better faster but not harder

... Pro/Arg+Pro/Pro genotypes, compared with the Arg/Arg genotype Figure ORs (log scale) of esophageal cancer associated with GSTP1 Ile106Val for the Ile/Val+Val/Val genotypes, compared with the Ile/Ile genotype ... polymorphism and esophageal cancer, but this conclusion was consistent with Hiyama T et al’ s review.[40] These findings suggest that the GSTP1 Ile105Val genotype alone does not show any association with ... has been reported and the Arg/Arg genotype seems to induce apoptosis with faster kinetics and to suppress transformation more efficiently than the Pro/Pro genotype.[15] It was shown that p53 Pro/Pro...

Ngày tải lên: 25/10/2012, 11:40

... with PR+F (not shown) Reliable methods for the measurement of anagrelide metabolites were not available at the time of study Effects on TPO and sIL-6R levels TPO PV and ET patients did not differ ... at start did not indicate whether a patient would obtain CR or not Likewise, there was no statistically significant difference at months between those achieving CR and those who did not (95.3±103 ... rise of TPO Future studies of TPO interactions with its receptor, not only on platelets but also on megakaryocytes, might yield a better understanding [9] One may ask if the TPO rise observed here...

Ngày tải lên: 03/11/2012, 10:52

... am not overambitious I am happy with my work I am not famous but I have independence I cannot create some of the more daring clothes that I would perhaps have been able to create in Europe but ... mistress He even wanted to buy me jewelry but I did not accept That's why I am not wearing any.” “They would add nothing to your appearance Nobody would notice them,” I said “That's sweet Don't ... the US but my immaturity, Lisa and my college failure landed me back in my family‟s lap I could not decide if that, finally, was good or bad luck It was the easy way out, that was certain, but as...

Ngày tải lên: 06/11/2012, 17:33

... able to interact, but to differing extents, with Fyn-SH3 This suggests that the results shown here are not artefactual, owing to incorrect folding of the tau mutants, at least not in the regions ... a major role in mediating interactions between tau and Fyn-SH2 However, a contribution from other tyrosines cannot be excluded, as a greater proportion of Y18F than of YallF mutant tau cosedimented ... phosphorylation of Tyr394 did not appear to influence the binding of tau to Fyn-SH2, as there was no significant difference in the amount of Y394F 2930 Fig Tau interactions with Fyn-SH3 are not influenced by...

Ngày tải lên: 14/02/2014, 14:20

... additional effects (not shown) In marked contrast, post-addition of MRS2179 did not affect the thrombin-induced Ca2+ response (Fig 1) To determine whether the P2Y12 contribution to the thrombin-evoked ... not shown) As a comparison, the general PI3-K inhibitor wortmannin was given after thrombin + ADP; wortmannin had a slower, but similar type of effect as AR-C (Fig 2B) To quantify the contribution ... either case, AR-C (but not MRS2179) suppressed the Ca2+ integral to a similar degree; 38 ± 1% and 37 ± 1% (n = 3) Thus, the P2Y12-dependent part of the Ca2+ signal with thrombin does not rely on PAR4...

Ngày tải lên: 18/02/2014, 16:20

... not involved in contacts with any of the interacting proteins described so far, and is not affected by the 19-residue insertion in Rac1b Therefore, the impairment of Rac1b ubiquitination is not ... increase in Rac1b ubiquitination (see white bars in Fig 3A below for quantitative analysis), but did not sensitize it significantly to proteasome-mediated degradation in HEK293 cells (Fig 1D, right ... requirements for Rac1 ubiquitination, which may not be fulfilled by Rac1b pull-down C Lys147 The main target site for Rac1 ubiquitination is Lys147, a surface residue not hampered in Rac1b We first reasoned...

Ngày tải lên: 18/02/2014, 16:20

... These observations indicate that ECM components contribute to the microenvironment of GC, but their specific roles in follicular development have not yet been established LN is one of the most abundant ... index and pyknotic index GC proliferation and survival were assessed by measuring the thymidine labeling index (percentage of labeled cells) and the pyknotic index (percentage of pyknotic cells) ... containing different ratios of LN and RGD peptides that specifically recognize the α5/ α8/ αv/ αIIb but not the α6 integrin subfamilies [35] Lastly, the consequences of inhibiting the ERK1/2 (Extracellular...

Ngày tải lên: 05/03/2014, 17:20

... (yearling vs older) Percent any fledglings per year Pair Better conditions for breeding Ratio of change (worse/ better) 3 Incremental change (worse − better) 4 Group Ratio G/P1 2.29 2.00 0.9 − 0.29 1.3 ... Comparison Group 0.48 Species Ratio G/P1 Better conditions for breeding 0.87 Pair Increment2 Ratio of change (worse/ better) 3 Incremental change (worse − better) 4 Group Ratio G/P1 0.86 1.58 1.8 ... conditions may be even lower It is therefore not surprising that many studies have not detected group-size effects A greater ratio of effect in poor conditions does not necessarily mean that there is a...

Ngày tải lên: 14/03/2014, 16:20

... East As a result of these perceived attributes, the Iranian leadership has shown a marked tendency not only to push for a greater role in regional affairs but also to exaggerate Iran’s strategic ... international s ­ ystem but not because of its revolutionary foundations Iranian leaders no longer seek to radically reshape the regional order as they did after the revolution, but rather to raise ... Division, Center for Strategic Research, Expediency Council, 2006 14 Dangerous But Not Omnipotent In recent years, these attributes have informed a policy outlook that attaches inflated geopolitical...

Ngày tải lên: 15/03/2014, 21:20

... symmetryequivalent contributors) is not the most useful indicator, because it does not take into account the multiplicity of measurements More elaborate versions of Rmerge have been proposed [32,33], but they ... assumed that the true resolution is not as good However, if this number is much higher than 2.0, it indicates that the crystal is able to diffract better but the resolution of data was limited ... refinement not only permits finer structure details to be observed, but also removes possible bias from the model, as higher resolution improves the data-to-parameter ratio It has to be noted that...

Ngày tải lên: 16/03/2014, 06:20

... different concentrations of menadione (10, 30, 83, 90 and 110 mM) on cell viability (results not shown) and noticed that 83 mM menadione produced a viability similar to that evoked by 1.5 mM H2O2 ... and results not shown) Although its UV spectrum coincides with that of adenosine, both compounds are different because (a) they elute in a slightly different chromatographic position (not shown) ... 2, and mM H2O2 A concentration of H2O2 as high as mM did not change the HPLC nucleotide prole obtained with untreated cells (results not shown) In a different experiment, yeast cells were grown...

Ngày tải lên: 17/03/2014, 10:20

... Cheaper, Better, Faster will give you the choices And now to answer the question you will ask if you haven’t already: No, I not everything recommended in Cheaper, Better, Faster There’s not a person ... they can be reinforced Buttons—sewing in some slack Place a toothpick between the button and fabric as you sew When the button is secured, remove the toothpick This gives the button a little slack ... operate Buttons—sewing in spares Sew extra buttons into the seams of jackets and pants If you need a spare, you’ll always know where it is Buttons—sewing in to stay When attaching a four-hole button,...

Ngày tải lên: 17/03/2014, 20:09

... 2002 Ruk is ubiquitinated but not degraded by the proteasome (Eur J Biochem 269) 3407 proteins Many ubiquitinated proteins are targeted for degradation by 26S proteasomes, but some undergo endocytosis, ... human and yeast proteins Therefore, Ub is not an optimal antigen and anti-Ub Ig rarely possess good affinity Taking this into account and that anti-Ruk Ig are not very efficient in immunoprecipitation ... [21] Taking this into account, we speculated that association of Ruk M and Ruk S with Cbl is not direct, but could be mediated via heterodimerization with the longest isoform, Ruk L In order to test...

Ngày tải lên: 17/03/2014, 23:20

... the same ideas to build better, faster, lighter Java • Errata • you tend to value a book by the weight of its pages, go find another one If you'd rather Academic If Better, Faster, Lighter Java ... working Better, Faster, Lighter Java on an older compiler And let's further assume that the loop is a little longer Would you really notice the difference? Unless you were doing nothing but processing ... you build with Java are distributed, and it's easy to distribute more broadly than you need Distribution can add flexibility, scalability, and availability In Better, Faster, forces some decisionsBruce...

Ngày tải lên: 22/03/2014, 12:20

... conditions, is a general property of the polypeptide chain [10,11] This ability not only has pathological consequences, but can be turned into good use as functional amyloid, serving as structural ... three different types of amyloid according to solid-state NMR [39] that differ from one another in subtle but distinct ways, such as variations in the mobility of the aromatic Tyr ring There is ... both type A and Bunagitated fibrils can grow exponentially at low concentrations, but type Bunagitated fibrils have a faster exponential growth (a more shallow slope FEBS Journal 277 (2010) 4591–4601...

Ngày tải lên: 23/03/2014, 03:20

... long-term incubation These results indicate that insulin may be not only a natural inhibitor of amylin aggregation, but also a contributor to the amyloid formation and pathogenesis of T2D We also ... caseins during their fibrillation Altogether, these results indicate that insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation, and insulin can eventually promote fibril ... formation However, our study demonstrates that insulin itself does not act simply as a natural inhibitor of amylin aggregation but has opposite influences on amylin aggregation during different...

Ngày tải lên: 23/03/2014, 04:21

... signal transduction Regulated by thioredoxin, OGDHC is at the intercept of not only energy production and glutamate turnover, but also mitochondrial production ⁄ scavenging of reactive oxygen species ... although the mechanism(s) of their solubilizing action on the complexes have not been systematically studied In order to better preserve native enzyme regulation and protein–protein interactions, ... et al the distribution of OGDHC activity between the supernatant and the detergent extract of the broken mitochondria pellet Mitochondrial disruption with the probe sonicator did not reproducibly...

Ngày tải lên: 23/03/2014, 06:20

... is not reduced by low pH It is possible therefore that in pH-activated gelsolin, the helical latch may be the last event to occur being triggered not by direct disruption of the interface but ... ionpair exchanges, presumably initiated at histidine residues, that also disrupts interdomain bonds but not those formed through the G2–6 interface Methods Proteins and peptides Rabbit skeletal muscle ... similar to those obtained at pH 7.5 It appears that the interaction between G2 and G4–6 is calcium but not pH sensitive Fig Binding of G4–6 domain with 159–193 and 197–226 fragments derived from gelsolin...

Ngày tải lên: 23/03/2014, 21:20

... best health category This population does not combine a paid job and have fewer familial constraints so that they not have a multiple roles burden They not have to cope with many expectations and ... literature, researchers tend to clarify the concept of social capital but there is still no consensus As Grootaert and Seragelgin (2000) have noticed, “social capital means different things to different ... transactions grow Moreover, it has been noticed that norms of cooperation and social trust restrict individual interest, which enable people to be more willing to contribute to the public good provision...

Ngày tải lên: 28/03/2014, 20:20

Ngày tải lên: 28/03/2014, 20:20