carcinoma of unknown primary prognosis

... gemcitabine or irinotecan in carcinomas of unknown primary site: results of a randomized phase II study trial for the French study group on carcinomas of unknown primary (GEFCAPI 01) J Clin Oncol ... Neoplasms, Unknown primary, Immunohistochemistry, Pathology, Molecular, Prognosis, Sarcomatoid carcinoma Background Cancer of unknown primary site (CUP) is a hetero-geneous group of malignancies ... treatment and follow-up of cancers of unknown primary site (CUP) Ann Oncol 2005;16(Suppl 1):i75 –6 PubMed PMID: 15888766 Epub 2005/05/13. 2 Varadhachary GR, Raber MN Cancer of unknown primary site N Engl

Ngày tải lên: 17/06/2020, 18:18

... Resembles cancer of target tissue more Gastric adenocarcinoma Lung adenocarcinoma Lung, squamous cell carcinoma Ovarian, endometrioid carcinoma Ovarian, serous carcinoma Prostate adenocarcinoma Testis, ... AccessClassification of unknown primary tumors with a data-driven method based on a large microarray reference database Abstract We present a new method to analyze cancer of unknown primary origin ... since many of the current treatment regimes rely on knowledge of the type and origin of the primary tumor Several methods for identifying CUP samples based on their gene expression profiles have

Ngày tải lên: 11/08/2014, 12:21

... strategies and treatment Keywords: Carcinoma of unknown primary, Chromosome instability Background Cancers of unknown primary origin (CUPs) are a het-erogeneous group of cancers with variable clinical ... about 85% of the primary cancers exhibited a characteristic expression of their individual histomarkers, only 10 of the 28 (35%) CUP - where a putative primary site was identified and 3 of the 29 ... adenocarcinoma, PDA: poorly differentiated adenocarcinoma; Carc: carcinoma; PDC: poorly differentiated carcinoma; SCC: squamous cell carcinoma; PDSCC: poorly differentiated SCC; CCC: cholangiocarcinoma;

Ngày tải lên: 30/09/2020, 11:05

... that of copy number gains There were 11 regions of loss found in more than 13% of the primary tumors and 16 regions of loss found in more than 13% of blood (Tables and 4) Thirty other regions of ... amplified in 90% of the presently studied tumors We identified 46 regions of gain present in more than 30% of the primary tumor samples and 70 regions of gain present in more than 30% of blood samples ... in at least 30% of both primary tumors and blood (Table 5) Among these, seven regions of copy number gain were found in more than 50% of both primary tumors and blood A gain of 5p15.33 was evident

Ngày tải lên: 09/08/2014, 03:21

... develop-ment of targeted therapies Despite large number of studies profiling the tran-scriptome of EOC primary ovarian tumors, only limited number of reports have compared gene expression between primary ... aspects of metastatic transformation of HGSOC, with potentially important implications for prognosis and therapy Conclusions In this study we provide evidence that the gene expres-sion profile of primary ... of HGSOC described by Tothill et al and TCGA [10,11] Methods Sample collection Samples of primary adnexal tumor and paired omental metastases of 10 HGSOC patients were included in the study Primary

Ngày tải lên: 17/06/2020, 19:28

... cell carcinoma and 3496 patients with large-cell neuroendocrine carcinoma were included A total of 1161 cases with primary pulmonary HGNEC, including 1022 SCLC and 139 LCNEC, developed a cohort of ... incidence ratio, SIR) of second primary malignancies (SPMs) by latency period after the diagnosis of lung HGNEC over time Table 6 Distribution of histology and stage in second primary lung cancer ... neuroendo-crine carcinoma (HGNEC), including small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC), is a heterogeneous group of poorly differenti-ated neoplasms and covers 20% of all

Ngày tải lên: 19/09/2020, 22:04

... AccessTranscriptome analysis of paired primary colorectal carcinoma and liver metastases reveals fusion transcripts and similar gene expression profiles in primary carcinoma and liver metastases ... average depth of coverage was >89 fold of that of the human transcriptome Genes expression profiling The normalized expression level of each gene was expressed as Fragments Per Kilobase of Exon ... high concordance of gene expres-sion in the primary carcinoma and liver metastases Functional enrichment analysis of differentially expressed genes The common 1895 DEGs in primary carcinoma and

Ngày tải lên: 20/09/2020, 15:07

... poor prognosis of HCC negated the prognosis of EHPM in most patients The epidemiology and etiology of HCC differ among countries, and the prognosis of HCC is improving Moreover, a few studies of ... worse survival because of extrahepatic causes of death, which should be considered in the management of HCC in the future Keywords: Hepatocellular carcinoma, Multiple primary neoplasms, Mortality, ... virus (HCV) on the basis of the serological presence of hepatitis B surface antigen or anti-HCV antibody, respectively, or alcohol on the basis of a history of alcohol intake of more than 80 g/day

Ngày tải lên: 30/09/2020, 11:12

... * * wild type of TNRC6B mutated type of TNRC6B Figure 1 Process of retrieving target genes of several miRNAs A) Homology of the sequence between miRNA and TNRC6B Complementary of the sequence ... information (grade of histological dif-ferentiation, recurrence of HCC after resection, size of tumor, the background of liver disease, age, and gender) and our analysis of the efficiencies of miRNAs ... water was added to 3 ml of 5× RT primer, 10× 1.5 μl of reverse transcriptase inhibitor, 4.16 μl of nuclease free water, and 50U of reverse transcriptase in a total volume of 15 μl The reaction

Ngày tải lên: 05/11/2020, 07:17

... is not possible because of localized infection, and produces profound analgesia of the maxillary primary/permanent molars It results in a block of the posterior and often middle superior dental ... If primary incisors are involved then: ° fifth: maxillary incisors This approach would of course start with the right side of the mouth for a left-handed dentist because of the ease of giving ... extractions of primary teeth under general anaesthesia for thousands of children, particularly in the UK, a practice that should have only a small place in the dental care of young children Philosophy of

Ngày tải lên: 16/02/2014, 15:20

... list of the names, the official designations and specimen signatures of the officers of the bank who are authorized to sign on behalf of the bank Returns prescribed under Section 42(2) of the ... the excess of the total of demand and time liabilities (DTL) of the bank as shown in the return referred to in Section 42(2) of the RBI Act, 1934 over the total of its DTL at the close of the business ... Instruments Act, 1881 (26 of 1881) for one or more offices of a scheduled State Co-operative bank, the Return shall give the preceding working day's figures in respect of such office or offices, but shall

Ngày tải lên: 29/03/2014, 07:20

... estimation of reverberation time,” Journal of the Acoustical Society of America, vol 112, no 6, pp 2583– 2588, 2002 [11] G Marsaglia, “Ratios of normal variables,” Journal of Statisti-cal Software, ... are synchronized, the time-of-flight may be easily obtained as the difference in the times of transmission and reception However, in a majority of cases the sources of interest will not be specifically ... knowledge of the relative microphone posi-tions, the source-microphone range may easily be obtained from estimates of the relative position of the source—an end to which a variety of solutions

Ngày tải lên: 22/06/2014, 19:20

... Properties of G η (1) We note that G η is of dimension MK × (M(M − 1)(K − L)/2) and the orthogonal complement of the columns of  H is of dimension MK − (K + L). Since the columns of G η spans ... based on the tr ansmission of pilot signals [3–5]. However, the insertion of pilot signals often means a decrease of band- width efficiency, and the resulting limitation of effective data throughput ... correlated and unknown as is often encountered in practice, the performance of the SS method degrades severely. In this paper, we address the problem of estimating FIR channels in the presence of arbit

Ngày tải lên: 22/06/2014, 23:20

... the amplitude of a pair of simple cells in quadrature of phase localized in the same position, orientation, and scale (illus-trated as dark-gray discs inFigure 2) The activities of simple cells ... y) ⊗x(x, y). (1) The activities|h| of the complex cells are defined as the square quadratic sum of the pairs of simple cells(h) and(h), that is, the modulus of the log-Gabor wavelet coefficients ... being the number of pixels in the image andM the size of the dictionary (with M > N). The previous steps of thresholding, inhibition, and facil-itation allowed to extract a set of active cells

Ngày tải lên: 22/06/2014, 23:20

... 1Chapter 019 Fever of Unknown Origin (Part 3) Source: From a study of 347 patients referred to the National Institutes of Health from 1961 to 1977 with a presumptive diagnosis of FUO of >6 months' ... al Prolonged fever of unknown origin Clin Res 26:558A, 1978) More than 200 conditions may be considered in the differential diagnosis of classic FUO in adults; the most common of these are listed ... environmental, occupational, and professional history, with early notification of public health authorities in cases of suspicious etiology (Chap 214) Table 19-3 Causes of FUO in Adults in the United

Ngày tải lên: 06/07/2014, 13:20

... llie insidious nature of the signs and symptoms, of carcinoma of the ovary, b u l rnav sometimes b-: due to a rapidly growing I u [Hour Due to the non-ipecillc nature of most of these symptomSj ... adverse features, ] CANCER OF THE FALLOPIAN TUBE Primary carcinoma of the Fallopian tuberare, comprising only 0.3 per cent ofmalignancies However, only t-arly Fallopiancarcinomas mn be distinguished ... significant incidence of bilaleralily.Hementi of [mm d In re t e r a t o m a , volk we t u m o u r or Trang 10152 Carcinoma of Hie ovary and Fallopian tubeaic found in a bunt Jti per cent ofdvspier.mmoma.s

Ngày tải lên: 05/08/2014, 16:20

... 8% of patients with carcinoma of the cervix; these being commonly found in the rectosigmoid as a result of local extension [3] Gastric lesions are identified in less than 2% of patients with carcinoma ... confirmation of the exact nature of this neoplastic lesion, the patient was investigated with computed tomography (CT) scans as part of pre-surgical workup The CT scans confirmed the presence of large soft-tissue ... within 48 hours of admission As no autopsy was conducted, the exact cause of death is unknown though it is presumed to be as a result of multiple organ failure due to disseminated carcinomatosis

Ngày tải lên: 09/08/2014, 02:21

... Babiera G Treatment and outcome of patient with intracystic papillary carcinoma of the breast Am J Surg 2002; 184: 364-368 papillary carcinoma of the breast: a report of 2 cases with axillary lymph ... wall was investigated as intracystic carcinoma of the breast Patients with intracystic carcinoma of the breast tend to be older than patients with other forms of breast cancer In our study, the ... incidence of intracystic carcinoma of the breast in men appears to be higherand and there is equal to or more than 5 % of report [5,6] Most patients with intracystic carcinoma of the breast have symptoms

Ngày tải lên: 09/08/2014, 02:21

... study to assess the feasibility of evaluation of markers of response to chemotherapy at one day & 21 days after first cycle of chemotherapy in carcinoma of breast: a prospective non-randomized ... cycle of chemotherapy, with emphasis on patient acceptance and complications of the procedure b) Assays of apoptosis (Caspase-3 &Bcl-2) and prolifera-tion index (Ki-67) in patients of carcinoma ... with a mean age of 51 years We were successful 95.6% times in performing a core biopsy and of these 84.6% had adequate tissue in the cores harvested After a mean of 4 cycles of PCT, 26 patients

Ngày tải lên: 09/08/2014, 04:21

... will be made available soon Intensity-Modulated Radiotherapy for Squamous Cell Carcinoma of the Anal Canal: Efficacy of a Low Daily Dose to Clinically Negative Regions Radiation Oncology 2011, 6:134 ... original work is properly cited Intensity-Modulated Radiotherapy for Squamous Cell Carcinoma of the Anal Canal: Efficacy of a Low Daily Dose to Clinically Negative Regions Jason A Call1, Michael G Haddock1, ... Department of Radiation Oncology , Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA Division of Medical Oncology , Mayo Clinic, 200 First St SW, Rochester, MN 55905 , USA Division of Colon

Ngày tải lên: 09/08/2014, 09:21