bone marrow failure syndromes ppt

... previously described [30] For human BMSC isolation, bone marrow aspirates were obtained from patients undergoing bone marrow harvest for autologous bone marrow transplantation, after informed consent ... [5,6], tumor-asso-ciated angiogenesis [7,8] and bone remodeling [9] Thus, the understanding of complex interactions between can-cer and bone cells/bone marrow stromal cells leading to these prometastatic ... metaphysis of long bones In addition, metastasis incidence variation among different bone segments (Figure 1C, D and 1E) made it possible to define two bone subgroups: 1) Bones with high metastasis

Ngày tải lên: 18/06/2014, 22:20

... conditional knockout mice bone marrow No changes in TNF-induced osteoclast precursor release from Cxcr4 f/f/CD11b+/Cre conditional knockout mice bone marrow (a) Bone marrow cells from 2-month-old ... whether SDF-1 levels are decreased in bone marrow stromal cells and long bone samples from TNF-Tg mice to account for the increased OCP mobilization from their bone marrow to their peripheral blood ... directly inhibits bone marrow stromal cell production of SDF-1 and reduces SDF-SDF-1 levels in the bone marrow, which is accompanied with an increase in the egress of OCPs from the marrow Decreased

Ngày tải lên: 09/08/2014, 10:23

... H, Kelly M Stages of bone marrow transplantation: a psychiatric perspective Psychosom Med 1976;38:439–446. 2 Brack G, LaClave L, Blix S The psychological aspects of bone marrow transplant: a ... psychological distress in patients undergoing autologous bone marrow transplantation Oncol Nurs Forum 1992;19:41–48. 4 Artinian B Fostering hope in the bone marrow transplant child, Matern Child Nurs J. ... consequences of bone marrow transplantation in children: a preliminary communication J Psychosoc Oncol 1987;5:73–81. 6 Andrykowski A Psychiatric and psychosocial aspects of bone marrow transplantation

Ngày tải lên: 10/08/2014, 08:20

... GFP labeled MSCs were noted in the lungs, liver, bone marrow and normal and necrotic femoral heads of rabbits, and the number of MSCs in bone marrow was higher than that in the, femoral head, ... tissues [2,3] Trang 2Re-searchers have transplanted the bone marrow stem cells into the necrotic femoral heads, and results show bone marrow stem cells can remove vascular lesions and promote ... in the lungs, liver, bone marrow and normal femoral head, and the amount of GFP positive 0 0.05 0.1 0.15 0.2 day normal MSCs MSCs after GFP labeling Trang 5MSCs in the bone marrow was higher than

Ngày tải lên: 25/10/2012, 11:18

... graft-versus-host disease after bone marrow transplantation Thorax 39:887, 1984 IO Graham J, Muller NL, Miller RR, Shepherd JD: Intrathoracic complications following allogeneic bone marrow transplantation ... disease following pediat- ric bone marrow transplantation Society for Pediatric Radiology, Colorado Springs, CO April 29, 1994 15 Thomas ED, Storb R, Clift RA: Bone marrow transplantation N Engl ... air-flow obstruction in marrow transplant recipients Am Rev Respir Dis 129541,1984 4 Holland HK, Wingard JR, Beschorner WE, Sara1 R, Santo GW: Bronchiolitis obliterans in bone marrow transplantation

Ngày tải lên: 22/03/2014, 10:20

... according to their tissue origin Introduction sues including cartilage, bone, muscle and fat They were initially isolated from bone marrow (BM) and characterized by the expression of various cell surface ... correspond to a subset of the adherent cell population, as MSC from the stromal compartment of the bone marrow (BM) The aims of the present study were, first, to better characterize the MSC derived ... http://arthritis-research.com/content/7/6/R1304 Research article Vol No Open Access Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells Farida Djouad1, Claire Bony1, Thomas

Ngày tải lên: 09/08/2014, 07:20

... bone marrow samples were obtained No OA patients were taking MTX or oral steroid Preparation of bone marrow CD34+ cells Mononuclear cells were isolated by centrifugation of heparinized bone marrow ... nuclear factor (NF)κB1 (p50) protein in bone marrow CD34+ cells Expression of nuclear factor (NF)κB1 (p50) protein in bone marrow CD34+ cells Purified bone marrow CD34+ cells from a rheumatoid ... (p65) in bone marrow CD34+ cells The expression of mRNAs for nuclear factor (NF)κB1 (p50), NFκB2 (p52) and RelA (p65) in bone marrow CD34+ cells Total RNA was isolated from purified bone marrow

Ngày tải lên: 09/08/2014, 07:20

... evaluations in two standard planes Classified by ARCO, there were 82 ARCO I bones, 20 ARCO II bones, 13 ARCO III bones and two ARCO IV bones No severe adverse effects were observed in any patients dur-ing ... Harris-Hip-Score of bone marrow oedema/avascular osteonecrosis patients before and at three and six months after treatment with iloprost The graph shows the average values in Harris-Hip-Score of bone marrow ... Knee-Society-Score of bone marrow oedema/avascular osteonecrosis patients before and at three and six months after treatment with iloprost The graph shows the average values in Knee-Society-Score of bone marrow

Ngày tải lên: 09/08/2014, 13:22

... Vol 11 No Open Access Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis Maria Rehnberg, Sylvie Amu, Andrej Tarkowski, Maria ... Introduction In the present study we evaluated changes in the B cell phenotype in peripheral blood and bone marrow (BM) of patients with rheumatoid arthritis (RA) following anti-CD20 treatment using rituximab ... down-regulated on plasma blasts/plasma cells The initial stages of B cell development take place in bone marrow (BM) where autoreactive immature B cells are eliminated by negative selection The maturation

Ngày tải lên: 09/08/2014, 14:22

... simvastatin and bone marrow-derived MSCs Bone marrow-derived MSCs have been identified as a potential new therapeutic option to induce therapeutic angiogenesis The main advantage of using bone mar-row-derived ... from bone marrow by aspiration and expanded ex vivo before implantation Under spe-cialized culture conditions, bone marrow-derived MSCs have the capacity to differentiate into cells such as bone, ... combination group among the four Trang 4Figure 1 Characterization of bone marrow-derived MSCs Flow cytometric analyses of bone marrow-derived MSCs Cells were uniformly negative for CD34, CD45, and

Ngày tải lên: 10/08/2014, 05:21

... PR: Adult bone marrow stromal cells differentiate into neural cells in vitro Exp Neurol 2000, 164:247-256. 50 Woodbury D, Schwarz EJ, Prockop DJ, Black IB: Adult rat and human bone marrow stromal ... neuronal degeneration In the present study, the effects of serotonin, gamma-aminobutyric acid and bone marrow cells infused intranigrally to substantia nigra individually and in combination on unilateral ... were carried out to confirm the biochemical and molecular studies Serotonin and GABA along with bone marrow cells in combination showed reversal of glutamate receptors and behaviour abnormality

Ngày tải lên: 10/08/2014, 05:21

... c) Chronic myelogenous leukemia (CML) 4 Bone marrow failure syndromes a) Severe aplastic anemia (SAA) b) Fanconi's anemia (FA) Trang 23Page 4B Since a marrow or stem cell source for allografting ... cell and bone marrow transplantation / Terry Wikle Shapiro, Deborah Branney Davison, Deborah M Rust p cm Includes bibliographical references and index ISBN 0-7637-0217-X (alk paper) 1 Bone marrow—Transplantation—Handbooks, ... and bone marrow transplantation In summary, we have attempted to provide the clinician with a pocket guide to assist in referencing clinical issues and problems common to stem cell and bone marrow

Ngày tải lên: 10/08/2014, 08:20

... undergoing autologous bone marrow transplantation Bone Marrow Transplant 1991;7:421–425 Ireland RM, Atkinson K, Conconnon AJ Serum erythropoietin changes in autologous and allogeneic bone marrow transplant ... Immunohematologic complications of bone marrow transplantation Bone Marrow Transplant 1991;8:159–170 Thrombocytopenia Adams JA, Gordon AA, Jiang YZ, MacDonald D Thrombocytopenia after bone marrow transplantation ... undergoing bone marrow transplantation Transplantation 1991;5:630–635 Or R, Mehta J Nagler A, Cvacium I Neutropenia enterocolitis associated with autologous bone marrow transplantation Bone Marrow

Ngày tải lên: 10/08/2014, 08:20

... unrelated donors, and non-HLA-identical marrowexperience problems with graft failure and sustained engraftment when receiving ex vivo T-cell-depleted marrow 6 Attempts to overcome these problems ... endogenous viral reactivation or primary infection through the transfusion of blood products or bone marrow Incidence is approximately 20% to 25% in allogeneic BMT patients whoare seropositive for ... IV over at least Trang 9neutropenia-2 hours Infusion generally started two to four hours after marrow/peripheral bloodstem cell (PBSC) infusion Continued until absolute neutrophil count is greater

Ngày tải lên: 10/08/2014, 08:20

... graft failure is thought to be due to infusion ofinadequate numbers of stem cells, ex vivo manipulation of marrow (purging), andcryopreservation.3 3 Risk factors a) Recipient of HLA-incompatible marrow ... countsc) Little or no hematopoiesis noted on bone marrow analysis perfumed 30 to 40 days or greater post-transplant Trang 3c) Reinfusion of allogeneic marrow with or without further conditioning ... condition necessitates limitation of pretransplantconditioning g) T-cell depletion of marrow graft orh) Ex vivo marrow manipulation (purging/cryopreservation) 4 Clinical features a) A complete absence

Ngày tải lên: 10/08/2014, 08:20

... determined histocompatibility differences exist between the bonemarrow recipient and the bone marrow donor b) Immunocompetent cells in the donor's marrow that can recognize the foreignhistocompatibility ... reduced hematopoieticprogenitor cells are seen upon examination of the bone marrow The bone marrowmay become hypoplastic Marrow fibrosis with transfusion-dependent anemia, aleukoerythroblastic ... mount an immunologicreaction against them are present c) The bone marrow recipient is unable to react against and reject the donor marrow d) It is thought that the underlying mechanism of GVHD

Ngày tải lên: 10/08/2014, 08:20

... bone marrow transplantation Bone Marrow Transplant 1991;8: 159–170. 2 Bosi A, Vannucchi AM, Grosi A Serum erythropoietin levels in patients undergoing autologous bone marrow transplantation Bone ... in children after bone marrow transplant for hematological malignancies Bone Marrow Transplant 1991;8(suppl 1)2–4. Savdie E Renal complications In: Atkinson K, ed Clinical Bone Marrow Transplantation. ... the serum of patients undergoing bone marrow transplantation Exp Hematol 1988;16:316–319. 5 Chisholm DJ Endocrine complications In: Atkinson K, ed Clinical Bone Marrow Transplantation Cambridge,

Ngày tải lên: 10/08/2014, 08:20

... avo possible; other SE: H/A, anemia, hypokalemia, hypomagnesemia, anorexia, malaise, generalize bone marrow depression, flushing (Fungizone) Class: antifungal Emperic dose: Initial: 0.25 mg/kg/d ... divided q8 h (Monistat) Topical: 2% (30 g) Topical: Apply 1–2 times IV form not commonly used in bone marrow per d transplantation (BMT) setting Vaginal, as nitrate: 2% Adults: IV: initial 200 mg, ... begin 2–4 h after marrow infusion, or not less than 24 h after chemotherapy; if toxicity is noted, then cut dose in half Adults: 250 µg/m 2/d IV over h to begin 2–4 h after marrow infusion, or

Ngày tải lên: 10/08/2014, 08:20

... PJ Nutrition support in bone marrow transplant recipients J Parent Enter Nutr 1993;8:19 Klumpp TR Immunohematologic complications of bone marrow transplantation Bone Marrow Transplant 1991;8:159–170 ... Philadelphia: WB Saunders; 1995 Tett S Therapeutic drug monitoring in bone marrow transplant patients In: Atkinson K, ed Clinical Bone Marrow Transplantation: A Reference Textbook Cambridge, United ... Clinical Bone Marrow Transplantation: A Reference Textbook Cambridge, England: Cambridge University Press; 1994 Lonergan JN, McBride LH, Kelley CH, Randolph SR Homecare Management of the Bone Marrow

Ngày tải lên: 10/08/2014, 08:20

... Cultivation of Rat/Mouse Mesenchymal Cells from Bone Marrow To obtain bone marrow cells, tibias and femurs were iso-lated, the epiphyses were removed, the bones were indivi-dually inserted in 1 mL ... deleterious effects of sev-eral types of tissue injury [1,2] Mesenchymal stem cells (MSCs) derived from bone marrow have the capacity to differentiate into a number of mesenchymal phenotypes, including ... Trang 1R E S E A R C H Open AccessOptimized labeling of bone marrow mesenchymal cells with superparamagnetic iron oxide nanoparticles and in vivo visualization

Ngày tải lên: 11/08/2014, 00:22