basal cell and squamous cell carcinoma

... understood, and literature data indicate that they might be at least cofactors in the development of certain cutaneous squamous cell carcinomas However, only few reports contain data on basal cell carcinoma ... these HPV was detected in 30–90% of actinic keratosis and squamous cell carcinomas of non-EV patients (14,15) but few data exist on basal cell carcinoma (BCC), the commonest NMSC Our study aimed ... and Akt, were investigated The expression pattern of p16INK4a in dysplastic squamous and glandular cervical cells in tissue sections and in cervical smears has been extensively investigated and...

Ngày tải lên: 10/08/2014, 10:21

... Carcinoma 71 Eijun Itakura Chapter 5 Metastatic Basal Cell Carcinoma 79 Anthony Vu and Donald Jr Laub Chapter 6 Genomics of Basal and Squamous Cell Carcinomas 93 Venura Samarasinghe, John T Lear, ... as basal cell carcinoma through UVB radiation (13, 79 to 82) Fig 1 Carcinogenesis of basal cell carcinomas Concept for the course of molecular changes in the cancerogenesis of basal cell carcinomas: ... recognize normal squamous epithelium and squamous cell carcinomas (139) It is well suited for differentiating carcinomas from negative adenocarcinomas and small cell carcinomas (140) Monoclonal anti-U36...

Ngày tải lên: 30/03/2014, 23:20

... Basosquamous Thể vảy đáy o Rare: less than 2% of cases o Well-defined nodular or superficial squamous cell carcinoma —appearance with underlying histological features of both basal cell andsquamous ... for acne (used before approximately 1950) and kidney 25 26 recipients will develop nonmelanoma skin cancer, usually basal cell carcinoma or squamous cell carcinoma 28 Hơn một nửa số người nhận ghép ... biopsy shows abnormal keratinocytes varying in shape and size with atypical nuclei  Squamous cell carcinoma (Related: Cutaneous Squamous CellCarcinoma) Trang 16o Malignant proliferation of epidermal...

Ngày tải lên: 14/06/2024, 14:49

... information, see the section, “Can basal and squamous cell skin cancers be found early?” Can basal and squamous cell skin cancers be found early? Basal cell and squamous cell skin cancers can be found ... Unlike basal cell and squamous cell carcinomas, Merkel cell carcinomas often spread to nearby lymph nodes and internal organs They also tend to come back after treatment Treatment of Merkel cell carcinoma ... years Squamous cell carcinoma About 2 out of 10 skin cancers are squamous cell carcinomas (also called squamous cell cancers) The cells in these cancers share features with the squamous cells...

Ngày tải lên: 22/03/2014, 16:21

... esophageal squamous cell carcinoma (ESCC) cell lines, OE21 (while bars) and TE10 (black bars), compared to the non-malignant esophageal squamous cell line, Het1A cells (A) On the other hand, miR-153, ... and exert distinct biological actions in ESCC cells Methods Cell lines and cultures I) Five cell lines of human ESCC cells (OE21, TE5, TE8, TE10, and TE11), a non-malignant human esophageal squamous ... adenocarci-noma cell lines (Caco-2 and DLD1), a human cervix epithelioid carcinoma cell line (HeLa), a human lung adenocarcinoma cell line (A549), and human hematolo-gical malignant cell lines (acute...

Ngày tải lên: 18/06/2014, 19:20

... tumour tissues and oesophageal squamous cell carcinoma cancer cell lines, and is related to clinical pathology and prognosis of the patients with oesophageal squamous cell carcinoma Cellular function ... human oesophageal squamous cell carcinoma cell lines and an oesophageal adenocarci-noma cell line Moderate-differentiated cell lines OE19 (oesophageal adenocarcinoma cell line) and OE21 were obtained ... oesophageal squamous cell carcinoma We also provide new insights into the biological functions of MTSS1 and its role in oesophageal squamous cell carcinoma Material and methods Cell lines and human...

Ngày tải lên: 18/06/2014, 19:20

... patients with HNSCC and is a potential candidate molecule for targeted therapy Background The majority of tumors that arise in the head and neck region are squamous cell carcinomas arising from ... the three cell lines tested, MCF7 cells had high levels of Her3, BxPC3 cells had inter-mediate Her3, and A549 cells had low Her3 (Figure 1) We analyzed the expression pattern of Her2 and Her3 ... contributions J-YC and SMH conceived of the study and devised the experimental design SMH and CM designed and build the tissuemicroarrays MT, J-YC, and YK performed experiments RX, HC, J-YC and SMH performed...

Ngày tải lên: 18/06/2014, 22:20

... Karen Dyker1, Catherine Coyle1and Mehmet Sen1* Abstract Background: To establish recurrence patterns among locally advanced head and neck non-nasopharyngeal squamous cell carcinoma (HNSCC) patients ... patients had histologically confirmed squamous cell car-cinoma Histological grading was recorded in 134 patients and 76 (50.3%) had poorly differentiated squa-mous cell carcinoma Stage distribution was ... entire cohort of 151 patients the OS rates were 67.5% and 58.3%; the CSS rates were 75.1% and 66.8% and PFS rates were 72.5% and 67.2% at 2 and 3-years respectively Patterns of recurrence of patients...

Ngày tải lên: 09/08/2014, 09:20

... networks for head and neck squamous cell carcinoma Gurkan Bebek1,3,4, Mohammed Orloff1,2and Charis Eng1,2,4,5* Abstract Background: Advanced stage head and neck squamous cell carcinoma (HNSCC) ... and genes that are germane to HNSCC Background HNSCC is the sixth most common cancer and remains a major cause of cancer morbidity and mortality worldwide [1] More than 85% of head and neck squamous ... invaluable knowledge in understanding the inter-com-partmental and inter-network-based events in HNSCC tumorigenesis and importantly, guide empiric molecular and cellular biology experiments in...

Ngày tải lên: 10/08/2014, 09:22

... comparable to other cancer cells, e.g cervical adenocarcinoma cells [43], osteosarcoma cells [42], lung adenocarcinoma cells [37,41], and gastric and colon cancer cells [44] Despite this, nanoparticle ... nanoparticles, silica dioxide, surface properties, tumor cell line, uptake, endocytosis, cellular fate 1 Introduction Head and neck squamous cell carcinoma (HNSCC) comprise a group of epithelial cancers ... Nano ZS, Malvern Instruments Ltd., UK) 2.2 Cell Culture The head and neck squamous carcinoma cell line UMB-SCC-745 was kindly provided by Dr Robert Mandić, Department of Otolaryngology, Philips...

Ngày tải lên: 11/08/2014, 00:23

... OSMF and OSCC, in which viral integration and the expression of viral onco-genes (E6 and E7) have been shown [8] HPV detection in potentially malignant and malignant oral squamous cell carcinoma ... reaction; (OSMF): Oral submucous fibrosis; (HNSCC): head and neck squamous cell carcinoma; (HC-II): Hybrid Capture; (OSCC): Oral squamous cell carcinoma. Acknowledgements Authors are thankful to ... phosphatase conjugated antibody and detected by Figure 1 Figure 1 illustrated the oral sub mucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC) specimen collection and HPV DNA testing methods....

Ngày tải lên: 12/08/2014, 01:22

... specimen; SCC, squamous cell carcinoma; S, surgery; TNM, tumor-node-metastasis (staging system); UM-SCC, University of Michigan series head and neck squamous cell carcinoma Trang 4p53 genotype and protein ... UM-SCC cell linesFigure 1 p53 genotype and protein expression in UM-SCC cell lines (a) The p53 genotype of ten University of Michigan series head and neck squamous cell carcinoma (UM-SCC) cell ... distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma Addresses: * Head and Neck Surgery...

Ngày tải lên: 14/08/2014, 07:21

... population of cells with cancer stem cell characteristics in head and neck squamous cell carcinoma (HNSCC) The aim of this study is to investigate the expression of CD44s in squamous cell carcinoma ... severe combined immunodeficient SCC squamous cell carcinoma Trang 11CHAPTER 1 INTRODUCTION Trang 121.1 Head and Neck Cancers Squamous cell carcinomas of the head and neck (HNSCC) are epithelial ... epithelial cell assumes a mesenchymal cell phenotype It has a crucial role in embryogenesis - in the differentiation of various tissues and organs, and in tissue repair.28 During EMT, cell-cell and cell-extracellular...

Ngày tải lên: 02/10/2015, 17:14

... Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases and mainly includes three distant histological subtypes, i.e., lung adenocarcinoma (AC), lung squamous cell carcinoma ... Cancer Cell lines and culture The lung SqCC H1703, H2170, SK-MES-1, and H520 cell lines were obtained from the American Type Culture Collection (Manassas, VA, USA) The H1703, H2170, and H520 cell ... of cell colonies formed was not significantly different between H520-PCDH and H520-CLDN3 cells, or between SK-MES1-CON and SK-MES1-shRNA cells (p > 0.05 using the Student’s t-test) C Cell...

Ngày tải lên: 15/01/2020, 11:10

... immunotherapies in head and neck squamous cell carcinoma Oral oncology 2013; 49: 1089-96 20 Deng WW, Wu L, Sun ZJ Co-inhibitory immune checkpoints in head and neck squamous cell carcinoma Oral Dis ... Chen W, Gutkind JS, et al Loss of TGF-beta signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation Oncogene 2012; 31: ... head and neck squamous cell carcinoma Oncotarget 2017; 8: 52889-900 36 Wu L, Deng WW, Yu GT, Mao L, Bu LL, Ma SR, et al B7-H4 expression indicates poor prognosis of oral squamous cell carcinoma...

Ngày tải lên: 15/01/2020, 18:14

... The association between serum squamous cell carcinoma antigen and recurrence and survival of patients with cervical squamous cell carcinoma: a systematic review and meta-analysis Gynecol Oncol ... Pretreatment and posttreatment SCC antigen levels can be used in evaluating the lymph node metastases and prognosis of patients with cervical squamous cell carcinoma Keywords: Cervical squamous cell carcinoma, ... AccessClinical value of serum squamous cell carcinoma antigen levels in predicting chemosensitivity, lymph node metastasis, and prognosis in patients with cervical squamous cell carcinoma Peng Chen1,...

Ngày tải lên: 30/05/2020, 21:44

... tumorigenesis, and suggest opportunities for the future development of miRs and mRNAs as biomarkers for early detection, diagnosis, and prognosis in ESCC Keywords: Esophageal squamous cell carcinoma, ... clinicopathological factors and 260 miRNAs, including metastasis (no vs yes), tumor grade (grade 1 and 2 vs grade 3 and 4), and tumor stage (stage I and II vs III and IV) Twenty-six miRNA expressions ... C L E Open AccessIntegrated analysis of genome-wide miRNAs and targeted gene expression in esophageal squamous cell carcinoma (ESCC) and relation to prognosis Howard Yang1†, Hua Su2,3†, Nan Hu3,...

Ngày tải lên: 30/05/2020, 22:03

... gastric [18] and colon [19] adenocar-cinoma but upregulated in oral and pharyngeal squa-mous cell carcinoma [20], cervical adenocarcinoma [21], hepatocellular carcinoma [22], and non-small cell lung ... of Sgk1 and NDRG1 in carcinoma cells play pivotal roles in tumor progression and development of chemo-resistance in patients with ESCC undergoing NAC Keywords: Esophageal squamous cell carcinoma, ... cytoplasm and membrane of carcinoma cells Trang 4Evaluation of immunoreactivityGR immunoreactivity was evaluated in the nuclei of tumor cells and Sgk1 and NDRG1 in the cytoplasm of tumor cells All...

Ngày tải lên: 17/06/2020, 03:21

... aV ,min and aV ,max , respectively The search lines S1 and S2 for b and c are on the height of the mouth middle point and parallel to the W axis They are bounded by −bW,max , −bW,min and bW,min ... upper and lower bounds, tests were carried out Here, 60 facial images (30 female and 30 male faces) from an image database were selected The true positions of eyes and mouth middle positions and ... and chin and cheek contours were manually determined from the facial images, and the parameters aV , bW , cW , dW , eW , |bW | + |cW |, and |dW | + |eW | were calculated First, the upper and lower...

Ngày tải lên: 23/06/2014, 01:20

... CD4+ T cells at the indicated B cell: T cell titrations (A) Percentage of CFSElow T cells and (B) T cell IFN-gamma production (left panel) or T cell IL-2 production (right panel) for T cells incubated ... effect of CP-870,893 on B cell activation and B cell stimulation of T cells, and we analyzed the effects of co-stimulating B cells with the TLR9 agonist CpG ODN 2006 Materials and methods In mice, ... Percentage of CFSElow T cells and (B) T cell IFNgamma production (left panel) or T cell IL-2 production (right panel) are shown for responding T cells at a B cell to T cell ratio of 1:2 Mean values...

Ngày tải lên: 18/06/2014, 15:20