bridging between basic research and clinics

... – Bridging Between Basic Research and Clinics, Edited by Alina González-Quevedo p cm ISBN 978-953-51-0375-2     Contents   Preface IX Chapter The Etiology and Evolution of Fetal Brain Injury Andrew ... cause for motor deficits and cognitive disability that become evident in early life and result in permanent disability 2 Brain Damage – Bridging Between Basic Research and Clinics Hypoxia is central ... (Volpe 1997) Considerable Brain Damage – Bridging Between Basic Research and Clinics research documents that children born very prematurely (

Ngày tải lên: 28/06/2014, 12:20

... trials and/ or clinical research networks We began with an environmental scan of academic and trade journals, the internet, and public- and private sector reports of clinical and community-engaged research ... identifying and choosing appropriate research opportunities, acquiring necessary data collection and other research skills and equipment, working with institutional review boards, and handling other ... excessive Research training Local research training efforts are not rigorous enough Assuring privacy Accessing IRB and HIPAA certification is burdensome and time-consuming Research engagement Research...

Ngày tải lên: 10/08/2014, 10:23

... patients Develop and articulate clinical research principles that value clinicians and patients and with a clear set of standards that clinicians and other research participants must adhere to Information- ... recognized at local and national meetings for their participation in research and encouraged to give presentations describing their research involvement and their particular studies and outcomes Organizations ... registry and designing relevant research questions are likely to be the most challenging steps to fostering research: the cost and effort required to develop a registry and promote relevant research...

Ngày tải lên: 10/08/2014, 10:23

... are common and timing- and sex-specific Hum Mol Genet 2009, 18:4046-4053 doi:10.1186/gm201 Cite this article as: Burdge GC, Lillycrop KA: Bridging the gap between epigenetics research and nutritional ... Authors’ contributions GCB and KAL contributed equally to the planning and writing of this manuscript Both authors read and approved the final manuscript Acknowledgements Research in the authors’ ... methylation in the promoters of several imprinted and non-imprinted genes in white blood cells [20,21] However, the difference between ex­ posed and unexposed individuals was small (around 5%)...

Ngày tải lên: 11/08/2014, 12:21

... L Dreyfuss and H B Nader 73 83 Basic Research and Clinical Application of Drug Delivery Systems for the Treatment of Age-Related Macular Degeneration 99 Giuseppe Lo Giudice and Alessandro Galan ... substantial change in the management of AMD patients. The online book Age Related  Macular Degeneration – The Recent Advances in Basic Research and Clinical Care presents  the  most  recent  advances  in  basic research and clinical  care  of  AMD.  Different  from  other  ... to  cover  the  new  findings  from  basic and translational research on the biological and genetic mechanism of AMD, and the new  interventions to prevent and treat this disease.  The book has a total of 15 chapters, grouped into two sections. Section one includes six ...

Ngày tải lên: 27/06/2014, 15:20

... understand the relationship between credit risk, including the risk of default, migration and recovery, and interest rates Toward this goal, we analyze the relationship between interest rates and ... rates and real interest rate, and a strong positive correlation between default rate and lagged 2-year real interest rate We find negative correlation between changes in interest rates and default ... positive correlations between instantaneous default rate and interest rate Lin and Curtillet (2007) take another look at the relationship between credit spreads and interest rates, and try to reconcile...

Ngày tải lên: 26/10/2012, 11:21

... development of national standards, profiles and benchmarks Two summary reviews of the research literature on factors related to the development of literacy and research on the teaching and learning of ... Department of Education and Arts (1994), the review of research into language and literacy by Freebody and Gilbert (1999), and the review of recent developments in language and literacy development ... into language and literacy is considered under two main headings: developments in theorising and research methodologies applied to language and literacy, and distinctive domains of research Under...

Ngày tải lên: 17/02/2014, 06:20

... the friend and guide in this process and hence, needs to be managed effectively through promotion programmes and incentives to promote the brand of a company In order to bridge the gap between Philip ... market should essentially operate at the basic and expected level of product classification They should essentially meet the basic needs of the consumer and should be a no-frill product, as the ... marketing is the art of identifying and understanding customer needs and creating solutions that deliver satisfaction to the customers, profits to the producers and benefits for the stakeholders.”...

Ngày tải lên: 08/03/2014, 02:21

... (rhIKK2) and Nandini Kishore for providing the SC-514 inhibitor We thank also Paul Hayter, Sasha Sreckovic and Matthew Strawbridge with help in growing and analyzing the A549 cells and nally ... trichloroacetic acid and the plot shows the number of repeats Phosphorylation of tagged IjBa (d; A) and autophosphorylated rhIKK2 (j; B) is shown In (A), s is the control assay, and in (B), s and D represent ... Km,GST-IjBa, kcat and Vmax were 2.3 0.6 lM, 3.7 0.9 lM, 1.51 ã 10)3 s)1 and 18.7 nMặmin)1, respectively, in kinase buffer Tris HCl MgCl2 MnCl2 and 2.5 1.2 lM, 6.1 1.3 lM, 2.15 ã 10)3 s)1 and 16.2...

Ngày tải lên: 16/03/2014, 11:20

Ngày tải lên: 23/03/2014, 05:23

... ẳ v(x*, y*) is the reference ux, ex and ey are n ã m and n ã my elasticity matrices, and log(x x*) and log(y y*) are vectors with components log(xi xi*) and log(yi yi*), respectively Implicit ... costly and time-consuming, and moreover many may be difcult or impossible to determine experimentally The in vivo molecular kinetics of some important processes like oxidative phosphorylation and ... The discrepancy between the real and FBA solution is due to FBA disregarding the branches of the pathway not involved in ATP production, namely glycerol, glycogen, succinate and trehalose synthesis...

Ngày tải lên: 23/03/2014, 07:20

... multi-path routing) ¯ Storing and processing large numbers of routes and policies ¯ Expressing, coordinating, and exchanging route policies ¯ Achieving stability and fast convergence storage overhead, ... objective is to find a path Ô between a source and a destination, such that the constraints are all satisfied Figure gives an example network where Ò = (e.g., bandwidth, delay, and loss rate constraints), ... complexity, but their path computation time complexity usually depends on both Î and , e.g., Wang and Crowcroft [20] and Guerin and Orda [21] present algorithms which are Ç´ Î ÐÓ Î · µ Many current proposals...

Ngày tải lên: 29/03/2014, 20:20

... patients, providers, and researchers alike have included headaches, arthralgias and myalgias, allergies, eczema, hypothyroidism, 10 Endometriosis - Basic Concepts and Current Research Trends fibromyalgia, ... progesterone and androgen are mediated through their respective receptors - Estrogen Receptors (ER), Progesterone Receptors (PR) Endometriosis and Androgen Receptors (AR) - these receptors must be and ... both estrogen and progesterone receptors and respond to changes of hormonal levels with bleeding or production and release of inflammatory mediators, especially prostaglandins E2 and F For a long...

Ngày tải lên: 30/03/2014, 19:20

... focused by grand challenges identified by the AFOSR and by experiments conducted in distributed research and experimentation environments 4 BASIC RESEARCH FOR AIR FORCE IS&T NEEDS NETWORKS AND COMMUNICATIONS ... vehicles and the networks are taskable by groundand air-based commanders • Mixed-reality training environments Research to enable training for air crews, command post staff, and commanders in ... an audit was not within its mandate, and the committee took a blank-slate approach to defining an IS&T vision and a basic research program By identifying the basic research challenges that underpin...

Ngày tải lên: 31/05/2014, 23:40

... 2 Fixed Point Theory and Applications We present new definitions of asymptotic center and asymptotic radius that is for a mapping and obtain new results Definition 1.1 Let C ... nonempty and compact subset of C Example 1.4 Let X be a normed space and C a nonempty subset of X It is clear that i if C is a compact set, then Za C, {xn } in nonempty compact set and so has ... } is empty and so fail to have Property Z Main Results Our new results are presented in this section Proposition 2.1 Let X be a Banach space and let C be a nonempty closed bounded and convex...

Ngày tải lên: 21/06/2014, 11:20

... model and simulations If we consider that TTX j are uniformly distributed between and TAMAX , the random variable z has a triangular distribution function over the range [−TAMAX , +TAMAX ], and ... generality, that only node A is in the coverage range of nodes C and D and only node B is in the coverage range of nodes E and F Nodes A and B simply forward the CRT components Finally, when the sink ... considering that nc and n p can be expressed according to the number of sent messages Nm and the mean number of nodes that receive the above messages in the case of CRT and SP schemes, NHcrt and NHsp ,...

Ngày tải lên: 21/06/2014, 11:20

... throughout: R and C denote the real and complex number fields, and N is the set of nonnegative integers z denotes the complex conjugate of z ∈ C (·) and (·) represent the imaginary and real part ... expression on the right-hand side, the limits limn→∞ Rn and limn→∞ xn exist and X = limn→∞ xn > For the sums on the right, since ∞ Rn is convergent and n= N N {1/xn }∞1 is positive and decreasing, both ... for all λ ∈ C and M is said to be in the limit-circle (LC) case, see Atkinson [11] and Hinton and Lewis [6] Note that in the limit-circle (LC) case, the defect numbers are equal and the limit-point...

Ngày tải lên: 22/06/2014, 19:20

... prevention of, understanding and modulation of, and recovery from developmental disorders and pathologic processes in human health Although no clear boundary exists between systems biology and systems ... predictive, and therapeutic applications Accordingly, advances in systems medicine must be assessed on both a medical and more basic biologic scale, as the correspondence between medicine and biology ... entities and the specific nature of their relations that determine disease pathophysiologic processes? What challenges might be resolved and opportunities opened for both basic research and clinical...

Ngày tải lên: 11/08/2014, 12:20

... strategies Beyond the basic and clinical sciences, Australian researchers have also been active in epidemiological and social research related to HIV infection The effectiveness of needle and syringe programmes ... investigation and disease surveillance, though research collaborations in Thailand and Cambodia, and donor funded bilateral programs in extremely resource-poor countries such as Myanmar and more recently ... exciting and innovative program that will highlight cutting edge research in each of the three major themes of basic science, clinical research and biomedical prevention We encourage established researchers,...

Ngày tải lên: 13/08/2014, 09:20