date and time function in php with example

... lowering the pain threshold and increasing the likelihood of experiencing resting pain Interestingly, individuals with depressive symptoms had a non-significant association with night pain Greater ... increased knee pain intensity during daily living in a non-task-specific manner and is associated with functional limitation in patients with knee OA, even after controlling for covariates, including ... sub-category Since few of the individual pain scores were high, individual scores of 2, 3, and were combined into one level (moderate/severe pain), and included in the ordinal logistic regression

Ngày tải lên: 10/01/2020, 12:37

... reducing both pain and improving function in hand OA However, Stamm and colleagues [34] reported a higher proportion of patients with an at least 10% increase in global hand function using exer-cise ... carpometacarpal (CMC) joints, and the prox-imal interphalangeal (PIP) joints, as the most commonly affected hand joints, in decreasing order, are the DIP joints, thumb CMC joints, and the PIP joints [19] The ... one study In this study [31], use of a splint resulted in a large improvement in hand function in both the short and long term as measured by the Cochin hand functional scale (SMD = 1.10 and 3.73,

Ngày tải lên: 12/08/2014, 15:22

... Her2-pDNA vaccination in conjunction with GM-CSF and IL-2 administration is safe, well tolerated and can induce long-lasting cellular and humoral immune responses against Her2 in patients with advanced ... (Herceptin), a recombinant humanized monoclonal antibody binding Her2, induces durable objective clinical responses and/ or improved time to relapse when administered in the adjuvant setting in women ... binding activity of patients evaluable at all time points (patient #3, 4, 8, pre, post and late) C Binding activity in the serum of all patients at all available individual time points (pre- and

Ngày tải lên: 18/06/2014, 16:20

... patients with stable angina, where a model mapping clini-cal measures on to the EQ-5D index explained 37% of the variability in the EQ-5D index and also performed poorly in individuals with EQ-5D index ... clinical measures in combination in a single model to predict the EQ-5D index In this case, disease severity was taken into account using a single variable, and more implicitly from the point of view ... EQ-5D index was compared in ACRE and the other studies using an interaction term The results for models with ASS and AFS have also been presented with the ACRE data excluded (Tables 5 and 6) The interaction

Ngày tải lên: 20/06/2014, 16:20

... germination, including or excluding premature germination, in fully imbibed alder and birch seeds in response to chilling and priming. Chilling duration (weeks) 0918 Premature germination included ... content, chilling and priming duration on germination and mean germination time (MGT) of alder and birch seeds. Values in bold are significant at p < 0.05. Alder Birch Germination MGT Germination ... for nine weeks, two days priming significantly increased ger- mination from 49% (control) to 63% in alder and from 19% (control) to 29% in birch. Although 7 days priming increased germination in

Ngày tải lên: 07/08/2014, 16:21

... methods, including verifying the clinical attendance records and with direct telecommunication with the patient or their family Statistical Analysis Disease-free interval (DFI) was defined as the interval ... conceived of the study, and participated in its design and coordination and helped to draft the manuscript All authors read and approved the final manuscript. Competing interests The authors declare ... (LMS) was defined as the interval between the date of first diagno-sis of lung metastadiagno-sis(es) and the date of death or final follow-up The factor analysis for OS and LMS included gender,

Ngày tải lên: 09/08/2014, 09:21

... disease involv-ing the skin and internal organs The disease hallmark is an overproduction and accumulation of collagen and other extra-cellular matrix proteins, resulting in thickening of the skin and ... analysis accounting for these factors, however, failed to demonstrate a significantly increased use in these patients Azathioprine, originally introduced in transplantation medicine in the 1960s, ... erythematosus With an oral daily dose between 1 and 2.5 mg/kg/day and together with prednisone, cyclophosphamide was able to improve pulmonary function and to increase survival in fibrosing alveolitis

Ngày tải lên: 09/08/2014, 13:22

... distribution of insulin receptors in the brain and the presence of insulin-dependent glucose transporters suggest that brain insu-lin participate in several cognitive functions, including learning and memory ... diabetic rats with sig-nificant increase (p < 0.001) in the affinity Treatment with pyridoxine alone and in combination with Aegle marmeloseand insulin in diabetic rats reversed the Bmax and Kd to ... 0.01) and DAP (p < 0.001) to near control in diabetic rats treated with pyridoxine alone and in combination with insulin and Aegle marmelose leaf extract (Table-1) 5-HT and 5-HT2Areceptor binding

Ngày tải lên: 10/08/2014, 05:21

... best-fitting straight line to a data set when searching for a linear increasing or decreasing trend and subsequently determining the probability that the slope of the best-fitting line is different ... patients’ mean awake time during the nighttime was 95 minutes Daytime inactivity in our control population was 46.5 minutes, while our patients’ daytime napping time was 3.5 hours/day Finally, the patients’ ... Among both inpatients and outpatients, the relationship between ECOG performance status and PSQI domain score in daytime dysfunction worsened with worsening performance status score. Wake Minutes

Ngày tải lên: 10/08/2014, 09:20

... 24 listed in Table 1 Patients who have Hp β and α-1 chains indicate a Hp 1-1 type; patients with Hp β and α-2 chains are Hp 2-2 type and patients with all the Hp β, α-1 and α-2 chains indicate ... before being methodically eliminated in proteomic profiling studies Increased serum Zn-alpha-glycoprotein and decreased complement C4 in patients with cGVHD in our study were in agreement with this ... the proteins, clusterin precursor, alpha-2-macroglobulin, serum amyloid protein precursor, sex hormone-binding globulin, serotransferrin and complement C4 were decreased in patients with extensive

Ngày tải lên: 10/08/2014, 22:20

... related to independent living and justify inclu-sion in the SMI group Needs in the domain of alcohol and drugs indicate comorbidity in the area of substance use, which suggests a shared underlying liability ... was introduced in one region in South Limburg (the Netherlands) in 1998 (REGION-1998) and in the rest of South Limburg in 2004 (REGION-2004) By comparing these two regions, changes after the introduction ... baseline was an independent variable in most of the analyses (see below) It was calculated by subtracting the baseline date (in days) from the assess-ment date (in days) and dividing the result

Ngày tải lên: 11/08/2014, 16:22

... content. JPL and NS were involved in the interpretation of data, and critical drafting and revising of the manuscript for important intellectual content. All authors read and approved the final manuscript. ... vs all other), baseline body mass index (BMI), baseline CGI and baseline PANSS. Choice of the independent vari- ables was based on clinical relevance and their inclusion in all 6 studies. Analysis ... change in PANSS total score at week 6 end point. Tolerability end points included adverse event (AE) reports and weight. AEs with rates ≥5% and with a ≥2% difference between paliperidone ER and

Ngày tải lên: 11/08/2014, 16:23

... IP-10: interferon-inducible protein 10; KGF: keratinocyte growth factor Competing interests SDA has no competing interests KLV has no competing interests TR has no competing interests CZ, ZA, TN and ... associations between individual protein levels and lung function and dyspnea using a linear mixed effect model adjusting for age and gender In these models lung function variables and dyspnea scores ... http://respiratory-research.com/content/11/1/41 including disease (COPD or control), smoking, and the interaction between disease and smoking as fixed effects, and visit number within each subject as a random effect for each protein A

Ngày tải lên: 12/08/2014, 11:21

... clusters in a) the extracellular domain (exons 2-4) and b) the serine/threonine protein kinase domain (exons 9-11) Four mutations occurred in more than one independent patient/family: p.R491W and ... mutation Only in 3 out of the 22 families with HPAH (13.6%, Figure 3) examination of the BMPR2 gene (promoter and coding regions including flanking intronic regions) and the coding regions of ... independent patients including those with a known PAH family his-tory, sporadic disease and PAH associated with other diseases [1] In a few PAH patients mutations in other genes participating in the BMPR2

Ngày tải lên: 12/08/2014, 13:22

... polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations Michaela Schedel†1, Martin Depner†1, Carola Schoen1, Stephan K Weiland2, ... status Finally, environmental factors such as passive smoke exposure could potentially interact with ADAM33 in exerting its remodeling function in the lung as ADAM33 also seems to be involved in COPD ... defined as having asthma In Dresden and Munich, children underwent skin prick testing for six common aeroallergens (Dermatophagoides pteronyssinus, D farinae, Alternaria tenuis, cat dander, and

Ngày tải lên: 12/08/2014, 16:20

... pulmonary hyperinflation and gas trapping in addition to ventilation inhomogeneities and in conjunction with CFTR genotyping provides a means for monitoring functional progression in CF disease ... incompletely explained and most likely reflects the influence of multiple, interrelated factors These may include differences in CFTR mutation and presence of infective organisms within the respiratory ... obtained at each follow-up visit and cultured for various bacterial species including H influenzae, S aureus and P aeruginosa [46] Sampling, transport, culture and identification of strains from

Ngày tải lên: 12/08/2014, 16:20

... norepinephrine to versus phenylephrine 3.2 phenylephrine [11] 12 Epinephrine 0.7 ±0.1 LD ↑ in mucosal blood flow NA Epinephrine, norepinephrine in versus norepinephrine 1 ±0.6 with epinephrine and ... the combination of norepinephrine and dobutamine in patients with septic shock on gastric mucosal flow, as assessed using a laser Doppler technique. Epinephrine and dobutamine–nor- epinephrine led ... random order to achieve MAP versus norepinephrine + norepinephrine + dobutamine, 70–80 mmHg dobutamine 1.1 ± 0.6 and 5 as compared with norepinephrine alone [46] 11 Epinephrine 0.3 ±0.2 LD epinephrine

Ngày tải lên: 12/08/2014, 20:20

... vasoconstrictor and water-retaining and sodium-retaining systems such as the renin–angiotensin–aldosterone system and the sympathic nervous system, and in the nonosmotic release of arginine vasopressin. ... C-reactive protein), to excretory and desintoxication function (ammonia, bile acids, bilirubin), to synthesis capacity (albumin, prothrombin time), to renal function (creatinine, ureum, sodium) and to ... norepinephrine, (d) vasopressin and (e) nitric oxide metabolites (NOx) after treatment with standard medical therapy (SMT) alone (grey shading) shading), with the molecular adsorbent recirculating

Ngày tải lên: 13/08/2014, 01:20

... determinations Plasma creatinine, C-reactive protein (CRP), glucose, albumin, leukocytes, and platelets were determined daily for clinical purposes, and aspartate amino transferase, alanine amino ... lowest in SAH (6.2 mmol/L) and decreasingsignificantly over time (P = 0.005), the decrease being similar in the AOX and placebo groups Insulin requirements Insulin requirements per day during the ... both selenium and zinc to within the normal ranges The GPX activity increased with plasma selenium Plasma C-reactive protein Mean CRP value peaked by day 2 and decreased in both AOX and placebo

Ngày tải lên: 13/08/2014, 11:22