effects of drought on oxidative stress and gene expression

... regulation of gene expression - 6 3 Regulation of gene expression and role of Nrf2 and HO-1 in tumorigenesis and chemoresistance - 9 4 Role of Sirt1 in tumorigenesis and chemoresistance - 11 ... Abbreviations - x Abstract - 1 I Introduction - 6 1 Metformin and reduced risk of cancer - 6 2 Role of the AhR, CYP1A1 and CYP1B1 in carcinogenesis and mechanisms of regulation of gene expression ... Inhibition of CYP1A1 and CYP1B1 expression by metformin is independent of ER - 41 1.5 Metformin suppresses endogenous AhR-ligand-induced CYP1A1 and CYP1B1 expression by reducing TDO expression in

Ngày tải lên: 26/03/2021, 10:18

... regulation of gene expression - 6 3 Regulation of gene expression and role of Nrf2 and HO-1 in tumorigenesis and chemoresistance - 9 4 Role of Sirt1 in tumorigenesis and chemoresistance - 11 ... Abbreviations - x Abstract - 1 I Introduction - 6 1 Metformin and reduced risk of cancer - 6 2 Role of the AhR, CYP1A1 and CYP1B1 in carcinogenesis and mechanisms of regulation of gene expression ... Inhibition of CYP1A1 and CYP1B1 expression by metformin is independent of ER - 41 1.5 Metformin suppresses endogenous AhR-ligand-induced CYP1A1 and CYP1B1 expression by reducing TDO expression in

Ngày tải lên: 30/03/2021, 12:30

... regulation of gene expression - 6 3 Regulation of gene expression and role of Nrf2 and HO-1 in tumorigenesis and chemoresistance - 9 4 Role of Sirt1 in tumorigenesis and chemoresistance - 11 ... Abbreviations - x Abstract - 1 I Introduction - 6 1 Metformin and reduced risk of cancer - 6 2 Role of the AhR, CYP1A1 and CYP1B1 in carcinogenesis and mechanisms of regulation of gene expression ... Inhibition of CYP1A1 and CYP1B1 expression by metformin is independent of ER - 41 1.5 Metformin suppresses endogenous AhR-ligand-induced CYP1A1 and CYP1B1 expression by reducing TDO expression in

Ngày tải lên: 19/06/2021, 07:23

... regulation of Raf-ERK signaling through the use of methformin is essential for the down-regulation of Prf2 expression in pancreatic cells The effects of methformin on the phosphorylation of Raf and ... part of a master's thesis from Thai Nguyen University, focusing on the analysis of these gene expressions and their implications.Figure 1 illustrates how metformin down-regulates the expression of ... levels of catalase protein in the same treatment condition were regulated The expression of SOD2, catalase, and HO-1 plays a crucial role in controlling the balance of ROS and cellular protection

Ngày tải lên: 24/07/2023, 17:09

... promoter.Regulation of gene expression and role of Nrf2 and HO-1Heme oxygenase-1 (HO-1), a crucial member of the heat shock protein family, acts as a sensor and regulator of oxidative stress by catalyzing ... linked to tumorigenesis by influencing oncogenes and tumor suppressor genes Additionally, Sp1 is significant in regulating AhR transcriptional expression under constitutive conditions through a ... strong suppression of Nrf2 mRNA expression in HepG2 cells, indicating that metformin's reduction of Nrf2 activation is linked to the inactivation of Raf-ERK signaling Notably, the combination of

Ngày tải lên: 18/10/2023, 11:25

... the control group, #p < 0.05 compared with the H2 O 2 -treated group) Induction of Nrf2 and HO-1 expression by baicalein in HEI193 cells The effect of baicalein on the expression of Nrf2 and ... expression of heme oxygenase-1 (HO-1), a critical target enzyme of Nrf2, although the expression of kelch-like ECH-associated protein-1 was decreased However, the inhibition of Nrf2 expression ... relationship between the activation of Nrf2/HO-1 signaling and the protective effect of baicalein against oxidative stress in HEI193 cells As shown in Figure 3A, the increased expression of Nrf2 and

Ngày tải lên: 15/01/2020, 22:53

... tumor models through disruption of tubulin palmitoylation and microtubule organization and FASN inhibition- mediated effects on oncogenic signaling and gene expression Timothy S Heuer†*, Richard ... FASN inhibition-mediated effects that include gene expression changes and inhibition of -catenin Together the results strongly support investigation of combined FASN inhibition and taxane treatment ... localization and plasma membrane architecture; (3) inhibition of oncogenic signal transduction (e.g Wnt-beta-catenin and Akt); (4) gene expression reprogramming; and (5) induction of tumor cell

Ngày tải lên: 26/07/2023, 07:39

... the basis for the conservation of this precious and rare gene source in the artificial environment, the research project titled “Effects of pH on the growth and development of Cordyceps militaris ... body of C militaris 18 4.2 Effects of different pH levels on the average number and color of C militaris’s fruit bodies 19 4.3 Effects of different pH levels on the average height (cm) of ... pH 23 PART V: CONCLUSIONS AND RECOMMENDATIONS 25 5.1 Conclusions 25 5.2 Recommendations 26 REFERENCES 27 APPENDIX 31 Trang 7LIST OF FIGURES Figure 2.1 Natural morphology of the mushroom

Ngày tải lên: 06/01/2020, 11:29

... of a h/ ratio on nonlinear dynamic response of the FGM sandwich plates with porosity I .37 Fig 4.7 Influences of Pasternak foundation on nonlinear dynamic response of the FGM sandwich plates ... Influences of Winkler foundation on nonlinear dynamic response of the FGM sandwich plates with porosity I 38 Fig 4.9 Effect of parameter characterizing the duration of the blast pulse T son nonlinear ... objective of this thesis is to investigate the effects of porosity on vibration and nonlinear dynamic response of multi-layered FGM subjected to blast load  Studies the effects of porosity to FGM sandwich

Ngày tải lên: 04/09/2020, 08:38

... oxygen va-cancies and electrons on the grain boundaries can easily trap those conduction electrons and block the ionic conduction across the grain-boundaries promoting an increase of the resistivity ... investigate the dynamics of bond or mobile charges in the bulk or interfacial regions of any kind of solid or liquid materials: ionic, semiconducting, mixed electronic-ionic and insulators To extract ... BBT - 0 and BBT - 2 Using an equivalent circuit including the contribution of grain and grain-boundaries, it was observed activation energies of 1.169 and 0.874 eV for the grain and 1.320 and 0.981

Ngày tải lên: 24/09/2020, 04:41

... foundation on nonlinear dynamic response of the FGM sandwich plates with porosity I 38 Fig 4.9 Effect of parameter characterizing the duration of the blast pulse T s on nonlinear response of the ... deformation theory (HSDT) in conjunction with the stress function areused to establish the governing motion, compatibility equations and determine thenonlinear dynamic response and vibration of the ... deformation and a general von Kármán-type function to obtain small- andlarge-amplitude vibration of compressive and thermal post-buckling sandwich plates withFGM face sheets under uniform and non-uniform

Ngày tải lên: 27/10/2020, 19:59

... of a h/ ratio on nonlinear dynamic response of the FGM sandwich plates with porosity I .37 Fig 4.7 Influences of Pasternak foundation on nonlinear dynamic response of the FGM sandwich plates ... Influences of Winkler foundation on nonlinear dynamic response of the FGM sandwich plates with porosity I 38 Fig 4.9 Effect of parameter characterizing the duration of the blast pulse T son nonlinear ... objective of this thesis is to investigate the effects of porosity on vibration and nonlinear dynamic response of multi-layered FGM subjected to blast load  Studies the effects of porosity to FGM sandwich

Ngày tải lên: 06/12/2020, 19:09

... of a h/ ratio on nonlinear dynamic response of the FGM sandwich plates with porosity I .37 Fig 4.7 Influences of Pasternak foundation on nonlinear dynamic response of the FGM sandwich plates ... Influences of Winkler foundation on nonlinear dynamic response of the FGM sandwich plates with porosity I 38 Fig 4.9 Effect of parameter characterizing the duration of the blast pulse T son nonlinear ... objective of this thesis is to investigate the effects of porosity on vibration and nonlinear dynamic response of multi-layered FGM subjected to blast load  Studies the effects of porosity to FGM sandwich

Ngày tải lên: 27/01/2021, 04:35

... oxygen va-cancies and electrons on the grain boundaries can easily trap those conduction electrons and block the ionic conduction across the grain-boundaries promoting an increase of the resistivity ... investigate the dynamics of bond or mobile charges in the bulk or interfacial regions of any kind of solid or liquid materials: ionic, semiconducting, mixed electronic-ionic and insulators To extract ... BBT - 0 and BBT - 2 Using an equivalent circuit including the contribution of grain and grain-boundaries, it was observed activation energies of 1.169 and 0.874 eV for the grain and 1.320 and 0.981

Ngày tải lên: 27/01/2021, 06:22

... of a h/ ratio on nonlinear dynamic response of the FGM sandwich plates with porosity I .37 Fig 4.7 Influences of Pasternak foundation on nonlinear dynamic response of the FGM sandwich plates ... Influences of Winkler foundation on nonlinear dynamic response of the FGM sandwich plates with porosity I 38 Fig 4.9 Effect of parameter characterizing the duration of the blast pulse T son nonlinear ... objective of this thesis is to investigate the effects of porosity on vibration and nonlinear dynamic response of multi-layered FGM subjected to blast load  Studies the effects of porosity to FGM sandwich

Ngày tải lên: 17/03/2021, 08:55

... oxygen va-cancies and electrons on the grain boundaries can easily trap those conduction electrons and block the ionic conduction across the grain-boundaries promoting an increase of the resistivity ... investigate the dynamics of bond or mobile charges in the bulk or interfacial regions of any kind of solid or liquid materials: ionic, semiconducting, mixed electronic-ionic and insulators To extract ... BBT - 0 and BBT - 2 Using an equivalent circuit including the contribution of grain and grain-boundaries, it was observed activation energies of 1.169 and 0.874 eV for the grain and 1.320 and 0.981

Ngày tải lên: 17/03/2021, 20:14

... the basis for the conservation of this precious and rare gene source in the artificial environment, the research project titled “Effects of pH on the growth and development of Cordyceps militaris ... body of C militaris 18 4.2 Effects of different pH levels on the average number and color of C militaris’s fruit bodies 19 4.3 Effects of different pH levels on the average height (cm) of ... pH 23 PART V: CONCLUSIONS AND RECOMMENDATIONS 25 5.1 Conclusions 25 5.2 Recommendations 26 REFERENCES 27 APPENDIX 31 Trang 7LIST OF FIGURES Figure 2.1 Natural morphology of the mushroom

Ngày tải lên: 10/04/2021, 07:30

... importance of context in language teaching and learning, and language comprehension and oral production The third chapter is the presentation of the research methodology, including a description of the ... students understand and remember information well because, in stories, events and concepts are connected In terms of speaking performance, in a study on the effects of storytelling on the student’s ... Students’ contributions to the enhancement of the storytelling method 76 4.5.2.1 Students’ contributions to the enhancement of comprehension of the opaque idioms 76 4.5.2.2 Students’ contributions

Ngày tải lên: 14/04/2021, 18:21

... effect of CSE on oxidative stress (reduced glutathione and 4-hydroxy-2nonenal), cell toxicity (lactate dehydrogenase release, apoptosis and necrosis) and proinflammatory cytokine release (IL-6 and ... shrinkage, condensation and fragmentation of nuclear material Necrosis on the other hand, is a passive response characterized by cytoplasmic swelling, rapid loss of plasma membrane integrity, and eventually ... endogenous levels of glutathione status and the amount of 4-HNE is formed IL-8 and IL-6 are important in the recruitment and activation of inflammatory cells The induction of these proinflammatory...

Ngày tải lên: 12/08/2014, 16:20

... between parents and other adults, the microcontext of interactions between parents and children, the macrocontext of the neighborhood one lives in and the availability of basic educational and health ... educational levels of parents Once a convergence is reached on the net and correlation effects of poverty on a variety of indicators, the task ahead is to decompose this effect further and to ... conflict, as well as conflict between parents and children over money (19) High levels of family conflict, anxiety, and concerns over the family financial situation decrease marital satisfaction and...

Ngày tải lên: 14/03/2014, 11:20