basal insulin glargine lantus ® and detemir levemir ®

... both insulin glargine[ 30] and insulin glargine[ 80]; †P Ͻ 0.05, pairwise comparison with insulin glargine[ 30]; ‡P Ͻ 0.001 for insulin glargine[ 30] and insulin glargine[ 80] compared to NPH insulin ... plasma glucose levels for insulin glargine[ 30] (᭹), insulin glargine[ 80] ( ᭿), and NPH insulin (᭡) is shown DIABETES CARE, VOLUME 23, NUMBER 8, AUGUST 2000 1139 Basal insulin glargine in type diabetes ... Fewer patients receiving NPH insulin (93.2%) reported a hypoglycemic episode than patients receiving insulin glargine (97.6 and 100.0% for insulin glargine[ 30] and insulin glargine[ 80], respectively)...

Ngày tải lên: 12/08/2014, 20:59

... - and with a possible pre- and intraoperative medical intervention available (i.e insulin sensitizers and insulin) A recent study showed an approximately 2-fold increased risk of mortality and ... (95% CI) and categorical data as counts and frequencies HOMA and adiponectin were logarithmically transformed prior to correlation with baseline and procedural characteristics Both baseline and procedural ... cross clamp time, and inversely with male gender, body mass index, former myocardial infarction, eGFR, and the levels of glucose, insulin and HOMA as well as the use of beta blockers and statins (Table...

Ngày tải lên: 10/08/2014, 09:23

... of action (NPH insulin and lente insulin [Lente; Eli Lilly and Company]), and long-acting insulins (ultralente insulin and insulin glargine) Short-Acting Insulins Short-acting insulins are used ... mimicking physiologic basal insulin secretion The only currently available long-acting analog is insulin glargine Insulin Glargine Insulin glargine is an extended-action insulin analog and was created ... conducted a similar comparison of insulin glargine and NPH insulin in 518 patients with type diabetes Both insulins significantly improved glycemic control, but insulin glargine was associated with...

Ngày tải lên: 12/08/2014, 20:59

... in mealtime or basal insulin dose In contrast, with glargine there was a decrease in mealtime insulin lispro and an increase in basal insulin requirements The decrease in lispro insulin requirements ... patients with type diabetes on intensive insulin treatment and lispro insulin at mealtime, given basal insulin either as NPH four times/day or insulin glargine once daily at dinnertime or bedtime ... between glargine at dinnertime and bedtime Plasma insulin concentrations were greater with glargine before breakfast, lunch, dinner, and between 0400 and 0730 (P Ͻ 0.05) However, with NPH, plasma insulin...

Ngày tải lên: 12/08/2014, 20:59

... self-injected insulin dose Shown is versus self-injected insulin dose the correlation between the duration of glucose infusion and the selfinjected insulin dose in 25 cases of insulin self-poisoning ... the glucose uptake of insulin- sensitive cells, stimulating oxidative and nonoxidative glucose metabolism and suppressing hepatic glycogenolysis and gluconeogenesis At plasma insulin concentrations ... of the delayed and erratic absorption of the injected insulin, varying kinetics (especially when different types of insulin were injected) and the likelihood of both immediate and recurrent hypoglycaemia...

Ngày tải lên: 13/08/2014, 08:20

... glycerol and glycerophospholipid formation and the citric acid cycle Simplified diagram of the intermediary metabolism of the glycolytic chain and its relation to the formation of glycerol and glycerophospholipids ... already been reported that insulin receptors were widely distributed within the brain [8] The functions of insulin receptors and their expression in the developing and adult brain have become ... Since the observation by Schlenk and colleagues is not explained by a decrease in cerebral blood flow or by the direct effect of insulin on cerebral glucose uptake and metabolism, we may finally...

Ngày tải lên: 13/08/2014, 10:20

... glycosylated hemoglobin and hypoglycemia outcomes across eleven Phase III and IV studies of insulin glargine compared with neutral protamine Hagedorn insulin in type and type diabetes mellitus ... G, Höer A, Häussler B: Comparison of Cost and Utilisation among Propensity Score Matched Users of Insulin Glargine and Users of NPH Insulin in Type and Type Diabetes Berlin: IGES Institut GmbH; ... glucose self-monitoring and lancets between the different basal insulins in type diabetes This last point clearly shows, that claims data analyses and primary data collection of insulin consumption,...

Ngày tải lên: 13/08/2014, 11:22

... glucose and choline measurements In experiments and 3, rats were killed by rapid decapitation 10 after choline administration and Ó FEBS 2003 trunk blood was collected for serum insulin and glucose ... blood insulin by a peripheral mechanism The effect of choline on serum insulin involves parasympathetic activation and is mediated both by peripheral muscarinic and nicotinic receptors Insulin ... autonomic blockade by methylatropine and optical isomers of propranolol on plasma insulin levels in the basal state and after stimulation Acta Physiol Scand 112, 57–63 ´ Ahren, B., Taborsky,...

Ngày tải lên: 17/03/2014, 09:20

... exceptional patient care and organization This work was supported, in part, by grant of Zhejiang Science and Technology Agency (2008C03002-1) and Zhejiang Major Medical and Health Science and Technology ... linear regression analysis, suggesting a link between IMT, insulin resistance and dyslipidemia Insulin resistance is a common phenomenon and plays an important role in the cardio-cerebrovascular ... [17,18] In our study, the obese and MetS group both demonstrated increased fasting insulin than control group rather than fasting blood glucose Meanwhile, fasting insulin and HOMA-IR levels were significantly...

Ngày tải lên: 25/10/2012, 11:40

... reduced insulin resistance and inflammation) in these study subjects Research Design and Methods Subject characteristics Sixty-two Hispanic individuals, 55 years and older with type diabetes were randomized ... choices and physical activity, and compliance with medications and doctor’s visits [24] Subjects in this group received phone calls every other week and came to the HNRCA for testing at baseline and ... < 0.05 Data are shown as mean and standard error (SE), except for non-normally distributed variables (insulin, HOMA-IR, CRP, adiponectin) for which group median and interquartile ranges are shown...

Ngày tải lên: 31/10/2012, 15:28

... behavioral and/ or language problems can present [20] Image studies reveal in all cases basal encephalocele, agenesis of the corpus callosum, and well-preserved cerebral structures and anterior ... Guion-Almeida ML and Richieri-Costa A New Syndrome of Growth and Mental Retardation, Structural Anomalies of the Central Nervous System and First Branchial Arch, Anophthalmia, Heminasal A/hypoplasia, and ... Hodgkins P, et al Optic disc anomalies and frontonasal dysplasia Br J Ophthalmol, 1998 82: 290-93 Chen CS, David D and Hanieh A Morning glory syndrome and basal encephalocele Childs Nerv Syst,...

Ngày tải lên: 03/11/2012, 10:05

... changes in blood fasting glucose, plasma insulin and lipid parameters, such as TC, TG, HDL, and PI, in comparison with untreated ND fed mice Therefore, obesity and insulin resistance were the important ... Moreover, blood glucose and insulin concentration unusually increase in obese mice in comparison with the control (ND mice) Namely, blood glucose level increased by 48.11% and plasma insulin icreased ... significant Results and discussion 3.1 Body weight, biochemical parameters of ND and HFD fed mice Table indicated that the body weight, blood lipid parameters, such as TC, TG, LDTc, and plasma insulin concentration...

Ngày tải lên: 12/02/2014, 17:20

... that trigger excessive insulin secretion, and you can restore your slow-twitch muscles’ sensitivity to insulin You it by cutting out a handful of bland and unexciting foods and engaging in some ... is meat and dairy product, and how much is bun, french fries, and soft drink—that is, how much is fat, and how much is starch and sugar? Fast food isn’t so much fatty as it is starchy and sugary ... only meat and raw vegetation, as our prehistoric ancestors did The body doesn’t need much insulin to handle those foods Meat contains virtually no glucose, and the glucose in fresh fruit and vegetables...

Ngày tải lên: 15/02/2014, 15:20

... triglyceride, glucose, leptin and insulin, and insulin sensitivity, in TG mice After weeks of normal or HF diet, serum levels of triglyceride, glucose, leptin and insulin were deter- 1 Duration ... the liver and WAT Paraffin sections of liver and WAT from WT and TG mice (S55) were stained with antibody against human H-PGDS Bars: 100 lm (D) PGDS activity in liver of WT and S41, S55 and S66 ... family, and is also called GSTS1 [17] On the other hand, L-PGDS has been purified from rat brain [18], and is expressed in brain, heart, and male genital organs, as well as in adipocytes and omental...

Ngày tải lên: 16/02/2014, 09:20

... of four determinations for insulin and three determinations for EGF) See text for statistical analysis of insulin and EGF effects on Grb7 and Grb14 content in the PM and GE fractions p-EGFR, phosphorylated ... kinetics and dose– response studies with insulin and superactive insulin analogs, a striking correlation between the IR phosphorylation state and the content of Grb14 in the plasma membrane and ⁄ ... interaction between the insulin receptor and Grb7 A role for two of its binding domains, PIR and SH2 Oncogene 19, 2052– 2059 Daly RJ, Sanderson GM, Janes PW & Sutherland RL (1996) Cloning and characterization...

Ngày tải lên: 18/02/2014, 18:20

... accelerates muscle and motor neuron regeneration FASEB J 17, 53–55 Rosenthal SM & Cheng ZQ (1995) Opposing early and late effects of insulin- like growth factor I on differentiation and the cell cycle ... pattern (Fig 4C) Surprisingly, both transfected and parental cell lines exhibited a similar pattern, with GM3 ganglioside as a major component, and GM2 and GD1a gangliosides present in lower amounts ... biosynthesis, P4 [26], and characterized for their proliferation and FEBS Journal 273 (2006) 3709–3721 ª 2006 The Authors Journal compilation ª 2006 FEBS A Fanzani et al Insulin- like growth factor...

Ngày tải lên: 19/02/2014, 06:20

... and C) or pGL3Enhancer (B and D) Resulting recombinant plasmids or, as controls, pGL2Basic ⁄ pGL3Enhancer empty vectors were cotransfected with pRL-TK into HEL92.1.7 (A and B) and HEK293 (C and ... autoradiography, as outlined (C and D) Western blot analysis of Oct-1 (C) and Oct-2 (D) expression in whole cell protein (60 lgÆ lane)1) prepared from HEL (C and D; lane 1) and HEK293 (C and D; lane 2) cells ... the left and right of the (C) and (D), respectively, whilst the position of the Oct-1 (98 kDa approximately) and the two major forms of Oct-2 (75–80 and 55–60 kDa) detected in HEK293 and HEL cells,...

Ngày tải lên: 19/02/2014, 16:20

... anti-a, -b, -c, -d, -e, and -f for immunoblotting were obtained from Gibco (Grand Island, NY, USA) Rabbit anti-PKCf for immunoprecipitation and activity determination, and the antiPKCf blocking ... the action of insulin As reported previously [42], ATP (> 10 lM) inhibited basal and insulinactivated glycolysis (results not shown) Furthermore, we observed that the addition of insulin stimulated ... is shown in Fig 4A Control and agonist-stimulated hepatocytes Ó FEBS 2003 Insulin signalling in rat hepatocytes (Eur J Biochem 270) 4639 Fig Modulation of basal and insulin- stimulated glycogen...

Ngày tải lên: 20/02/2014, 02:21

... migration and invasion (A) Inhibition by mAbs of the adhesion to HUVECs of untreated control and insulin treated cells (B) Inhibition by monoclonal antibodies of the migration and invasion of insulin ... 201% and 253% of the UnC and mock values, respectively, after insulin treatment The PKB protein was also increased to 233% and decreased to 55% of the mock values in S-PKB/ Ó FEBS 2003 Insulin ... HRP-labelled goat anti-(rabbit IgG), insulin, L-poly(L-lysine), laminin, LY294002 and tumour necrosis factor-a (TNF-a) were from Sigma TRIzol, DNA restriction endonucleases and random primer labelling kit...

Ngày tải lên: 21/02/2014, 00:20

... expression in insulin- secreting cells b-TC-6 cells were transfected with 60 nM of precursors of mir-control and mir-9 (A) and 1.5 lg of pSuper and pSuper-mir-9 plasmids (B, C) for 72 and 24 h, respectively ... antibodies (Sigma cat nos A0545 and A2554) and Lumi-Light Western Blotting Substrate (Roche cat no 12 015 196 001) were used to visualize the bands Insulin ELISA Sera and culture supernatants from ... and 60 nM of precursors of mir-control, mir-9 and mir-34a b-Actin was used as a loading control The relative protein levels were quantified using Adobe Photoshop and are indicated Sirt1 mRNA and...

Ngày tải lên: 06/03/2014, 00:21