applications in basic research and translational medicine

... homing and invasion process, including selectins and selectin-ligands, integrins and their receptors, and other cell-cell and matrix-binding molecules [240,242] However, ordered expansion and ... BCR/ABL-targeting tyrosine kinase inhibitors (TKI) induce major and long-lasting responses [203] Other similar treatment concepts are emerging in other types of cancers and leukemias as well as in lymphomas ... that in normal stem cells These factors include cytokines and cytokine-receptors, niche-related factors, including stem cell-homing and chemotactic molecules, pro- and anti-apoptotic molecules, and

Ngày tải lên: 02/11/2022, 09:03

... (glomerulus and Bowman’ capsule), the proximal tubule, the thin and thick ascending and descending limbs of the loop of Henle, the distal tubule and the connecting tubule (1) The remaining collecting ... the cell-containing cartridges and BAKs in clinical trials These issues will be discussed in more details in the following section 1.2 Development of BAKs and applications of HPTC in such devices ... up and perfusion culture 34 3.7 Treatment with recombinant BMP-2 and recombinantBMP-7 34 3.8 Treatment with human recombinant TGF- β1 and human recombinant A2M 35 3.9 Immunostaining and

Ngày tải lên: 09/09/2015, 10:19

... brain anatomy andintroduces some background information related to brain imaging and imaging analysis thatshall be used in the rest of the thesis We also present a review of related work in brain ... its Applications in Brain Structural and Functional Studies Jidan Zhong NUS Graduate School for Integrative Sciences and Engineering National University of Singapore A DISSERTATION SUBMITTED IN ... MM-LDDMM registration intothe average template generation in Chapter5and in the resting state functional MRI analysis inChapter6and7 Finally, in Chapter8, we list our conclusions and recommendations

Ngày tải lên: 09/09/2015, 18:53

... dividing tool to divide the input space into inlier and outlier sub-spaces and to use dedicated classifiers to handle the inliers and outliers in the corresponding spaces before non-linearly combining ... training patterns in the input space X needed to generate the I1 training samples for training the individual weak learner h2 I3 is used to denote the number of training patterns in the input ... effectiveness in preventing overfitting and its ineffectiveness in handling Trang 17input pattern space in the S-AdaBoost algorithm is analyzed followed by proposing the structure of an S-AdaBoost machine;

Ngày tải lên: 12/09/2015, 10:37

... MEMBRANES FOR APPLICATIONS IN WATER TREATMENT AND BIOENGINEERING HAN WEI NATIONAL UNIVERSITY OF SINGAPORE 2010 DEVELOPMENT OF NOVEL CHITOSAN-BASED HOLLOW FIBER MEMBRANES FOR APPLICATIONS IN WATER ... Changkun, Mr. Wee kinho, Ms. Han Hui, Ms. Liu Cui, Ms. Zhang Linzi, Mr. Zhu Xiaoying and Ms. Tu Wenting. In addition, I also appreciate the assistance and cooperation from lab officers and technicians ... WATER TREATMENT AND BIOENGINEERING HAN WEI (B. Eng., Tianjin University) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMICAL AND BIOMOLECULAR ENGINEERING NATIONAL

Ngày tải lên: 14/09/2015, 08:49

... University of Singapore for the award of research scholarship and Institute of Chemical and Engineering Science Ltd for the financial support to carry out the research work reported herein Finally, ... Teck-Chia, Ms Poon Yin-Fun and Dr Zhang Wei-Guang for their support and useful discussions; Dr Liu Shou-Ping, Mr Zou Yong, Mr Zhang Sheng, Xia Hai-Bing and Cheng Da-Ming for their advices and friendship ... in our collaboration on this research project presented in this thesis Their encouragements and suggestions help me very much in my research career My acknowledgement also goes to all peers in

Ngày tải lên: 16/09/2015, 08:30

... entering (in whole or in part) the cavity and forming noncovalent host-guest inclusion complexes Almost all applications of CDs involve complexation The mechanism of inclusion complexation in CE ... recognition is obtained mainly by charge-charge interactions, hydrogen bonding, hydrophobic inclusion and π-π interactions These interactions can be either attractive or repulsive Proteins also have ... of both anions and cations in one single run, using CZE in moving boundary electrophoresis In moving boundary electrophoresis, the separation system is filled with a so-called leading electrolyte

Ngày tải lên: 16/09/2015, 08:30

... care and assistance during the whole period Besides, I am indebted to all other faculty members of the Department of Industrial and Systems Engineering for their kind attention and advice in my ... SERVICES AND DISTANCE LEARNING ZHANG YU (B ENG.) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ENGINEERING DEPARTMENT OF INDUSTRIAL AND SYSTEMS ENGINEERING NATIONAL UNIVERSITY OF SINGAPORE ... 1ANALYZING SERVICE QUALITY VIA QFD AND SERVQUAL: APPLICATIONS IN ACCOMMODATION SERVICES AND DISTANCE LEARNING ZHANG YU NATIONAL UNIVERSITY OF SINGAPORE 2003 Trang 2SERVQUAL: APPLICATIONS IN ACCOMMODATION

Ngày tải lên: 29/09/2015, 13:01

... fluorophore and induces a marked increase in fluorescence Using a similar strategy, Imperiali and co-workers incorporated a chelation-sensitive sulfamido-oxine (Sox) unnatural amino acid into a kinase ... proteases and phosphatases, their subsequent development and have since branched into two major applications: i) high-throughput screening and ii) bioimaging Fluorescent assays employing coumarin-based ... enhancement is ineffective when the fluorophore diffuses away, leading to both an increase in fluorescence and MR signal in response to enzymatic activity In a similar vein, Xiong and co-workers incorporated

Ngày tải lên: 04/10/2015, 15:45

... subtopic in the course plan Questions below are intended to correspond to slides, in content and in ordering I appreciate hearing about questions that don’t correspond fully In certain versions ... returns an infinite quantity; (c) is defined; (d) is undefined; (e) is random Trang 96 When a function returns , it (a) returns 0; (b) returns an infinite quantity; (c) is defined; (d) is undefined; ... set of recursively-defined strings; (d) the same as regular expressions; (e) a set of proofs in predicate logic 24 An alphabet is (a) finite; (b) infinite; (c) finite or infinite; (d) uncountable;

Ngày tải lên: 08/12/2016, 20:47

... reduction, seeding, coprecipitation,and inverse microemulsion will be outlined Silica- and amino-coated nanoparticles are suitable for several applications in biomedicine and the environment The applications ... 434 bp for HBV in samples in lanes 1 and 3, and very bright bands of 434 bp for HBV in samples in lanes 2, 4, and 6 Meanwhile, no band was observed in the sample in lane 5 The data indicates that ... HBV were observed in the samples in lanes 2’, 4’, and 6’ However, intensities of those bands were weaker compared to those in the same samples in lanes 2, 4, and 6 obtained in the case of Fe3O4/SiO2

Ngày tải lên: 16/12/2017, 05:38

... receptor NLRP3 (NOD-, LRRand pyrin domain-containing 3) and the PYHIN (pyrin and HIN200 domain-containing) family protein AIM2 (absent in melanoma 2) are two PRRs that survilliance intracelluar DAMPs ... future  research.   The  book  is  targeted  at  researchers  and clinicians  who  are  interested  in learning  about  new  advances  in the  understanding and treatment of AMD, and insights into future research of AMD.  ... (Martinon et al., 2009) NLRs contain a central nucleotide-binding oligomerization domain (NACHT), an N-terminal effector domain (pyrin domain, caspase-recruitment domain or BIR domain) and C-terminal...

Ngày tải lên: 27/06/2014, 15:20

... DATA HANDLING IN SCIENCE AND TECHNOLOGY -VOLUME Advanced scientific computing in BASIC with applications in chemistry, biology and pharmacology DATA HANDLING IN SCIENCE AND TECHNOLOGY ... PRonSsING Classical mthods Interpolation Smmthing Differentiation Integratim Spline functions in signal prccessing Interpolating splines Smmthing splines Fourier transform spectral methods Continuous ... coefficients and interpolated valws Local cubic interpolation 5-pint cubic smoothing by Savitzky and Golay Determination of interpolating cubic spline Function value, derivatives and definite integral...

Ngày tải lên: 22/03/2014, 23:20

... Tissue Engineering Applications 33 3.1 Introduction As explained in chapter 1, inadequate vascularization is a major bottleneck limiting widespread clinical applications of tissue engineering, and ... bonds, and evaluated its efficacy in stimulating angiogenic signaling and vascular infiltration This study is described in detail in the following chapter 32 Chapter Incorporation of a PHI into ... in the late 1980s, its clinical applications remain limited mainly to thin or avascular tissues, such as skin, cartilage, and the cornea, due to difficulties in inducing adequate vascularization...

Ngày tải lên: 09/09/2015, 11:11

... 'Pluralism and Integration in the Indian and Chinese Medical Systems', in A Kleinman (ed.) Medicine in Chinese Cultures Washington D.C.: U S Government Printing Office, 401-417 1976 'Introduction', in ... within biomedicine and in late-capitalist production, and as a dominant organising principle in various forms of praxis in Western culture In spite of limitations in studies of elective affinity ... in China; and biomedicine, Ayurvedic medicine and Un ani medicine in India; and to the fact that all of these traditions include major medical texts, educational institutions, and professionalised...

Ngày tải lên: 22/03/2014, 20:21

... working in the area of women’s and children’s health, with a focus on adolescent sexual and reproductive health and increasing investment in family planning in the Pacific • Research interest in ... understanding & interpretation of common accounting reports, budgeting & financial analysis An introduction to basic economic theory relevant to clinicians & clinical managers, including funding ... issues in clinical research; sampling & inference; selecting items, reducing items & creating aggregate scores; inter-rater & intro-rater reliability & interval consistency of responses; assessing...

Ngày tải lên: 23/03/2014, 06:20

... molecules and cells, tissues and organs, individuals, and populations) The crossing of translational barriers (T1, T2, and T3) can be enabled using translational bioinformatics and clinical research informatics ... biomedical informaticians in translational medicine teams Biomedical Informatics Biomedical informatics is an over-arching discipline that includes sub-disciplines such as bioinformatics, imaging informatics, ... organizing and sharing data associated with clinical research[ 112,126], including those from HL7 and the Clinical Data Standards Interchange Consortium (CDISC) Within public health, the International...

Ngày tải lên: 18/06/2014, 16:20

... Advances in Wavelet Theory and Their Applications in Engineering, Physics and Technology (a) (b) Fig The original license plate candidate image is shown in (a) and prominent edges in the LP candidate ... image (a) and image (b) shows prominent edges (a) (b) Fig The original license plate candidate image is shown in (a) and prominent edges in the LP candidate are shown in (b) using single level ... divided into four parts These are input image normalization, edges enhancement using filters, edges finding and linking to rectangles using connected component analysis (CCA) and plate candidate finding...

Ngày tải lên: 27/06/2014, 00:20

... fingerprints only for improving the fingerprint retrieval efficiency 2.2 Exclusive fingerprint classification Exclusive fingerprint classification groups fingerprint images into some predefined ... patterns, mouse movements, and online behaviors Detailed examples and intriguing descriptions of biometric data-mining and its implications are presented in this chapter Continuing in the theme of privacy ... fingerprint configuration, as less than 5% of all fingerprints is arches Plain Arch is defined as a type of fingerprint in which ridges enter one side and 26 Biometrics - Unique and Diverse Applications...

Ngày tải lên: 27/06/2014, 06:20

... CT, and MRI scans are today usually 28 Brain Damage – Bridging Between Basic Research and Clinics done at defined intervals after birth in order to evaluate the timing and evolution of brain injury ... monitoring and intervention that underlie good obstetric care and underpin optimal fetal outcome including the lowest chance of brain injury occurring for any reason In the context of intrapartum ... slowing of fetal somatic and brain growth (intrauterine growth retardation) and increasing risk of acute placental insufficiency leading to fetal distress, again with the likelihood of hypoxia and...

Ngày tải lên: 28/06/2014, 12:20