emt met in breast cancer and its clinical implications
Estrogen receptor α-coupled Bmi1 regulation pathway in breast cancer and its clinical implications
... Accesspathway in breast cancer and its clinical implications Huali Wang1†, Haijing Liu1†, Xin Li1, Jing Zhao1, Hong Zhang1, Jingzhuo Mao1, Yongxin Zou1, Hong Zhang2, Shuang Zhang2, Wei Hou1, Lin Hou1, ... p16 INK4a , PR, cyclin D1, pRB and Ki-67 in breast carcinoma The left column: the representative images for staining of ER α, Bmi1, p16 INK4a , PR, cyclin D1, pRB and Ki-67 in non-cancerous breast ... aberrant staining of tumor cells in 29.35% (27/92) of breast cancers, and this positive staining was generally present in both the nuclei and cytoplasm (Figure 2) Even in some cases, staining was...
Ngày tải lên: 05/11/2020, 01:21
báo cáo hóa học:" BMP-2 signaling in ovarian cancer and its association with poor prognosis" pot
... pancreatic carcinoma cells and prostate cancer cells in absence of androgen [18,19] On the other hand, BMP-2 clearly inhibits the growth of tumor cells of many origins including cancers arising from ... (PMSF, pepstatin, leu-peptin and aprotinin) After swelling the cells for 30 min on ice, 0.1% Nonidet P-40 and 10% glycerol (v/v) were added and the lysates centrifuged for 1 min at 4°C and 5,000 ... lines In addi-tion several reports have shown a role of BMP-2 in inva-sion of lung, prostate, breast cancer cells and BMP-4 in ovarian cancer [21,40,41] To confirm the role of BMP-2 in the metastatic...
Ngày tải lên: 20/06/2014, 07:20
Glutamate metabotropic receptor 4 (GRM4) inhibits cell proliferation, migration and invasion in breast cancer and is regulated by miR-328-3p and miR-370-3p
... decreased in thyroid cancer and suppressed progression and inhibited the Wnt signaling pathway in thyroid cancer [21] miR-370 functions as a sponge of hsa_circ_0061140 in ovarian cancer and inhibits ... miRNA-370 in breast cancer tissues and cell lines and their correlation with GRM4 a + d The expression levels of miRNA-328 (a) and miRNA-370 (d) between breast cancer and normal tissue in TCGA ... E Open AccessGlutamate metabotropic receptor 4 (GRM4) inhibits cell proliferation, migration and invasion in breast cancer and is regulated by miR-328-3p and miR-370-3p Bin Xiao1†, Daxiang Chen2,3†,...
Ngày tải lên: 17/06/2020, 17:46
Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer and its microenvironment
... (without glutamine, argin-ine and lysargin-ine; Silantes 282,986,444) containing 10 % (v/v) dialyzed FBS Isotopically labeled L-lysine [13C6 15N2 -labeled] 0.798 mM and L-arginine [13C6 15N4 ... labeling with amino acids incell culture; TCGA, The Cancer Genome Atlas Background Galectins are a family of carbohydrate-binding proteins involved in immune response, angiogenesis and cancer development ... nodes and adding edges with the following parameters: Organism > Homo sapiens, protein identifiers only; Data Settings > protein-protein interactions; all data sources and all experimental methods;...
Ngày tải lên: 20/09/2020, 17:45
Expression of Oct3/4 and Nanog in the head and neck squamous carcinoma cells and its clinical implications for delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma
... borderline, with tumor infiltration in solid cords, bands, or strands; grade 3: no distinct borderline, margin con-taining small groups of infiltrating tumor cells; and grade 4: diffuse invasion ... AccessExpression of Oct3/4 and Nanog in the head and neck squamous carcinoma cells and its clinical implications for delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma Noboru Habu1,2, ... and/or Nanog aberrantly expressed in CSCs of human cancer may be implicated in the malignant behavior of cancer cells, including tumori-genicity and metastasis However, the functional and clinical...
Ngày tải lên: 22/09/2020, 23:50
Modification of topoisomerases in mammospheres derived from breast cancer cell line: Clinical implications for combined treatments with tyrosine kinase inhibitors
... topoisomerases in mammospheres derived from breast cancer cell line: clinical implications for combined treatments with tyrosine kinase inhibitors Refael Peleg, Marianna Romzova, Inga Kogan-Zviagin, Ron ... im-portant role in tumor development and progression [1,4] Evidence for the existence of CSCs were found in many types of cancer, including brain, pancreatic and head and neck cancers, in addition ... [11-13] In previous studies we and others have demonstrated the increased anti-cancer effect of topoisomerase inhibi-tors in combination with other anti-cancer agents, such as tyrosine kinase inhibitors...
Ngày tải lên: 14/10/2020, 13:21
Estrogen receptor, progesterone receptor, interleukin-6 and interleukin-8 are variable in breast cancer and benign stem/progenitor cell populations
... origin or to breast cancer cell lines [9,10,38,39] Data presented here are innovative and expand the field in that we mea-sured gene and protein expression of ERα and ERβ, PR IL-6 and IL-8 in ... benign and cancerous breast tissues [32-34] In this study we compared the gene and protein expression of ERα and ERβ, PR, IL-6 and IL-8 in cells isolated from invasive ductal carci-nomas and benign ... me-diated [21,22] In contrast, Interleukin-8 (IL-8) was shown to have an inverse correlation with ERα expres-sion in breast tumors, and IL-8 increases the invasive potential of breast cancer cells...
Ngày tải lên: 14/10/2020, 16:20
MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells
... CW, Chen JY: Osteopontin promotes integrin activation through outside-in and inside-out mechanisms: OPN-CD44V interaction enhances survival in gastrointestinal cancer cells Cancer Res 2007, 67(5):2089 ... decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells Yu Zhao, Jie Huang, Li Zhang, Ying Qu, Jianfang Li, Beiqin Yu, Min Yan, Yingyan Yu, Bingya ... Jimeno A, et al: Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers Cancer Res 2007, 67(5):2187 –2196. 49 Varnat...
Ngày tải lên: 05/11/2020, 02:01
The landscape of immune cell infiltration and its clinical implications of pancreatic ductal adenocarcinoma
... (http://creativecommons.org/licenses/by-nc-nd/4.0/) Introduction Pancreatic cancer is the fourth leading cause of cancer-related death in the USA In contrast to the declining mortality from breast and lung cancer, the mortality ... Medical University, Dalian, Liaoning 116044, PR China d Department of Breast Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, ... 1The landscape of immune cell infiltration and its clinical implications ofpancreatic ductal adenocarcinoma Caiming Xua,b,1, Silei Suic,1, Yuru Shangd,1, Zhiyong Yud, Jian Hana,b, Guixin Zhanga,b,...
Ngày tải lên: 11/05/2020, 10:52
β1 and β2 adrenergic stimulation induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications
... 1β 1 - and β 2 -adrenergic stimulation-induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications Bo Gyung Kim1, Jin Young Kim2, JinSei Jung3, In Seok ... dehydrated and embedded in paraffin Paraffin blocks were sectioned into 5 μ m-thick slices and were attached to glass slides The samples were deparaffinised twice in xylene for 5 min and hydrated ... struc-ture of the inner ear is filled with fluid of a unique ion composition called the endolymph, which is essential for maintaining hearing and balance Endolymph in the cochlea and vestibule has...
Ngày tải lên: 19/11/2022, 11:34
LRIG1 gene copy number analysis by ddPCR and correlations to clinical factors in breast cancer
... by ddPCR and correlations to clinical factors in breast cancer Mahmood Faraz1, Andreas Tellström1, Christina Edwinsdotter Ardnor1, Kjell Grankvist2, Lukasz Huminiecki3,4, Björn Tavelin1, Roger ... Hedman1and Ingrid Ljuslinder1* Abstract recently shown to predict early and late relapse in stage I-II breast cancer and used these assays to analyzeLRIG1 in twelve healthy individuals, 34 breast ... both in-creased and dein-creased copy numbers in breast cancer In our previous studies, in which fluorescence in situ hybridization (FISH) was used to determine gene copy numbers, LRIG1 showed increased...
Ngày tải lên: 30/05/2020, 21:38
Monitoring the responsiveness of T and antigen presenting cell compartments in breast cancer patients is useful to predict clinical tumor response to neoadjuvant chemotherapy
... Hypaque (GE) and cryopreserved in liquid nitrogen in freezing media (RPMI-1640 50%, FBS 40% and 10% of DMSO) until used Clinical data of the included patients is shown in Table 1; clinical response ... control in vaccinated animals Despite Doxorubicin in combination with Cyclophosphamide (A/C) is widely used to treat breast cancer patients, the stimulating effect of A/C on T and APC compartments and ... nodes and diameter of largest metastasis Flow cytometry For the analyses of different sub-populations and pheno-type of T and APC we use specific staining panels For ex vivo sub-populations in the...
Ngày tải lên: 24/07/2020, 00:17
Estrogen receptor α dependent regulation of estrogen related receptor β and its role in cell cycle in breast cancer
... pathological implications in breast cancer To define the role of ERRβ in breast carcinogenesis, we elucidated the expression of ERRβ in ER + ve and ER-ve breast cancer patients in tissue microarray ... sug-gesting the anti-tumorigenic role in breast cancer (Fig.1d) [47] Thus our results indicate that ERRβ expression is decreased in breast carcinoma patients, breast cancer cell lines and also ... examined and scoring was done by an experienced pathologist The intensity score was calcu-lated based on staining for ERRβ and was assigned from 0 to 3 (0 indicating no staining; 1+ weakly stained;...
Ngày tải lên: 24/07/2020, 01:21
The prognostic value of stromal and epithelial periostin expression in human breast cancer: Correlation with clinical pathological features and mortality outcome
... staining in 30 % of cells Taken together, our findings and those re-ported in the literature confirm that in BCa tissues PN is mostly and highly expressed in stromal cells but that the protein ... focused on individual gene or protein candidates with a potential causative role in breast carcinogenesis, in the hope of identifying novel prognostic/predictive markers able to refine the informa-tion ... obtained by multiplying the intensity value of im-mune coloration by the percentage of stained cells, and the score is applied to both epithelial and stromal cells The intensity of staining is...
Ngày tải lên: 21/09/2020, 11:39
Targeting connexin 43 with α–connexin carboxyl-terminal (ACT1) peptide enhances the activity of the targeted inhibitors, tamoxifen and lapatinib, in breast cancer: Clinical implication for
... would be instrumental in clarifying the role of Cx43 in breast cancer and the therapeutic potential of targeting this molecule However, studies examining the role of Cx43 in mammary/breast cells ... progression and enhanced activity of lapatinib and tamoxifen, implicating ACT1 as part of a combination regimen in breast cancer Keywords: Connexin43, ACT1 peptide, Cancer therapeutic, Gap junction intercellular ... of a combination regimen in breast cancer Discussion Our current findings demonstrate a role for the gap junction protein Cx43 in breast cancer growth and pro-gression Using a therapeutic agent,...
Ngày tải lên: 30/09/2020, 12:32
Land deformation monitoring using synthetic aperture radar interferometry
... (HH) C-band Single (VV) C-band Single (HH) X-band Single (VV) C-band Single, Dual (Altenating) C-band Single, Dual, Quad L-band Single, Dual, Quad X-band Single, Dual X-band Unknown C-band Single, ... Quad X-band Single, Dual, Quad X-band Unknown X-band Single, Dual, Quad X-band Single S-band Single (HH or VV) X-band Unknown C-band Single, Dual, Quad L-band Single, Dual, Quad L-band Single, ... polarimetry and interferometry The research on SAR interferometry can be divided into two parts: • Chapter and Chapter introduce the fundamental concepts and methods of interferometry and differential...
Ngày tải lên: 13/10/2015, 15:55
PID ALGORITHM AND TUNNING METHODS
... setpoint, the measurement, and the output Proportional—units The proportional or gain term may be calibrated in two ways: Gain and Proportional Band Gain = Output/Input Increasing the gain will ... Nichols tuning method: open loop point of inflection Another means of determining parameters based on the ZN open loop After "bumping" the output, watch for the point of inflection and note: Ti ... proportional and integral only Calculation of repeat time: (gain and reset terms used in controller) With the error set to zero (measurement input = setpoint), make a change in the input and note...
Ngày tải lên: 22/01/2014, 08:26
Algorithm and Networking for Computer Game docx
... 6.1 Linear congruential method for generating random numbers Las Vegas method for generating random numbers from an interval Generating random numbers using weights Generating ... Vegas method distributes the original interval uniformly by defining the excess area as invalid Algorithm 2.2 Las Vegas method for generating random integer numbers within the interval [ , u) Random-Integer( ... Algorithm 2.1 Linear congruential method for generating random integer numbers within the interval [0, m) Random() out: random integer r (0 ≤ r ≤ m − 1) constant: modulus m; multiplier a; increment...
Ngày tải lên: 08/03/2014, 09:20
Báo cáo hóa học: " Research Article Novel VLSI Algorithm and Architecture with Good Quantization Properties for a " docx
... the main instrument in our design procedure that clearly puts into evidence the main elements involved in the proposed algorithm Using this method, we can map the proposed VLSI algorithm into ... the DCT algorithm into a cycle and a pseudo-cycle convolution using only a new single input restructuring sequence It can be used to obtain an efficient VLSI architecture using a linear memory-based ... into two linear systolic arrays Then, a hardware sharing method to unify the two systolic arrays into a single one with a reduced complexity can be obtained as shown in Figure Using a linear systolic...
Ngày tải lên: 21/06/2014, 07:20
Báo cáo hóa học: " Research Article Efficient Algorithm and Architecture of Critical-Band Transform for Low-Power Speech Applications" pdf
... various parameters used in the CBWT and CQT is given in Table By combining the Hamming window w[kcb , n] and the exponential part into kern[kcb , n], we can compute the critical-band spectrum ... discrete-time input speech signal and w[kcb , n] is a window function for each critical band The length of each window is N[kcb ] The fixed bandwidth in the low frequency range and constant-Q bandwidths in ... coefficient kern in (10) The coefficient consists of a real part (the cosine function) and an imaginary part (the sine function) Applying the symmetry property of the cosine function and antisymmetry property...
Ngày tải lên: 22/06/2014, 19:20