dose response information to support drug registration guideline step 4 1994

... middle high P Dose- response Men FEV1 (ml) FVC (ml) FEV1/FVC (%) -46 .8 (-215 .4 to 121.7) 63.9 (-167.5 to 295.3) -1.2 (-3.7 to 1.6) 34. 3 (- 140 .5 to 209.1) 147 .9 (-89.1 to 385.0) -1.0 (-3.5 to 1.6) 0.3 ... Anto JM, Rodriguez-Roisin R, Quanjer PH, Nowak D, Burney P: References values for forced Page of 10 (page number not for citation purposes) Respiratory Research 2005, 6:13 40 41 42 43 44 45 46 ... doctor's or hospital visit because of respiratory problems Past month medication use for respiratory problems 0.6 (0.2–2.2) 0.5 (0.2–1 .4) 1 .4 (0 .4 4. 6) 1 .4 (0.9–2.1) 1.0 (0.5–1.7) 1.2 (0.3 4. 5)...

Ngày tải lên: 12/08/2014, 18:21

... P4-2, 5'-GCACACCTATCAATCACC-3') was designed to amplify a 43 4 bp sequence of the Hz-2V genome [6] PCR reactions using P4-1 and P4-2 primers were brought to a final volume of 20 ul using the Bioneer ... Journal 20 04, 1:15 http://www.virologyj.com/content/1/1/15 progeny was related to virus dose, such that eggs laid on early oviposition days received a low virus dose resulting in more asymptomatic ... with EtBr to visualize DNA bands under ultraviolet light Competing interests The second set of primers (P4-3, 5'-GCTGTGCTGTACAAGTGC-3'; and P4 -4, 5'-CCCTTGACGATCCCTTTTG3') was designed to amplify...

Ngày tải lên: 18/06/2014, 22:20

... not for citation purposes) Implementation Science 2008, 3:35 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 http://www.implementationscience.com/content/3/1/35 Hurst K: Primary and Community ... need to be covered, which in turn suggests occupations to deliver the competencies The principle is to scope occupations without regard to current regulatory and professional restrictions to reflect ... Australia; 46 guidelines as at 29th June 2007 ▪ NZ Guidelines Group 2003; 73 guidelines and reports as at 27th June 2007 ▪ National Institute for Health linical Excellence (NICE); 57 guidelines...

Ngày tải lên: 11/08/2014, 05:21

... not for citation purposes) Implementation Science 2008, 3:35 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 http://www.implementationscience.com/content/3/1/35 Hurst K: Primary and Community ... need to be covered, which in turn suggests occupations to deliver the competencies The principle is to scope occupations without regard to current regulatory and professional restrictions to reflect ... Australia; 46 guidelines as at 29th June 2007 ▪ NZ Guidelines Group 2003; 73 guidelines and reports as at 27th June 2007 ▪ National Institute for Health linical Excellence (NICE); 57 guidelines...

Ngày tải lên: 11/08/2014, 16:21

... Cross-over, 14- day 96 144 ‡ Parallel-group, 52-week 1732 43 7 42 8 41 8 123 130 42 0 For Sal Tio 600 72 72 43 2 43 5 42 5 123 Parallel-group 26-week 2059 Crossover, 14- day 68 Parallel-group, 12-week 41 6 211 ... approved dose (i.e 75 μg), and two lower doses (18.5 and 37.5 μg) The responses to the comparators are included for reference Renard et al Respiratory Research 2011, 12: 54 http://respiratory-research.com/content/12/1/ 54 ... the doses evaluated [1 -4, 6] Conventional dose- ranging trials rely on hypothesis testing and use placebo corrected mean responses to compare dose levels and determine the existence of a dose response...

Ngày tải lên: 12/08/2014, 13:22

... 8.7E-1 2.0E -4 Mouth and pharynx nc 0.017 2.0E-3 0. 045 6.6E-3 1.4E0 0. 043 0.97 3.8E -4 Esophagus excluded Stomach nc 0 .46 0 0 .46 8.4E-6 0.111 4. 7E-3 nc Small Intestine nc 0.591 0.09 3.0E-5 0 .48 0 2.9E-5 ... to average organ dose as long as the dose- response curve is linear At high dose it could be that the dose- response relationship is non-linear and as a consequence, OED replaces average dose to ... 0.17 6.4E-3 0.065 4. 8E-3 0.317 8.7E -4 1.9E-3 R CV Female breast nc 0. 044 0.15 1.1E-5 0. 041 8.6E -4 0.115 Lung nc 0. 042 0.83 2.0E-5 0.022 1.2E-2 0.056 1.7E-3 Rectum Colon nc nc 8.7E-1 7.2 1.8E -4 0.001...

Ngày tải lên: 13/08/2014, 16:20

... of information system will support effectively for manager in making decision 2, Information system in organizations The information system is a system that includes elements linked together to ... the information needs to be organized into a scientific system, allowing managers can harness the information thoroughly In management, information system is responsible for providing the information ... database, management information systems can support many different functional areas and can give managers the tools and the ability to easily access information, management information system...

Ngày tải lên: 06/08/2016, 15:25

... processing package R .4. 1 Register into “incoming book” R .4. 2 Store into database R .4. 3 View new incoming documents R .4. 4 Decide destination R .4. 4.1 Public R .4. 4.2 Forward to subordinates R.5 New ... Uc41 Edit task Uc42 Delete task Uc43 View task status Uc 44 View task Uc45 Give comments Uc46 View due date Uc47 View related documents Uc48 Read reminded task Uc49 Provide suggestion/solution Uc50 ... information into “incoming book” form and store into database - References R .4. 1 - Process description Action Response Click on “incoming book” button Show information form Insert information “Submit”...

Ngày tải lên: 23/11/2012, 15:04

... Implementing DNS to Support Active Directory $ Installing and Configuring DNS to Support Active Directory Slide Objective To introduce the topics related to installing and configuring DNS to support an ... Implementing DNS to Support Active Directory DNS Requirements for Active Directory Slide Objective To describe the DNS requirements necessary to support Active Directory DNS Requirements to Support Active ... DNS to support an installation of Active Directory ! Apply best practices for setting up DNS to support an installation of Active Directory Module 2: Implementing DNS to Support Active Directory...

Ngày tải lên: 10/12/2013, 16:15

... contradictory nodes; to carry out four to six circularly in regard to all the contradictory nodes to be eliminated; to withdraw these nodes from the inference structural net and to check whether ... the user information needed to only demographic information and describe in details how a related knowledge-based system can be built to support an adaptive on-line store in providing customized ... possible to provide customized services to further raise the customer satisfaction level In this paper, we describe in detail how to implement a knowledge-based recommender system for supporting...

Ngày tải lên: 13/12/2013, 01:15

... according to expertise, and sends the new information to the Information Fusing Agent (IFA) In the process of assessment, if SDPA found the new information useful to the other BOS, it sends the new information ... information to HA; if SDPA found the new information important, it sends the new information to Situation Assessment Agent (SAA) to analyze the information thoroughly When HA accepts the new information ... knowledge According to the knowledge from MKA, HA sends the new information to the related BOS When IFA accepts the new information from SDPA, it fuses the new information with historical information...

Ngày tải lên: 13/12/2013, 01:15

... necessary to apply Group Policy according to the provided plan 23 24 Module 5: Designing Active Directory to Support Group Policy Tasks Log on to your computer Detailed Steps a Log on to your computer ... Applied to a User or Computer Keep your GPO design as simple as possible to keep logon time to a minimum The following are general guidelines for applying Group Policy to Active Directory objects to ... the Run command to find the source of the effective policy Module 5: Designing Active Directory to Support Group Policy 19 Design Guidelines Slide Objective To describe design guidelines for...

Ngày tải lên: 17/01/2014, 09:20

... know | Information, information, information: relevance, quality and presentation Example Politicians can be too tolerant of poor information, and need to challenge those who provide their information ... want to ensure that they have the management information they need to make 24 In the know | Information, information, information: relevance, quality and presentation decisions, as well as PIs to ... have to consider the information Otherwise important information will be ignored or misunderstood, or inconvenient information may cause an unhelpful In the know | Information, information, information: ...

Ngày tải lên: 18/02/2014, 05:20

... Sinks 40 Restrooms 40 Sinks 41 Event Infrastructure—Recycling and Trash 42 Recycling 42 Trash 43 ... authorized to submit written amendments to your initial permit application due to unique or changing circumstances related to the event Amendments to your permit application must be submitted to the ... through Labor Day due to the summer event moratorium A waiver to apply for a special event permit to hold a special event in these parks during the summer moratorium or other moratorium time periods...

Ngày tải lên: 19/02/2014, 03:20

... authenticated protocol steps in this paper should include some nonce identifying the speci c application, version, protocol, and step This nonce serves to limit damaging protocol interactions, ... NIST93 NIST 94 ElG85 T ElGamal, A Public-Key Cryptosystem and a Signature Scheme Based on Discrete Logarithms," IEEE Transactions on Information Theory, V IT-31, n 4, 1985, pp 46 9 47 2 HS91 S Haber ... 1985, pp 46 9 47 2 HS91 S Haber and W.S Stornetta, How to Time Stamp a Digital Document," Advances in Cryptology | Crypto '90, Springer-Verlag, 1991, pp 43 7 45 5 RS98 KS96 J Kelsey and B Schneier,...

Ngày tải lên: 06/03/2014, 19:20

... described above, and used 24 h later Prior to the assay, cells were washed in a Hank’s Hepes buffer, pH 7 .4 (137 mM NaCl, 5 .4 mM KCl, 0 .44 1 mM KH2PO4, 0.16 mM NaH2PO4, 0.885 mM MgCl2, 5.55 mM ... followed the response of populations of cells expressing a single olfactory receptor, either I7 or OR17 -40 The results Ó FEBS 2003 Ligand-specific dose response of olfactory receptors (Eur J Biochem ... tend to support the interpretation that the bellshaped dose response curve indeed arises from an intrinsic response of the olfactory receptor itself Desensitization mechanisms may be evoked to...

Ngày tải lên: 08/03/2014, 02:21

... writer to attach control information to the constraints in the grammar Neither can they be used for dynamic preference assignments The model of control proposed in this paper can be used to implement ... the grammar need to be enriched by control information 238 leads to clashes more often than the value of the attribute definiteneness, it would in general be more efficient to unify agreement ... supposed to take place in several steps There is a second criterion to consider Some unifications with conjuncts build a lot of structure whereas others not Even if two conjuncts lead to failure...

Ngày tải lên: 08/03/2014, 07:20

Ngày tải lên: 09/03/2014, 12:20

... will need opportunities to apply their skills to a range of real and realistic topics, relevant to life and work The topics should be plainly relevant to learners, appealing to them by being motivating, ... ‘why’ – and ask them to compose a question on a given topic using each word • They will need to respond to simple questions, such as giving information about themselves to a doctor, teacher or careers ... a speaker plans to organise a dialogue People speaking face to face or on the phone often use anyway to show that they wish to finish that particular topic or return to another topic Similarly,...

Ngày tải lên: 10/03/2014, 05:20