... evaluation of vaccines (5)). 1.3 General principles The purpose of stability testing is to provide evidence of how the quality of an API or FPP varies with time under the infl uence of a variety of environmental ... 2009 Annex 2 Stability testing of active pharmaceutical ingredients and fi nished pharmaceutical products 1 Introduction 1.1 Objectives of these guidelines 1.2 Scope of these guidelines 2.1.10 Statements ... overall quality of the batches Trang 4of API placed on stability studies should be representative of the quality of the material to be made on a production scale.For existing active substances
Ngày tải lên: 04/12/2017, 04:45
... summarises the outcome of the peer review of the risk assessment of theactive substance and the representative formulation, evaluated on the basis of the representative uses of flurtamone as a herbicide ... ‘theRegulation’) lays down the procedure for the renewal of the approval of active substances submittedunder Article 14 of Regulation (EC) No 1107/2009 The list of those substances is established inCommission ... BayerCropScience AG for the renewal of approval of the active substanceflurtamone Complying with Article 8 of the Regulation, the RMS checked the completeness of the dossier and informed the applicant,
Ngày tải lên: 04/12/2022, 16:01
The Classification of Pulmonary Tuberculosis and An Outline of Standardised Principles of Management pot
... respective localisations of the first lesion of primary and that of secondary disease In explanation of the localisation of the first lesion of primary disease in the absence of acquired resistance ... demonstration of the truth of this law is to be found in the study of a large series of cases (I have personally observed several hundreds) in which the course of the primary type of the disease ... has attempted to combine the classification of Bard and Ranke He believes that the ‘cycle of the infection’ can Ind J Tub., Vol IV, No 4. Trang 2156 THE CLASSIFICATION OF PULMONARY TUBERCULOSIS
Ngày tải lên: 06/03/2014, 04:20
IN THIS ISSUE: CLASSIFICATION OF FINANCIAL ASSETS AND LIABILITIES UNDER IFRS 9 pot
... risk of the underlying pool of instruments This condition would be met in respect of a tranche if, for example, in the event of the underlying pool of instruments losing 50% as a result of credit ... are not consistent with a HTC objective: • active management of a portfolio to realise fair value changes; • management and evaluation of performance of a portfolio on a fair value basis; and ... are of a fund concluding that the management of a portfolio that was previously HTC is no longer consistent with the HTC business model following a change to an ongoing frequent level of sales of
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: Role of active-site residues of dispersin B, a biofilm-releasing b-hexosaminidase from a periodontal pathogen, in substrate hydrolysis pptx
... binding of the terminal GlcNAc residue and enable the active site of DspB to be flexible Differences R27 E332 W330 W237 E184 A B D183 GlcNAc Fig 5 Active site of DspB (A) Active-site residues of DspB ... Biofilm detachment activity of the aromatic residue mutants W237A and W330Y (C) Biofilm detachment activity of the aromatic residue mutants Y187A and Y278A (D) Biofilm detachment activity of ... through superposition of the active-site regions of the reported crystal struc-tures of b-hexosaminidases [15–18] and noted that, in addition to the well-conserved pair of acidic residues D–E
Ngày tải lên: 16/03/2014, 06:20
Báo cáo khoa học: Protective effect of active oxygen scavengers on protein degradation and photochemical function in photosystem I submembrane fractions during light stress pdf
... magnitude ofDA830signal remained stable during the first 4 h of strong light treatment of PSI submembrane fractions in the absence of active oxygen scavengers It indicated an unchanged amount of photooxidizable ... fractions because of the low rates of electron flow through PSI in the absence of an electron donor system (Fig 1) As P700+is known to be a very efficient quencher of exci-ted singlet states of Chls close ... II The occurrence of and properties of two different types of photoinactivation Plant Cell Physiol 11, 29–38 9 Satoh K & Fork DC (1982) Photoinhibition of reaction centers of photosystem I
Ngày tải lên: 16/03/2014, 18:20
Đề tài " Classification of prime 3manifolds with σ-invariant greater than RP3 " docx
... least one of the manifolds has nonnegative σ-invariant, then the σ-invariant of the connect sum of two manifolds is at least the smaller of the two σ-invariants [9] Hence, any finite number of connect ... not admit a metric of positive scalar curvature has σ = 0 For a more detailed survey of the σ-invariants of 3-manifolds, see the works of Mike Anderson [2], [3] and the works of Claude LeBrun and ... problem is to compute the σ-invariants of finite con-nect sums of one or more S2 bundles over S1 with one or more of RP3 and RP2× S1 At the time of the publication of this paper, Kazuo Akutagawa and
Ngày tải lên: 22/03/2014, 16:20
Đề tài " The classification of torsion endo-trivial modules " docx
... 1). Moreover 2 h is the index in G of a maximal elementary abelian subgroup. [...]... is the centralizer of a noncentral element of order p in G Proof The proof of the theorem is contained ... thing with k Because the emphasis of our theorem is different from that of the results of [Ca2] we give a brief sketch of the proof here However, all of the ideas as well as the ... proof of Proposition 3.8 of [Ca2] for this part... number of generators of M as a kG-module is also Dim(M /Rad(kH)M ) = Dim(M )/|H| In order to prove the claim, we note THE CLASSIFICATION
Ngày tải lên: 22/03/2014, 20:20
Đề tài " The classification of pcompact groups for p odd " pdf
... upon 2 Skeleton of the proof of the main Theorems 1.1 and 1.4 The purpose of this section is to give the skeleton of the proof of the mainTheorems 1.1 and 1.4, but in the proofs referring forward ... Organization of the paper The paper is organized around Section 2 which sets up the framework of the proof and gives an inductive proof of the maintheorems, referring to the later sections of the paper ... the component of Aut(B ˘ N ) of the identity map, has the homotopy type of B( ˘ T W ) where ˘ T is a discrete approximation to T Trang 29Sketch of proof The statement on the level of component
Ngày tải lên: 22/03/2014, 20:21
Photocatalytic Degradation of Isoproturon Pesticide on C, N and S Doped TiO2
... be-tween adsorption of reactant molecules and the gene- ration of OH radicals from the active sites 3.2.4 Effect of Catalyst Amount The catalyst amounts 0.5, 1.0 and 2.0 g L−1 of TCNS5 are investigated ... degradation of isoproturon 3.2.5 Effect of pH The effect of pH is an important parameter because it commands the surface charge properties of the catalyst and therefore the adsorption of the pollutant ... the solar light taking 50 mL of isoproturon solution in glass reactor and only 2–4 % of degradation is observed after 10 h of solar irradiation 3.2.2 Determination of Thiourea Loading over TiO
Ngày tải lên: 26/03/2014, 00:20
INTERNATIONAL CLASSIFICATION OF GOODS AND SERVICES FOR THE PURPOSES OF THE REGISTRATION OF MARKS (NICE CLASSIFICATION) pptx
... common classification of goods and services for the purposes of the registration of marks (hereinafter designated as “the Classification”). (2) The Classification consists of: (i) a list of classes, ... competent Offices of the countries of the Special Union shall include in the official documents and publications relating to registrations of marks the numbers of the classes of the Classification ... to its registrations of marks the numbers of the classes of the Classification to which the goods or services for which the marks are registered belong. Use of the Nice Classification is mandatory
Ngày tải lên: 30/03/2014, 06:20
INTERNATIONAL CLASSIFICATION OF GOODS AND SERVICES FOR THE PURPOSES OF THE REGISTRATION OF MARKS (NICE CLASSIFICATION) doc
... Adoption of an International Classification; Definition and Languages of the Classification adopt a common classification of goods and services for the purposes of the registration of marks ... user of the Classification to find the equivalent product or service in the alphabetical lists of other language versions of the Classification Trang 308 For the purposes of the registration of ... to its registrations of marks the numbers of the classes of the Classification to which the goods or services for which the marks are registered belong Use of the Nice Classification is mandatory
Ngày tải lên: 30/03/2014, 06:20
a literature survey of active machine learning in the context of natural language processing
... in terms of accuracy reached,and in terms of the amount of data needed to reach top accuracy Melvilleand Mooney conclude that the superiority of ActiveDecorate is due to thediversity of the generated ... of emailing lists, including Corpora, BioNLP, UAI List, ML-news, IRlist, and Linguist list, in February of 2009 One of the main findingswas that active learning is not widely used; only 20% of ... create a committee of classifiers In the case of classification, an instance is assigned the label that the majority of the classifiers predicted(majority vote) In the case of regression, the
Ngày tải lên: 02/06/2014, 09:22
báo cáo hóa học: " Comparing the content of participation instruments using the International Classification of Functioning, Disability and Health" pdf
... Dvorak1 Address: 1 Division of Spine, Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada, 2 School of Population and Public Health, University of British Columbia, Vancouver, ... the content of these instruments to determine how participation has been operationalized The purpose of this study was to compare the content of participation instruments using the ICF classification ... Concept of Participation In the ICF model the concepts of activity and participation are differentiated, but in the classification these concepts are combined and there is a single list of domains
Ngày tải lên: 18/06/2014, 19:20
Báo cáo sinh học: "Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer: a meta-analysis and system review" pdf
... Stage III Con:26 of 44 Con:28 of 44 Exp:15of 33 Exp:15 of 33 Exp:14 of 80 Exp:17 of 80 Stage III Con:12 of 40 Con:17 of 40 Exp:16of 44 Exp:20 of 44 Exp:12of 25 Exp:135 of 310 Exp:20 of 42 Abbreviations: ... trials of ASI in suspected minimal residual CRC Ref ASI Stage of patient Overall Survival Disease-free Survival Follow up Jadad’s grades No of events/no of subjects (year) Exp:16 of 73 Exp:18 of ... characteristics of ASI, includ-ing the number of evaluated CRC patients, the type of vaccine, the route of vaccination, adjuvants, the toxicity, and the objective clinical responses. Meta-analysis of ASI
Ngày tải lên: 18/06/2014, 19:20
Báo cáo sinh học: "A novel multiplex assay combining autoantibodies plus PSA has potential implications for classification of prostate cancer from non-malignant cases" docx
... arising cancer cells Of particular interest to the serological analysis of human cancers is a panel of clinically relevant TAA recognized by autoAb present in the serum of cancer patients including ... gzeng@mednet.ucla.edu 3 Department of Urology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095-1738, USA Full list of author information is available at the end of the article ... of sera individually pre-adsorbed withE coli phage lysates for reduction of background; the latter require the purification of proteins encoding individual TAA To circumvent the requirement of
Ngày tải lên: 18/06/2014, 19:20
Báo cáo hóa học: " Single-trial classification of motor imagery differing in task complexity: a functional near-infrared spectroscopy study" ppt
... measure of signal spread ○ Skewness: measure of the asymmetry of signal values around its mean relative to a normal distribution ○ Kurtosis: measure of the degree of peakedness of a distribution of ... classification of single trials derived from a novel developed wireless fNIRS instrument [3] 1.1 Single-trial classification of fNIRS data Previous studies investigating single-trial classifications of fNIRS ... corresponding to ‘yes’ and ‘no’ in response to a series of questions An average offline classification accuracy of 80% was achieved in 40% of the locked-in participants using maximum and meanΔ[O2Hb]
Ngày tải lên: 19/06/2014, 08:20
Microfluidic methods for the crystallization of active pharmaceutical ingredients
... is one of the most important downstream processing steps of active pharmaceutical ingredients (APIs), signified by the fact that ∼90 % of all APIs are formulated as crystals The outcome of crystallization ... extensive use of such devices for research purposes took off with the development of rapid prototyping techniques, most notably soft lithography [97] Microfluidics offers a diverse toolbox of stationary ... population of particles and a lack of knowledge regarding the formation mechanism of the individual SAs While microfluidic devices are well known to be capable of generating monodisperse emulsions of...
Ngày tải lên: 09/09/2015, 11:29
Understanding dynamics in thin film spherical crystallization of active pharmaceutical ingredients from microfluidic emulsion
... values of classical nucleation theory parameters Comparison of simulated and experimental data at 65 ◦ C Summary of the model validation exercise Summary of the experiment results of ... affecting bioavailability of the API Thus, the efficient production of API crystals of desired size and polymorphic form is one of the primary challenges in downstream processing of pharmaceutical products ... tens to hundreds of micrometers[26], [27] One obvious characteristic of microfluidics is its small scale, which increases the specific surface area in microfluidics by a few orders of magnitude,...
Ngày tải lên: 30/09/2015, 10:11