diagnostic prognostic and therapeutic value of gene signatures

... cancers Moreover, the prognostic value ofRRM2 was comparable to the 70-gene signature and 21-gene recurrence score for breast cancer overall, and superior to these biomarkers and pathoclinical indi-cators ... the prognostic significance of RRM2 mRNA has been evaluated [30,31] Independent prognostic signifi-cance of RRM2 protein needs to be further investigated, and the prognostic performance ofRRM2 ... effects of the nucleo-side analogs [26] The RRM2 gene (mRNA) has been in-cluded in some gene signatures, such as the 3D-culture signature [27] and Five-gene Molecular Grade Index (MGI) [28,29], and

Ngày tải lên: 14/10/2020, 15:33

... distinguish cancer gene profiles from random gene profiles Both prognostic signatures are composed of genes associated with TP53 mutations and were able to stratify the good and poor prognostic groups ... the prognostic and predictive values of publicly available signatures, we have implemented a systematic method for high-throughput and efficient validation of a large number of datasets and gene-expression ... cross-validation and two robust signatures that differentiate TP53 mutation status and have prognostic and predictive value for breast cancer patients Keywords: Breast cancer, Gene expression profiles, Signatures,

Ngày tải lên: 30/09/2020, 11:04

... expression and activation of ALK and AKT p-mTOR + (n = 57) p-mTOR- (n = 14) No of patients % No of patients % ALK+ 39 of 57 68 of 14 36 ALK- 18 of 57 32 of 14 64 p-AKT+ 47 of 57 83 of 14 50 p-AKT- 10 of ... patients p-value % ALCL (n = 71) ALK+ 38 of 54 70 of 17 35 ALK- 16 of 54 30 11 of 17 65 29 of 39 74 of 80 ALK (c) 10 of 39 26 of 20 p-value p-p70S6K p-value + (n = 66) - (n = 5) ALK (n = 71) ALK+ ... expression of ALK, p-AKT, p-mTOR and its two downstream molecules, p-4E-BP1 and p-70S6K1, and the risk factors of the age of onset, sex distribution, clinical B symptoms, primary lesion of the tumor, and

Ngày tải lên: 05/11/2020, 05:15

... all three types of the profiled cells Genes commonly involved in both bleomycin induced and replicative senescence A total of 1410 genes were upregulated and a total of 1291 genes were downregulated ... analyzed using geneXplain bioinformatics soft-ware platform (http://www.genexplain.com) Using the work-flows in geneXplain framework, the sets of up and down regulated genes for both SIPS and RS were ... the sites located in genes downregulated both in RS and in SIPS Genes uniquely involved in replicative senescence A total of 1408 genes were upregulated and a total of 703 genes were downregulated

Ngày tải lên: 04/12/2022, 15:56

... Diagnostic and Therapeutic Fields of Cancer and Infectious Disease Presented to the Faculties of the Chung-Ang University in Partial Fulfillment of the Requirement of the Degree of Doctor of ... of Doctor of Philosophy in Department of Chemistry in the Graduate School of Chung-Ang University 2020 Trang 4i ABSTRACT Advanced Nanomedicine in Sensitive Diagnostic and Therapeutic Fields of ... Chung-Ang University Department of Chemistry Major in Biochemistry Le Minh Tu Phan Trang 3Advanced Nanomedicine in Sensitive Diagnostic and Therapeutic Fields of Cancer and Infectious Disease by

Ngày tải lên: 19/04/2023, 19:55

... maintenance and turnover of blood cells and immune system The high rate of regeneration of the liver, as compared to other tissues such as brain tissue, is due to prolifera-tion of two types of liver ... safety and efficacy of cell therapy pro-ducts The greater the understanding of the biology of stem cell self-renewal and differentiation, the more pre-cise the evaluation and prediction of potential ... associated to prolongation of the QT interval and risk of ventricular arrhythmia iPCSs retain the genotype of type 1 disease and generate functional myocytes lacking the KCNQ1 gene mutation Patients

Ngày tải lên: 18/06/2014, 16:20

... the Insti-tutional Animal Care and Use Committee of UCI and were in accordance with the guidelines of the National Institutes of Health Generation and purification of chimeric virus Figure 1A illustrates ... the majority of AD patients generated only low titers of anti-Ab antibodies, and approximately 50% of the patients failed to produce a measurable antibody response [12,17] The cause of the low ... Accordingly, we generated and tested for the first time the immunogenicity and protective efficacy of chimeric inactivated flu virus vaccines expressing 1-7 or 1-10 aa of Ab42 (flu-Ab1-7and flu-Ab1-10)

Ngày tải lên: 18/06/2014, 22:20

... phrenics) and 67–75% among outpatients, with 45 and 28% of combination therapies in in- and outpatients being reported, respectively [28-30]. The rates of prescrip- tion of conventional and atypical ... observed: benzodiazepines (69% of FPA patients; 69% of non-FPA patients), atypical (in 51 and 53% of patients respectively) and conventional antipsy- chotics (in 38 and 46% of patients respectively) ... BioMed Central Page 1 of 10 (page number not for citation purposes) Annals of General Psychiatry Open Access Primary research Clinical features and therapeutic management of patients admitted

Ngày tải lên: 08/08/2014, 23:20

... comparison of the degree of differentiation in neutral marker loci and genes coding quantitative... protocol, tracking of genotyping errors [53], standardization of data), tools (choice of ... ISAG/FAO sets of genetic markers for domestic... could be of general applicability for livestock species The efficiency of a set of markers is addressed with graphical tools and quantitative ... French and African... MCOA should Consensus structuring and typological value 561 play a major role in the choice of panels of markers, which is essential for an efficient design of

Ngày tải lên: 14/08/2014, 13:22

... promoter of this gene; three copies of CN1 (p-value = 0.052) and one copy of CN2 (p-value = 0.389) were found Again, it was very unlikely that a total of four copies of CN1 and CN2 (p-value = ... presence of nitrogen (b) The assignment of genes W, X, Y, and Z to InterAct classes. Model 1 (CN independent) N AND N AND N AND Model 3 (CN dependent/independent) N AND InterAct class Gene (a) ... significant number of genes that respond to carbon and/or nitrogen treatments compared to the general population of genes in the analysis For example, 31.6% (1,089/3,447) of the genes assigned to

Ngày tải lên: 14/08/2014, 14:21

... thousands of variables. The ability to divide data into groups of genes shar- ing patterns of coexpression allows more detailed biological insights into global regulation of gene expression and ... ASC and B-cell lym- phoma datasets and the partitioning of the gene-expression profiles observed. As expected, the robust clusters do not con- tain all variables because of the underlying lack of ... number of clustering methods that have placed gene i and gene j into the same cluster. In other words, the number represents the agreement between clustering methods concerning gene i and gene

Ngày tải lên: 14/08/2014, 14:21

... glucose oxidation’s generation of malonyl-CoA which can bind to and inhibit tissue-specific isoforms of. .. (50-100 nm) in the PM rich in lipids and cholesterol (80) Binding of GSVs to the ... promotes a loss of PIP2 and F-actin structure and that... there are 6 different isoforms of IRS, IRS1 and IRS2 have been established through knockdown studies in cell culture and mice to ... regulation of GLUT4 exocytosis and is particularly abundant in skeletal muscle (58, 59) The tissue-specific isoforms of Rab proteins targeted by AS160 and TCB1D1 are... regulation of protein

Ngày tải lên: 24/08/2014, 10:54

... images of CVT 2 To review some risk factors of CVT 3 To determine the sensitivity, specificity, positive predictive valueand negative predictive value of D-dimer test in the diagnosis ofCVT Trang ... OF THE THESIS1 Our study described some clinical features and brain images ofCVT 2 Our study found some genetic and acquired risk factors of CVT 3 Our study successfully determined the role of ... rate of 98.31% of all cases This result is similar to the result Trang 15of the study of Le Van Thinh and Trinh Tien Luc with headacheaccounted 88% In general, it is like other studies of other

Ngày tải lên: 21/10/2014, 21:52

... subsamples as the ‘Illiquid’ sample and as the ‘Liquid’ sample, respectively 7 Hasbrouck and Sofianos (1993) and Cao, Choe, Hatheway (1997) offer a detailed discussion of the NYSE specialist performance ... Socheat Chhay and Lourent Fournier of Euronext Paris for information on market structure in Paris, and to Pascal Samaran for providing us with the data Mann and Waisburd thank the Charles Tandy American ... paper measures the value of introducing a designated liquidity provider for a sample of stocks in the Paris Bourse, an automated order driven market, and adds to our understanding on this debate

Ngày tải lên: 11/09/2018, 13:59

... Madhavan and Sofianos (1998), Kavajecz (1999), and Madhavan and Panchapegesan (2000) for evidence at the NYSE, Kehr et al (2001) at the Frankfurt Stock Exchange, and Mayhew (2002) and Anand and Weaver ... takes the value of one when the session clears and zero otherwise The LP variable takes the value of one in the Post-LP period and zero in the Pre-LP period Morning variable takes the value of one ... spread and a minimum depth The more complex role of the NYSE specialist often requires active intervention in the trading process Assessing the value of such discretion is beyond the scope of this

Ngày tải lên: 13/12/2018, 16:08

... Oncology of Melanoma Epidemiology of human and canine melanoma 22 Comparative biology of melanoma 23 Comparative genetics and molecular biology of melanoma 25 Treatment of human and canine ... oncology of osteosarcoma Epidemiology of human and canine osteosarcoma 34 Comparative biology of osteosarcoma 37 Comparative genetics and molecular biology of osteosarcoma 40 Treatment of human ... analysis of gene expression profiles of canine and human osteosarcoma and corresponding normal tissues resulted in the separation of normal tissues by species, but Trang 17interspersion of all

Ngày tải lên: 07/08/2019, 02:33

... MINISTRY OF EDUCATION AND TRAINING MINISTRY OF DEFENCE 108 INSTITUTE OF CLINICAL MEDICAL AND PHARMACEUTICAL SCIENCES PHAM DANG HAI RESEARCH ON THE CHANGES AND PREDICTIVE VALUE OF LEFT VENTRICULAR ... Journal of 108 clinical medicine and pharmacy, vol (1), pp.46-50 INTRODUCTON The urgent and demand of the study Septic shock is the major cause of hospitalization and also the leading cause of death ... arterial pressure of 65 mmHg or greater and serum lactate level greater than mmol/L in the absence of hypovolemia 1.1.2 Risk factors of sepsis and septic shock Some risk factors of sepsis and septic

Ngày tải lên: 08/01/2020, 16:41

... central part of South-East Asia and occupies a total land area of 330,434 square kilometres. The land mass comprises three main components: Peninsular Malaysia and the two states of Sabah and Sarawak, ... overall development plans and land use decisions. • Department of Town and Country Planning (Ministry of Local Government) Controls land use patterns and pace of development as the Department ... the standards and procedures for handling the various types of domestic and industrial wastes. Stakeholders and Water Resource Management The conservation, use, and management of water...

Ngày tải lên: 06/03/2014, 15:21

... a shift of the labour supply curve, and this may tend to increase or decrease the effects of the tax rate increase on the quantity of labour supplied and the quantity of leisure demanded. ... to the economy of displacing $50 worth of private consumption and $50 worth of private investment: • the loss of $50 worth of private consumption costs $50 • the $50 worth of private investment ... estimate of the value of information. The value of information rises as: • the initial capital cost, K, rises; • the return in the low price environment, R L , falls; • the probability of a low...

Ngày tải lên: 16/03/2014, 01:20

... Society and the Centers for Disease Con- trol and endorsed by the Infectious Disease Society of America. The Diagnostic Standards are intended to provide a framework for and understanding of the diagnostic ... (148–150). Genetic variability of the subjects vaccinated, the nature of the mycobacteria endemic in different parts of the world, the use of different strains of BCG for immunization, and the use of ... focus of such studies has been rifampin re- sistance because of the pivotal role of rifampin in the treat- ment of tuberculosis, the conserved nature of the genetic basis for resistance (Ͼ 96% of...

Ngày tải lên: 15/02/2014, 12:20