extensions in 3-D SSY models for X65 pipeline materials. International

Ngày tải lên: 09/09/2015, 10:19

... NANOCOMPOSITES FOR BIOMEDICAL APPLICATIONS Erwin NATIONAL UNIVERSITY OF SINGAPORE 2014 Trang 2SYNTHESIS OF WATER SOLUBLE SUPERPARAMAGNETIC NANOCOMPOSITES FOR BIOMEDICAL APPLICATIONS Erwin (B Eng., ... the applied AMF For multi-domain magnetic nanoparticles, the heating mechanism involves the hysteresis losses due to magnetic domain walls movement In contrary, for single domain magnetic nanoparticles ... crosslinking reaction involving two functional groups 31 Figure 1 - 10: Nanomaterials development process flow for biomedical field The red dotted-line box indicated the development area to be investigated

Ngày tải lên: 09/09/2015, 11:31

... actin filaments It in turn promotes more integrin clustering, thus enhancing the matrix binding and organization by integrins in a positive feedback system As a result, ECM proteins, integrins, ... 1996) α subunit contains four cation binding sites, while β subunit contains one cation binding site The binding of divalent cations leads to an “open” or “closed” integrin conformation and thus ... conformation and thus regulates ligand binding The extracellular binding to integrins The extracellular binding can stimulate integrins to become clustered in the panel of cell membrane, and further

Ngày tải lên: 09/09/2015, 18:57

... fluorescence in rat brain after i.v injection of fluorescent dextran loaded NPs (Sun, et al,2004) significant increase in brain uptake in in vitro cell line experiment & in situ brain perfusion ... growth in the brain It can be divided into two categories: the primary brain cancer which is originated within the brain and the secondary brain cancer which is originated from cells in other ... developed to act as in vitro BBB model At present, there are more than 15 different cell line models, including immortalized bovine BEC lines, porcine BEC lines, murine cell lines, primary rat...

Ngày tải lên: 26/11/2015, 22:41

... Slew Rate Oscillating Flow Other MEMS Applications Micromachined Neurowell neuron trapping canopy grillwork neurite growing in micro-tunnel 30 µm gold electrode full-grown cell in neuron well Spontaneous ... Micromachines, MicroRobots Machine Size Quantity Micromachines (MEMS) Conventional Machines Molecular (Nano) Machines nm µm mm m km Pressure Sensors 200 µm Nitride diaphragm Poly strain gauges ... electrode Caltech Micromachining Group 1250 V 15 µm 15 µm On the Microbat Flying Onithopter Transceiver Antenna MEMS Wings Wing Control Actuators Acoustic Sensor Arrays CMOS Imaging Array Autopilot...

Ngày tải lên: 22/12/2013, 21:17

... providing accurate positioning PPAMs provide safe machine-man interaction By using the right material, the material deformation can be eliminated while getting high tensile forces Depending on ... rates Various applications for conducting polymer actuators being considered by researchers include actuators for micromachining and micromanipulation, microflaps for aircraft wings, micropumps, ... formed, by definition A gel cannot be fractured without breaking chemical bonds Therefore, the strength is higher at the gel point, but it does not increase indefinitely with more cross-linking...

Ngày tải lên: 14/03/2014, 14:20

... Metals for biomedical applications In: Fazel R, editor Biomedical Engineering- From Theory to Applications Rijeka: In Tech; (2011) , 411-430 Biomedical Applications of Materials Processed in Glow ... chain consisting of two molecules, b) chain consisting of eight molecules In dashed areas the collapsed chains are shown enlarged 2.3 1D water molecule chain Finally, we investigated the chain ... titanium-bone cell interface in vitro: the role of the surface in promoting osteoin tegration In: Brunette DM, Tengvall P, Textor M, Thomsen P, editors Titanium in Medicine Berlin: Springer; (2001)...

Ngày tải lên: 17/03/2014, 02:20

... composite electrode appealing for biosensing applications when used in combination with oxidase and dehydrogenase enzymes Including either glucose oxidase or alcohol dehydrogenase in the composite turned ... incorporating proteins in the polymer component Protein incorporation is an improved step towards biocompatible sensors and assemblies The nanowires were made using anodic alumina templates in ... differences in kinetic and mechanical behavior of the nanowires that are relevant to their use in sensors and self-assembling structures The proteins avidin and streptavidin were introduced into the...

Ngày tải lên: 20/03/2014, 13:05

... applications 1.2.5 Inkjet printing Inkjet printer creates images or texts by propelling ink droplets onto paper or overhead transparencies The concept of inkjet printing originated in the early 1980s ... adapted for printing of liquid-phase polymers other than inks Much effort has been made in accurate deposition of tiny quantities of polymers to turn it into a versatile tool for manufacturing processes ... MEMS for biomedical applications, as biomedical applications provide the perfect platform for integrating complex design and fabrication of articulation, recording and assistive systems with integrated...

Ngày tải lên: 28/04/2014, 11:29

... processing of fixed tissue samples, these techniques allow for the imaging of live and intact organisms both in vivo and in vitro, resulting in a more realistic picture of the processes occurring in ... possessing fluorescent and magnetic properties may be used in a number of biomedical applications in nanobiotechnology, such as bioimaging, bio- and chemo-sensing, cell tracking and sorting, bioseparation, ... staining for microglia and macrophages in rhodamine channel; (d) overlay of (a) and (c); (e) overlay of (a) and (b) Cy5.5-CLIO is internalised predominantly by microglial cells and in ltrating...

Ngày tải lên: 21/06/2014, 22:20