endothelin antagonists in clinical practice current developments

... 1NEOADJUVANT CHEMOTHERAPY – CURRENT APPLICATIONS IN CLINICAL PRACTICE Edited by Oliver F Bathe   Trang 2Neoadjuvant Chemotherapy – Current Applications in Clinical Practice Edited by Oliver F ... just beginning In such instances, the experiences related to more common tumor types may inform trials on these more rare clinical entities Interest in neoadjuvant chemotherapy also intensifies ... focus within 24hrs The labeling index and growth fraction were increased with a decrease in tumor doubling time There was minimal change in DNA synthesis and cell cycle time Minimal changes in these...

Ngày tải lên: 27/06/2014, 13:20

... 2Neuroimmunology in Clinical PracticeTrang 3Neuroimmunology inClinical PracticeEdited by Bernadette Kalman and Thomas H Brannagan III Trang 4© 2008 by Blackwell Publishing Ltd BLACKWELL PUBLISHING350 Main ... 7Neurology, as many other fields in medicine, hasevolved into a framework of rapidly developing sub-specialties increasingly dependent on technology-driven advances in clinical and basic sciences.Neuroimmunology ... Blackwell Publishing Ltd 1 2008 Library of Congress Cataloging-in-Publication Data Neuroimmunology in clinical practice / edited by Bernadette Kalman and Thomas H Brannagan III. p ; cm. Includes bibliographical...

Ngày tải lên: 10/08/2014, 00:20

... oligodendrocytes in primary cell culture canoverride this arrest in myelinogenesis and can syn-thesize myelin membrane and at least some myelin proteins (Xin et al., 2005) In Olig2-null mice, spinal cord ... Administration (FDA) in 1993 (TheIFNB Multiple Sclerosis Study Group, 1993) Sincethen, the methodology of designing, monitoring,and interpreting clinical trials has itself evolved into a new science ... concordance in monozygotic than in dizygotic twins • Higher risk for MS in full-sibs than in half-sibs; the presence of a maternal parental effect • Highly increased risk of MS in siblings of index...

Ngày tải lên: 10/08/2014, 00:20

... scanner used in clinical routine practice shouldoperate at a field strength higher than 1.0T With the introduction of 3T MRI systems into clinicalpractice, several questions arise, including the com-parison ... also be detected usingshort tau inversion recovery (STIR) sequences and, in certain scanning platforms, this sequence may besuperior to T2-WI in detecting spinal cord lesions in MS (Campi et al., ... consensus guidelinesfor imaging of the brain and spinal cord in patientswith MS (Simon et al., 2006) Recommended forimaging of the brain were sagittal and axial fast spin-echo fluid-attenuated inversion...

Ngày tải lên: 10/08/2014, 00:20

... Progressive Efficacy Clinical Trial ofRecombinant Interferon-beta-1a in MS (SPECTRIMS)Study Group 2001 Randomized controlled trial of interferon-beta-1a in secondary progressive MS: Clinical results ... rate inthe relapsing group The survival rate at five yearswas 90% in the monophasic and 68% in the relaps-ing group (Wingerchuck et al., 1999) Predictors of relapsing course included longerinterattack ... were used against mouse brain sections serolo-in an serolo-indirect immunofluorescence assay A distserolo-inctIgG binding pattern associated with capillaries andthe blood–brain barrier in the cerebellar...

Ngày tải lên: 10/08/2014, 00:20

... morelevels of the spine may be involved than is typical of MS In some instances the entire spine is involved as well as some of the brainstem In some instancesthe inflammatory sensitization involves both ... changes, in which case the termretrobulbar ON is applied The diagnosis of ON is made on the basis of a bination of clinical and laboratory findings In subtlecases, diagnosis can be clinically ... sclerosis beginning in infancy J Child Neurol, 2(4), 252– 6. Shintani, S., Fumimura, Y and Shiigai, T 2001 Acutedisseminated encephalomyelitis following aseptic meningoencephalitis Clin Neurol Neurosurg,...

Ngày tải lên: 10/08/2014, 00:20

... sweating, heatintolerance Vasomotor: Distal color changes, change in skin appearance, persistently cold extremities, Raynaud’s phenomenon, loss of skin wrinkling in water, heat intolerance, indoor ... immunoglobulin in IgM paraprotein asso- intra-ciated demyelinating neuropathy J Neurol, 249, 1370 – 7 Cornblath, D.R 1991 Research criteria for diagnosis of chronic inflammatory demyelinating polyneuro-pathy ... inflam-A review of clinical syndromes and treatment approaches in clinical practice J Clin Neuromusc Dis, 4, 174 – 89. Gorson, K.C., Ropper, A.H., Adelman, L.S andWeinberg, D.H 2000 Influence of diabetes...

Ngày tải lên: 10/08/2014, 00:20

... Cyclosporine A is an immunosupressant that blocksinterleukin-2 activation of T-helper cells by inhibit-ing calcineurin While a controlled, double-blindclinical trial has shown its effectiveness in ... terminal.Guanidine increases calcium within the nerve ter-minal by inhibiting uptake of calcium by subcellularorganelles (Kamenskaya et al., 1975) While guani-dine is occasionally utilized in ... LES The interpretation of positive serum antibody testsrequires correlation with the clinical picture Anti-bodies to VGCC can occur in other conditions not inassociation with clinical LEMS In SCLC...

Ngày tải lên: 10/08/2014, 00:20

... increase in intracellular freecalcium and inhibited 125I-α-bungarotoxin bind-ing in cells expressing α7nAChR The authors postulate that these antibodies may act by blocking the α7nAChR that influence ... but imaging is unrevealing inabout half of the patients Autopsy reports usuallyreveal perivenular and arteriolar infiltration by pre-dominantly T lymphocytes throughout the brainincluding the ... Normal initial MRI followed by hyperintensityand cortical atrophy over time 2 Initial focal hyperintensity followed by decrease in extent and degree of signal intensity 3 Sustained hyperintensity...

Ngày tải lên: 10/08/2014, 00:20

... exten-sion into the brain involving veins and arteries ofvarying caliber The clinicopathological syndromewas delineated and so named for the distinctivepathology (Cravioto and Fegin, 1959) For ... perivascularinflammation of the adventitia, and intimal prolifera-tion resulting in narrowing of arterial lumina Laterinvestigators (Kernohan and Woltman, 1938) sum-marized the clinical and pathological ... lamina with multinucleated giant cell formation (arrows), intimal proliferation (arrowhead), and lymphocytic infiltration of the adventitia and neighboring meninges (stain, hematoxylin and eosin;...

Ngày tải lên: 10/08/2014, 00:20

... plasmamembrane allowing direct coupling of glycolysis tothe proton pump (Lu et al., 2001) The monomer ofpyruvate kinase acts as thyroid hormone (T3) bind-ing protein Binding of T3 to pyruvate kinase inhibitsenzymatic ... There-fore using a biomarker, such as ABGA, in addition tospecific clinical features, may be appropriate in definingthis emerging group of disorders The apparent over-lap between the clinical phenotype ... protein homologs in Streptococci Interestingly, streptococcal enolase is also found on the surface ofthe bacterium and appears to function as an efficientplasmin(ogen) binding protein which influences...

Ngày tải lên: 10/08/2014, 00:20

... lineages such as intestine [52] and from the ectodermal tissues including skin [53], deciduous teeth [54] and nerve tissue [8,9,55,56] ASCs originate during ontogen-esis and remain in a marginal ... main clinical trials dividing them basing on their clinical applications, and taking into account the ethical issue associated with the stem cell therapy. Methods: We have searched Pubmed/Medline ... presents clinical manifestations in the skin, i.e maculopapular rash, which can spread throughout the body, dyskeratosis (in severe cases the skin may blister and ulcerate) [94], in the gastrointestinal...

Ngày tải lên: 10/08/2014, 10:20

... Studies that examined nurses’ use of research in clinical practice were considered for inclusion A nurse was defined as a professional who provides patient care in a clinical setting– e.g., registered ... any kind of research in any way in clinical practice) [29] Several published reviews have identified the complex-ity of, and challenges associated with, integrating research evidence into practice ... reported on nurses’ adher-ence to clinical practice guidelines, the rationale being that clinical practice guidelines can be based on non-research evidence (e.g., expert opinion) We did not have the...

Ngày tải lên: 10/08/2014, 10:23

... decision-making in their clinical practice These results should improve our understanding on how to effectively translate shared decision-making into health professionals' clinical practice Except ... implementing shared decision-making in clinical practice), specific search strategies were developed by an information specialist for the following databases: PubMed, Embase, CINHAL, et PsycINFO ... decision-making in their practices Shared decision-making was defined as a joint process of decision making between health professionals and patients, or as decision support interventions including decision...

Ngày tải lên: 11/08/2014, 05:22

... Targets in Clinical Practice: Glycemic Targets in Clinical Practice: Postprandial vs Preprandial Postprandial vs Preprandial and Fasting? and Fasting? Steven D Wittlin MD Steven D Wittlin MD ... Glucose Control Clinically ??     Frequent fingersticks HbA1C Fructosamine Continuous Glucose Monitoring Systems    Historical Real-time 1,5 Anhydroglucitol Postprandial Index vs A1C/1,5-AG ... 1998;21:336–40 Changes in Postprandial Glucose Metabolism in. .. analogues  DPP-IV inhibitors Pramlintide  Glycemic Index/Load  Importance of Post-Prandial Control in Managing Gestational...

Ngày tải lên: 13/08/2014, 09:38

... Trang 2Emergencies in Clinical Practice Trang 3London Berlin Heidelberg New York Hong Kong Milan Paris Tokyo Trang 4Emergencies in Clinical Practice Hashim Hashim, John Reynard, ... Springer Science +Business Media, Inc springeronline.com © Springer-Verlag London Limited 2005 Printed in the United States of America The use of registered names, trademarks, etc in this publication ... it radiates anteriorly to the abdomen and inferiorly to the ipsilateral groin The intensity may increase rapidly, reaching a peak within minutes or may increase more slowly over the course of 1...

Ngày tải lên: 14/08/2014, 11:20

... catheter removal increases the chances of voiding successfully (30% taking placebo voiding successfully, and 50% taking an alpha doing so; McNeill et al 1999) However, Trang 4whether continued use of ... obstruction, and malaria (presenting as bilateral loin pain and dark haematuria—black water fever)! The point, then, in making a diagnosis is to exclude other causes of flank pain, many of which are serious ... should undergo imaging to deter-mine whether or not they have a ureteric stone It goes without saying that any premenopausal woman who is going to undergo imaging using ionising radiation, should...

Ngày tải lên: 14/08/2014, 11:20

... tract infection (frequency, urgency, suprapubic pain, urethral burning or pain on voiding) that led to the ascending infection, which resulted in the subsequent acute pyelonephritis The infecting ... PERINEPHRIC ABSCESS, AND EMPHYSEMATOUS PYELONEPHRITIS— MAKING THE DIAGNOSIS Maintaining a degree of suspicion in all cases of presumed acute pyelonephritis is the single most important thing in ... drain in the kidney a Trang 9F 3.13 Continuedb c Trang 10and abdominal pain, with radiographic evidence of gas within and around the kidney (on plain radiography or CT) It usually occurs in diabetics,...

Ngày tải lên: 14/08/2014, 11:20

... of urine (i.e., collecting system intact) III >1 cm deep parenchymal laceration of cortex, no extravasation of urine (i.e., collecting system intact) IV Parenchymal laceration involving cortex, ... bleeding While this may control bleeding in some cases, in others a rising or persistently elevated pulse rate (with later hypotension) indicates the possibility of persistent bleeding and is an indication ... bleeding by this left renal vein left renal artery duodenum line of incision in retroperitoneum to expose aorta and renal vessels descending colon Left kidney with perinephric haematoma perinephric...

Ngày tải lên: 14/08/2014, 11:20

... psoas minor Hitch stitches between bladder and psoas minor Ureter reimplanted into bladder The incision is lengthened at right angles to the line of incision Oblique incision in bladder The incision ... ureteric injury is summarised in Figure 5.10 F 5.9 A retrograde ureterogram post–stent removal Trang 3Factors other than the level of injury are important in deter-mining the type of repair Blast injuries ... 1iatrogenic ureteric injuries in 43 patients, 28 (65%) of whom underwent definitive repair within 6 weeks of injury Delayed Treatment—Temporizing Procedures Temporary urine drainage may be achieved...

Ngày tải lên: 14/08/2014, 11:20