confer a significantly elevated lifetime risk for breast and ovarian cancer

... Jouali2, Nabila Marchoudi2, Mohcine Mechita Bennani1, Naima Nourouti Ghailani1, Amina Barakat1and Jamal Fekkak2 Abstract Background: Hereditary breast and ovarian cancer (HBOC) is an autosomal ... selected cases, Forty-six had breast cancer, fifteen had ovarian cancer and three had both breast and ovarian cancer The molecular analysis revealed that 18 patients from the 64 harbored a pathogenic ... 18 Amal Tazzite A, Hassan Jouhadi B, Sellama Nadifi A, Aretini P, et al BRCA1 and BRCA2 germline mutations in Moroccan breast/ovarian cancer families: Novel mutations and unclassified variants

Ngày tải lên: 19/09/2020, 22:10

... bilateral breast cancer and one with breast cancer, at least one before the age of 50. Families with a single case with breast cancer or ovarian cancer. 7) Single affected individual with breast ... breast cancer or ovarian cancer, at least two of which must be first degree. 1) Three or more family members with breast and/or ovarian cancer. (Br: Only breast cancer Ov: at least one ovarian ... Trang 1R E S E A R C H A R T I C L E Open AccessHereditary breast and ovarian cancer in Andalusian families: a genetic population study Bella Pajares1*, Javier Porta2, Jose María Porta2, Cristina

Ngày tải lên: 23/07/2020, 02:43

... REVIEW Open Access Platinum resistance in breast and ovarian cancer cell lines Niels Eckstein Abstract Breast and ovarian cancers are among the 10 leading cancer types in females with mortalities ... year survival rate is below 30%. Unfortunately, most cases (68%)arediagnosedatthedistantstage.Thus,ovarian cancer has a substantially shorter and more dramatic etio- pathology than breast cancer: ... breast cancer. Ovarian cancer Clinicians have designa ted ovarian cancer a “silent killer” bec ause, when diagn osed, the disease usually has already spread into the peritoneum [65]. If the cancer

Ngày tải lên: 10/08/2014, 10:21

... ovarian cancer and one with breast cancer D One family member with a male breast cancer and one or more with breast and/or ovarian cancer E Two family members with breast cancer, before the age ... three ovarian cancers and one squamous oesophagus cancer have been diagnosed Median age at diagnosis was 48 for breast (range 32–74) and 52 for ovarian cancer (range 48–60) Clinic and pathological ... deletion was identified in a woman with ovarian cancer at the age of 64 who had had a bilateral breast cancer at ages 42 and 61 respectively Her sister had also had an ovarian cancer at the age of

Ngày tải lên: 05/11/2020, 06:29

... impact overall survival in breast cancer and ovarian cancer patients 3.2 Survival Analysis for Breast Cancer and Ovarian Cancer Patients The patients with BRCA1 mutation had the worst survival ... 2.3.2 Breast and Ovarian Risk Prediction We calculated a risk score based on the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) [10,11] The breast cancer ... Vietnamese population We herein screen the entire BRCA1 and BRCA2 genes for breast and ovarian cancer patients with a family history of breast cancer and ovarian cancer, thereby, suggesting a risk

Ngày tải lên: 19/06/2025, 16:06

... pulmonary dis-ease (COPD) represent a major burden for patients and health care systems For patients, acute exacerbations are a common reason for hospital admissions and severely affect health-related ... the lack of access to rehabilitation has been pointed out as an important caveat in health care In these places patients could be randomized to additional respiratory rehabilita-tion or standard ... suggests that respi-ratory rehabilitation reduces unplanned hospital admis-sions and mortality and improves HRQL and exercise capacity when initiated immediately after acute exacerbations Abbreviations

Ngày tải lên: 12/08/2014, 18:21

... express a p53-mutation (R280K), are negative for ER and PR and express no amplification of HER2 [46,48] Both breast cancer cell lines were a kind gift of Göran Landberg (Sahlgrenska Cancer Center, ... screen for synergism Jérôme Ruhnau*†, Jonas Parczyk*† , Kerstin Danker, Britta Eickholt and Andreas Klein Abstract Background: Despite an improvement of prognosis in breast and colon cancer, ... Trang 1R E S E A R C H A R T I C L E Open AccessSynergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to

Ngày tải lên: 06/08/2020, 05:17

... caspase activation in human triple-negative breast and ovarian cancer cell lines Sporadic basal-like or triple-negative breast cancers strongly resemble breast cancers originating from her-editary ... mu-tant breast cancer) results in an accumulation of single strand breaks (SSBs) leading to replication fork collapse, DSB generation and cell death This reliance on alternative DNA repair pathways ... Chk1, Breast cancer, Ovarian cancer, V158411, DNA repair, Triple-negative Background Breast cancer is the most common cancer affecting wo-men and the second most common cause of death due to cancer

Ngày tải lên: 14/10/2020, 13:47

... time-consuming andexpensive Nowadays there are open-access breast cancer databases for research and literature such as BreaKHis,ICIAR 2018 BACH Challenge, Kaggle breast histopathological image, Tumor ... mean of real and fake image, Cr, Cg: covariance of real and fake image Therefore, FID hasthe same drawbacks as IS bout changing weight and data sample Lower FID score means two images to be approximately ... moment(variance of gradients) as combination of Momentum and AdaGrad • Early Stopping: after many train iterations, validation accuracy to be gradually decreasing or no anychanges means that training

Ngày tải lên: 18/11/2020, 10:07

... breast and colorectal cancer, for which the Ihh signalling pathway was found to be poten-tially important This pathway was also found in separate analyses for height-post-menopausal breast cancer ... as well as separately for clusters including height- and post-menopausal breast cancer risk-associated SNPs and clusters including height- and colorectal cancer risk-associated SNPs Results An ... same gene according to the HapMap or GRAIL annotation (or both, allowing that HapMap and GRAIL may yield different annotations) or a combination of HapMap and GRAIL annotations For each SNP in

Ngày tải lên: 19/11/2022, 11:48

... Food and Drug Administration (FDA), Food and Agricultural Organization of the United Nations (FAO), European Union (EU), the Institute of Public Health of Japan and many other local agencies have ... Johri, T.S.; Swain, B.K Effect of varying levels of aflatoxin, ochratoxin and their combinations on the performance and egg quality characteristics in laying hens Asian-australas J Anim Sci 2003, ... the Balkan Endemic Nephropathy and was also linked to human renal disease [55,57] Moreover, it has been described that OTA is genotoxic and associations have been found between OTA exposure and

Ngày tải lên: 04/12/2022, 15:58

... data by pathological expert is time-consuming and expensive Nowadays there are open-access breast cancer databases for research and litera- ture such as BreaKHis, ICIAR 2018 BACH Challenge, Kaggle ... Pathologi- cal Anatomy and Cytopathology, Parana, Brazil, it means that those results can’t gain the same accuracy on new dataset Deep learning is a branch of machine learning, representing data characteristic ... in collaboration with the P&D Laboratory — Pathological Anatomy and Cytopathology, Parana, Brazil 2 Breast Cancer Classification Challenge 2018: The BACH 2018 is been built on collaboration

Ngày tải lên: 15/01/2025, 21:46

... last transmitted symbols of all users) is estimated from the re-ceived signal, where Kalman parameters are adjusted using one noise parameter (variance and contamination constant) and one Gaussian ... −1) are the corresponding error covariance matrices K(k) is the so-called Kalman gain [33] 2.2.2 Non-Gaussian state noise Many works based on an approximate DS-CDMA state-space representation ... other cases, a suboptimal or a robust Kalman filtering becomes necessary Some Kalman-like filtering algorithms have been derived by Masreliez [24] and Alspach and Sorenson [25] The first approach

Ngày tải lên: 23/06/2014, 01:20

... Dick & Carey’s (1996) evaluation approach may be the best candidate, because this approach allows different types of evaluators (e.g., experts, individual, and group of evaluators) to evaluate ... (Belanger & Jordan, 2000) There are several formative evaluation approaches that can be used to identify problem areas or to draw inferences about the overall quality of Web-based learning ... interface design practice, this study borrowed Wallace & Anderson’s (1993) classification: the craft approach, enhanced software engineering approach, technologist approach, and cognitive approach

Ngày tải lên: 29/06/2014, 02:20

... Daily mean averages of hourly aggregated and area-averaged analysis increments for temperature 4.2 Daily mean averages of hourly aggregated and area-averaged analysis ... "odds ratio" for diagnosing forecast skill Weather and Forecasting 15:2, 221–232 Tarantola, A (2005) Inverse Problem Theory and Methods for Model Parameter Estimation Society for Industrial and Applied ... H., Sakamoto, M., Kobayashi, S., Hatsushika, H., Matsumoto, T., Yamazaki, N., Kamahori, H., Takahashi, K., et al (2007) The JRA-25 Reanalysis Journal of the Meteorological Society of Japan Ser

Ngày tải lên: 26/11/2015, 10:11

... Margareth MacDonald, Petra Skalicka and Hana Kostalova – who have been for several years steadily contributing to the quality of PIN’s educational programs and the value of this training manual ... name tags are on For the third round the participants take off the name tags and the participants are expected to say the names by memory In case a participant forgets the name of another participant, ... bring a change in the quality of teaching in primary and secondary schools and improve students’ learning Specifically, the manual aims to familiarize teachers with theoretical and practical understanding

Ngày tải lên: 13/08/2016, 19:32

... which can mean poor performance and durability. ■ Thermal Imaging - measures surface temperatures using infrared cameras and creates a visual image of heat loss. The cameras detect radiation ... showerheads and faucet aerators. ■ Install gaskets behind electric outlets and switch plates on exterior walls. ■ Seal air leaks to attic and crawl space with spray foam. ■ Caulk and weatherstrip ... or candle to detect air leaks ■ Flashlight ■ Ladder Safety Crawl spaces may contain a variety of dusts and animal droppings. You will want to wear appropriate clothing and safety equipment for...

Ngày tải lên: 06/03/2014, 23:20

... (VHS). Fungal. Fungi are unavoidable and always present in ponds. Saprolegnia is a common fun- gal disease that affects all freshwater fish and fish eggs. Saprolegnia attacks injured or dead tissue and ... by glands that make it water-resistant. The tail is broad, flat, and dark brown to black in color. The hind feet are very large and fully webbed. The front teeth are large and well adapted for ... by Disease. Fish kills can also be caused by disease and parasite infestations. Al- though more than 1,000 species of parasites and bacteria inhabit the freshwater of North America, only a few...

Ngày tải lên: 08/03/2014, 14:20

... Columbia, Vancouver, Canada Gonadotropin theory of ovarian cancer Ovarian cancer is the most lethal gynecological malig- nancy. Although epithelial ovarian carcinomas account for approximately ... molecular mechanisms that mediate GnRH actions and the clinical applications of GnRH analogs in ovarian cancer patients are also discussed. Abbreviations AP-1, activator protein-1; EGF, epidermal ... analogs at relatively high concentrations or for a prolonged time. Although Fas and FasL were detected in the majority of ovarian carcinomas and ovarian cancer cell lines [51,52], and GnRH agonists...

Ngày tải lên: 16/03/2014, 04:20

... breast cancer. It also does not cover treatments for women who already have breast cancer. For women who have never had breast cancer, both tamoxifen and raloxifene reduce invasive breast cancer risk ... risk for breast cancer. Having radiation treatment at a young age also raises the risk. 3 6 Two different medicines can reduce the risk of breast cancer for women who have never had breast cancer ... breast cancer. A woman’s risk of breast cancer depends on her age and other risk factors. Most women who get breast cancer have no risk factors other than growing older. And many women who have...

Ngày tải lên: 29/03/2014, 01:20