composition in multiple linguistic domains

... (flanking RT amino acids 288/289), SpeI (flanking RT amino acids 423/424) and ClaI (flanking IN amino acids 4/5) creating p8MJ4-HSC The MJ4 sequence also contains a natural and unique ApaI site in ... change in frequency betweentime points This analysis showed a cumulative increase in mutations in all RT domains (Table 1) Mutations were identified at 12 codon positions in DNA pol domain, namely, ... resistance but played a role in improving the replicative fitness of the Q151M-containing viruses Our findings confirm previous reports showing that the Q151M-con-taining virus replicates poorly

Ngày tải lên: 13/08/2014, 01:20

... protein-protein interactions THD2 consists of one or more PEST signals rich in proline, serine and threonine residues, while THD3 harbors a novel PHD zinc finger- and/or bromodo-main-interacting ... we have previously coined TRIP-homology domains (THD) [7] THD1 contains a cyclin A-binding motif (including a conserved nuclear localization signal, KRK) at the amino terminal, followed by heptad ... 1:300 Staining was visualized using a Leica DM LB2 microscope The intensity of TRIP-Br2 expression by immunostaining in the tumor TMAs was scored inde-pendently by three research pathologists in a

Ngày tải lên: 18/06/2014, 15:20

... Impact Scale; PDDS, Patient-Determined Dis-ease Steps Trang 7Changes in fatigue rating following a change in IMAFigure 2 Changes in fatigue rating following a change in IMA NARCOMS respondents who ... 2. Multiple Sclerosis Clinical Practice Guidelines Council: Fatigue and multiple sclerosis: evidence-based management strategies for fatigue in multiple sclerosis In Multiple sclerosis clinical ... reported that an increase in proinflammatory cytokines may be a possible contributor to primary fatigue in MS [40,42] GA has been shown to induce a shift from Th1 to Th2 response, resulting in lower

Ngày tải lên: 18/06/2014, 19:20

... connected domains 1 Introduction In this paper we consider the Dirichlet and the traction problems for the linearized n-dimensional statics The classical indirect methods for solving them consist in ... its adjoint In this subsection we determine the dimension of the following eigenspaces Trang 13W±= ϕ ∈ [Lp(Σ)]n : ±1We first observe that the (total) indices of singular integral systems in (28)-(29) ... following singular integral operator Rϕ(x) = Z Σ Trang 12Let us define R0ξ: [L1(Σ)]n→ [Lp(Σ)]n to be the singular integral operator3.4 The dimension of some eigenspaces Let T be the operator defined

Ngày tải lên: 18/06/2014, 22:20

... training mode As regards changes within one session, to distinguish between the changes in perfor-mance occurring during the Robot Training phase from those occurring during the Subject Training ... the training protocol: Baseline 1 (B1), Robot Training, Baseline 2 (B2), Subject Training, Wash-out The phases in which the robot generates no forces (B1, B2, Wash-out) are indicated in white ... compared (planned comparisons) Baseline 1 and Baseline 2 (effect of Robot Training), Baseline 2 and Wash-out (effect of Subject Training) and finally Base-line 1 and wash-out (overall phase effect)

Ngày tải lên: 19/06/2014, 08:20

... measured and compared using paired t-tests (a = 0.005) In addition, variability in these parameters during one-minute intervals was examined The fatigue index was defined as the number of significant ... leg being dragged or becoming unsteady Hence, recording patients’ perception of their function or change in function provides critical information for assessing a patient’s status Interestingly, ... patient during one minute of treadmill walking at the beginning and at the end of the physical exertion test, respectively * indicates significant differences between mean values at the beginning and

Ngày tải lên: 19/06/2014, 08:20

... Extensive IL-16 immunostaining, confined to infiltrating cells, was observed in MS lesions Less widespread immu-nostaining was found in normal-appearing white matter of brain and spinal cord IL-16 immunoreactivity ... was undetectable in control brain (Fig 1A), and was very low in control spinal cord white matter (Fig 1B), but was abundantly present in MS lesions in brain and spinal cord In brain, levels of pro-IL-16 ... detected in control brain and spinal cord, but T-bet levels were appreciable in MS lesions (Fig 3) Levels of T-bet were markedly increased in acute and chronic MS lesions in brain, (Fig 3A) and in

Ngày tải lên: 19/06/2014, 22:20

... engulfed lipid-containing debris, or subacute, containing demyelinated areas but demon-strating less recent myelin destruction Brain sections were stained for PD-L1 or PD-L2 and caveolin-1, a spe-cific ... brain tissues obtained from normal controls and MS patients (see description in Table 1) MS lesions were characterized using oil red 0 (ORO) and hematoxylin scoring as being acute, containing ... migrating through anin vitro BBB model (Figure 2), supporting a contributing role for these ligands expressed by the local endothelium in regulating immune cell infiltration into the CNS In contrast,

Ngày tải lên: 19/06/2014, 22:20

... NCR1 in disease Activating NK receptors recognise stress-induced ligands and viral products Following influenza virus infection, an increased recognition and binding of NK cells with infected ... stopped by rinsing in distilled water Sections were counterstained in Mayer’s Haemalum for 2-5 sec and rinsed for 5 min Sections were dehydrated and placed in 70% methylated spirit for 1 min, then ... conjugated (Invitrogen, Paisley, UK) After 45 min incubation the slides were washed twice, incubated with DAPI (2.5 ng/µL final concentration from Invitrogen, Paisley, UK) for 10 min, washed twice in

Ngày tải lên: 19/06/2014, 22:20

... unbounded cylinder domains instead of the entire space and also obtain the same results as in 4 Our arguments are similar to those in 5,6, which are based on Ekeland’s variational principle 7 ... u  ax|u| p−2u  fx in Ω has a solution that changes sign in Ω, in addition to two positive solutions whereΩ is an unbounded cylinder domain inRN Copyrightq 2009 Tsing-San Hsu This is an open ... a bounded smooth domain,Ω  ω × R nis a smooth unbounded cylinder domain inRN Trang 2It is assumed that ax and fx satisfy the following assumptions:a1 ax is continuous and ax ∈ 0,

Ngày tải lên: 21/06/2014, 20:20

... (CSI) is exploited at a multiple antenna RS allowing single-user beamforming at the RS In [19], multiuser beamforming is applied at multiple RSs in order to supply multiple destina-tions with their ... multinode computer network are jointly en-coded at intermediate network nodes, thus saving network resources, that is, DF two-way relaying can be interpreted as network coding in the original ... two-hop relaying defined as space division duplex (SDD) relaying is proposed In SDD relaying, multiple an-tenna beamforming techniques are applied at the intermediate relay station (RS) in order

Ngày tải lên: 21/06/2014, 22:20

... Channel-Aware Scheduling in Multiple Antenna Downlink Eduard A Jorswieck,1Aydin Sezgin,2and Xi Zhang3 1 Communications Laboratory, Faculty of Electrical Engineering and Information Technology, ... global fairness index (GFI) [13], provides a single number between zero and one that measures the fairness even for resource scheduling in finite windows The average fairness defined in [11] is developed ... robin scheduler (ORS), and the round robin scheduler (RRS) for a space-time coded multiple antenna downlink system The system applies TDMA based scheduling and exploits the multiple antennas in

Ngày tải lên: 21/06/2014, 23:20

... andZhou [19] First, we deal with the more general domains instead of the exterior domains,and second, we prove thatλ ∗is finite, and third, we also obtain the behavior of the twosolutions on (0,λ ∗) ... (3.6) Trang 6Now, by the Sobolev embedding theorem, we obtain thatu ∈ C b(Ω) It is well known thatthe Sobolev embedding constants are independent of domains (see [1]) Thus there existsa constantC ... embedding theorem, we obtain thatu ∈ C1,α(Ω) for α∈(0, 1)  We useLemma 3.5, and modify the proof in Hsu [11] We obtain the following preciseasymptotic behavior of solutions of(1.1)λand(2.4)λat infinity

Ngày tải lên: 22/06/2014, 22:20

... the increased risk of suicidal thoughts and behavior based on the FDA meta-analysis Since the FDA released their findings, clinicians using AEDs have sought to put the information into a clinical ... cannot be inferred The injury or potential for injury is clear, but why the individual engaged in that behavior is unclear. 6 Not enough information: death Insufficient information to determine whether ... controlled clinical studies [3] In the case of antidepressants, the results of such analyses led to the addition of a warning to prescribing information regarding increased suicidality risk in the

Ngày tải lên: 09/08/2014, 01:21

... rate of inbreeding when there is selection within families, but delays inbreeding for three or so generations in populations of this size and minimises the variation in inbreeding level within the ... from a slight decline in the L lines The estimate of linear regression of litter size at birth (assumed to be a trait of the dam) on the individual coefficient inbreeding in the C line was 0.6 pups ... genes which influence the quantitative trait, long-term experiments may provide more detailed information about its underlying inheritance [11, 18, 19] In the infinitesimal model introduced by

Ngày tải lên: 09/08/2014, 18:21

... overall selection index Still, the loss in efficiency (2.2% for the example) should be compared to the maximum gain obtained by including type traits (0.813/0.785 = 3.6% extra gain in the example). ... lead to a loss in response to selection compared to using the true marker effects because information from markers will usually be combined with phenotypic information in a selection index so that ... index so that an upward bias in the R from markers will result in too much weight given to the marker information In general, obtaining unbiased estimates of p2 is intractable, because the mean

Ngày tải lên: 09/08/2014, 18:22

... were measured and compared using paired t-tests (α=0.005) In addition, variability in these parameters during one-minute intervals was examined The fatigue index was defined as the number of significant ... the joints of the lower extremities during walking Interestingly, functional imaging studies have reported increasing evidence that patients with MS experience greater cerebral activity during ... mean index and the variability index showed comparable values (Table 1) Discussion According to guidelines proposed by the MS Council for Clinical Practice Guidelines in 1998, fatigue is defined

Ngày tải lên: 11/08/2014, 07:21

... been doing anything Associated features unrefreshing nocturnal sleep When I awake in the morning, I feel unrefreshed Examples of item wording representing the individual features of fatigue in the ... NFI-MS In practice, the resulting domains were in accordance with the conceptual dimensions found in the qualitative phase, including the notion that the sub-dimensions were part of a single, ... identifying the (ordinal) level of fatigue in patients by simply adding up the raw score for the scale, which lends itself to convenient everyday use in a clinical set-ting The ordinal-interval

Ngày tải lên: 12/08/2014, 01:21

... parent, T128, using Joinmap ver 4.0 In the paternal (E guineensis) map, 252 markers (199 AFLP, 38 RFLP and 15 SSR) could be ordered in 21 linkage groups (1815 cM) Interval mapping and multiple-QTL ... oleic and linoleic acid and lower levels of the pal-mitic acid and other saturated fatty acids, thus imparting a property quite akin to olive oil in composition In South America, interest in the ... developed in the course of this study, nine were informative and segregating in the mapping population Of the 20 single-locus SSR primer pairs reported by Billotte et al [18], seven segregated in the

Ngày tải lên: 12/08/2014, 03:21

... several packaging plasmids that encode the elements necessary for virion production in the packaging cell line The gene transfer plasmid contains a minimized self-inac-tivating (SIN) lentiviral ... (plus ~100 bp of common flanking sequence) as a self-contained expression cassette, and sequentially inserting them into a single vector via an infinitely expandable cloning strategy The PCR amplified ... population, indicating that even with extensive deletions a high level of protection was maintained The small increase in the number of infected cells that correlated with increasing deletions

Ngày tải lên: 12/08/2014, 04:20