Ngày tải lên: 21/06/2014, 08:20
... then there exists a point x0 ∈ ∂D0 such that the < /b> function V is bounded on a neighborhood of < /b> x0 Let be the < /b> power St Balint et al series development of < /b> V in x0 The < /b> domain of < /b> convergence D1 of < /b> the < /b> ... ) of < /b> the < /b> domain of < /b> attraction Da (0) At this step, the < /b> part D0 D1 of < /b> Da (0) is obtained If there exists a point x1 ∈ ∂(D0 D1 ) such that the < /b> function V is bounded on a neighborhood of < /b> x1 , then ... ρ ∂0 f < 1, (1.3) then is an asymptotically stable steady state Da (0) is an open subset of < /b> Ω and < /b> coincides with the < /b> natural domain of < /b> analyticity of < /b> the < /b> unique solution V of < /b> the < /b> iterative first-order...
Ngày tải lên: 23/06/2014, 00:20
NMR study of the human NCK2 SH3 domains structure determination, binding diversity, folding and amyloidogenesis 1
... One of < /b> the < /b> main objectives of < /b> this study < /b> is the < /b> structure determination < /b> and < /b> an insight into the < /b> binding diversity of < /b> hNck2 SH3 domains by the < /b> use of < /b> molecular techniques, NMR spectroscopy and < /b> other ... in cross-section, and < /b> the < /b> base of < /b> this triangle sits on the < /b> surface of < /b> the < /b> SH3 domain Two of < /b> the < /b> three ligand-binding pockets of < /b> the < /b> SH3 domain are occupied by two hydrophobic-proline (φP) dipeptides ... that the < /b> co-expression of < /b> Grb4 and < /b> v-Abl results in a complex formation between v-Abl and < /b> Grb4 independent of < /b> the < /b> kinase activity of < /b> v-Abl The < /b> interaction was identified as SH3-dependent but independent...
Ngày tải lên: 14/09/2015, 14:09
NMR study of the human NCK2 SH3 domains structure determination, binding diversity, folding and amyloidogenesis 2
... determined by measuring the < /b> absorbance at 280nm and < /b> using the < /b> Bear-Lambert Law: A = ε*l*C, where ε is the < /b> molar absorption coefficient (M-1cm-1), l is the < /b> path length (cm), and < /b> C is the < /b> protein ... according to the < /b> standard protocol After transformation, the < /b> bacteria were recovered in an LB broth and < /b> plated on an LB agar (Bio Basic INC.) plate containing ampicillin 2.1.5 Analysis of < /b> plasmid ... mixture consisted of < /b> 4.2 μl of < /b> autoclaved water, about 300 ng of < /b> the < /b> plasmid DNA, 0.8 μl of < /b> 2.5 μM primer and < /b> μl of < /b> BigDye The < /b> PCR reaction sequencing was carried out in an Eppendof Mastercycler...
Ngày tải lên: 14/09/2015, 14:09
NMR study of the human NCK2 SH3 domains structure determination, binding diversity, folding and amyloidogenesis 3
... relaxation rates of < /b> the < /b> nuclei of < /b> the < /b> ligand and < /b> the < /b> protein are completely averaged between the < /b> bound and < /b> free states and < /b> the < /b> weighted average spectrum is observed δobs =PLδL + PELδEL (4) R2,obs=PER2,E+PELR2,EL ... δL, the < /b> variant LT changes as the < /b> function of < /b> δobs, and < /b> the < /b> two parameters fitting can then be carried out for Kd and < /b> δEL In case of < /b> moderately fast exchange, the < /b> exchange contribution (the < /b> last ... On the < /b> other hand, the < /b> mWrch1 peptide was found to specifically bind the < /b> SH3-2 domain, while the < /b> Nogo-A and < /b> Prk2 peptides bind the < /b> SH3-3 domain exclusively On the < /b> basis of < /b> HSQC titration, the...
Ngày tải lên: 14/09/2015, 14:09
NMR study of the human NCK2 SH3 domains structure determination, binding diversity, folding and amyloidogenesis 4
... turn/strand, and < /b> 5% random coil by CONTINLL; 12% helix, 46% turn/strand, and < /b> 42% random coil by SELCON3; and < /b> 5% helix, 59% turn/strand, and < /b> 36% random coil by 94 Figure 4.1 Bioinformatics analysis of < /b> ... prediction of < /b> the < /b> first hNck2 SH3 domain by computational programs GOR4, PHD, Predator, SIMPA96 and < /b> SOPMA “E” stands for the < /b> β-strand, “H” stands for helix and < /b> “C” stands for the < /b> random coil The < /b> four ... those of < /b> the < /b> corresponding residues in the < /b> wild type at pH 2.0 On the < /b> other hand, for both the < /b> wild type at pH 2.0 and < /b> 4AlaMut at pH 6.5, no uniform shortening of < /b> T2 values were observed, and < /b> the...
Ngày tải lên: 14/09/2015, 14:10
NMR study of the human NCK2 SH3 domains structure determination, binding diversity, folding and amyloidogenesis 5
... contact is the < /b> hydrogen bond between the < /b> carbonyl oxygen of < /b> K3 and < /b> the < /b> amide proton of < /b> E5 The < /b> second contact is the < /b> mainchain-sidechain hydrogen bonding between the < /b> amide proton of < /b> K2 and < /b> the < /b> sidechain ... fourth strands, and < /b> seven between the < /b> two RT-loop strands No long-range NOEs in the < /b> fifth β-strand were detected, probably because of < /b> the < /b> loose packing in the < /b> rest of < /b> the < /b> molecule 131 Table 5.1 Non-native ... HB Arg55 HN Val53 HG Arg55 HN Val53 HB Table 5.2 Native like long range NOEs Between the < /b> first and < /b> second beta strands Val3 HN Leu26 HB Val3 HA Trp27 HE Between the < /b> second and < /b> third beta strands...
Ngày tải lên: 14/09/2015, 14:10
NMR study of the human NCK2 SH3 domains structure determination, binding diversity, folding and amyloidogenesis 6
... at the < /b> bottom, with each region corresponding to the < /b> sequences described above B) Analysis results of < /b> the < /b> globularity and < /b> disordered regions of < /b> the < /b> ApLLP by the < /b> VSL 2B 154 Figure 6.2 HPLC profile ... Figure 6.5 Bindings of < /b> the < /b> CRE DNA to two ApLLP proteins A B) Superimposition of < /b> the < /b> 1H–15N NMR HSQC spectra of < /b> ApLLP-87, A) and < /b> ApLLP-55, B) in the < /b> absence and < /b> in the < /b> presence of < /b> the < /b> DNA fragments ... we first studied the < /b> ApLLP DNA interactions by the < /b> HSQC titration For the < /b> full-length protein, the < /b> HSQC spectra of < /b> the < /b> 15 N-labeled ApLLP in the < /b> absence and < /b> in the < /b> presence of < /b> the < /b> DNA fragment...
Ngày tải lên: 14/09/2015, 14:10
NMR study of the human NCK2 SH3 domains structure determination, binding diversity, folding and amyloidogenesis 7
... Structure determinations and < /b> study < /b> of < /b> binding diversity are carried out for both SH3-2 and < /b> SH3-3 domain in this project However, whether the < /b> hydrogen bond network is involved in the < /b> binding between ... peptides The < /b> dynamic information of < /b> loops and < /b> 310-helix in the < /b> complex system will give us more functional implication 3) If the < /b> solubility and < /b> stability problems of < /b> whole hNck2 protein can be overcome, ... carried our either for complex system in which peptide is connected by poly-GS link region with N/C terminal of < /b> SH3 domain or the < /b> one in which no covalent bond exists between SH3 and < /b> proline-rich...
Ngày tải lên: 14/09/2015, 14:10
Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"
... in the < /b> long term lead to development of < /b> diabetes Although the < /b> incidence of < /b> hospital acquired hyperglycaemia differed between the < /b> three subgroups of < /b> patients, the < /b> risk for diabetes is similar The < /b> ... is an important contributing factor The < /b> difference in the < /b> incidence of < /b> hyperglycaemia is probably a consequence of < /b> those differences and < /b> the < /b> differences in the < /b> severity of < /b> disease However, it ... is the < /b> cut-off value in the < /b> Recommendations of < /b> the < /b> American Heart Association [35] and < /b> the < /b> trigger for initiation of < /b> insulin treatment for ICU patients recommended by the < /b> American College of...
Ngày tải lên: 25/10/2012, 10:02
Báo cáo y học: "Aplasia and Agenesis of the Frontal Sinus in Turkish Individuals: A Retrospective Study Using Dental Volumetric Tomograph"
... supraorbital craniotomy because of < /b> the < /b> proximity of < /b> the < /b> sinus to the < /b> orbit and < /b> the < /b> anterior skull base [5] The < /b> frequency of < /b> bilateral absence of < /b> the < /b> frontal sinus has been reported in 3-4% to 10% of < /b> ... inter-observer reliability between observers and < /b> was 0.86 Fig Unilateral absence of < /b> the < /b> frontal sinus; on the < /b> right, the < /b> absence of < /b> the < /b> frontal sinus, and < /b> on the < /b> left, the < /b> limited aeration of < /b> the < /b> ... Fig 2) The < /b> results from the < /b> present study < /b> are summarized in Table The < /b> weighted kappa values for intra-observer reliability were 0.89 and < /b> 0.93 for the < /b> first and < /b> second observer, respectively The...
Ngày tải lên: 25/10/2012, 11:04
. Scope and Limitations of the Study
... Objectives of < /b> the < /b> Study < /b> The < /b> objectives of < /b> the < /b> study < /b> are: 3.1 To assess the < /b> demand of < /b> skilled labor in Vietnam 3.2 To identify the < /b> gap between supply and < /b> demand of < /b> labor 3.3 To identify the < /b> factors ... problem Statement of < /b> the < /b> problem How to assessment the < /b> demand of < /b> skilled labor and < /b> how to solve the < /b> gap between demand and < /b> supply of < /b> skilled labor for sustainable economic growth in Vietnam Objectives ... will reach the < /b> standards of < /b> the < /b> bets institutions of < /b> the < /b> region by the < /b> year 2010 32 The < /b> same objective will be pursued in higher education with the < /b> aim of < /b> attaining regional standards by the < /b> year...
Ngày tải lên: 13/04/2013, 10:31
Scope and Limitations of the Study
... Strategy is the < /b> determination < /b> of < /b> the < /b> basic long-term goals and < /b> objectives of < /b> an enterprises, and < /b> the < /b> adoption of < /b> courses of < /b> action and < /b> the < /b> allocation of < /b> resources necessary for carrying out these goals” ... concentrated and < /b> dominated by a few large companies? • The < /b> number of < /b> buyers and < /b> their relative sizes • The < /b> prevalence of < /b> backward and < /b> forward integration • Ease of < /b> entry and < /b> exit • The < /b> pace of < /b> technological ... low, and < /b> buyers believe substitutes have equal or better features 60 As a rule, then, the < /b> lower the < /b> price of < /b> substitutes, the < /b> higher the < /b> quality and < /b> the < /b> performance, and < /b> the < /b> lower the < /b> user’s switching...
Ngày tải lên: 13/04/2013, 10:32
Methodology and framework of the study
... the < /b> profitability of < /b> an industry is presented in Table 2.1 Low EXIT BARRIERS High High High and < /b> stable profit High but possibly unstable profit Low Low and < /b> stable profit Low and < /b> unstable profit ... including the < /b> rationale of < /b> the < /b> study,< /b> the < /b> identification of < /b> the < /b> problem, the < /b> objectives, the < /b> scope and < /b> limitations as well as the < /b> methodology and < /b> framework of < /b> the < /b> study < /b> Chapter shows the < /b> literature ... Although the < /b> import procedures are simple and < /b> the < /b> source of < /b> raw materials is consistent, this limits the < /b> bargaining power of < /b> BPC From the < /b> beginning of < /b> the < /b> last year, 1994, BPC has been given the < /b> right...
Ngày tải lên: 13/04/2013, 10:32
Potential biogas production from sewage sludge: A case study of the sewage treatment plant at Kwame Nkrumah university of science and technology, Ghana
... generation The < /b> estimation of < /b> the < /b> biogas potential of < /b> the < /b> sludge the < /b> quality of < /b> the < /b> sludge was analysed and < /b> the < /b> results is presented below in Table The < /b> average litre of < /b> biogas produced from a kg of < /b> TVS ... establish the < /b> component of < /b> the < /b> sewage that can be converted to biogas The < /b> Total Solids (TS) was also determined to establish the < /b> dry matter content of < /b> the < /b> sewage There was no flow meter at the < /b> ... biogas largely depends on the < /b> type of < /b> substrate Human excreta based biogas contains 65-66% CH4, 32-34% CO2 by volume and < /b> the < /b> rest is H2S and < /b> other gases in traces whiles the < /b> biogas composition for...
Ngày tải lên: 05/09/2013, 16:11
A STUDY OF THE RELATIONSHIP BETWEEN CEO COMPENSATION AND FIRM PERFORMANCE IN THE US AIRLINE INDUSTRY 2002 2006
... the < /b> strategic plans and < /b> policies established by the < /b> board of < /b> directors As the < /b> leader of < /b> the < /b> firm, the < /b> CEO has an astounding impact on the < /b> performance of < /b> the < /b> firm and < /b> many believe this to be the < /b> ... firm diversity, the < /b> percentage of < /b> insiders on the < /b> board, and < /b> the < /b> percentage of < /b> shares owned by the < /b> board A study < /b> conducted by Veliyath and < /b> Bishop (1995) on a sample of < /b> 47 U.S drug and < /b> pharmaceutical ... and < /b> the < /b> availability of < /b> talent (Dorf, 2006) Executive compensation has become one of < /b> the < /b> most public components of < /b> the < /b> decision-making process of < /b> a firm’s board of < /b> directors The < /b> Corporate Library...
Ngày tải lên: 11/09/2013, 11:44
A study of the linguistic features of suggestion verbs in english and their vietnamese equivalents
... awareness of < /b> Vietnamese learners of < /b> English in terms of < /b> this kind of < /b> verbs so that they can apply the < /b> right use of < /b> these verbs in using the < /b> English language 1.2.2 Objectives The < /b> objectives of < /b> this study < /b> ... terms of < /b> the < /b> syntactic and < /b> semantic features The < /b> analysis results of < /b> the < /b> ESVs and < /b> VSVs will be compared and < /b> contrasted in order to find out the < /b> similarities and < /b> differences between them The < /b> analysis ... on the < /b> theoretical background by Quirk et.al [33] such as the < /b> construction of < /b> the < /b> verbs, verb phrases The < /b> semantic characteristics are shown like the < /b> meaning nuances and < /b> the < /b> powerful degree of...
Ngày tải lên: 26/11/2013, 13:17
A study of the linguistic features of saying verbs used in political documents in english and vietnamese
... Vietnamese Besides, the < /b> study < /b> will also help Vietnamese learners be able to use these verbs flexibly on the < /b> basis of < /b> mastering the < /b> meaning and < /b> the < /b> relationship among these verbs 1.6 THE < /b> ORGANIZATION OF < /b> ... delivered by the < /b> leaders of < /b> the < /b> Socialist LITERATURE REVIEW AND < /b> THEORETICAL BACKGROUND Republic of < /b> Vietnam 1.4 RESEARCH QUESTIONS What are the < /b> semantic and < /b> syntactic features of < /b> the < /b> saying verbs in ... frequency of < /b> these semantic role and < /b> syntactic relations The < /b> finding of < /b> the < /b> study < /b> may be verbs and < /b> expressions in different discourses From this study,< /b> we in one way or another beneficial for the < /b> language...
Ngày tải lên: 26/11/2013, 13:19