conditions due to abnormal amounts of insulin in the

... relevance of V55 regarding the structural integrity of the catalytic site of the protease This finding can readily be explained by the smaller size of the side chain of alanine in contrast to serine ... 2) T54 is at the very end of the strand β3, next to a loop directly involved in the ligand binding cavity at the protein surface The side chains of V36 and T54 point towards each other We identified ... structure models The ligand binding mode of the inhibitor VX950 was investigated by computational protein-ligand docking Structural changes in the binding pocket and the catalytic triad of the protease...

Ngày tải lên: 14/08/2014, 08:20

... potential source of bias and limit the generalizability of the findings As with any single-site study, the generalizability of the results may be called into question Although the external validity ... Inouye and coworkers [17] The instrument includes a series of nonverbal tasks to rate the four key criteria: acute change from baseline or fluctuating course, inattention, disorganized thinking, ... determined each day of the ICU stay based on the following hierarchy Priority was assigned to the rating determined by the CAM-ICU, completed via direct observation by the study nurse If the CAM-ICU...

Ngày tải lên: 13/08/2014, 03:20

... diarrhoea They also demonstrated how to mark the day that symptoms first started and the day that the illness ended or the child succumbed to the illness The information was reported to investigators ... household was defined as people sharing the same cooking pot (Hussain et al 1999) Using this definition, 820 households in 10 sub-districts were identified during the preliminary survey Of the 350 households ... al 1994) Final data were recorded only if the data were consistent with the mothers’ performance levels in defining the symptoms and counting the days of illness We developed a series of household-level...

Ngày tải lên: 05/09/2013, 10:15

... meV In the case of the intra-dot doping, the dot charge nq is equal to the dot population n reduced by the number of dopants p in the dot, i.e., nq = n - p In the case of the inter-dot doping, the ... depend on doping The pre-exponential factor in Equation describes the increase of the absorption with increasing number of electrons in the dot n The exponential factor describes the effect of potential ... our data related to the operation of a QD solar cell and present basic contours of the model for the description of doping-induced effects in the kinetics of bipolar photocarriers in QD structures...

Ngày tải lên: 20/06/2014, 22:20

... exploit the separation of time scales in the analysis of these (k + l)-dimensional models by splitting the system into the k-dimensional fast subsystem obtained in the singular limit ε → of (1) ... that in some cases in which a Hopf bifurcation involves the fast variables, all the information needed to determine the criticality of the bifurcation is contained in the fast subsystem but in other ... determining the nature of the Hopf bifurcation in the layer problem and then asserting that the Hopf bifurcation in the slow-fast system will be of the same type However, the existence of a Hopf...

Ngày tải lên: 20/06/2014, 23:20

Ngày tải lên: 07/08/2014, 17:22

... tube In our cases the indication of open surgery ACS was complicated of the presence of the large retroperitoneal hematoma We didn’t proceed to a decompressive laparotomy because all of the hematomas ... participated in the design of the case report MNK participated in the design of the case report SS participated in the design and culled relevant information RK participated in the design of the case ... tachycardia are most of the time present Any abnormal and sudden increase in the volume of any component of the intra-peritoneal or extra-peritoneal spaces can cause Intra-abdominal Hypertension...

Ngày tải lên: 10/08/2014, 09:22

... investigates the reality of the teaching oral skills to the first year students in HaUI when the teachers are considered to be applying CLT approach in their teaching The main goal of the research is to ... considering the following issues: - Creating interesting topics because interesting topics motivate the students and create enjoyable atmosphere in the class When they are interested in something, they ... think the researcher wants to read rather than their real feelings Moreover, the number of the subjects is small which may influence the implications of the thesis to some extent The results of...

Ngày tải lên: 07/11/2012, 15:01

... learning of linguistic devices to attribute source of information in newspaper writing 1.3 RESEARCH QUESTIONS What are the linguistic devices to attribute source of information in terms of syntax, ... raising the awareness of the role and functions of linguistic devices to attribute source of information to language learners, and providing them with pragmatic knowledge to use linguistic devices to ... as The Washington Post, The New York Times, The Daily Telegraph, The Los Angeles Times, and The U.S.A Today in English; and The Thanh Nien, The Tuoi Tre, The Tien Phong, The Vietnamnet, and The...

Ngày tải lên: 26/11/2013, 13:24

... to detect the binding interactions between the peptides and the Grb4 SH2 domain The affinity of the binding interactions was evaluated by measuring the changes of fluorescence polarization of the ... ephrinB2(301–333) to the SH2 domain of Grb4 and to the PDZ domain of PDZ-RGS3 In the combination experiments, the two C terminal tyrosine residues were ignored due to their distant positions ND, not determined ... conformation of the PDZ binding domain of ephrinB2(301–333) is essentially independent of tyrosine phosphorylation within the SH2-binding element of ephrinB2(301–333) On the other hand, tyrosine phosphorylation...

Ngày tải lên: 19/02/2014, 12:20

... possible to quantify the amount of recovered protein owing to the presence of a high molar excess of BSA remaining in the buffer Therefore, a fixed aliquot of the protein was incubated with the indicated ... protein belonging to the GTPbinding elongation factor family, which promotes the GTPdependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis and the capture of ... Thus, in these high basic proteins it might be that either methylation of the lysine or specific substitutions in the amino acid sequence, increasing the number of basic residues of lysine, arginine...

Ngày tải lên: 21/02/2014, 00:20

... GUIDE is the last section This provides a discussion of the main themes as they emerged in the service user interviews (as listed above in the ‘Findings’ section) It breaks the themes down into manageable ... allows them to meet the outstanding needs in their community and to supplement the work of the statutory sector Mutual support within a community can sustain the health of its members in otherwise ... Westminster Camden Camden Islington Wandsworth Islington Tower Hamlets Islington Kensington and Chelsea Hounslow Hounslow Barnet Islington Hounslow Camden Camden Haringey Haringey Islington Enfield...

Ngày tải lên: 24/02/2014, 18:20

... transmission of HIV to the uninfected partner Of 28 cases of HIV infection documented to be genetically linked to the infected partner, 27 occurred in the 877 couples in which the HIV-infected partner ... that adding week of zidovudine therapy to infant single-dose nevirapine reduced risk of transmission by 36% compared with infant single-dose nevirapine alone.6 To define the optimal infant prophylaxis ... barriers to prevention.10, 11 Important obstacles to elimination of perinatal transmission in the United States include the continued increase in HIV infection in women of childbearing age;12...

Ngày tải lên: 05/03/2014, 13:20

... whereas the second offers an ontology of attack types in support of intrusion detection Currently 354 classes of software fault are represented in the Cyc KB At the top of the relevant multiple-inheritance ... faults of that class, four hundred uninterestingly distinct plans result To avoid a combinatorial explosion, we implemented multi-binding of variables When the inference engine returns the bindings ... is not interesting in itself; rather, system administrators care about determining what the dangerous vulnerabilities of the system are and prioritizing them in order of urgency By analyzing plans’...

Ngày tải lên: 05/03/2014, 23:20

... binding of the inhibitor a-NAPAP to the thrombin active site The effects of pH (5.5–10) on the hydrolysis of d-Phe-PipArg-pNA substrate by both WT and DK9 mutant thrombin and binding of the inhibitor ... thrombin show that the A-chain closely follows the contour of the catalytic B-chain, hinging the two interacting six-stranded barrel-like domains of the B-chain [17] A well-structured network of ... side-chains to the solvent the smaller the intrinsic fluorescence of the enzyme The smaller gain in the intrinsic fluorescence of DK9 upon Na+ concentration (9 vs 18% in WT) may reflect not only the...

Ngày tải lên: 07/03/2014, 12:20

... assets of the banking system, it is increasing rapidly 3.7 Finally, given the need to encourage the growth of the Microfinance sector and the vulnerable nature of the borrowers in the sector, there ... aggregate margin cap is maintained This will also facilitate monitoring by the regulator on the basis of the Annual Financial Statements If the regulator finds on examination of the Annual Financial ... charged to the borrower and the cost of funds to the MFI While this, too, suffers from the drawbacks of an interest cap, it is fairer to the MFI since it is not exposed to the risk of volatility of...

Ngày tải lên: 15/03/2014, 14:20

... subject to uncertainties The data used in this study is the best available, but some account must be made of the size on the inherent uncertainties Some concept of the uncertainties due to year to ... Dunedin 22 11 Rest of North Is 177 71 21 11 Rest of South Is 75 38 19 10 (NB In Tables 6.4a and 6.4b, the sum of the areas may not add to the totals presented earlier due to rounding in the calculations) ... respectively There is also a strong regional difference in the fraction of total mortality to vehicle related mortality In Auckland and Wellington, the fraction due to vehicles is 60-70% of the total,...

Ngày tải lên: 15/03/2014, 16:20

... factors in the UK in 2010: II Meat consumption DM Parkin S27 14 Cancers attributable to occupational exposures in the UK in 2010 DM Parkin Cancers attributable to dietary factors in the UK in ... consumption of alcohol in the UK in 2010 DM Parkin S19 12 Cancers in 2010 attributable to ionising radiation exposure in the UK DM Parkin and SC Darby Tobacco-attributable cancer burden in the UK in 2010 ... 2010 DM Parkin S14 11 Cancers attributable to infection in the UK in 2010 DM Parkin S77 S6 10 Cancers attributable to exposure to hormones in the UK in 2010 DM Parkin S73 The fraction of cancer...

Ngày tải lên: 22/03/2014, 16:21

... cycles of planning, translating, and reviewing interesting to note that many of the components included in a recent description of the NWP model (peers working together, inquiry, and sentence-combining; ... students in activities that improves the quality of their Students examine and infer the qualities of a number of objects in order to describe them in writing The students touch objects while wearing ... for the writing they are to complete It includes identifying the purpose of the assignment (e.g., to persuade) as well as characteristics of the final product Specific goals in the studies SETTING...

Ngày tải lên: 24/03/2014, 19:20