drugs and poisons in humans a handbook of practical analysis pdf

... dead on a bed of a hotel In her room, 2 tablets of Vegetamin (a combined drug containing, phenobarbital, promethazine and Trang 11chlorpromazine) and one capsule of Insumin (fl urazepam) were ... by GC and HPLC are presented Incidence of fatal barbiturate poisoning cases Since fatal cases due to Vegetamin ® tablets containing phenobarbital are many, its incidence rate is also shown in this ... MO, USA); pure powder of metharbital was donated by Dainippon Pharmaceu-tical Co., Ltd., Osaka, Japan • Each barbiturate is dissolved in methanol to prepare 1 mg/mL stock standard solution and

Ngày tải lên: 15/12/2013, 12:15

... metabolite following intravenous and oral administration J Clin Pharmacol 26:529–533 3) Hattori H, Yamamoto S, Iwata M et al (1992) Determination of diphenylmethane antihistaminic drugs and ... Diphenylmethane antihistaminics HPLC analysis of chlorpheniramine and its metabolites in blood and urine [8] Chlorpheniramine is one of the most popular antihistaminics, and has been being used ... 11) Matsuda M, Mizuki Y, Terauchi Y (2001) Simultaneous determination of the histamine H1-receptor antagonist ebastine and its metabolites, carebastine and hydroxyebastine, in human plasma using

Ngày tải lên: 15/12/2013, 12:15

... analysis of non-steroidal anti-inflammatory drugs in plasma. J Chromatogr 416:293–302 9) Shinozuka T, Nakajima R, Takei S et al. (1999) Simultaneous analysis of propionic acid analgesic and antipyretic ... Terada M (1995) Standard methods of chemical analysis in poisoning VII, analgesics and anti- pyretics, the 115th Annual Meeting of the Pharmaceutical Society of Japan, the data of the Public Health ... Pharmaceutical Society of Japan, Tokyo, pp 81–86 (in Japanese) 3) Shinozuka T, Terada M, Ogamo A et al. (1996) Data on high-performance thin-layer chromatography of analgesic and antipyretic drugs.

Ngày tải lên: 15/12/2013, 12:15

... soluble in water and ethanol and almost insoluble in acetic anhydride, ether and chloroform; melting point: about 250° C Epidural, conduction and spinal anaesthesias Amide type mepivacaine hydrochloride ... in paracervical block-plasma levels and changes in maternal and foetal acid-base balance Br J Anaesth 41:603–608 28) Matouskova A, Hanson B (1979) Continuous mini-infusion of bupivacaine ... injection of Xylocaine™ solution (contain- ing 2 % lidocaine and a small amount of epinephrine) at a dental clinic; the amount of lido- caine hydrochloride salt administered was estimated to be

Ngày tải lên: 24/12/2013, 18:15

... Techniques in CGC Maruzen, Tokyo, pp 256–266 (in Japa-nese) 10) Study Group of Gas Chromatography of Japanese Society of Analytical Chemistry (translation) (1999) Inactiva-tion of an insert and packing ... poison-ing cases, convulsion, facial edema and cyanosis were characteristic, and edemas of the epiglot-tis and vocal folds were observed in all cases [3] In this chapter, a method for GC/MS analysis ... was dark), and activated charcoal and Nifl ec® (2 L aqueous solution containing 2.93 g NaCl, 1.485 g KCl, 3.37 g NaHCO3 and 11.37 g Na2SO4) were administered orally At night of the 1st day of

Ngày tải lên: 24/12/2013, 18:15

... Drugs and Poisons in Humans A Handbook of Practical Analysis Osamu Suzuki and Kanako Watanabe Drugs and Poisons in Humans A Handbook of Practical Analysis With 236 Figures and 90 Tables ... Suzuki and Dr Watanabe have gathered an extensive array of methods for the measurement of xenobiotics and metabolites in biological matrices Drugs and Poisons in Humans A Handbook of Practical Analysis ... throughout Japan contributed analytical methods for a wide variety of therapeutic and illicit drugs, pesticides, and natural toxins and alkaloids In fact, rarely has such a wide spectrum of analytes and

Ngày tải lên: 22/01/2014, 00:20

... benzodiazepines, cocaine metabolites, amphetamines, a cannabinoid metabolite, opiates, phencyclidine and tricyclic antidepressants in only about 10 min Some similar kits are being sold in U.S.A and ... elements having molecular weights not smaller than that of Na can be easily analyzed qualitatively and quantitatively; the method is very suitable for elemental analysis of inorganic and metal compounds ... integration and data processing For analysis of inorganic anions and cations, anion and cation exchanger columns are used, respec-tively Since the change in electric conductivity caused by a target inorganic

Ngày tải lên: 22/01/2014, 00:20

... arrythmia, atrial arrythmia, intraventricular aberrant conduction, QT elongation and torsades de pointes were observed. Transfusion, gastrolavage and administration of activated charcoal and a purgative ... the analysis of AAs in body  uids of aconite-poisoned patients in every area of Japan, and thus accumulating the data [8–14]. > Table 1.1 shows the concentrations of AAs in blood and urine ... benzoylmesaco- nine, benzoylhypaconine, 14-anisoylaconine, aconine, mesaconine and hypaconine were donated by Tsumura (Tokyo, Japan). Benzoylaconine and aconine can be obtained also Structures of Aconitum

Ngày tải lên: 22/01/2014, 00:20

... Th e toxins of Amanita mushrooms are usually analyzed by HPLC. As toxins, α-amanitin, β-amanitin, γ-amanitin and phalloidin are known Th eir authentic standards can be purchased from Sigma (St ... to be amanitin (> Figure 2.4) or phalloidin (> Figure 2.5) Th e amanitin is subdivided into α-, β- and γ-amanitins In Japan, Amanita virosa and Amanita verna glow generally, while in Europe ... Japan, because a very similar edible species Rhodophyllus crassipes is available and grows at similar locations Th e poisoning symptoms are vomiting, diarrhea and abdominal pain appearing 30 min–3

Ngày tải lên: 22/01/2014, 00:20

... methanol containing 0.5 % acetic acid and transferred to a small glass vial with a Tefl on cap, and again evaporated to dryness under reduced pressurei viii A 10-µL aliquot of dimethylformamide and ... was found dead in a ship on ocean navigation In Case No 4, the victim was found dead in an automobile in a public park Th e cases Nos 3 and 4 were treated as unnatural death In other cases, all ... Detection of tetrodotoxin in autopsy material by gas chromatography Arch Toxicol 44:291–297 7) Yasumoto K (1989) Analysis and applications of marine toxins Chemistry and Biology 27:401–406 (in Japanese)

Ngày tải lên: 22/01/2014, 00:20

... nicotine and conitine. HPLC analysis of nicotine and cotinine in blood and urine Reagents and their preparation •  e standard solutions of nicotine and cotinine, and spiked serum specimens are ... solutions are presented. GC/MS analysis of nicotine and cotinine in blood and urine Reagents and their preparation • Nicotine and cotinine (Sigma, St. Louis, MO, USA and other manufacturers) are dissolved ... [17]. In animal experiments using male Poisoning cases, and toxic and fatal concentrations 506 Nicotine and cotinine Sprague-Dawley rats with single oral administration each of tobacco exudates

Ngày tải lên: 22/01/2014, 00:20

... Identification of compounds and analytical database Identification of compounds and analytical database Analytical database The identification of a compound in a specimen can be made by comparing ... compounds Substantiation of the database of RI values may give rapid and reliable informations, but actually the RI database is much less than the mass spectral data In addition, such RI data are useless, ... sarin had been adsorbed into the paint material and protected from decomposition by water Analysis of chemical warfare agents in human specimens d) Two intermediate reagents are separately packed

Ngày tải lên: 26/01/2014, 18:20

... storage with shading at –80 is most desirable. GC analysis See [4]. Reagents and their preparation • Solution of saponin and potassium ferricyanide: 500 mg of saponin (obtainable from many manufacturers) ... absorbances at 532 and 558 nm (A 532 and A 558 ) are read against distilled water in another cuvette as a blank. vi.  e percentage of HbCO can be calculated by the following equation: COHb %=(2.44–A 558 /A 532 ) ... concentration in the air and duration of CO inhalation.  e table shows only an outline of its toxicity; 50% or more of COHb in blood is an indicator of fatality. ⊡ Table 1.1 COHb saturation percentages

Ngày tải lên: 26/01/2014, 18:20

... death cases Notes a) Kawanishi et al [20] analyzed thiosulfate in urine and plasma of 5 healthy subjects; thio-sulfate concentrations in urine and plasma were 31.2 µmol/24 h (0.0288 µmol/mL) and ... analysis of thiosulfate (a metabolite of hydrogen sulfi de) in blood and urine Trang 8⊡ Figure 2.2 TIC and mass chromatograms of a derivative of thiosulfate obtained from blood of a victim who died of ... Kangas J, Savolainen H (1987) Urinary thiosulfate as an indicator of exposure to hydrogen sulphide vapour Clin Chem Acta 164:7–10 5) Kage S, Nagata T, Kudo K (1991) Determination of thiosulfate

Ngày tải lên: 26/01/2014, 18:20

... of nitrogen-contain-ing compounds; it is also included in cigarette smoke and gases produced in a fi re Th ere are many kinds of qualitative and quantitative methods for analysis of cyanide in ... ecting the great needs of its analysis Th e Japanese Industrial Standard (JIS) standard-ized a method of cyanide analysis for factory waste water [1] Nonomura [2] published a review for analytical ... glycosides in the stomach In the tropical areas, it is also contained in cassaba; its poisoning by ingesting a large amount of cassaba is being a problem for health HCN can be produced during imperfect

Ngày tải lên: 26/01/2014, 18:20

... others; in rare cases, visual disturbance appears at an early stage Th ese symptoms usually appear 12–24 h aft er the injgestion, but in severe cases they can appear in about 1 h aft er the intake ... the fi ber in it iv Quantitation: to vials containing the above components each, one of various amounts of methanol and 2 µL of IS were added and processed as above to construct a calibration curve ... [1–5] In this chapter, GC methods for analysis of them in blood and urine using a wide-bore capillary column and using solid-phase microextraction (SPME) [6–9] are presented Analysis of methanol

Ngày tải lên: 26/01/2014, 18:20

... cartridges and wide-bore capillary gas chromatography of organoposphate pesticides. Forensic Sci Int 41:67–72 2) Hayasaka M, Kawabata S, Haba A et al. (1994) Analysis of malathion metabolites in biological ... derivatives. ⊡ Figure 2.3 541 HPLC and LC/MS analysis Reagents and their preparation  ey are almost the same as described in the section of GC and GC/MS analysis. Analytical conditions LC: any instrument ... Table 2.2 Distribution of malathion and its metabolites in blood, bile and some organs of a human victim in fatal malathion poisoning [8] Concentration (µg/g) Sample Malathion Malaoxon Monoacid

Ngày tải lên: 26/01/2014, 18:20

... than paraquat and are easily obtainable; they, thus, have come into wide use since 1980 Th e PAAHs include glufosinate (GLUF), glyphosate (GLYP) and biala-phos (BIAL) In Japan, there are many ... reported that any plot below line A indicated a mild case, and one above line B a severe case; in the area between lines A and B mild and severe cases were mixed Both GLUF and coexisting surfactant ... linear lines A and B by connecting a point of 70 µg/mL at 2 h aft er GLUF ingestion with a point of 5 µg/mL at 8 h for A and by connecting a point of 200 µg/mL at 2 h with that of 15 µg/mL at

Ngày tải lên: 26/01/2014, 18:20

... than that of carbofuran; the both compounds are metabolized into a highly toxic metabolite carbofuran in mammals. In furathiocarb and benfuracarb poisoning cases, carbofuran should be analyzed ... bendiocarb and methiocarb (10 µg/mL each). It is useful for the testing of retention times and as the standards for quantitative analysis. c) In GC and GC/MS analysis, one or two of carbofuran, carbaryl ... Methomyl in the blood of a pilot who crashed during aerial spraying J Anal Toxicol 5:339–340 13) Tsatsakis AM, Tsakalof AK, Siatitsas Y et al (1996) Acute poisoning with carbamate pesticides:

Ngày tải lên: 26/01/2014, 18:20

... separetely detect paraquat and diquat, when specimens obtained from a victim of poisoning by a paraquat-containing product are analyzed For simultaneous analysis of paraquat and diquat, the methods ... Trang 10580 Paraquat and diquat 6) Kawase S, Kanno A, Ukai S (1984) Determination of the herbicides paraquat and diquat in blood and urine by gas chromatography J Chromatogr 283:231–240 7) Tayama ... of diquat, are described together with that for paraquat and diquat Reagents and their preparation • Standard solutions of paraquat and diquat (1 mg/mL each) are prepared as described in the

Ngày tải lên: 26/01/2014, 18:20