driven flexible machine learning strategy for the classification of biomedical data

... to address the role of heme degrada-tion in the populadegrada-tion of hemoglobin-positive cells To the best of our knowledge, there has been no report on the promoter function of the human HO-2 ... address the question of whether hypoxia influences the promoter activity of the human HO-1 or HO-2 gene, we performed transient expression assays Prior to the functional analysis of the HO-2 gene promoter, ... ahead-to-head orientation, and their transcription start sites are  1.5 kb apart We therefore analyzed the promoter function of the 1.5 kb 5¢-flanking region of the HO-2 gene in the present study YN-1...

Ngày tải lên: 19/02/2014, 06:20

... Results In the following, we discuss the results of a five-fold cross-validation study on the entire data set of HP and non-HP species and compare the performance of PaPrBaG with that of the other ... reflects the larger bias towards HPs in the training set Overall, the effect of the larger database is small We further assessed the performance of all approaches in a ROC analysis Here, instead of the ... repeated for each fold Comparison with other methods We further compared the performance of PaPrBaG with a range of other tools, most of which were originally developed for taxonomic classification...

Ngày tải lên: 04/12/2022, 15:55

... intervention The vast availability of social media data offers a unique opportunity to leverage machine learning techniques to analyze text data for signs of Trang 12mental health issues, thereby ... Their model achieved impressive accuracies of 88.29% for text-only classification and 87.69% for text and emoji classification, demonstrating the potential of leveraging multimodal features for ... machine learning methods for the automatic classification of mental illness types among young people in Vietnam based on social media text data Recent studies have demonstrated the effectiveness of...

Ngày tải lên: 08/10/2024, 02:12

... improve their classification performance.The mention of the Unsupervised algorithm performing poorly in gene classification highlights the importance of choosing appropriate algorithms for specific ... regarding the ability to classify cancer patients based on gene expression data but also lays the foundation for the widespread application of machine learning in the fields of diagnosis and cancer classification ... unrelated to the presence of any other feature.The Naive Bayes classifier is widely used for classification tasks such as text classification, belonging to the family of generative learning algorithms...

Ngày tải lên: 02/10/2024, 02:55

... DEVELOPMENT STRATEGY FOR THE DISTRICT OF COLUMBIA Trang 2November 14, 2012Office of Mayor Vincent C Gray The District of Columbia Trang 3November 14, 2012Office of Mayor Vincent C Gray The District of ... collaborative effort While we served as co-chairs of the Strategy Executive Committee, the work brought together the talents of the entire committee, the project’s Strategy Advisory Group and the business ... collaboration with the private sector and local universities Before I became mayor, I spoke often about the need for a transformative economic development strategy for Washington, DC With the help of local...

Ngày tải lên: 17/02/2014, 05:20

... is the only curative therapy for HCC However, due to the extent of the tumor and associated cirrhosis at the time of diagnosis, it is inappropriate in the majority of patients The search for ... macrophages nor the depletion of CD4 or CD8 T lymphocytes nor a sublethal dose of whole-body radiation before the injection of the tumor cells prevented the effect of TNF-a On the other hand, the method ... expression of mediators of pathogensis is an important approach that can be utilized in the use of gene therapy of the liver SUMMARY The liver synthesizes a large variety of proteins and, therefore,...

Ngày tải lên: 10/04/2014, 22:11

... : 40 000 for the classic form The incidence of the variant form of Fabry disease was found to be higher Screening of various ethnic groups revealed that the incidence of cardiac variant Fabry ... progress in the development of ASSC therapy for Fabry disease Particularly, 1-deoxygalactonojirimycin (DGJ) is explored as an example of the development of ASSC therapy Structural basis of Fabry ... [28] The first domain contains the active-site formed by the C-terminal ends of the b strands at the center of a barrel Thirteen amino acid residues were predicted to be directly involved in the...

Ngày tải lên: 30/03/2014, 03:20

... TARGETS FOR GENE THERAPY The concept of genetic correction or modification of HSCs has been an ongoing primary focus of gene therapy research The properties of both self-renewal and differentiation of ... division The mechanism for this property is not fully understood But, the dissection of the HIV genome and incorporation of the nuclear transport mechanism(s) into otherwise standard MuLV vectors for ... limitations to the use of MuLV vectors for hematopoietic stem cell transduction First, cells must pass through the mitotic phase of the cell cycle in order for the vector to gain access to the chromatin...

Ngày tải lên: 10/04/2014, 22:10

... characterized Furthermore, it has been hypothesized that one can enhance the function of these endothelial cells via the transfer of genes prior to seeding of the cells on the graft surface The initial ... with the increased safety of ex vivo transfection For gene therapy of the heart, genetic manipulation of the myocardium has generated considerable interest in the use of gene transfer of the b-adrenergic ... normalization of myocardial function than either therapy alone factors or the genes encoding these factors have been administered to a small number of patients These studies have involved either the use of...

Ngày tải lên: 10/04/2014, 22:11

... to produce a therapeutic benefit for the patient Therefore, AIDS may be amenable to treatment by gene therapy approaches to inhibit the replication of HIV-1 The ultimate goal of gene therapy is ... pattern of HIV-1 .The diagram depicts the organization of the nine predominant genes of HIV-1 The diagram represents the major RNAs derived from the HIV-1 genome by alternative splicing of the HIV-1 ... with the use of DNA oligonucleotides is that the gene inhibition that is observed is often nonspecific In other words, the inhibition of expression is most often not the direct result of the interaction...

Ngày tải lên: 10/04/2014, 22:11

... recoveries in the range of to million per gram of lung tissue The CD11c+ cells were then seeded into 12-well plates at 105 cells per well and cultured for 48 hours in the presence of 10 mg of chitosanpVAX ... 1C); therefore, the decrease in IFN-c production observed in the CD8+ T cells does not appear to be the result of destruction of the cells but represents an IFN-cmediated downregulation of IFN-c ... FACScan gated for CD11c cells The figure shows the percentage of cells that were positive for CD11c and for each of the markers Activation marker expression in CD11c+ cells from the bronchoalveolar...

Ngày tải lên: 08/08/2014, 21:20

... in the formation of hemorrhagic ascites and a reduction in microvessel density Virotherapy Utilization of the oncolytic potential of viruses for killing of tumor cells predates the concept of ... into the adenovirus genome to control the expression of the early genes such as E1A, which is essential for viral replication The utility of these agents is subservient to the identification of ... gene therapy Antiangiogenic gene therapy Virotherapy Virotherapy Measles virus Virotherapy Measles and mumps viruses Virotherapy Adenovirus AAV Delivery of p73 HSV-TK suicide gene therapy Virotherapy...

Ngày tải lên: 22/03/2014, 11:20

... ppm) of the N-acetyl groups of the HA-grafts to -methylene protons (3.0 ppm) of the PLL backbone, the content (wt % and grafting-%) of HA in the copolymer was determined The results of the synthesis ... is the molecular weight at the peak of the GPC curve and is therefore independent of the peak integration Therefore, it is useful to compare different batches of polymer Degas the solution in the ... of the resulting complexes and to increase the solubility of the complexes Furthermore, the grafting degree of the copolymer affects the DNA conformation in the complex, allowing regulation of...

Ngày tải lên: 11/04/2014, 09:59

... forming the viral envelope The newly synthesized virions then pass through the ER and cytoplasm and into the extracellular space The first newly formed capsids appear in the nucleus within h of ... HSV vector for gene transfer A detailed discussion of the many applications of these vectors is beyond the scope of this chapter We have, however, shown the efficacy and safety of these vectors ... Genome shutdown of host protein synthesis The importance of this observation is that nonessential genes may be deleted in the generation of gene therapy vectors, allowing the insertion of exogenous...

Ngày tải lên: 11/04/2014, 10:39

... consisting in the induction of type I IFNs followed by the transcriptional activation of hundreds of IFN-stimulated genes (ISGs) [12] In turn, the activation of ISGs promotes the rapid expression of proteins ... diluted in 250 μl of Opti-MEM I, then added into the lipofectamine mixture and incubated for an additional 20 The lipofectamine/DNA mixture was added to each well, incubated at 37°C for h and aspirated ... all genes of potential relevance for pathways analysis [25,26] To verify the relevance of the gene selection in spite of the low significance threshold a permutation test [27,28] was performed following...

Ngày tải lên: 18/06/2014, 16:20

... that the overall number of open trials is encouragingly higher However, while the number of cellular therapy trials remained the same, the clear trend was towards an increase in the number of vaccine ... and quality of life to become integrated into the standard of care regime [5,52-54] The number of slots open for patient accrual to the immunotherapy protocols contained in our list of open trials ... outlined the direction of, and drafted the manuscript MJH, CCM and KLE refined the search for information, gathered references and generated the tables and figure MRJ, RMP, LML provided information...

Ngày tải lên: 18/06/2014, 16:20

... length of the amplified cDNA was 434 bp PCR was performed as follows: first cycle at 95°C for min, and then 30 cycles at 94°C for 45 s, 54°C for min, 72°C for and a final extension cycle of 72°C for ... vitro for testing including phagocytic, epithelial, endothelial and various cancer cell lines [20] Therefore, besides the renal cancer cell OS-RC-2, we further observed the toxicity of the three ... cross-linker [19] The folic acid-coupled PEAs were prepared by the reaction of the activated folate ester with the amine group on the PEAs Evaluation of cytotoxicity of three PEI-derived materials The cytotoxicity...

Ngày tải lên: 18/06/2014, 19:20

... review the data up to day 30 for each dosing cohort and will then give written recommendation on whether or not to continue the study Members of the committee will also recommend on whether the ... al: Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) ... effects of organ transplantation with chronic immunosuppressive therapy, however, are clinically significant and limit the overall success of the procedure [3-11] Therefore, the objective of this...

Ngày tải lên: 18/06/2014, 22:20