an emerging trend in tuberculosis drug development

... Trang 1R E S E A R C H A R T I C L E Open AccessThe design, analysis and application of mouse clinical trials in oncology drug development Sheng Guo1* , Xiaoqian Jiang1, Binchen Mao1and Qi-Xiang ... processes Protein-protein interaction network analysis A list of top ranked genes were analyzed for protein-protein interactions in the STRING database (version 10.5 at https://string-db.org) [23] ... readouts, handling of mouse drop-outs, missing data and difference in tumor growth rates, study of mechanisms of action (MoA) for drugs We will also show MCTs can explain discrepant clinical trial

Ngày tải lên: 17/06/2020, 16:45

... Vietnam in teaching and assessing English in high school also shows the trend of standardization in foreign language teaching in general and English in particular (6) Ensure flexibility The point ... through listening, speaking, reading, and writing The point of view of building a curriculum in the direction of developing learners' competencies is one of the current prominent trends in many countries ... presented for an educational and training activity of a course in a specified period, and can show the following four factors: 1) Training objectives clearly show learning outcomes; 2) Training content

Ngày tải lên: 22/09/2022, 12:14

... invites articles regarding career counseling, individual and organizational career development, work and leisure, career education, career coaching, and career management Methodologies can include ... coherently and writing is clear and concise Avoid jargon, acronyms, and sexist terminology Headings and subheadings should be used to structure the content Article titles and headings in the articles ... figure) and should contain a clear and concise summary of the study (including rationale, objectives, design, instruments, sample, analyses, results, and implications for research and practice) Manuscripts

Ngày tải lên: 18/10/2022, 20:29

... Organizations routinely succeed in identifying and promoting these individuals as leaders because they are easy to recognize Individuals in this quadrant understand the importance of learning, ... leaders), that would be linked to Quadrant 4 Likewise, disagreeing would be linked to Quadrant 3; agreeing to Quadrant 2; and strongly disagreeing to Quadrant 1 The linking is balanced across the 40 ... a large role in influencing leader selection and effectiveness within an organization, the model suggests that individual characteristics alone provide an incomplete picture and in fact only

Ngày tải lên: 20/10/2022, 07:57

... making, and educational planning (Robinson, 2015) Trang 32In addition to functions and intended outcomes, common academic advising frameworks include developmental advising, intrusive advising, ... support me, and for inspiring a new world of advising and coaching in higher education I especially thank my husband, Matt Robinson, and daughter, Laura Robinson, for all your love and encouragement ... experienced individual in an organization and a junior, less experienced colleague” (p 2) Defining characteristics of mentoring include establishing a longstanding relationship (quantified as

Ngày tải lên: 02/11/2022, 00:48

... alternative and sustainable technique in terms of minimal water exchange and reduced feed input making it a low-cost sustainable technology for sustainable future aquaculture development (Avnimelech and ... of the biofloc and reported that bioflocs have a better essential amino acid index (0.92–0.93) with histidine and taurine as the most abundant amino acids However, arginine and lysine were found ... performance in terms of fecundity, spawning, and egg biochemical composition in Farfantepenaeus duorarum and L Vannamei (Emerenciano et al.2012a,2014) Tilapia culture inactivated suspension ponds indicated

Ngày tải lên: 19/11/2022, 11:46

... findings, and assessment of impact.9 Academic librarians participating in any type of research would have more knowledge and skills that prepare them to be partners than those not involved in ... in data management remain low, a majority anticipate future involvement.13 Ann Morgan, Nel Duffield, and Liz Walkley Hall point out that a significant trend is for libraries to work in conjunction ... global rank-ings by such international bodies as the Academic Ranking of World Universi-ties of the University of Shanghai, Scimago Institutions Rankings, or the Times Higher activity and publications

Ngày tải lên: 16/12/2021, 16:28

... policy Ceiling rate on deposit and loan rate imposed by central bank induces to severe credit rationing in formal financial sector Resulting from inter-linkage between formal and informal financial ... plan such as urban development policy, real estate institution, housing development and housing finance With· housing finance, the authority specifies two aspects are municipal housing fund and ... demand of house and housing system in urban VietNam - The demand of housing loan of urban household - The_ of housing credit program for urban household including· probability of credit and

Ngày tải lên: 26/05/2015, 08:40

... economies." Incentives and expectations play a vital role in the financial world that is infamous for uncertainty Institutions form the foundations and facilitate a well-functioning currency and banking ... is 50% in 2007, 34% in 2008 and estimated 30% in 2009 by Economist Intelligence Unit After the booming in stock and real estate market in 2007 with capital inflow mainly for portfolio investment, ... averse investors invest in several countries Financial diversification and lender's information have an interesting relationship Investors with highly diversified portfolio have lower incentives

Ngày tải lên: 26/05/2015, 08:42

... within-host-country strategy and structure in a single emerging market Second, China is an emerging market in which the government preserves an active involvement in business affairs (Peng, 2000), in which there ... of many emerging markets in terms of scale and substance (Peng, 2003) Accordingly, the year 1979 serves as a clear starting point for examining MNEs’ within-China strategy and structure during ... facing in emerging markets by differentiating the isomorphic mechanisms and discriminating isomorphic origins I argue that the adoption of a foreign group subsidiary among MNEs in an emerging

Ngày tải lên: 12/09/2015, 10:54

... where managers pursue private benefits at the cost of the shareholders‟ interests In continental Europe and Japan, ownership is highly concentrated in the hands of main banks and financial institutions ... issue opinions, guidance opinions, and other non-legally binding guidance for listed companies For example, in 2001, the CSRC issued the Guidance Opinions on the Trang 27Establishment of an Independent ... shares are held in private hands, and an increasing number of stakeholders are willing to take an active role in monitoring dominant shareholders‟ behavior By the end of 2008, the China stock market

Ngày tải lên: 12/09/2015, 11:24

... finishing process to obtain a high degree of dimensional accuracy and surface finish on a part Grinding is used in a large and diverse area of manufacturing and toolmaking It can produce very fine ... surface finish and form accuracy using grinding, it is an obvious requirement to have the grinding wheel dressed in-process There are several methods of in-process dressing of the grinding wheel, ... during the grinding process to achieve stable grinding The above mentioned technologies for in-process dressing of grinding wheel have their own advantages and disadvantages The comparative analysis

Ngày tải lên: 14/09/2015, 08:44

... mirror internal surface on an ordinary grinding machine by applying ELID 2 grinding Electrode-less ELID (ELID 3) ELID 2 system has an inherent drawback of extra dressing time, for which the grinding ... that ELID grinding produces much lower grinding force because of the insulating oxide layer produced during in-process dressing The simulated grinding force and the experimental grinding force ... conventional grinding without ED truing and ELID 2.2 ELID Grinding The best known method for super abrasive grinding wheel dressing is electrolytic in-process dressing (ELID) grinding which was

Ngày tải lên: 14/09/2015, 08:44

... Trang 1Chapter 3 Development and performance evaluation of an intelligent ELID grinding machine 3.1 Introduction Nano-scale surface finish with no subsurface defect is a principal requirement ... transparent surface on hard and brittle materials Loading, dulling and shedding frequently occur while grinding hard and brittle materials like glass with super fine abrasive grinding wheel and ... without any post-grinding polishing process because of its inherent ability to overcome loading, dulling of the wheels So introduction of ELID grinding can be considered as a milestone for generating

Ngày tải lên: 14/09/2015, 08:44

... workers; and the extension of social insurance to rural–urban migrants” To avoid overcrowding in the major cities such as Beijing and Shanghai, the government is building infrastructure and rewarding ... Huang, Y 2005, ‘Urban Housing in China: Market Transition, Housing Mobility and Neighbourhood Change’, Housing Studies, Vol 21, No.5, 613-623, September 2006 Manquand, R 2004, ‘China’s peasants ... urban China has significantly influenced business opportunities for organizations doing business in China on both the supply and demand side The future economic growth of China is reliant on the...

Ngày tải lên: 27/06/2014, 23:20

... increasing feed angle may be attributed to an increase in the initial band width An increase in the feed angle increases the first and second moments, which are related to the elution angle and ... 81 Mg2+-independent Neutral Sphingomyelinases 84 Alkaline Sphingomyelinase from the Intestinal Tract 85 Bacterial Sphingomyelinase-phospholipase C 85 Sphingomyelinase Mechanism 85 Binding of Magnesium ... Ions 85 Binding of Substrate 85 Mechanism of Catalysis 86 Sphingomyelinase Assay 88 Sphingomyelinase Inhibitors 89 Sphingomyelinase–Membrane Interactions 89 Lipid Effects on Sphingomyelinase Activity...

Ngày tải lên: 17/02/2014, 05:20

... products and services that support continue to improve their capabilities Knowledge Management: An Emerging Discipline Rooted in a Long History and can participate in creating and supporting innovations ... relevant support information and knowledge, making preliminary sense of the situation, and locating and presenting suggestions for how it should be handled Knowledge Management: An Emerging Discipline ... concepts inherited from prior generations References Austin, Robert D (1996) Measuring and Managing Performance in Organizations New York: Dorset House Bechara, Antoine; Damasio, Hanna; Tranel, Daniel;...

Ngày tải lên: 23/03/2014, 23:21

... path to investigations of synchronous gating and the role of oscillations in generating and maintaining a stable phenotype Are equal numbers of genes transcribed at all points in the cycle? In their ... reported an oscillation in oxygen consumption in the 40-min range The CEN.PK strain cells in our hands have a period that varies, quantally between and h The report from Tu et al [16] describes an ... determining such relationships If by treating cells with a drug such as phenelzine and following the changes that occur in the surface as the system responds, we have at least the beginnings of...

Ngày tải lên: 30/03/2014, 04:20

... The information to be obtained includes rubber production information in the border areas in China, rubber trading and marketing in the Lao-Chinese border, and current and future demand and supply ... growth in China’s demand for rubber is influencing the Chinese investment in rubber planting in northern of the Lao PDR and is very likely influencing the Vietnamese proposals for rubber plantation ... rapidly in Lao PDR, the Government and different international organisations, including institutional arrangements, planning, policy, regulation and the information, are paying great attention and...

Ngày tải lên: 31/03/2014, 09:21

... Combinatorial Mixture Screening / 103 In Vivo Drug Screening / 106 Pharmacokinetics / 109 In Vitro Drug Screening / 115 Metabolic Stability Screening / 118 Membrane Permeability / 119 Drug- Drug Interaction ... of academic, instrument manufacture, and industry 10 INTRODUCTION interests However, the current industry trends highlight the tremendous challenge of drug development and an expanding need for ... establishing efficacy, determining the effective dose range, and obtaining safety and tolerability data In phase II, the dose and dosing interval to be employed in the patient population and the...

Ngày tải lên: 11/04/2014, 07:01