as a biomarker of brain function and plasticity

... JJ, Altman DG Measuring inconsistency in meta-analyses BMJ 2003;327(7414):557 –60. 21 Zamora J, Abraira V, Muriel A, Khan K, Coomarasamy A Meta-DiSc: a software for meta-analysis of test accuracy ... For example, the diagnostic meta-analysis is mainly for Asians and Africans while the prognostic meta-analysis only fo-cused on Caucasians and Asians Therefore, more re-searchers should pay attention ... the Natural Science Foundation of China (no 81874230) in collecting and analyzing data. Availability of data and materials The data that support the findings of this study are available from

Ngày tải lên: 17/06/2020, 19:12

... Medicine, Massachusetts General Hospital, Boston, MA 02114, USA 9Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL 35294, USA 10Penn Cardiovascular Institute, ... Trang 1Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis Graphical Abstract Highlights d PRKAG2 cardiomyopathy ... PGC-1a/b (PPARGC1A and PPARGC1B), insulin receptor (INSR), PPARa/g (PPARA and PPARG), IGF1R, hepatocyte nuclear factor 4a (HNF4A), and estrogen receptor related a (ESRRA) The pathways regulated

Ngày tải lên: 05/05/2024, 03:35

... Diseases The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Availability of data and materials Data and materials are available ... Depth of tumor invasion Regional lymph node metastasis Tumor location TNM classification Table 4 Univariate analyses and multivariate analysis of factors associated with relapse-free survival for ... survival and overall survival TMN stage was composed of depth of tumor invasion (T), regional lymph node metastasis (N) and distant metastasis (M) There were collinearities between TNM stage and

Ngày tải lên: 20/09/2020, 15:05

... Assay System (Promega) Statistical analysis All data were presented as means ± SD SPSS 18.0 was used for data analysis Statistical differences were carried out by using of one-way analysis of ... cancer [13], breast cancer [14] and hepatocellular cancer [15] The BACE1AS has been reported play an vital role in the aetiology of Alzheimer Disease (AD) [16] The Gas5 transcript was linked with ... choninic acid assay kit (BCA assay kit, Beyotime) Immunoblotting assay was carried out on a 12% SDS-PAGE gel to separate protein extracts The membrane was incubated by a anti-p-p65 or anti-SP1(1:500,

Ngày tải lên: 04/12/2022, 15:14

... P sub-scales, such as age, sex, marital status, edu-cational level, religious affiliation, SpR attitude, disease and duration of disease Using the method of univariate analyses of variance we ... covariate for any of the five forms of SpR practice • Disease itself has an impact on NoP (and a minor impact on HuP and USP), while the duration of disease has no impact on the forms of SpR practice ... religious and philosophical practice Finally the fact that the valida-tion was performed in a sample with at least two different types of life-changing diseases (cancer and MS, and other chronic diseases)

Ngày tải lên: 20/06/2014, 15:20

... Refflat file) and finally to non-coding RNA classes (fRNAdb, database of ncRNA.org): piwi-interacting RNA (piRNA), tRNA, rRNA, small nucleolar RNA (snoRNA) and other non-coding RNA (ncRNA) Reads ... to any annotated small RNA Our small RNA cloning strategy only captures small RNAs that are, as miRNAs, 5’-phosphorylated and, thus, eliminates RNA degradation products generated by the major ... mature miRNAs that each represented > 0.03% of the reads, 131 had a relative abundance that was below 1% while miR-21 and miR-29a were highly abun-dant and accounted for 30.2% and 13.8% of

Ngày tải lên: 09/08/2014, 23:20

... proposal was the fact that his treatment of quantum gravity was semiclassical, and thus it could be that all the Hawking excitement was noth-ing else but an artifact of the bad/crude/unjustifiable ... and time! Clearly, while the global states are as physical and as real as any other states, still they are unattainable for direct observation to a local observer They make themselves noticeable ... seeds of dramatic and radical changes, if the crisis is looked upon as an opportunity In our case at hand, since the Standard Model, based upon standard QFT, works extremely well, we had not

Ngày tải lên: 10/08/2014, 00:21

... equation into a stochastic differential equation ableto successfully describe both evolution and “measurement” of quantum systems At the same time, a unified picture of the quantum and classical ... cells, the cells of all animals and almost all plants on Earth, account for their changing shape, movement, etc This extremely important cytoplasmic struc-tural and dynamical organization is due ... moves material and thus is of fundamental importance for the maintenance and regulation of synapses The structural bridges formed by MAPs stabilize MTs and prevent their disassembly The MT-MAP “complexes”

Ngày tải lên: 10/08/2014, 00:21

... properties of the spin-glass phase makes it optimal for computational applica-tions The spin-glass phases allow easy formation of local ordered states, each of which carries some information content and ... expected random phase, where all dipoles are distributed randomly To understand the existence and properties of the spin-glass phase better, it helps to notice that an MT, as a regular array of coupled ... classical treatment of a system, one goes directly to quantize the dynamics of the system in a standard way Alas, things here are not so easy We have seen that there are very important, dissipative,

Ngày tải lên: 10/08/2014, 00:21

... In such a case, a quantum superposition, initiated presumably in a parasitic way, may last much longer than a normal state case, and thus, eventually, may get lost in the environmental background, ... the workings of general anesthesia seem to explain easily some of its key features For example, it is a rather remarkable fact that general anethesia can be induced by a large number of completely ... modmod-ules, and, eventually the whole brain, may be viewed as the “measuring apparatus” providing the bulk of the “mass”/“energy” needed in synchordic collapse Recall that, in the case if quantum mechanics

Ngày tải lên: 10/08/2014, 00:21

... Corresponding author Abstract Ultimately, asthma is a disease characterized by constriction of airway smooth muscle (ASM) The earliest approach to the treatment of asthma comprised the use of xanthines and ... vis-a-vis, decreased cytosolic levels of Ca2+ (through a variety of actions on plasmalemmal K+ -and Ca2+-channels [33], as well as the Ca2+-pumps on the plasmalemma and the SR [34]), inhibition of ... explain many lung/airway phenomena and offer clues for novel therapeutic intervention A major and fundamental limitation in studies aimed at better understanding and treating asthma has been the lack

Ngày tải lên: 12/08/2014, 16:20

... This second phase was called the phase of excitation and damage by Nasonov's school Substantial changes in the cell in this phase are remarkably reminiscent of denaturation of isolated proteins; ... present paper will consider the meaning and significance of native tion as the universal structural basis of the active cell The basis of pathological states is aggrega-the inability of aggrega-the ... state of rest, means that nativeaggregation is completely reversible, and the structures appearing in the course of native aggregation are temporary and are disassembled as soon as they cease to

Ngày tải lên: 13/08/2014, 16:20

... mean APACHE II score was 20.9 and mean SAPS was 45.3 Those patients classified as GOS <3 had a mean APACHE II score of 17.9 and a mean age of 45.4; the mean APACHE II score for those classified ... classified as GOS >2 was 22.1, and their mean age was 38.3 Of the 27 patients included, one died of multi-organ failure in the acute phase as a result of his concomitant injuries This patient was ... Subdural haematoma, Epidural haematoma, Traumatic subarachnoid haemorrhage, skull fracture, skull base fracture, spine fracture Fentanyl, remifentanyl, midazolam, propofol, ketamin, esketamin,

Ngày tải lên: 13/08/2014, 20:21

... and 1.8308 and 1.8748 for the data of Coutinho et al [40] Pooled standard variations were unavailable in McBride et al [74] We have earlier assumed that normal and autistic groups have the same ... consistently measurable levels of free 5-Platelet levels as a function of α and γ Figure 2 Platelet levels as a function of α and γ Platelet 5-HT levels, ser(α, γ), plotted as a function of α (the factor ... that the bio-logical regulation of 5-HT release in the gut is simple The human gut is a remarkably complex organ that uses a wide range of neurotransmitters and that may have at least as many

Ngày tải lên: 13/08/2014, 23:20

... classed as financial contributions even though they are not within the strict meaning of the term.21 In a debate of Canada over two dispute cases, Canada – Dairy and Canada – Aircraft it was considered ... the Panel as the Appellate Body of the WTO has provided explanations thatcreate the general principles to be used in cases For example, in the case “Canada – Measures Affecting the Export of Civilian ... programs on ruraldevelopment, renewable energy and land conservation An amber subsidy is technically called the Aggregate Measurement of Support(AMS) and is subject to ASM reduction commitments as

Ngày tải lên: 18/08/2014, 12:35

... non-invasivetechnique for the diagnosis of CVT which is considered as a goldstandard and can replace invasive conventional cerebral angiographyand is used as a leading mean of diagnosis in case ... brain and lie in the subarachnoid space.They pierce the arachnoid mater and the meningeal layer of thedura and drain into the cranial venous sinuses Blood from bothbrain is drained by cerebral ... 44%,subacute onset was 35% and chronic onset was 21% In general, theonset characteristics of CVT are varied, but the majority of patientshave cubacute onset and our study data was equivalent to

Ngày tải lên: 21/10/2014, 21:52

... friends: Jiang Yi, Wang Tongshang, Mao Zhaohui, Wang Dan, Shi Yan, Zhao Chunyan, Yang Lili and Wu Yayun, for their friendship and the happy days we have been together Finally, I would like to thank ... Chapter five further investigates the syntactic distributions of micro-construction as well as their functions and meanings, based on which I put forward the synchronic grammaticali- zation analysis ... of how its form and meaning/function suited in a pair is emphasized in this chapter This leads to me to tackle the stratification and extension of this construction in chapter four, where I argue

Ngày tải lên: 09/09/2015, 17:57

... b-sandwich, a core (which contains a transamidation site and a Ca2+-binding site, and has a helices and b sheets in equal amounts), and two C-terminal b-barrel domains It has been suggested that glutamyl ... extrusion of TG4 from the coagulating gland [129] FXIII Coagulation FXIII is a plasma TG, and circulates in blood as a heterotetramer consisting of two catalytic A (XIIIA) and two noncatalytic B ... intracellular signalling and apoptosis, as well as in neurodegenerative and autoimmune diseases Consequently, its function may depend on its subcellular and cellular localization and on access to...

Ngày tải lên: 30/03/2014, 15:20

... (accepting) accepting and negative and neutral expresssions: activation accompanied by in amygdala, evaluation of: hippocampus, Task performance: parahippocampal recognition of gyrus, medial type of emotion ... conceptually and then experimentally Pharmacological Treatments and the Neurobiology of Social phobia The demonstrated efficacy of various pharmacological compounds reducing distress and avoidance has ... (noradrenaline, adrenaline, and/ or dopamine) and are assumed to reflect a pronounced and persistent increase in sympathetic activity Studies reporting performance-related elevations in noradrenaline and adrenaline...

Ngày tải lên: 01/11/2013, 08:20

... longitudinal study, although uTWEAK levels did increase as the flare approached, the peak was at the time of the flare rather than in advance of it As the measurements were based on a relatively small ... renal disease that dictates uTWEAK levels, as a significant association was found between LN activity as measured by the rSLEDAI, and uTWEAK (r = 0.388, P = 0.047) Urinary TWEAK is a marker of ... patient's renal disease activity is therefore highly desirable We show here that uTWEAK can serve as a biomarker of LN, both as a one-time measurement and as a means of monitoring individual patients...

Ngày tải lên: 09/08/2014, 14:22