drug therapy pharmacotherapy of autistic spectrum disorders

... The results of this comparison have been published elsewhere [25,32] The primary aim of this secondary analysis was to assess the psychometric properties of the GIPD scale in terms of validity ... for Hyperkinetic Disorders) , a structured instrument which is routinely used for the diagnostic assessment of ADHD in Germany [42] The items of this instrument correspond to those of the ADHD-RS ... point single-item rating scale of the clinician's assessment of the severity of ADHD symptoms [28,29] The WREMB-R-Inv scale is based on the Daily Parent Rating of Evening and Morning Behavior...

Ngày tải lên: 13/08/2014, 18:21

... dose of drug delivered depends on the surface area of the patch and the length of time that the patch is worn, which allows for tailoring the duration of medication effect with reductions of first-pass ... dose of MTS after weeks of treatment Subjects and Methods Subjects Children aged 6-12 years, with a confirmed diagnosed of ADHD (any subtype) by the Diagnostic and Statistical Manual of Mental Disorders ... satisfied with the efficacy of the study medication on their child's attention The majority of caregivers (93.1%) indicated a high level of satisfaction with the duration of effect of the study medication...

Ngày tải lên: 25/10/2012, 10:06

... Safety, efficacy and extended duration of action of mixed amphetamine salts extended-release capsules for the treatment of ADHD Expert Review of Pharmacotherapy 2005, 6:1003-1017 Sallee FR, Ambrosini ... PL, Graetz BW, Baghurst P: Health-related quality of life of children and adolescents with mental disorders Journal of the American Academy of Child and Adolescent Psychiatry 2002, 41:530-537 ... Quality of life of adolescent males with attention-deficit hyperactivity disorder Journal of Attention Disorders 2004, 7:163-173 Landgraf JM, Abetz LN: Functional status and well-being of children...

Ngày tải lên: 20/06/2014, 15:20

... prevalence of psychiatric disorders in the adolescent population and called for a total of 200 students for a power of 0.80 However, statistically significant results were reached after analysis of 144 ... games? How often your grades or schoolwork suffer because of the amount of time you spend playing video games? How often you play video games before something else that you need to do? How often does ... how many joints per week on average? Other drugs and amount: How often you use alcohol/cigarettes/drugs while playing video games? (Circle one) How often you neglect household chores to spend...

Ngày tải lên: 08/08/2014, 21:20

... Network Group: Identification of new putative sus‑ ceptibility genes for several psychiatric disorders by asso‑ ciation analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission ... ADHD Know­ ledge of such genes will allow us to identify specific diagnostic biological markers In addition, defining target genes is the first step toward the development of novel drug therapies ... than specific aspects of the disorder, may contribute to ADHD develop­ ment; common variants in these genes could then confer susceptibility to a group of related psychiatric disorders Further evidence...

Ngày tải lên: 11/08/2014, 12:20

... have also been reported [15] The effects of methylphenidate on the neuropsychological profiles of subtypes of ADHD patients are still controversial [16,17] Of the stimulant medications, MPH is the ... aggression scale of the CBCL, with a cutoff point of 60 Chisquare was used to compare the rate of lost to followup between subtypes The Student’s t-test or One-way analysis of variance (ANOVA) ... mean age of 7.84 ± 1.64 years Fifteen of them were inattentive type, 11 were hyperactive-impulsive type, and 24 were combined type Using a cutoff point of 60 on the aggression scale of the CBCL,...

Ngày tải lên: 11/08/2014, 15:22

... extraction form Title, year of publication, total number of participants, age of participants, design of study (parallel vs crossover), blinding, name and dose of drug, number who dropped out ... with the largest number of participants was of short duration of three weeks [19] This time period may not be adequate as optimal efficacy of atomoxetine requires 4-6 weeks of treatment [40] Two ... 0.87-1.71, p = 0.25) Heterogeneity Heterogeneity is a measure of variation of effect size I2 is an estimation of the proportion of the observed variance reflecting real differences among studies...

Ngày tải lên: 11/08/2014, 16:20

... equation modelling software [18] The overall fit of a model was assessed by calculating twice the difference between the negative log-likelihood (-2LL) of the model and that of a saturated model ... Given the non-independent nature of the phenotypes under investigation, we did not correct any of the association findings for the number of phenotypes studied None of the associations at either ... However, the literature is mixed with regards the effects of dominance and contrast effects, a feature of ADHD that is often found in samples of older children [21] Dominance and contrast effects...

Ngày tải lên: 11/08/2014, 16:22

... and coexisting disorders, such as SUD, ASD, personality disorders, mood- and anxiety disorders Previous studies reported increased frequencies of major mental disorders, personality disorders, and ... Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden 2Karolinska Institutet Center of Neurodevelopmental Disorders, Stockholm, Sweden 3Department of Molecular ... Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden, Karolinska Institutet Center of Neurodevelopmental Disorders, Stockholm, Sweden, Department of Molecular...

Ngày tải lên: 11/08/2014, 16:22

... disorder (mostly specific developmental disorder of motor function) and 44% had at least two comorbid disorders (mostly specific developmental disorders of scholastic skills) Control children did not ... length of the break was determined by the children Page of 10 Each trial began with a 1000 ms instruction slide depicting the nature of the required saccade by a prominent symbol the meaning of which ... and right) Additional sources of no interest (Cerebellum (CB) - left and right) were placed to increase the sensitivity of the sources of interest The sensitivity of a source describes its ability...

Ngày tải lên: 11/08/2014, 16:22

... levels of scientific evidence [56] In view of the large numbers of children and adolescents being diagnosed with AD/HD and the increased use of CAM therapies, of which chiropractic care is one of ... management of paediatric and adolescent AD/HD?" The inclusion of a log of rejected trials is an important aspect of any systematic review [90] As part of the Cochrane review process a log of rejected ... Statistical Manual of Mental Disorders 4th Edition Text Revision; DSM-IV: Diagnostic and Statistical Manual of Mental Disorders 4th Edition; DSM-III: Diagnostic and Statistical Manual of Mental Disorders...

Ngày tải lên: 13/08/2014, 14:20

... and intensity of pharmacotherapy With the introduction of new products commanding higher units costs (cf Table 1), growth of pharmaceutical spending has outpaced the rising number of prescriptions ... psychotropic drugs in 2012, compared to 1.8% in 2002 This increase is driven by the multiplicative effects of increasing awareness and recognition of ADHD, growing rates of pharmacotherapy, somewhat ... out of 193,000 per physician in 2012, assuming a 5% growth rate of nonADHD pharmaceutical spending) of total drug costs induced by this group These figures compare with average drug costs of 83,000...

Ngày tải lên: 13/08/2014, 18:21

... well-being [46] and the quality of life (QoL) of both patients and their families [7-12] Psychostimulants and behavioral therapy are known to be effective in the treatment of ADHD, as reported in the ... ADHD that go beyond the core symptoms of the disorder and reflect various dimensions of health-related quality of life However, such questionnaires are often rated by the investigator alone, ... response captures the severity of 48 adverse event items on a five-point Likert scale (0–4) The main assumption of this post-hoc analysis was that 10 of the 48 items of the PAERS are directly related...

Ngày tải lên: 13/08/2014, 18:21

... Lindemulder E, Wigal S: Development of a new once-a-day formulation of methylphenidate for the treatment of attentiondeficit/hyperactivity disorder: proof -of- concept and proof-ofproduct studies Arch Gen ... settings) of symptoms and the impact of these symptoms on daily functioning Indeed, it has been suggested that the primary focus of assessment of ADHD should be on functional behavioural assessments of ... validity of some of the results Of note, parental assessment in this survey showed relatively small differences between medicated and non-mediated children with ADHD, in terms of the impact of their...

Ngày tải lên: 13/08/2014, 18:21

... Clinical Professor of Pediatrics, University of Pennsylvania School of Medicine, Division of General Pediatrics, The Children's Hospital of Philadelphia; Gabrielle A Carlson, Professor of Psychiatry ... Fegert, Professor and Chair of Child and Adolescent Psychiatry and Psychotherapy, University of Ulm, Medical Director of the Department of Child and Adolescent Psychiatry and Psychotherapy, Ulm ... that there is a systemwide push towards the diagnosis of mental disorders and the use of drugs in preference to behavioral therapy because drugs are easier to administer and, perhaps wrongly,...

Ngày tải lên: 13/08/2014, 18:21

... therapy are known to be effective in the treatment of ADHD, as reported in the MTA study [13] Since the introduction of various longacting ADHD medications, interest in the efficacy profile of ... towards the evening hours [19] Thus, the impact of ADHD medications on core symptoms of ADHD over the day, on emotional well-being and QoL of patients is of considerable interest both to clinicians ... Hyperkinetic Disorders) assessment tool, a structured instrument which is routinely used for diagnostic assessment of ADHD in Germany [42] The items of this instrument correspond to those of the ADHD-RS...

Ngày tải lên: 13/08/2014, 18:21

... speculation based on differential response to ADHD pharmacotherapy that the co-occurrence of ADHD and dyslexia is more related to the inattentive subtype of ADHD, and reduction in hyperactive symptoms ... efficacy of atomoxetine in reducing symptoms of ADHD in individuals aged 10 to 16 years meeting DSM-IV diagnostic criteria for ADHD and dyslexia As part of this investigation, a smaller group of individuals ... during the course of the study; a history of substance abuse or dependence within the past months (excluding nicotine and caffeine); a positive urine drug screen for any substances of abuse; and...

Ngày tải lên: 13/08/2014, 18:21

... on the HR-QoL of the individuals and their family 4.1 Limitations The results of this meta-analysis need to be interpreted in light of a number of limitations First, the samples of the five clinical ... Third, 8-12 weeks of follow-up might have been too brief for the evaluation of the improvement of HR-QoL Though the findings of Perwien et al [19] indicate that the treatment effect of atomoxetine ... Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) [40] diagnostic criteria for ADHD and had a symptom severity of at least 1.5 standard deviations (SD) above the normative values of the Attention...

Ngày tải lên: 13/08/2014, 18:21