analysis of transcriptional regulatory networks in cancer research

... of carrot In addition, transcript levels of genes related to gibberellins, auxin, cytokinins, abscisic acid and brassinolides were altered in response to increased or reduced gibberellins Conclusions: ... development of carrot We attempted to gain novel insights into GA functions in carrot growth based on transcript profiles of genes involved in hormone metabolic and signaling pathways Morphological and ... levels of genes involved in auxin, cytokinin, abscisic acid and brassinolide metabolism Error bars represent the standard errors among three independent replicates Data are the means ± SD of three

Ngày tải lên: 26/05/2020, 20:33

... immune response, regulatory region DNA binding, pro-tein binding, sequence-specific DNA binding, transcrip-tion factor activity, sequence-specific DNA binding, cadherin binding involved in cell-cell ... also involved in the tumorigenesis and progression of cancers, including colorectal cancer, Fig 4 The prognostic value of IRFs in pancreatic cancer A The overall survival of pancreatic cancer patients ... genetic alteration of IRFs in pancreatic cancer A Correlation heat map of each member of IRFs in pancreatic cancer B Summary of genetic alterations of IRFs in pancreatic cancer C Overall survival

Ngày tải lên: 30/01/2023, 20:31

... coverage, the equality in (61) must hold, and thus,PS is reduced to (18), completing the proof Inserting (41) and (42) into (44), one obtains (62) whereGB andCB are defined in (46) and (48), respectively ... M.S degrees in Telecommunica-tions Engineering from HoChiMinh City University of Technology (HCMUT), Vietnam, in 2001 and 2003, respectively, and the Ph.D degree in Electrical Engineering from University ... effect of CII and primary interference in UCCNs This strategy selects the relay SRb that obtains the largest end-to-end SINR5, i.e b = arg max k∈Kmin (γSk1, γkD2) , (8) where γkD2 is the SINR of

Ngày tải lên: 16/12/2017, 07:59

... by lining up wave packet selection with the beginning of each swing phase, we captured the contraction of the muscle over the course of the swing 3 Theory of Application of Time-Frequency Analysis ... number of injuries and deaths and the economic impact of falls continue to rise, the greatest cost is in the loss of mobility, independence, and autonomy in the later years of life Examining methods ... States in 2000 [2], and is one of the significant factors for unintentional injury resulting in death in people aged 65–85 As the number of older adults increases, the number of fall-related injuries

Ngày tải lên: 06/10/2018, 07:52

... Management in Research and Development: An Analysis of Public / Private Partnerships in Ireland” Dissertation submitted in part fulfilment of the requirements for the Degree of Masters in Business Administration ... Management) at Dublin Business School James Hayes August 2016 Name of Institution: Dublin Business School Programme of Study: Masters In Business Administration (Project Management) Year of Submission: ... Risk Pertaining to Availability of Resources 38 7.5 Risks pertaining to Suitability of Resources 39 7.6 Risk Pertaining to Stakeholder Alignment 41 7.7Risks pertaining to Research

Ngày tải lên: 09/01/2020, 17:44

... Quantification of anthocyanidins We quantified six anthocyanidins (delphinidin, cyanidin, pelargonidin, peonidin, malvidin, and petunidin) known to be involved in color development Two high contents of malvidin ... se-quences of the C cultivar, and analyzed the DEGs in different flower development stages of C and M using Illumina sequencing platform We obtained 140,995 isoforms, including 513 novel isoforms ... contents of malvidin and petunidin were detected in C-S4, the anthocya-nidins were detected in the cream flowers of M-S4 (Fig.1b) Sequencing and analysis of the floral transcriptome using the PacBio

Ngày tải lên: 16/05/2020, 20:01

... production of the two anti-cancer bisindole alkaloids vinblastine and vincristine [61] cyp83B1 is involved in the biosynthesis of gluco-sinolates, which have anticancer and flavoring functions ... in the cluster analysis Trang 4phenolics and methionine are involved in conferringthermotolerance in R stricta The results of starch and sucrose metabolism pathway indicated the involvement of ... and downregulation of transcripts encoding U-box containing proteins likely contributed to thermotolerance in R stricta leaf by correcting protein folding and preventing protein degradation Transcription

Ngày tải lên: 22/05/2020, 05:01

... in blocking ethylene biosynthesis and preventing woolliness in peach More-over, the transcriptional reprogramming of auxin biosyn-thesis and signaling genes in response to exogenous GA may indicate ... underlying the prevention of chilling injuries in peaches by the application of GA at the initial stages of pit hard-ening, coupling physiological analyses of a responsive cultivar to global transcriptional ... the initial stages of pit hardening impairs woolliness incidence, however the mechanisms controlling the response remain unknown We have employed genome wide transcriptional profiling to investigate

Ngày tải lên: 26/05/2020, 20:19

... complex networks of transcriptional regulation in tree growth [14] However, most studies about genome wide analysis of TFs in plants concentrate in a few species, such as Arabidopsis and kinds of ... Phylogenetic analysis of TFs in the paper mulberry Genetic distances were calculated according to the align-ment of the conserved domain of the three TFs families chosen from 9 species including the ... growth are mediated mainly by the interplay between cytokinin and auxin Cytokinin activates ARR-B TFs which promote the expression of SHY2 and affects auxin signaling path-way [37] ARR10 and ARR12

Ngày tải lên: 27/05/2020, 00:56

... participating in inferred interactions are expressed in roots An important question regarding our networks is to deter-mine if the TFs participating in the inferred interactions Trang 3are actually being ... mechanism involving protein-protein interactions, protein phosphorylation and protein degradation [64] It is Table 3 List ofANAC030/VND7 interactors in the FullNet obtained at DPI 0.0 MI: mutual information ... patterning via transcriptional regulation of, or protein-protein inter-actions with SHR and SCR The second pathway involves auxin signaling through the activation of as yet unidentified Auxin Response

Ngày tải lên: 27/05/2020, 01:42

... China Full list of author information is available at the end of the article Trang 2Increasing evidence indicates that the tumour phenotypeis shaped not only by the intrinsic properties of cancer ... significant advances in understanding cancer biology, including the functional role of the TME, the treatment of patients with BC still remains challenging As migration of immune cells into the tumour ... Identification of protein-protein interactions (PPIs) of DEGs Identification of protein complexes and functional mod-ules was performed by constructing PPI networks using an online database resource

Ngày tải lên: 17/06/2020, 11:41

... including tes-ticular and ovarian cancer Evaluation of long-term risk of second cancers due to cisplatin-based chemotherapy has become increasingly important in the context of the large number of ... eligible for inclusion (Fig 1) [20–47] Two studies included multiple cisplatin arms, which were combined for this analysis Of the 28 RCTs, 2 trials reported no incidence of any second cancers in both ... consisted of other platinum-based therapy in eight trials (carboplatin, 7; oxaliplatin, 1) and non-platinum-based therapy in 20 trials The leading underlying malignancies were head and neck cancers

Ngày tải lên: 23/07/2020, 23:48

... the Fig 4 Diagram showing a summary of HSPs expression grouped in subfamilies in breast cancer according to the intrinsic molecular subtypes. In the figure, the diameter of the circles shows the ... various proteins including actin and tubulin upon ATP hydrolysis and, as part of the BBS/ CCT complex, they are involved in the assembly of the BBSome, which in turn is implicated in ciliogenesis ... are clinical trials for various can-cers, including BRCA, using HSP-inhibitor compounds gathered from diverse studies regarding the role of the HSPs in different situations associated with cancer

Ngày tải lên: 24/07/2020, 01:51

... cycles of 1 min of denaturing at 95 °C, 1 min of anneal-ing at 60 °C, and 1 min of extension at 72 °C The insertion and deletion alleles were detected by amp-lifying genomic DNA with the following ... rs17227231 which is linked with an r2= 92 to rs17227210 could change the protein bind-ing of GATA3 (GATA bindbind-ing protein3) as well as the transcription factor binding site of GATA GATA3 was ... effect in splicing The variant C do not bind SF2/ASF which is involved in alternative mRNA splicing It is a member of the serine/arginine rich protein family and was found to be up regulated in diverse

Ngày tải lên: 21/09/2020, 02:06

... C-terminus of initiation factor 4E-binding protein contains multiple regulatory features that in uence its function and phosphorylation Mol Cell Biol 23, 1546–1557 Regulatory motifs in 4E-BP1 34 Gingras ... Previous work has shown that mutation of the phenylalanine to alanine in the TOS motif eliminates the binding of raptor to the C-terminal fragment of human 4E-BP1 in the overlay assay [19] (see also ... C-terminus of 4E-BP1 that are involved in its binding to raptor The data for the other truncation mutants shown in Fig 1C indicate that other regions of 4E-BP1 also contribute to stable binding...

Ngày tải lên: 16/03/2014, 06:20

... over 100 random trials, in which the interactions of both networks are reassigned while maintaining the same number of interactions per protein, resulting in a distribution of random subnetwork ... HTP networks [55] To reveal potential bias in the extent of investigation of any given node in the LC datasets, we determined the number of total interactions (that is, including redundant interactions) ... spawned a host of functional genomic tools for interrogation of gene and protein function, including DNA microarrays for global gene-expression profiling and location of DNA-binding factors, and...

Ngày tải lên: 06/08/2014, 18:21

... based on areas of the raw spectra, averaging of technical repeats, binning of neighboring points to reduce data complexity, removal of the spectral area below baseline and normalization of the total ... identifying subgroups of patients with different patterns of changes in intensities of spectral components in time (between samples B and C) In this analysis the procedure of unsupervised clustering ... question of detecting therapy-related changes in the mass profiles registered for blood samples collected from breast cancer patients SELDI-ToF analysis of the plasma proteome of breast cancer...

Ngày tải lên: 18/06/2014, 16:20

... evaluation of the spectrum-sharing mechanisms, but also provides a clue for future researches on strategies of primary and secondary systems in joint leasing and sensingbased CRNs The interactions ... probabilities in the NP mechanism is presented in Appendix B The main purpose of deriving the steady-state probabilities is to evaluate the performance metrics in the joint leasing and sensing-based ... delay of SU T Delay-su , mean waiting time of PU t wait-pu , and blocking probability of PU P BL-pu The expressions of these metrics are described as follows We define f(i) ≡ min(N-i, N-R) Page of...

Ngày tải lên: 20/06/2014, 22:20

... large data set involving sampling of many variables, instead of examining convergence based on [26, chapter 11.6], we adopted a more practical strategy by running a single MCMC chain for 10000 ... the corresponding elements in loading matrix must be nonzero This may overwhelmingly constrain the loading matrix, resulting the MCMC chain gets trapped in a local mode (Figure 6(c)) In the next ... noise increases, the bias of the minimum mean square estimates (MMSE) of X increases (Figure 4(a)), the mean squared error (MSE) of the MMSE of X also increases (Figure 4(b)), and the clustering...

Ngày tải lên: 21/06/2014, 16:20

... improved accuracy of Boolean network esimation Using the theoretically grounded stochastic complexity instead of ad hoc encodings genuinely reflects the intent of the MDL principle In addition, the ... Remarks Using a universal codelength when applying the MDL principle eliminates the relativity of applying ad hoc codelengths and user-defined tuning parameters In our case, this has resulted in improved ... findings, we recommend using the SF primarily for networks composed of canalizing functions and networks too large to run NML MDL with fixed K in a reasonable amount of time We also suggest using...

Ngày tải lên: 21/06/2014, 22:20