data sources and computational tools for cancer systems biology

... Differences were largest for men with prostate cancer, and for women with breast cancer, and smallest for lung cancer in both sexes (Table 4) The greatest difference was 3.6% for prostate cancer in Mississippi ... New Zealand Cancer Registry and the Penang Cancer Registry (Malaysia) provided mortality rates by ethnicity at a national level Both the Polish National Cancer Registry and the Austrian Cancer ... mortality rates for the sub-regions covered by their registries (voivodeships for Poland, bundeslands for Austria) Neither registry submitted data by ethnicity We classified the data we received

Ngày tải lên: 20/09/2020, 01:26

... developed the Cancer Systems Biology Database (CancerSysDB), a resource for highly flexible queries and analysis of cancer-related data across multiple data types and multiple studies The CancerSysDB ... analysis and machine learning on cancer genomics data using the Cancer Systems Biology Database (CancerSysDB) Rasmus Krempel1, Pranav Kulkarni2, Annie Yim3,4, Ulrich Lang1, Bianca Habermann3,4and ... the newly developed Cancer Systems Biology Database (CancerSysDB) portal which allows integrated analyses across multiple data types and across multiple cancer cohorts from The Cancer Genome Atlas

Ngày tải lên: 25/11/2020, 15:45

... NGS data, there are few tools for somatic CNV detection for WES data in cancer Results: In this study, we evaluated the performance of the most recent and commonly used CNV detection tools for ... detection methods and chal-lenges for WES data and then introduce the recent CNV detection tools for WES data Then we present the performance analysis of the tools in terms of sensitivity and specificity ... log-ratios and read count data, it relies on the case sample being largely copy number neutral But this might not be true for cancer data, and results in poor performance for real cancer data cn.MOPS

Ngày tải lên: 25/11/2020, 16:56

... distribution, and reproduction in any medium, provided the original work is properly cited. Trang 2Spine is the most common place of cancer metastasis, especially for lung cancer and breast cancer Each ... contributions YG and JW contributed equally in design of the study, col-lection of data and drafting the manuscript; SB and XJ worked on analysis of data; FX provided the conception of this study and the ... pub-lished And all authors read and approved the final man-uscript Acknowledgements We thank Dr Xin Wang and technicians Renming Zhong, Xiaoyu Li and Yinbo He for their assistance in data collection.

Ngày tải lên: 09/08/2014, 09:22

... of XGAP database for genotype and phenotype experiments Store Store genotype and phenotype experimental data using only four ‘core’ data types: Trait, Subject, Data, and DataElement For example: ... text-file format for data exchangeTo enable data exchange using the XGAP model, we produced a simple text-file format (XGAP-TAB) based on the experience that for data formats to be used, data files ... ‘orphaned’ data are loaded into the database - forexample, genetic fingerprint data cannot be added before all information is uploaded on the markers and subjects involved Standard paths through the data

Ngày tải lên: 09/08/2014, 20:21

... delivery, financing, human resources and regulation functions [32,33] The conclusion empha-sizes the need for concerted data collection efforts and identifies variables for further analysis of medical ... tourism AND Asia” (92) and “medical travel AND Asia” (806), generating a range of mostly conceptual research Abstracts were scanned for reference to Thailand, Singa-pore and Malaysia and/or reference ... medical tourism for both foreign and local consumers and mitigate the risks Research methodol-ogy is outlined below, followed by the policy implica-tions of medical tourism for health systems at their

Ngày tải lên: 11/08/2014, 14:21

... role is in cancer formation and progression ADAMs shown to play a role in cancer include ADAM9, ADAM10, ADAM12, ADAM15 and ADAM17 Two of the ADAMs, i.e., ADAM10 and 17 appear to promote cancer progression ... Therapeutics for Cancer Ireland for funding this work. Author details 1 Department of Pathology and Laboratory Medicine, St Vincent ’s University Hospital, Dublin 4, Ireland 2 UCD School of Medicine and ... indicating a cancer biomarker potential for different ADAMs are promising, they all require confirmation in larger and prospective studies For evaluating a potential cancer diagnostic role for the

Ngày tải lên: 13/08/2014, 13:20

... automatically but also highlightscandidate genetic defects using micro-CT images of normal and transgenic miceand computational tools like registration and deformation vectors Trang 22CHAPTER ... fields of biomedical and healthcareresearch Today, medical scans produce thousands of images and tera bytes ofdata for a single patient in mere seconds The global size of data in healthcare is ... processing and computer graphic technologies to designreporting, analysis and diagnostic tools for healthcare and biomedicalapplications that not only better utilize existing, otherwise discarded,data

Ngày tải lên: 09/09/2015, 11:23

... control packet, and it can also be used for collectinginfrequent and periodic data as in LWB [45] that allows to achieve a low duty-cycling ratio Onthe other hand, large data dissemination and collection ... coding 47 3.7 Performance of Splash with and without opportunistic overhearing 49 3.8 Performance of Splash with and without channel cycling 50 3.9 Performance of Splash for two different ... generated bulk data is mandatory for all these plications The state-of-the-art bulk data collection protocol that specifically targets energy Trang 17ap-1.3 Case for Collection of Large Data Objects

Ngày tải lên: 10/09/2015, 09:10

... order to design a database model for storing and retrieving online social-network-related data Standarddata models, query languages and access methods, such as the relational model and SQL,are often ... data objects are recursive and associative in nature, so relationaldatabase cannot always be the appropriate tool for data storage and data access, concerningits poor modeling capabilities, and ... also in databases.The conceptual graph model is a data representation formalism, in which data structuresfor the schema and instances are modeled as graphs or generalizations of them, and datamanipulation

Ngày tải lên: 04/10/2015, 10:24

... corresponding information vector, and the modeling database is employed for the standard use by JITL for the modeling purpose The PID parameters are obtained from controller database according ... 4.2 Input and output data used to construct the modeling database for JITL in polymerization reactor example 57 Figure 4.3 Input and output data used to construct the initial controller database ... process information from controller database and modeling database to realize on-line tuning of PID parameters The controller database contains the PID parameters and the corresponding information

Ngày tải lên: 04/10/2015, 10:25

... solid lines performance the upper and lower bounds Results for K eff , μeff are taken by chapter and for 2D-space problem Estimations of E eff and ν eff rely on Hill’s relations for twophase transverse-isotropic ... primarily for periodic materials For materials with randomly arranged forms such as random spheres mentioned in the previous chapter, it will be difficult for calculation because we must consider for ... VIETNAM ACADEMY OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY o0o VU LAM DONG ESTIMATION AND COMPUTATIONAL SIMULATION FOR THE EFFECTIVE ELASTIC MODULI OF

Ngày tải lên: 20/05/2016, 10:45

... Trang 1VIETNAM ACADEMY OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY -o0o - VU LAM DONG ESTIMATION AND COMPUTATIONAL SIMULATION FOR THE EFFECTIVE ELASTIC MODULI OF ... upper and lower bounds for the effective elastic moduli of isotropic multicomponent materials • The numerical method using MATLAB program to set the formula, matrix optimal geometric parameters for ... models) For the evaluation narrower than the rated HS, the following authors have researched and built the variational inequalities containing random function describing additional information

Ngày tải lên: 09/08/2016, 08:37

... iterative equations for D(k) and D2(k), as given respectively by Eqs (4.16) and (4.30), and with the initial conditions for the function and its derivative The first elements for the y, D, and D2 arrays ... y(2 N ) + y(2 N + 1)   that is, the weights are equal to for the first and last elements, equal to for even elements, and equal to for odd elements Example 4.7 Using Simpson’s rule, compute ... Question: Compute analytically from Eqs (4.58) and (4.59), the steady-state values for the higher excited state population and for the photon number, and compare with the numerically obtained asymptotic...

Ngày tải lên: 13/08/2014, 02:21

... analytically MATLAB has a built-in command that finds all the roots (real and complex) for any polynomial equation As previously noted, the MATLAB command for finding the polynomial roots is roots: ... that it satisfies, and its value and that of its derivative at x = 0, namely: J ( x = 0) = and J ( x = 0) = ′ The problem that we want to solve is to find the zeros of J0(x) and compare to these ... The command is poly poly(r) In-Class Exercise Pb 5.14 Find the roots of the polynomial p = [1 pute their sum and product 3], and com- Pb 5.15 Consider the two polynomials: p1 = [1 3] and p2 =...

Ngày tải lên: 13/08/2014, 02:21

... values for the lower and upper cutoff frequencies and the sampling time: f1 = 200 Hz; f2 = 400 Hz; τ = 10–5 s find f0 and plot the gain curve as function of the normalized frequency for the bandpass ... rules for the addition and subtraction of vectors Example 6.2 Find the sum and difference of the complex numbers © 2001 by CRC Press LLC z1 = + 2j and z2 = + j Solution: Grouping the real and imaginary ... Analytically and numerically, obtain in the standard form an expression for each of the following quantities: a + 4j + 5j b 3+j (1 − j )(3 + j ) 1− 2j + j  − c   2j  2 + 3j Pb 6.9 For any pair...

Ngày tải lên: 13/08/2014, 02:21

... element of the space; and b If a and b are constants, and ϕ and ψ are elements belonging to the space, then a ϕ + b ψ is also an element of the space There is an inner (dot) product for any two elements ... by CRC Press LLC for − ≤ x ≤ a for a < x ≤ (7.112) Solution: The conditions for the above theorem are satisfied, and  cl = l +  1 2 ∫ P (x)dx a l (7.113) From Eq (7.96), and noting that Pl(1) ... Rseries Rparallel (7.43) The proof is straightforward Using Eq (7.37) and recalling Ohm’s law for n resistors {R1, R2, …, Rn}, the equivalent resistances for this combination, when all resistors are...

Ngày tải lên: 13/08/2014, 02:21

... C = 0.25 F, and L = H: a Write the equations for the phasors of the voltages and currents b Form the matrix representation for the equations found in part (a) c Plot the magnitude and phase of ... primary tool for understanding and solving physical problems at the atomic and subatomic scales In this section, we define these matrices and find key properties of their eigenvalues and eigenvectors ... as these form the tools for the matrix formulation of ray optics and Gaussian optics, which are two of the major sub-fields of photonics engineering Example 8.16 Find the eigenvalues and eigenvectors...

Ngày tải lên: 13/08/2014, 02:21

... matrix form, this transformation can be represented by: −1 P= 0 0 −1  (9.2) • For the reflection about the x-axis, denoted by Px, and the reflection about the y-axis, denoted by Py , the transformation ... transformation matrix for simultaneously compressing the x-coordinate by a factor of 2, while expanding the y-coordinate by a factor of Apply this transformation to the trapezoid of Example 9.1 and ... strategy for solving the problem goes as follows: Perform a translation to place Q at the origin of a new coordinate system Perform a π/4 rotation around the new origin, using the above form for rotation...

Ngày tải lên: 13/08/2014, 02:21

... same results by noting that the events E and O (B and C) are disjoint and that their union spanned the set S Therefore, the probabilities for events O and C could have been deduced, as well, through ... error bars and the confidence level for any experimentally obtained result, through a methodical analysis and reduction of the raw data In future courses in probability, random variables, ... components have unequal values Therefore, while a can have any of 10 possible values, b can have only 9, and c can have only Therefore, n(A) = × × 10, and the probability for the event A is P( A) = ×...

Ngày tải lên: 13/08/2014, 02:21