androgen regulation of gene expression

... division Oncogene   Mutation in protooncogene Cancer-causing gene Effects:  Increase product of proto-oncogene  Increase activity of each protein molecule produced by gene  Ras gene: stimulates ... transforming a zygote Compare oncogenes, proto-oncogenes, and tumor suppresor genes What are the roles of the ras gene and the p53 gene? Chapter 18         Genes can be activated by inducer ... control of cellular functions The role of gene regulation in embryonic development and cancer Transcription Operon: Operon cluster of related genes with on/off switch Three Parts: Promoter – where

Ngày tải lên: 18/05/2017, 08:54

... Lecture Connections 28 | Regulation of Gene Expression © 2009 W H Freeman and Company CHAPTER 28 Regulation of Gene Expression Key topics: – DNA elements that control ... classes of promoters – Allows coordinated expression of different sets of genes • Binding other proteins (transcription factors) to promoters – These recognize promoters of specific genes – These ... post-translational modifications – Allows expression of a specific genes in response to signals in the environment Regulation by  Factors Regulation of Transcription in Eukaryotes • General transcription factors

Ngày tải lên: 15/06/2017, 20:50

... TỐ PHIÊN MÃ Trang 7Quorum sensingTrang 8Regulation of Porin Proteins by a Two Component Signal Transduction SystemTrang 9POSITIVE REGULATION OF GENE EXPRESSION – ĐIỀU HÒA DƯƠNG BIỂU HIỆN GEN“Bật” ... hiện ở operon lacTrang 18The lac operon allows the option of lactose utilization as a carbon source Trang 19NEGATIVE REGULATION OF GENE EXPRESSION – ĐIỀU HÒA ÂM BIỂU HIỆN GEN“Tắt” biểu hiện gen ... Trang 1ĐIỀU HÒA BIỂU HIỆN GEN – REGULATION OF GENE EXPRESSIONTrang 3CÁC VẤN ĐỀ CẦN TÌM HIỂU1 Điều hòa biểu hiện gen ở prokaryote 2 Điều hòa

Ngày tải lên: 09/09/2019, 10:52

... factors play an important role in regulating the expression of the stress-response genes Another level of regulation of gene expression is at the epigenetic level and involves modi fications either ... effects on the growth and development of plants (Abdeen et al 2010) Post-transcriptional regulation of gene expression Besides stress-induced regulation of gene expression at the tran-scription level, ... and in intracellular signal-ling Transcriptional regulation of gene expression A large number of genes are seen to be involved in the expres-sion of the stress phenotype (Xiong et al 2002, Shinozaki

Ngày tải lên: 07/10/2021, 01:20

... discovery of structural elements governing stability of mammalian mRNAs, the generation of an atlas of mammalian RBPs and the identification of target RNAs via high-throughput sequencing of cross-linked ... Posttranscriptional control of gene expression has recently moved into the focus of scientists working in various areas of life sci-ences This is owed to the discovery of miRNA-mediated gene silencing mechanisms ... target of both the ATM/Chk2 and the ATR/Chk1 branch of the DDR are members of the Cdc25 family of dual specificity phosphatases Phosphorylation-dependent inhibition of Cdc25 prevents activation of

Ngày tải lên: 04/12/2022, 16:01

... includes activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) and reorganization of the actin filament network Signaling of tumor-cells may further involve up-regulation of pore forming ... anti-androgen drug flutamide It was paralleled by and presumably accounted for a profound increase of store operated Ca2 + entry The effects required activation of Rac1 GTPase and reorganization of ... the up-regulation of Orai1 was virtually abrogated by Rac1 inhibitor NSC23766 and by disruption of the actin filament network with cytochalasin B. Orai1 contributes to the regulation of cell

Ngày tải lên: 22/09/2020, 23:09

... representation of differences in gene expression of adult and cord blood monocytes in response to LPSFigure 2 Heat map representation of differences in gene expression of adult and cord blood monocytes ... identifi-cation of the genes within clusters by visual inspection and subsequent functional analysis of genes within clus-ters (Figures 3A &3B) Figure 3A represents 110 genes of the same cluster ... organizastimula-tion of the elements in this representation provides a measure of the overall sim-ilarity of the dynamic behaviour of these samples The greatest temporal changes in gene expression for

Ngày tải lên: 11/08/2014, 08:21

... of a narrow genetic base, comparative gene expression profiling is an alternate way to identify pathways and genes regulating the stress response [2] Plants induce expression of a number of genes ... of microarrays and protein profiling has generated a lot of information on gene expression during stress response, conventional gene-by-gene analysis is needed to validate these claims Most of ... into 11 clusters based on their expression profiles (A), the SOTA clustering tree (B), expression profiles of SOTA clusters The expression profile of each individual gene in the cluster is denoted

Ngày tải lên: 12/08/2014, 03:21

... elucidate gene expression strategy in ampeloviruses The results indicate that transcription regulation of GLRaV-3 sgRNAs appears to be different from members of the genus Closterovirus An analysis of ... region are generally expressed higher than those ORFs that overlap or do not have an upstream nontranslated region With CTV, the cis-acting elements that regulate the level of expression of genes ... upstream of p7 and p4 Thus, it appears that p7 and p4 are unique to GLRaV-3 and counterparts of these genes are not present in other clos-teroviruses Additionally, the order of arrangement of CP

Ngày tải lên: 12/08/2014, 04:20

... fiber The agreement of the known expression of these genes with expression of these genes on microarrays vali-dated the microarray results Global analysis of gene expression Genes that vary greater ... numbers of genes However, it can be difficult tocomprehend the simultaneous change in expression of so many genes The use of GO provides a tool to grasp the meaning of the changes of expression of ... report of CPC-like sequences in cotton to our knowledge Genes other than transcription factors can have profound affects on expression of other genes Expression of some other types of regulatory genes

Ngày tải lên: 12/08/2014, 05:20

... Does smoking alter the gene expression pattern of GABAergic system genes in the respiratory epithelium? Assessment of our database of airway epithelial gene expression generated by micro-arrays ... enzyme in GABA synthesis, the correlation of GAD67 gene expression with MUC5AC expressions suggests that the up-regulation of airway epithelium expression of GAD67 may contribute to the increase ... of changes in GAD67 gene expression levels in large airways of 10 healthy nonsmokers and 12 healthy smokers D TaqMan confirmation of changes in GAD67 gene expression levels in small airways of

Ngày tải lên: 12/08/2014, 11:22

... surface expression of these genes Comparing the gene profiling of G3 versus G2, six genes stood out in our analyses (Table 3) Although G3 animals have not developed ANFH, their gene profile reflects ... only the genes with a change of ± 1.8-fold (FC = fold change) are represented due to the exhaustive list of genes Although rat exon array demonstrated a significant upregulation of 51 genes when ... in order to study the pathogenesis at an early disease stage Knowledge of the gene expression pattern and the events that contribute to the genesis and progression of ANFH in this rat model could

Ngày tải lên: 12/08/2014, 14:22

... analysis indicates that although the SLE risk haplotype of IRF5 is associated with high expression of the gene, cis-regulation of IRF5 expression is not enough to fully account for IRF5 association ... http://arthritis-research.com/content/13/3/R80 Page 4 of 12 Best genetic models of IRF5 cis-regulation The forward entry multiple linear regression process led to the identification of four best models, one for each of the data sets ... analysing IRF5 expression in blood cells from SLE patients did not find any signifi- cant effect of this SNP or of any of the functional polymorphisms [26]. These contrasting pieces of evidence

Ngày tải lên: 12/08/2014, 15:23

... effects of IFN-γ on IL-1βstimulated BDNF and NT-3 mRNA expression were studied at both and 48 h of stimulation with a combination of IL-1β (10 U/ml) and IFN-γ (0.1–30 ng/ml) The effects of IL-4 ... after 72 h of culture (not shown) Effects of IL-1β on neurotrophin mRNA and protein expression We next investigated the ability of the proinflammatory cytokine IL-1β to induce neurotrophin expression ... an involvement of COX in the induction of BDNF but not of NGF To test this, we evaluated the effects of the COXinhibitors indomethacin and NS-398 (both 10 µM) on the secretion of these two neurotrophins

Ngày tải lên: 12/08/2014, 16:20

... efficiency of proviral gene expression from an HIV-1 vector in four out of five experiments. As with all other methods of gene expression determination, puromycin resistance measures a threshold expression ... estimates on the efficiency of proviral gene expression using this method. Discussion In this report, we present a method to estimate the effi- ciency of proviral gene expression of retroviral vectors. ... cycle only if gene expression from the provirus occurs. Studying the efficiency of proviral gene expression can potentially yield insights into the biology of this impor- tant class of viruses.

Ngày tải lên: 13/08/2014, 09:20

... serotonergic neurons Using the FoxQ2 gene as marker of the apical organ and Mox as a Expression of Wnt genes in lithium and zinc treated embryos Figure 2 Expression of Wnt genes in lithium and zinc treated ... those exhibiting a minimal expression change of 1.3 and a significant reproducibility value (P value) of minimally e-3 from the set of all regulations We selected genes of good (P < e-5), medium ... draft of the sea urchin genome sequence verifies that the established gene catalog contains a tag for more than 50% of all sea urchin genes Out of a total of 28,944 predicted sea urchin gene Normal

Ngày tải lên: 14/08/2014, 07:21

... related expression data that demonstrate significant differen- tial expression of a single gene of interest or a list of signifi- cant genes related to a specific cancer type. Differential expression ... percentage of the total number of genes in the signature. 'Discordant Similarity' is the number of discordant genes expressed as a percentage of the total number of genes in the signature. ... to identify bio- logically related datasets on the basis of inherent properties of gene expression signatures. The use of expression profiles as biomarkers to predict dis- ease prognosis and outcome

Ngày tải lên: 14/08/2014, 07:22

... http://genomebiology.com/2007/8/9/R189 decreased expression of the GR NR3C1 gene, post-translational modification of GR protein, increased expression of GR antagonists, and decreased activity of GR transcription cofactors [37] ... gene expression In these analyses, the profile of expression of each gene across participants (denoted y) was first adjusted to remove any variance attributable to a covariate (based on the general ... prevalence of distinct leukocyte subsets within the mononuclear cell RNA pool [45-47], analyses of covariance (ANCOVA) were employed to adjust gene expression profiles for the relative prevalence of...

Ngày tải lên: 14/08/2014, 08:20

... regulate the expression of genes in Arabidopsis We predicted six general models that could describe the possible modes of gene regulation due to carbon, nitrogen and CN together Three of these models ... qualitatively compare gene- expression profiles across multiple treatments For each gene, each treatment is assigned a value representing the effect of the treatment on the expression of that gene Treat- ... classes represent a broad spectrum of expression patterns that validate each of the six general models for gene regulation This analysis shows that of the 3,652 genes in the analysis, the vast majority...

Ngày tải lên: 14/08/2014, 14:21

... regions of the Sall4 gene in ES cells 106 Figure 3.24 Esrrb binds to Oct4 gene in ES cells 107 Figure 3.25 The regulation of Esrrb on ES cell-associated genes 108 Figure 3.26 Expression profiles of ... region of Sox17 gene in ES cells 122 x Figure 3.31 Esrrb binds to Gata6 gene in ES cells 123 Figure 3.32 The regulation of Esrrb on developmental genes 125 Figure 3.33 Expression profile of Jmjd3 ... mapping of Esrrb binding sites 3.4.3 Distribution of Esrrb binding and gene expression profiling 3.4.4 Functional relevance of the target genes 3.4.4.1 Esrrb binds to ES cell-associated genes 3.4.4.2...

Ngày tải lên: 12/09/2015, 08:19