combined modality therapy in cancer management

... colorectal cancer as well as in the adjuvant setting in colon cancers [11-15] Capecitabine has also been investigated in a variety of protocols in rectal and other gastrointestinal cancers in combination ... T, Sutter T, Zühlke H, Hinke A, Kölling-Schlebusch K, Frings S: Phase I trial evaluating the concurrent combination of radiotherapy and capecitabine in rectal cancer J Clin Oncol 2002, 20:3983-3991 ... radiotherapy and capecitabine for locally advanced, potentially resectable rectal cancer Br J Cancer 2004, 91:1019-1024 37 Shen W, Liu Y, Ma X: Capecitabine combined with radiotherapy in Chinese...

Ngày tải lên: 09/08/2014, 09:20

... phospho-inositide breakdown in human colon cancer cell line, causing translocation of protein kinase C to the membrane, and increasing [Ca2+]i by both releasing calcium stores and promoting calcium influx ... positivity in breast carcinomas CYP27B1 expression is slightly lower in invasive carcinomas (44.6%) than in benign lesions (55.8%) In contrast, CYP24A1 expression was augmented in carcinomas (56% in in ... disproportionate increase in middleand lower income countries Accordingly, the war on cancer is being fought on a global scale both in the laboratory and in clinical settings This book presents advances in...

Ngày tải lên: 27/06/2014, 13:20

... promoting cellular calcium entry and increasing the inotropic effect of insulin [21,24] Recommendations for the use of HIET in CCB poisoning Although there is wide variation in insulin dosing in ... phenylephrine were discontinued 30 minutes and hours later, respectively However, adrenaline, dopamine and milrinone had to be maintained for 72 to 90 hours Insulin administration was discontinued ... hypothesis that high-dose insulin therapy could be beneficial in the management of CCB overdose by overcoming hypoinsulinaemia and insulin resistance and thereby breaking the vicious circle of...

Ngày tải lên: 12/08/2014, 23:23

... protein tyrosine kinases Breast cancer src, yes, fgr fps/fes, abl Nonreceptor protein tyrosine kinases Colon cancer raf, pim0-1, mos, cot Cytoplasmic protein-serine kinases Small-cell lung cancer ... GENE THERAPY IN THE TREATMENT OF CANCER now in development Such inhibition results not only in growth inhibition in vitro but also results in growth inhibition of tumors in animal models of carcinogenesis ... administered intradermally In a long-term clinical trial, idiotype vaccination resulted in tumor regression in cancer patients and cancer immunity in patients in remission Thus, idiotype vaccination,...

Ngày tải lên: 10/04/2014, 22:11

... these CHK1 inhibitors in combination with gemcitabine would be more effective in treating pancreatic cancer patients than gemcitabine alone Moreover, in vivo experiments demonstrating that inhibitors ... sensitizing target for improving Figure Validation of CHK1 as a sensitizing target to gemcitabine in pancreatic cancer cells Validation of CHK1 as a sensitizing target to gemcitabine in pancreatic cancer ... therapies involving gemcitabine and other agents, such as axitinib, cisplatin, and fluorouracil are currently being studied [26-28] Our approach to identifying combination partners for gemcitabine involves...

Ngày tải lên: 18/06/2014, 15:20

... implying that the items in each scale contain a similar proportion of information concerning the construct being measured, except for one item in the 11-item Coordination of Care scale These findings ... friends were not closely involved in their care experiences Two domains (attitude of health care professionals; interpersonal care) were combined to form a single domain (interpersonal care) because ... measuring patients’ experiences of care rather than satisfaction per se Pre-testing of the questionnaire in 16 patients at NHNN undergoing relapse management resulted in minimal changes in wording...

Ngày tải lên: 20/06/2014, 15:20

... thestateofcurrentknowledgeandlatestresearchfindingsintheareaofcancertherapy. For this purpose research articles, clinical investigations and review papers that are thoughttoimprovethereadersunderstandingofcancertherapydevelopmentsand/or ... like, for example, delineating the killing mechanisms of MCC 18 Advances in Cancer Therapy These conflicting reports might indicate that there seem to be other factors determining the relationship ... marks cargo proteins for endosomal sorting Monoubiquitination appears to mark cargo proteins for protein sorting within the MVBs In yeast, recruitment of ubiquitinated cargo proteins depends on...

Ngày tải lên: 27/06/2014, 17:20

... breast is inflated with exactly 40 cc, 50cc, 60 cc, or 70 A CEDandinserted through a small incision in the lateral cc A CED is inserted through a small incision in the lateral breast and inflated ... A: Limited-field radiation therapy in the management of early stage breast cancer J Natl Cancer Inst 2003, 95:1205-1210 King TA, Bolton JS, Kuske RR, Fuhrman GM, Scroggins TG, Jiang XZ: Long-term ... source It can be inserted through a single incision at the time of surgery or post-lumpectomy using ultrasound guidance Initial results regarding cosmesis and local control using the MS catheter...

Ngày tải lên: 09/08/2014, 04:21

... USA) Based on the original investigation of K Otto (10), RapidArc(r) was recently introduced in clinical practice in several institutes after an intensive validation at planning level where it was ... In patient receiving Cetuximab, administration was initiated one week before RT at loading dose of 400 mg/ mq of body surface area over a period of 120 minutes, followed by weekly 60 minute infusion ... Volume (GTV) was defined as the gross extent of tumour shown by imaging, including all involved (positive) lymph nodes MRI, and in few cases FDG-PET, were used in the delineation of GTV On the...

Ngày tải lên: 09/08/2014, 09:20

... needing knowledge on the combination of underlying biological information The presented results were obtained in a preclinical study in prostate cancer xenografts, and suggest that the combination ... when using a BPNN, care should also be taken when training the network, in order not to under- or overtrain it [25] Since our RMSE function (Figure 4A) from training, testing and validating the ... cannula with saline-diluted Gd-DTPA (Magnevist ® , Schering, Berlin, Germany) was inserted into the tail vein Dynamic T1-weighted (T1W) imaging was acquired by performing 20 minutes of dynamic...

Ngày tải lên: 09/08/2014, 09:20

... metastases from breast carcinoma Cancer 1997, 80:1746-1752 Patchell RA, Tibbs PA, Regine WF: Postoperative radiotherapy in the treatment of single brain metastases to the brain JAMA 1998, 280:1485-1492 ... was indicated in single brain metastases with diameter less or equal than cm, favorable localization and control systemic disease The supportive care (prednisone oral) was introduced in begin ... demonstrated in table Discussion Brain metastases are the most common form intra cranial tumor accounting significantly more than one- half of brain tumors in adults Because of advanced in the diagnoses...

Ngày tải lên: 09/08/2014, 10:21

... hIL-12: Human interleukin-12; IL-3: Interleukin-3; IL-4: Interleukin-4; IL4-PE: Interleukin-4Pseudomonas exotoxin; Mab: Monoclonal antibody; mIL-12: Murine interleukin 12; mGM-CSF: Murine granulocyte-macrophage-colony ... modified or recombinant toxins This is achieved by deleting the DNA coding for the toxin binding region and replacing it with various complementary DNA encoding other cellbinding proteins has been ... these toxins need to be targeted to specific sites on the surface of cancer cells This process is accomplished by eliminating binding to toxin receptors by conjugating the toxins to cell-binding proteins...

Ngày tải lên: 10/08/2014, 05:21

... following LA administration; supports the overall feasibility of using LA as a dietary supplement [3] In recent years, LA has gained considerable attention in the cancer field as an anticancer ... growth inhibition assay Human HL-60 cells were obtained from American Tissue Culture Collection (Manassas, VA) and maintained in RPMI 1640 supplemented with penicillin, streptomycin and 10% heat inactivated ... nucleus and promoting the caspase-independent induction of apoptosis chrome c in the activation caspase-independent apoptosis, as involving the nucleus accumulation of cytochrome c instead of a more...

Ngày tải lên: 10/08/2014, 22:20

... cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone as first-line therapy in EGFRexpressing advanced non-small-cell lung cancer Ann Oncol 2008 in press Pirker R, Szczesna ... trial comparing bexarotene (L1069-49)/cisplatin/vinorelbine with cisplatin/vinorelbine in chemotherapy-naive patients with advanced or metastatic non-small-cell lung cancer: SPIRIT I J Clin Oncol ... from the National Comprehensive Cancer Network, Inc (NCCN) include cetuximab/vinorelbine/cisplatin as a first-line therapy option in patients who meet criteria for therapy with cetuximab (i.e NSCLC...

Ngày tải lên: 10/08/2014, 22:20

... seen at day These findings imply that VOR may restore hormone sensitivity in hormone-refractory breast cancer patients VOR was investigated in combination with capecitabine (CAP) in a phase I/II ... was overall disappointing in early clinical trials [22,37,40,41] New HDAC inhibitors HDAC inhibitors generally consist of three parts in the chemical structure: (1) a zinc-chelating group; (2) a ... development HDAC inhibitors may have more potential in the combination therapy of a wide range of malignancies Combination of novel epigenetic agents, including hypomethylating agents and HDAC inhibitors,...

Ngày tải lên: 10/08/2014, 22:20

... these agents The results of ongoing clinical trials with mTOR inhibitors, as single agents and in combination, will better define their activity in cancer Competing interests RY, AK, WJB, and DL ... weekly) in patients with MBC showed that continuous daily administration produced greater tumor shrinkage [55] In 2006, a phase III trial evaluating temsirolimus in combination with endocrine therapy ... patients [52,53] mTOR inhibitors have shown clinical activity in patients with advanced breast cancer [54,55] and are being actively investigated in this setting in combination with other agents...

Ngày tải lên: 10/08/2014, 22:20

... imatinib intolerance is minimal, indicating that there is a lack of cross-intolerance in patients presenting with imatinib intolerance After months of follow-up in the pivotal phase II study in ... Lee FY, Heinrich MC, Deininger MW, Druker BJ: In vitro activity of Bcr-Abl inhibitors AMN107 and BMS354825 against clinically relevant imatinib-resistant Abl kinase domain mutants Cancer Res ... Bristol-Myers Squibb, for assistance in compiling the published literature and in providing writing support in the form of editing, formatting, styling, and administrative tasks associated with...

Ngày tải lên: 10/08/2014, 22:20

... oxaliplatin and 5-FU/leucovorin over either therapy alone in patients with progressive colorectal cancer following irinotecan and 5-FU/leucovorin: interim results of a phase III trial J Clin Oncol ... oxaliplatin and cisplatin in non-seminomatous germ cell cancer cell lines Invest New Drugs 1997, 15:109-114 12 Rixe O, Ortuzar W, Alvarez M, Parker R, Reed E, Paull K, Fojo T: Oxaliplatin, tetraplatin, ... Oxaliplatin, tetraplatin, cisplatin, and carboplatin: spectrum of activity in drugresistant cell lines and in the cell lines of the National Cancer Institute’s Anticancer Drug Screen panel Biochem...

Ngày tải lên: 10/08/2014, 22:20

... as first-line metastatic therapy in February 2002 for four months The chemotherapy regimen was then changed to 40 mg/m2 vinorelbine plus 600 mg/m2 gemcitabine on days one and eight in a 21-day ... imaging in December 2003 (Figure 2) On completion of the chemotherapy regimen, the patient continued to receive maintenance trastuzumab monotherapy (6 mg/kg every three weeks), and she remains in ... define a time point beyond which trastuzumab might not offer additional benefit Furthermore, evidence in the literature supports the idea that continuing anticancer treatments as maintenance therapy...

Ngày tải lên: 11/08/2014, 02:22