bioprocess chemical process intensification and tissue engineering

... been applied in different tissue engineering fields and some of their recent applications are reviewed below 4 Applications of Fibrin Gel in Tissue Engineering Tissue engineering is a revolutionary ... preparation and delivery processes Further engineering the fibrin gel through chemical modification can be used to develop tissue engineering scaffolds with improved mechanical properties and multifunctional ... two-stranded protofibril Subsequent cleavage of FPB releases𝛼-chain from E-region and contributes to the lateral aggregation of two-stranded protofibrils and fibrin formation [24] gel in tissue engineering

Ngày tải lên: 05/12/2016, 23:12

... sciences and medicine with the methods of engineering The purpose of TE is to develop a biological substitute that can replace, repair and/or improve tissue function Scaffold-based tissue engineering ... withstand in vivo stress and loading [13] and the choice of material should have a degradation and resorption rate so that the scaffold is retained until the fracture is remodelled by the host tissue ... Scaffold-based tissue engineering (TE) aims to aid in the repair and regeneration of bone defects Bone defects due to high energy trauma, bone resections, congenital malfunction and severe non-union

Ngày tải lên: 10/09/2015, 15:51

... in Tissue Engineering and Repair Chen Zhen Cheng, Clarice (B Appl Sci Hons.) NUS A thesis submitted for the degree of Doctor of Philosophy NUS Graduate School for Integrative Sciences and Engineering ... Martinez
s help, patience and guidance with the animal studies Special thanks to my husband and collaborator, Dr Andrew Krishna Ekaputra, who kept me smiling when times were tough, and generously shared ... assembly 68 3.6.2 Results and Discussion 68 3.6.3 Conclusion 71 Chapter 4 Peri-implantational fibrosis: a bottleneck in tissue engineering 72 4.1 Biomaterials in tissue engineering 73 4.2 Foreign

Ngày tải lên: 10/09/2015, 15:52

... donor organs and tissues available This severe organ shortage led to the inception of Tissue Engineering Tissue Engineering is about developing new approaches to encourage tissue growth and repair ... integrate with the host native tissues 2.2 Biomaterials for Tissue Engineering Biomaterials is one important component in tissue engineering and regenerative medicine and the applications of these ... 3D tissue engineering construct Trang 17The focus of this work is to design and synthesize a novel fibrous material imbued with collagen type I and cells to improve the performance of tissue engineering

Ngày tải lên: 11/09/2015, 09:10

... Cartilage tissue engineering using hydrogels……… 21 2.3.4.2 Cartilage tissue engineering using polymeric scaffolds……… 23 2.4 Cartilage formation and regeneration using ESCs……… 24 2.4.1 Homogeneity and ... phenotypic stability of differentiated cells and tissues, delivery systems and biomaterials for cartilage repair, and survivability and integration of the tissue graft to the host cartilage This ... cartilaginous tissue in the pellet system, and stable with a normal karyotype and normal somatic cell cycle kinetics In Phase IV, hESC-derived chondrogenic cells were used in cartilage tissue engineering

Ngày tải lên: 11/09/2015, 09:57

... 2NANOFABRICATION, ARCHITECTURE CONTROL, AND CROSSLINKING OF COLLAGEN SCAFFOLDS AND THE POTENTIAL IN CORNEAL TISSUE ENGINEERING DEPARTMENT OF CHEMICAL AND BIOMOLECULAR ENGINEERING NATIONAL UNIVERSITY ... 18Background and progress on tissue engineering, especially corneal tissue engineering and the status use of the electrospinning will be extensively reviewed in chapter 2 Trang 19Chapter 2 Background and ... start to age and demand better quality-of-life standards, people will expect science and engineering to develop and implement strategies that address the challenges of disabling diseases and disorders

Ngày tải lên: 14/09/2015, 09:33

... availability, high processability, and controllable mechanical Trang 4and biochemical properties Most synthetic polymers degrade via chemical hydrolysis and insensitive to enzymatic processes so that ... suitable material for thermoplastic processing of scaffolds for tissue engineering (Perrin and English, 1998a) The first generation of bioresorbable scaffolds for tissue-engineering applications has ... Structures and Properties The second important issue to be addressed in tissue engineering is the macro- and microstructures of the scaffolds From materials engineering point of view, tissues are

Ngày tải lên: 14/09/2015, 10:20

... properties and resorption rates of the original PCL scaffold 4.4 Scaffold Design and Processing The requirements for tissue engineering scaffolds like, morphological, mechanical and biochemical ... polymers before and after processing; (a): polymers before processing into scaffolds, (b): polymers after processing All polymer samples melted in the temperature range of 65°C to 70°C and found to ... crystallize The thermal and molecular properties of the polymers determined via DSC and GPC analyses before and after processing into scaffolds are presented in Figure 4.1 and Table 4.2 Polymers

Ngày tải lên: 14/09/2015, 10:23

... 0/60/120° and 0/30/60/90/120/150°) using two polymers (PCL and PCL-PEG) The process conditions i.e liquefier temperature, extrusion pressure and deposition speed were set at 90°C, 4.0 bars and 300 ... glycol, monohydroxyl PEG (mPEG) and dihydroxyl PEG were supplied by Fluka and used as received DL-lactide (DL-LA) was obtained from Purac (Gorinchem, Holland) and recrystallized from acetone ... differential refractometer and a PL gel 5µm mixed-C 60 cm column, the mobile phase being THF and the flow rate 1 cm3/min Data were expressed with respect to polystyrene standards from Polysciences

Ngày tải lên: 14/09/2015, 11:12

... should be similar to natural tissue and degrade gradually during the new tissue formation process until the new tissue is eventually mechanically competent Tissue engineering bioreactors are generally ... Ligaments and tendons are soft tissues which connect bones to bones and muscles to bones, and stabilize human joints Ligament and tendon injuries often occur in human joints during sports and trauma ... nutrients and metabolites, and a provision of molecular and mechanical regulatory factors Cells, scaffolds templates and biochemical/biomechanical signals can be utilized in various ways to engineer tissue

Ngày tải lên: 14/09/2015, 14:05

... injuries and the results of selected treatment modalities can provide a guide to strategies for tissue engineering Finally, a review of the principles of tissue engineering and current tissue engineering ... have fueled the search for tissue engineering substitutes 2.4 Tissue Engineering Approaches To Improve Tendon Healing 2.3.1 Tissue Engineering Principles The term tissue engineering was initially ... mediated processes involve in tissue formation and the rate at which these developmental and physiological processes occur If these observations are applied to the reparative processes of skeletal tissue,

Ngày tải lên: 17/09/2015, 17:18

... produce tissues and organs of the desired shape and size z Porosity and pore interconnectivity: The scaffold should be highly porous (exceeding 90%) in its surface and microstructure and have ... arose from an application in tissue engineering The loss or failure of an organ or tissue is one of the most frequent, devastating, and costly problems in health care, and transplantation surgery ... regeneration of tissues and organs, which includes cell survival, signaling, growth, propagation and reorganization, as well as cell shape modeling, and gene expressions that relate to cell growth and the

Ngày tải lên: 30/09/2015, 14:24

... expanded cells and extracellular matrices will organize into tissue that retain the shape of the scaffold and exhibit cellular, biochemical and biomechanical properties similar to the desired tissue ... research on tissue engineering strategy in recent years to reconstitute its function when lost by replacing with a functional neotissue (engineering tissue) with similar mechanical and functional ... ligament tissue engineering Hence, the objectives of this study are: (i) To design and develop a bi-axial cyclic loading and low shear stress perfusion bioreactor system for ligament tissue engineering;

Ngày tải lên: 04/10/2015, 10:25

... by Tissue Engineering 195 Moulin VJ, Mayrand D, Laforce-Lavoie A, Larochelle S and Genest H Chapter Mesenchymal Stem Cells for Cell Therapy and Tissue Regeneration in Urology 209 Yingai Shi and ... Gordon Campbell and Julie Campbell VII VIII Contents Chapter 27 Cell Responses to Surface and Architecture of Tissue Engineering Scaffolds 569 Hsin-I Chang and Yiwei Wang Preface Tissue Engineering ... of the principles and methods of engineering and life sciences toward fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and the development...

Ngày tải lên: 28/06/2014, 05:20

... bread making and the activated sludge process, by also classifying them as biochemical processes Similarly, we could also have electrochemical, photochemical, and thermochemical processes and so on, ... Economics, Harry Silla 97 Process Engineering Economics, James R Couper 98 Re -Engineering the Chemical Processing Plant: Process Intensification, Andrzej Stankiewicz and Jacob A Moulijn ADDITIONAL ... Oils and Residua, Second Edition, Revised and Expanded, James G Speight 79 Reaction Kinetics and Reactor Design: Second Edition, Revised and Expanded, John B Butt 80 Regulatory Chemicals Handbook,...

Ngày tải lên: 01/04/2014, 11:33

... In the frame of globalisation and sustainability, Process Intensification, a path to the future of chemical and process engineering (molecules into money) Chemical Engineering Journal, Vol 134, ... reprinted from Kothare, M.V Dynamics and control of integrated microchemical systems with application to micro-scale fuel processing Computers and Chemical Engineering, Vol 30, pp 1725–1734, 2006, ... of processes both in terms of QA (Quality Assurance) approaches (e.g HACCP/ HAZOP/HAZAN) and process engineering control approaches; the validation and verification of the effectiveness of processing...

Ngày tải lên: 02/04/2014, 16:24

... creative, and iterative process that applies engineering principles to conceive and develop components, systems, and processes that meet a specific set of needs It is a dynamic and evolutionary process ... Automation Science and Engineering and the ASME Journal of Computing and Information Science in Engineering He has also served on the program committees for the Geometric Modeling and Processing Conference, ... Edition mechanical and electromechanical products; aircraft systems and subsystems; electronic packaging and fabrication; building design and construction; and in the development and procurement...

Ngày tải lên: 01/04/2014, 11:39

... development of material concerned with both chemical and environmental engineering calculations The resulting end product is the Handbook of Chemical and Environmental Engineering Calculations As is usually ... engineering This Handbook provides the reader with nearly 600 solved problems in the chemical and environmental engineering fields Of the eight parts, two are concerned with chemical engineering and six ... include and what to omit has been particularly difficult However, the problems and solutions in the Handbook attempt to address calculations common to both chemical and environmental engineering...

Ngày tải lên: 01/04/2014, 11:45

... Batch Chemical Process Integration Thokozani Majozi Batch Chemical Process Integration Analysis, Synthesis and Optimization 13 Prof Dr Thokozani Majozi Department of Chemical Engineering ... Sibisi, my former science and mathematics teacher, who instilled in me the love and understanding for these two wonderful subjects and further advised me to pursue chemical engineering at my most ... traditionally encountered in batch processes This omission was not seen as a major drawback in process integration within the chemical engineering community, since continuous processes have largely been...

Ngày tải lên: 02/04/2014, 16:23

... engineering manhours, and construction Figure 1.2 Rate of application of engineering manhours by engineering function: process engineering, project engineering, and design engineering A large body ... the National Bureau of Standards Measurement and standards research, standard reference materials, standards reference data, weights and measures, materials science and engineering a bounded region ... for Refineries and Chemical Plants, Gulf, Houston, 1979, vols R.G.E Franks, Modelling and Simulation in Chemical Engineering, Wiley, New York, 1972 J Happel and D.G Jordan, Chemical Process Economics,...

Ngày tải lên: 02/04/2014, 16:24