drug induced long qt syndrome pdf

... Trang 1LONG QT SYNDROMEIN CHILDREN Vu Minh Phuc MD PhD. Trang 31 ETIOLOGY Congenital LQTS  Acquired LQTS Trang 4? 3 211p15.5 7q35-36 3p21-24 4q25-27 21q22.2-22.2 21q22.2-22.2 KCNQ1/KVLQT1 KCNH2/HERG ... normal QTc - LQT1 : broad-based, prolonged T waves (IKs) - LQT2 : low-amplitude, delayed T waves (IKr) - LQT3 : normal duration and amplitude T waves, significant late in onset (INa) 4. QTc depends ... next best  QTc = QT/√ RR (normal upper limit = 0.44sec)  QTc > 0.46 sec in LQTS  Abnormal T wave morphology (bifid,diphasic, notched)  Considered risk factors of suddent death  QT interval...

Ngày tải lên: 14/04/2020, 06:34

... Meletis, N.D and Jason E Barker, N.D Asperger Syndrome: Natural Steps toward a Better Life Suzanne C Lawton, N.D Trang 4Natural Treatments for Chronic Fatigue SyndromeDaivati Bharadvaj, N.D. Complementary ... 978–0–275–99374–0 (alk paper) 1 Chronic fatigue syndrome—Alternative treatment I Title II Series: Complementary and alternative medicine (Westport, Conn.) [DNLM: 1 Fatigue Syndrome, Chronic—therapy 2 Naturopathy ... Chronic Fatigue Syndrome? Chapter 1 Concepts, Controversies, and Conventional Medicine 3 Chapter 3 Stress, Adrenal Fatigue, and Cognitive Disorder 33 Part II: How Is Chronic Fatigue Syndrome Diagnosed?...

Ngày tải lên: 15/03/2014, 09:20

... antiphospholipid syndrome registry and clinical and laboratory differences between paediatric and adult patient with antipphospholipid syndrome (Rotar Z, et al; 2009, Avcin T, Silverman ED; 2007) Trang 16long-The ... randomized trial Blood 2008; 112: 4432-4436 Khamastha MA Hughes Syndrome: History In Khamastha MA (Ed): Hughes Syndrome: Antiphospholipid syndrome Springer-Verlag London Berlin Heidelberg 2000; 3-7 ... 2 -Glycoprotein I and the Antiphospholipid Syndrome 23 Çetin Ağar, Philip G De Groot and Joost C.M Meijers Chapter 3 Genetics of Antiphospholipid Syndrome 35 Jesús Castro-Marrero, Eva Balada,...

Ngày tải lên: 22/03/2014, 09:20

... cleaves the IFN-induced, ubiquitin-like modifier ISG15 from its target proteins [29], and was also reported recently to block phosphorylation of JAK1 [30] The examined genes were strongly induced by ... proteins that modulate termination of pathway activation Furthermore, the expression of IRF9 is induced, constituting a positive feedback loop IRF9 plays an important role in IFNa signalling [7] ... modelling approaches analysing the JAK⁄ STAT pathway focussed on the impact of phos-phatases and induced negative inhibitors [14–16] that primarily influence pathway termination Here, we have developed...

Ngày tải lên: 23/03/2014, 03:20

... primes contain arbitrarily long arithmetic progressions By Ben Green and Terence Tao* Annals of Mathematics, 167 (2008), 481–547 The primes contain arbitrarily long arithmetic progressions By ... prime. The problem of finding long arithmetic progressions in the primes has also attracted the interest of computational mathematicians. At the time of writing the longest known arithmetic progression ... small atoms Then THE PRIMES CONTAIN ARBITRARILY LONG ARITHMETIC PROGRESSIONS. .. ZN 1/2 THE PRIMES CONTAIN ARBITRARILY LONG ARITHMETIC PROGRESSIONS 499 Putting all this...

Ngày tải lên: 29/03/2014, 07:20

... Trang 1MCP-1-induced protein 1 RNaseLukasz Skalniak, Danuta Mizgalska, Adrian Zarebski, Paulina Wyrzykowska, ... the identification of a novel gene, termed ZC3H12A The gene, which encodes a protein named MCP-1-induced protein 1 (MCPIP), undergoes rapid and potent transcription induction upon stimulation of ... executor of MCP-1 action in chronic inflam-mation-related ischaemic heart disease [1,3] and MCP-1-induced angiogenesis [4] MCPIP was also proved to be a negative regulator of macrophage activation...

Ngày tải lên: 29/03/2014, 22:21

... apoptosis in chronic fatigue syndrome J Clin Pathol 2004, 57:891-893. 14 Streeten DHP, Bell DS: Circulating blood volume in Chronic Fatigue Syndrome J Chronic Fatigue Syndrome 1998, 4:3-11. 15 Yoshiuchi ... affects individuals across all ages worldwide and severe forms of prolonged fati-gue may be diagnosed as Chronic Fatifati-gue Syndrome (CFS) usually accompanied by other disabling symp-toms CFS ... (Sewon Meditech, Korea) The elongation index was measured between shear stres-ses of 0.5 to 20 Pa Shear stress for half-maximal defor-mation (SS1/2) and the maximum elongation index (EImax) was...

Ngày tải lên: 18/06/2014, 16:20

... central cord syndrome Angel Gil-Agudo1*, Soraya Pérez-Nombela1, Arturo Forner-Cordero2, Enrique Pérez-Rizo1, Beatriz Crespo-Ruiz1, Antonio del Ama-Espinosa1 Abstract Background: Central cord syndrome ... 30% of cases, is the most frequent form of SCI [1] The central cord syndrome (CCS) is considered the most common incomplete SCI syndrome with a reported inci-dence varying from 15.7% to 25% [2] ... simultaneously from both sides Data collection All CCS patients were asked to walk barefoot along a 10-m long walkway at a self-selected speed while temporal-spatial and kinematic data were recorded...

Ngày tải lên: 19/06/2014, 08:20

... on Long-Span Bridges." Bridge Engineering Handbook Ed Wai-Fah Chen and Lian Duan Boca Raton: CRC Press, 2000 Trang 2Wind Effects on Long-Span Bridges 57.1 Introduction 57.2 Winds and Long-Span ... on July 1, 1940 Its 853-m main suspension span was the third longest in the world This bridge became famous for its serious wind-induced problems that began to occur soon after it opened “Even ... also experienced large wind-induced oscil-lations, although not to the point of collapse In 1953, the Golden Gate bridge was stiffened against aerodynamic action [2] Wind-induced vibration is one...

Ngày tải lên: 08/07/2014, 12:20

... gene usage, lymphocytes, Sjögren’s syndrome Review Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren’s syndrome Thomas Dörner1 and Peter ... noteworthy that the JH6 segment encodes the longest CDR3 compo-nent (29 nucleotides) of all JHgenes and can thereby con-tribute to rearrangements with longer CDR3 regions This confirms conclusions ... emphasis that class switching, but not somatic hypermutation, could be induced, although the recently discovered activation-induced deaminase (AID) [79] has been found to be expressed in these...

Ngày tải lên: 09/08/2014, 01:21

... in an animal model of RA, collagen-induced arthritis was induced in a total of 124 DBA/J1 mice Treatment was started on day 21 (early disease) or on day 35 (longstanding disease) with the blocking ... Trang 1Open AccessVol 8 No 5 Research article CD97 neutralisation increases resistance to collagen-induced arthritis in mice Else N Kop1, Janik Adriaansen1, Tom JM Smeets1, Margriet J Vervoordeldonk1, ... CD97 Ab = antibody; ANOVA = analysis of variance; CFA = complete Freund's adjuvant; CIA = collagen-induced arthritis; cIg = control immunoglobulin; DMEM = Dulbecco's modified Eagle's medium; EDTA...

Ngày tải lên: 09/08/2014, 08:22

... offers the advantage of local drug deliverywithout the invasiveness of intravitreal injection This route also allowsfor the use of drug depots to prolong the duration of drug therapyand avoids much ... time—thetime for drug to traverse the cornea and appear in the aqueous humor—issufficiently long to extend time to maximal concentration in the aqueous tobetween 20 and 60 minutes for most drugs (8) Due ... by prolonging precorneal retention ofthe dose to 480 minutes It was concluded that modest formulation changeswill have little effect on systemic absorption for extremely hydrophilic drugs.Drugs...

Ngày tải lên: 10/08/2014, 00:20

... changes in the pathophysiology of the eye is the diffusivity ofdrugs in the vitreous Changes in drug diffusivity will be most significantwhen drugs of different molecular weight are used to treat different ... by changes to the drug diffusivity However, thetime at which the peak concentration occurred increased as the drug diffu-sivity decreased because the average time required for a drug molecule toreach ... the injectionlocation and the retinal permeability of the drug If the drug has a low retinalpermeability, then the half-life of the drug in an aphakic eye is highly depen-dent on the distance...

Ngày tải lên: 10/08/2014, 03:20

... có đồng bằng Cửu Long vào những thế kỷ đầu Công nguyên Bước đầu xin được giới thiệu vắn tắt một số tác phẩm điêu khắc của hai tôn giáo này, chúng đều có xuất xứ ở đồng bằng Cửu Long và khác với ... đăng loạt bài của tác giả Phạm Hy Tùng Bách, dưới tiêu đề chung “Tìm hiểu cổ vật đồng bằng Cửu Long”. PHẦN III: CỔ VẬT CHẠM, KHẮC Bài 9: TƯỢNG PHẬT, TƯỢNG THẦN LINH VÀ CỔ VẬT CÓ MINH VĂN BẰNG ... Trang 1TÌM HIỂU CỔ VẬT ĐỒNG BẰNG CỬU LONG (Tiếp theo)Phạm Hy Tùng Bách * LTS: Nền văn hóa Óc Eo gắn liền với lịch sử phát triển vùng...

Ngày tải lên: 10/08/2014, 13:21

... sequences [17] NtMMP1 mRNA is induced within 30 min after the treatment of BY-2 cells with P. syringae and to a lesser extent by A tumefaciens (Figure 6). Other MMP genes induced by pathogenic bacteria ... include soybean GmMMP2, which is induced after treatment with compatible and incompatible P syringae pathovars [1], and Arabidopsis At3-MMP, which is rapidly induced after treatment of Arabidopsis ... increase sharply after the onset of senescence in cotyle-dons and leaves [3] GmMMP2 mRNA in soybean is induced by certain types of stress, including wounding, dehydration and infection with the oomycete...

Ngày tải lên: 12/08/2014, 03:20

... upset Notes: Do not chew or puncture the caps Benztropine (Cogentin) Uses: *Parkinsonism & drug-induced extrapyra- midal disorders* Action: Partially blocks striatal cholinergic receptors Dose: ... PO q4h PRN, max 6 tabs/d; avoid w/ CrCl <10 mL/min & severe liver Dz Caution: [C (D w/ prolonged use or high doses at term), ?] Contra: ASA allergy, GI ulceration, bleeding disor- der, porphyria, ... prior to surgery; avoid/limit ETOH Atazanavir (Reyataz) WARNING: Hyperbilirubinemia may require drug D/C Uses: *HIV-1 Infxn* Action: Protease inhibitor Dose: 400 mg PO daily w/ food; when given...

Ngày tải lên: 12/08/2014, 03:21

... biomarker to assess the severity of drug-induced pneumonitis Based on these observations, this study was conducted to evaluate the risk factors of EGFR-TKIs induced ILD and the usefulness of monitoring ... non-survivors who developed EGFR-TKIs induced ILD Week 0 is designated as the week when EGFR-TKIs induced ILD was diagnosed Before and after the onset of EGFR-TKIs induced ILD, the serum levels of ... life-threatening types, such as the DAD and CIP patterns, of drug induced ILDs [27], absolute serum KL-6 levels at the onset of EGFR-TKIs induced ILD did not correlate with clinical outcomes in the...

Ngày tải lên: 12/08/2014, 13:22

... mouse In the presence of GTP, ACh induced a further contraction even in the constant Ca2+ concentration at pCa 6.0, i.e., ACh-induced Ca2+ sensitization (a) The ACh-induced Ca2+ sensitization was ... between normal and antigen-induced AHR animals in ACh-antigen-induced increase in intrac-ellular Ca2+ concentration in BSMs, irrespective of a great difference in ACh-induced BSM contraction [29,30] ... whereas no significant change in the Ca2+-induced contraction of the high K+-depolarized muscles was observed between groups (B). Trang 6Acetylcholine (ACh)-induced Ca2+ sensitization of murine bronchial...

Ngày tải lên: 12/08/2014, 18:21

... wasting syndrome and porcine dermatitis and nephropathy syndrome naturally affected pigs J Virol Methods 2004, 117:75-80. 30 de Groot J, Ruis MA, Scholten JW, Koolhaas JM, Boersma WJ: Long-term ... wasting syndrome (PMWS) affected farms in Spain and Denmark Vet Microbiol 2009, 135:272-282. 13 Madec F, Rose N, Grasland B, Cariolet R, Jestin A: Post-weaning multisystemic wasting syndrome ... lesions of pigs with postweaning multisystemic wasting syndrome Can Vet J 1998, 39:44-51. 2 Segalés J, Domingo M: Postweaning multisystemic wasting syndrome 3 Ramamoorthy S, Meng XJ: Porcine circoviruses:...

Ngày tải lên: 12/08/2014, 18:22

... MPs such as acute coronary syndromes, severe chronic renal failure (defined as creatinine clearance <30 mL/minute), heparin-induced thrombocytopenia, antiphospholipid syndrome, sickle-cell disease, ... respiratory distress syndrome decreased over time? A systematic review Am J Respir Crit Care Med 2009, 179:220-227. 4 Ware LB, Matthay MA: The acute respiratory distress syndrome N Engl J Med ... Introduction Acute Lung Injury (ALI) and its most severe clinical presentation, Acute Respiratory Distress Syndrome (ARDS), occur after a variety of insults, including sepsis, trauma, or aspiration of gastric...

Ngày tải lên: 14/08/2014, 07:21