drugs and their complexes with dna bases
A study on the use of listening test-taking strategies and their relationship with students' performance at Que Vo I Upper Secondary School in Bacninh
... during, and after a test, then further investigated any correlation with listening test performances, and finally a student report was used to examine how HLP and LLP students adjusted their strategy ... upper-secondary school students’ test-taking strategies and their relationship with listening performance It further looks into how students adjust their strategies under different task conditions The ... and discussion, and recommendations Chapter one, literature review of listening comprehension problems, listening comprehension strategies and Listening Task in Relation to Task Performance and
Ngày tải lên: 10/08/2015, 19:48
Electrospun titanium dioxide nanostructures and their composites with carbon rich materials for energy conversion and storage
... AND THEIR COMPOSITES WITH CARBON RICH MATERIALS FOR ENERGY CONVERSION AND STORAGE ZHU PEINING NATIONAL UNIVERSITY OF SINGAPORE 2013 Trang 2ELECTROSPUN TITANIUM DIOXIDE NANOSTRUCTURES AND ... knowledge in materials science and engineering and the skills to carry out the specific researches Also, he spent so much time to advise me and help me with my experiments And I would like to thank ... fibers and rice grains The electrospun nanofibers are with uniform diameters and porous structures The rice grain shaped TiO2 nanostructure is uniformly distributed, single crystalline, and with
Ngày tải lên: 10/09/2015, 09:12
Synthesis and structure investigation of stabilized aromatic oligoamides and their interaction with g quadruplex structures 1
... (peptidomimetics and their abiotic analogues) as well as multiple-stranded foldamers that both fold and associate (nucleotidomimeitics Trang 2and their abiotic analogues) Generally, single-stranded abiotics ... trimer and tetramer According on this three-center H-bonding, a 9-mer and a 11-mer were synthesized and structures were investigated.13b-d The longer oligoamides adopt, both in the solid state and ... with a large hole or those with few units per turn permit easy access to objects with a high aspect ratio at minimal synthetic efforts.18 On the other hand, helices with a large diameter can be
Ngày tải lên: 10/09/2015, 15:49
Synthesis and structure investigation of stabilized aromatic oligoamides and their interaction with g quadruplex structures 2
... stacking and van der Waals’ interactions provide the driving forces for the observed formation of columns With their persistent shapes, tunable sizes and tendency to aggregate into column- and channel-like ... between axis ac and plane of the molecules, all the other three dimers (2a, 2c and 2d) are stacked along axis a with angles of 90º, 53º and 70º, respectively, between axis a and plane of the ... constructing higher-order supramolecular structures with non-collapsible pores and channels capable of conducting ions and small molecules.10m 2.2 Result and Discussion 2.2.1 Synthesis of Oligoamides
Ngày tải lên: 10/09/2015, 15:49
Synthesis and structure investigation of stabilized aromatic oligoamides and their interaction with g quadruplex structures 3
... slow evaporation of 5a and 6a in mixed solvents containing hexane and chloroform Trang 4(1:1 v/v) for 5a and hexane and dichloromethane (1:1 v/v) for 6a at room temperature Their crystal structures ... between proton 1 and proton 24 in 6c (Figures 3.5d and 3.5e), we decided to replace the methyl side chain at the nitro end with an isopropyloxy side chain to generate 5b and with an octyloxy ... protons and their adjacent interior methoxy protons, (f) Chemical structure of 6b More NOESY, ROESY and TOXSY studies of 6b were demonstrated in Figure 3.8 and Figure 3.9 Figure 3.8c and 3.8d
Ngày tải lên: 10/09/2015, 15:49
Synthesis and structure investigation of stabilized aromatic oligoamides and their interaction with g quadruplex structures 4
... robustness and predictablity.6,7 Owning to their specific structural features, these aromatic macrocycle have enabled extensive applications in chemistry and biology For example, their well-defined ... symmetric aromatic circular oligoamides with tunable interior functional groups were designed and synthesized Trang 24.2 Results and Discussion 4.2.1 Design and Computational Molecular Modeling ... hours and then quenched with water (20 mL) The aqueous layer was neutralized with 1M KHSO4 (1.2 mL) The precipitated crude product 1y was collected by filtration Compound 1y (0.763 g, 1.0 mmol) and
Ngày tải lên: 10/09/2015, 15:49
Synthesis and structure investigation of stabilized aromatic oligoamides and their interaction with g quadruplex structures 5
... been used very often in quadruplex-targeting ligands to enable the ligand to efficiently interact with the grooves and loops of quadruplex DNA and the negatively charged backbone phosphates In ... NaCl, and without salts A control experiment was carried out with an oligonuclotide (ODN-4) that contains one G to A mutation in every guanine tandem repeat (5’-GAGTTAGAGTTAGAGTTAGAGT-3’) and ... solubility between the macrocycles and DNA with the involving of hydrophobic side chains a) b) c) Figure 5.12 Comparison of the effect of 9b and 9a on the double-stranded PCR product by using
Ngày tải lên: 10/09/2015, 15:49
Synthesis and structure investigation of stabilized aromatic oligoamides and their interaction with g quadruplex structures 6
... Figure 6.1 UV-Vis spectra of gold nanoparticles before and after modification with DNA Two Thrombin aptamers TBA (15-mer) and TBA2 (29-mer) and their analogues were chemically coupled to AuNPs via ... shorter complimentary DNA strand containing a region of about 12-20 nucleotides complementary to DNA apamer and (3) gold nanoparticles (13 nm in diameter) functionalized with DNAs that enable the ... both Au-T6 and thrombin Our earlier observation and discussion in the duplex approach shows that the interaction of TBA with its complementary DNA strand is stronger than that between TBA and thrombin
Ngày tải lên: 10/09/2015, 15:49
Synthesis and structure investigation of stabilized aromatic oligoamides and their interaction with g quadruplex structures 7
... TBA2: Au-TBA2 with (a) thrombin only, (b) with both thrombin and 1, (c) with both thrombin and 9a, (d) with both thrombin and 10b, (e) with both thrombin and 11a, (f) with thrombin and 10a 7.3 ... nonspecific interactions between lysozyme and DNAs attached to the AuNPs With the addition of various pentamers into the solution containing DNA-modified AuNPs and lysozyme, AuNPs aggregation was ... presence of thrombin, (c) Au-TBA in the presence of thrombin and 10a (2 μM) Figure 7.4 UV-vis spectra of Au-TBA with both thrombin and 10a and with thrombin only 7.2.3 Sensitivity of Aptamer-Based
Ngày tải lên: 10/09/2015, 15:49
A numerical study of h2 o2 detonation waves and their interaction with diverging converging chambers
... WAVES AND THEIR INTERACTION WITH DIVERGING/CONVERGING CHAMBERS QU QING NATIONAL UNIVERSITY OF SINGAPORE 2008 Trang 2A NUMERICAL STUDY OF H2/O2 DETONATION WAVES AND THEIR INTERACTION WITH DIVERGING/CONVERGING ... reaction, and γ ratio of the specific heat of the gas ρ1,p1, and u 1 represent the density, pressure, and velocity of the unburnt gas, and ρ2,p2, and u 2 represent the density, pressure, and velocity ... research scholarship and an opportunity to pursue my Ph.D degree My sincere appreciation will go to my dear family Their love, concern, support and continuous encouragement help me with tremendous
Ngày tải lên: 11/09/2015, 16:07
Numerical modeling of three dimensional water waves and their interaction with structures
... the other hand, Li & Fleming (1997) solved the Laplace equation in σ-coordinate with the use of FDM. Frandsen & Borthwick (2003) and Frandsen (2004) proposed another FDM model with σ-coordinate ... Hanbin, Dr Fernando and Dr Anuja, for their friendship and valuable discussion during the study Special thanks go to Mr Cheng Yonggang for helping me to solve the problems of CAD and other softwares ... compared with the well-known MacCamy and Fuchs closed form analytical solution Good agreements are obtained Finally, the breaking wave interaction with a spar platform in deep ocean is demonstrated and
Ngày tải lên: 13/09/2015, 20:56
Mycobacterium tuberculosis genotypes and their relationships with clinical and immunological phenotypes in singapore
... Sin-Yew and Ann Lee, for the permission to use their precious mycobacterial DNA samples and IS6110 RFLP films for drug-susceptible and drug-resistant M tuberculosis isolates. A/P Lim Tow Keang and ... primary and recurrent episodes If the paired isolates of primary and recurrent episodes of one patient are identical (or nearly identical, with one or two band difference) in their DNA fingerprints ... progressive disease and reactivation of latent infection are both associated with increased production of IL-4 (Hernandez-Pando et al., 1996; Howard and Zwilling, 1999), and overexpression of
Ngày tải lên: 15/09/2015, 17:10
Surface functionalized substrates and their interactions with biomolecules and cells
... SUBSTRATES AND THEIR INTERACTIONS WITH BIOMOLECULES AND CELLS CEN LIAN NATIONAL UNIVERSITY OF SINGAPORE 2004 Trang 2SURFACE FUNCTIONALIZED SUBSTRATES AND THEIR INTERACTIONS WITH BIOMOLECULES AND ... PPY surface grafted with 5 vol.% HEA and subsequently silanized with 1 vol.% ATS in dioxane; (c) PPY film graft-copolymerized with 5 vol.% HEA and subsequently silanized with 1 vol.% ATS in dioxane ... with 5 vol.% HEA and subsequently silanized with 1 vol.% ATS in dioxane) after storage in (a) and (b) air at room temperature for 2 days; (c) and (d) air at room temperature for 4 days; (e) and
Ngày tải lên: 16/09/2015, 17:12
Báo cáo khoa học: The bI/bIII-tubulin isoforms and their complexes with antimitotic agents pptx
... interact with Arg320 The models of the complexes of IDN5390 with the bI and bIII-tubulin isoforms are shown in Fig The bound conformation of the ligand is quite similar in the I1 and I3 complexes, ... ring and His229 In E3, the ligand is farther away from the M-loop and shifted towards helix H1 and the S9–S10 loop with respect to the E1 complex, and therefore is Table Free energy, enthalpy and ... paclitaxel resistance and IDN5390 sensitivity, through the analysis of the complexes between these two ligands and the isotypes I and III of the human b-tubulin We also investigated the complexes involving...
Ngày tải lên: 16/03/2014, 13:20
Tài liệu an analySiS of euro area Sovereign CDS anD their relation With government bonds docx
... Netherlands and Austria is quite substantial and is approximately - 0.2; for France and Belgium it is smaller, namely - 0.005 For Italy, Ireland, Spain, Portugal and Greece is not significant and ... relative to the volume of total bonds outstanding For Greece, the net open CDS amount to around 3% of their outstanding sovereign debt and for Portugal and Ireland around 7% This magnitude is in contrast ... 2010 or Bharot and Guo, 2010) In contrast, we have documented that Euro area sovereigns with the temporary exception of Ireland, Greece and Portugal have a positive basis 16 14 Gorton and Metrick...
Ngày tải lên: 16/02/2014, 02:20
Tài liệu Báo cáo khoa học: Post-translational modifications of the linker histone variants and their association with cell mechanisms docx
... associated with X-chromosome inactivation will always have their CpG islands methylated Histone modifications The N-terminal tails of the core histones extend beyond the nuclesomes and can have their ... ⁄ SNF and TFIID [5] Methylation of H3 Lys10, H3 Lys28 and H4 Lys21 has been associated with gene silencing, whereas H3 Lys5, H3 Lys37 and H3 Lys80 (genomic position numbering) correlate with actively ... Mutations and amplification of the androgen receptor gene, without loss of gene expression, play a key role in the development of advanced, androgen-independent prostate cancer [4] Methylation of the androgen...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: Plant a-amylase inhibitors and their interaction with insect a-amylases ppt
... known modes of a-amylase inhibition A standard colouring scheme is used with enzyme drawn in magenta and inhibitor helix, strand and coil drawn in red, cyan and yellow, respectively The calcium ... activity PPA and HSA 0.19 T aestivum PPA and HSA 0.53 T aestivum HSA and PPA (low) 0.28 WRP25 T aestivum T aestivum PPA and HSA None WRP26 T aestivum None WRP27 T aestivum None 1,2 and BIII S cereale ... 1) and forms a separated folding unit, exclusively made of b sheet Eight of the 10 strands fold into a b sandwich structure with ÔGreek keyÕ topology The conservation of the interface of A and...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khoa học: Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate potx
... activity and the activity bands for corresponding peaks are labeled with arrows In this gel, peak appeared as a doublet (band a and b) Each peak was further separated on nondenaturing PAGE and the bands ... the 5¢- and 3¢-RACE products were cloned and sequenced The complete cDNA for this carboxylesterase was cloned by amplifying rat liver cDNA with the primers 5¢-CTGAGATTCAACCATGCCTTTGGC-3¢ and 5¢-TTG ... nucleotide and 2.5 U of Amplitaq The rat liver cDNA was denatured at 95 °C for and amplified using a DNA Thermal Cycler (Perkin-Elmer) with 35 cycles of 95 °C for min, 58 °C for 30 s and 72 °C...
Ngày tải lên: 08/03/2014, 10:20
Báo cáo khoa học: Crystal structure of RNase A tandem enzymes and their interaction with the cytosolic ribonuclease inhibitor potx
... maps, with the o and coot programs [36,37] The final refinement was performed with refmac from the ccp4 suite [32], with TLS parameterization Both cns and refmac used the same Rfree set (randomly ... dithiothreitol and mm EDTA, and purified further by anion exchange chromatography with a Mono Q column (Amersham Biosciences; 20 mm Tris ⁄ HCl, pH 7.5, containing 10 mm dithiothreitol and mm EDTA, with ... [16] Additionally, the bands containing the RI–RNase A or RI–SGRSGRSG-RATE complexes (Fig 4, lanes and 4) were excised and subjected to SDS ⁄ PAGE, in which the noncovalent complexes dissociate...
Ngày tải lên: 22/03/2014, 16:21
Báo cáo khoa học: Polysaccharide binding sites in hyaluronate lyase – crystal structures of native phage–encoded hyaluronate lyase and its complexes with ascorbic acid and lactose docx
... SerB198, ThrB204, GlnC214 and ThrA228, and water molecules, W73, W101 and W103 The third lactose molecule is located near the b-strands b11, b12 and b13 (Table 3) It interacts with GlyA223, AsnB241, ... hyaluronate lyase and its complexes P Mishra et al perturbations in the protein not occur The superimpositions of two complexes formed with ascorbic acid and lactose indicate that both ligands bind to ... However, with the help of the structures of the native protein and its two complexes with ascorbic acid and lactose, we were able to obtain insight into the regions that are critical for ligand binding...
Ngày tải lên: 23/03/2014, 04:21