an attractor model of lexical conceptual processing

... Activation of the transcription factor nuclear factor kappa B (NF-B) controls the transcription of many acute-phase proteins and inflammatory genes both in humans and rodents, and is one of the ... However, despite advances in our understanding of depression, resistance is still a significant challenge for clinicians and their patients, with non-response in at least one-third of cases [3] Exposure ... decide to study the main com-ponent of the anti-inflammatory mechanism: levels of 15-deoxy-Δ12,14 -prostaglandin J2 (15d-PGJ2), an anti-inflammatory product of COX-2, were decreased in pre-frontal

Ngày tải lên: 19/06/2014, 22:20

... osteo-clastogenesis and angiogenesis [17] In the current study, during the course of the establish-ment of a pasteurized bone model in rats, a preliminary analysis of the effect of the presence of muscle-covering ... graft matrix [5] Other advantages of the method include a precise ana-tomical fit, and no risk of disease transmission or immu-nological reaction [4-10] Regardless of such advantages, clinical problems, ... osteoprogenitor cells, and it plays an impor-tant role in bone metabolism and in the regulation of osteoblastic cell proliferation and differentiation [13-16] Furthermore, FGF-2 also plays an important role

Ngày tải lên: 20/06/2014, 04:20

... in expession of types I, II and III collagen, aggrecan, biglycan and lumican, concomitant with downregulation of decorin and connective tissue growth factor The increases in type I and III collagen ... collagens types I and III and a change in the relative levels of the fibril-associated SLRPs In particular there is decrease in synthesis of decorin and an increase in biglycan and lumican, with the ... thank Diana Pethick of Murdoch University for her assistance with the animal handling and care. References 1. Maroudas AI: Balance between swelling pressure and collagen tension in normal and

Ngày tải lên: 09/08/2014, 06:23

... Groningen, Netherlands.2Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada. Authors ’ contributions BGJD: design of the study, acquisition of data, data analysis and interpretation, ... represent means ± SEM of 5-7 animals. Trang 9Figure 5 Effects of immobilized and soluble YIGSR on basal and PDGF-induced human ASM cell proliferation (A) Culturing of human ASM cells on immobilized ... interpretation, manuscript writing; ISTB: design of the study, acquisition of data, data analysis and interpretation; AJH: preparation of ASM cell lines and critical revision of the MS; JZ: design of the

Ngày tải lên: 12/08/2014, 13:22

... demonstrated and the mechanisms of virus-induced exacerbations are poorly understood Development of a human experimental model would provide evidence of causation and would greatly facilitate understanding ... Levels of IL-6 and IL-8 in nasal lavage Figure 4 Levels of IL-6 and IL-8 in nasal lavage (A) Time course of IL-6 (B) Time course of IL-8 (C) Mean levels of IL-6 in nasal lavage when stable and at ... obstruction and less reversibility and are smokers or ex-smokers To investigate the feasibility and safety of developing a model of COPD exacerbation and to investigate a causa-tive role of virus

Ngày tải lên: 12/08/2014, 16:20

... g; Harlan Nossan; Italy) were housed in a controlled environment and provided with standard rodent chow and water Animal care was in com-pliance with Italian regulations on protection of animals ... the figures and text are expressed as mean ± standard error of the mean (SEM) of N observations For the in vivo studies N represents the total number of ani-mals studied, dead aniani-mals were ... Lungodegenti, University of Messina, Messina, Italy and 4 Department of Clinical and Experimental Medicine and Pharmacology, Catania, Italy Email: Marco Failla - marcofailla@yahoo.it; Tiziana Genovese -

Ngày tải lên: 12/08/2014, 16:20

... presented as mean ± standard error of the mean. Trang 7Figure 4 Antinociceptive effects of NASHA, Hylan GF20 and sodium hyaluronate during an observation period of 56 days (a) Primary mechanical hyperalgesia ... long-term antinociceptive effects of HA preparations can be assessed in an animal model of joint pain based on the repeated intra-articular injection of bradykinin and PGE Trang 10Injection of these ... between NASHA and Hylan GF20 as well as between NASHA and sodium hyaluronate Data are presented as mean ± standard error of the mean (a and c) + comparison between NASHA and Hylan GF20 * comparison

Ngày tải lên: 12/08/2014, 17:22

... effects of inhaled iloprost on RV afterload and contractility in animals with and without blockade of the ANS The effects of inhaled iloprost on RV afterload and contractility in animals with and ... were analyzed using Friedman's analysis of variance, the Mann-Whitney U-test and the Wilcoxon signed rank test In all conditions, a P value < 0.05 was considered statistically significant Results ... sample size of five pigs to detect a 33% effect in mean PA pressure and RV-Mw, when a level of significance of 0.05 and a power of 80% were to be achieved Results were statistically analyzed using

Ngày tải lên: 13/08/2014, 11:22

... role of Ado as an angiogenesis modulator by enhancing VEGF activity and antagonizing sVEGFR-1 Results: We implemented an algorithmic model of angiogenesis consisting of the dynamic interaction of ... Trang 1R E S E A R C H Open AccessProof-of-principle investigation of an algorithmic model of adenosine-mediated angiogenesis Francisco Azuaje1*, Frédérique Léonard1, Magali Rolland-Turner1, ... reformulation of some aspects of our hypothesis about the combined effects of Ado, VEGF and sVEGFR-1 Methods Model foundations and study phases A pivotal conceptual premise of our model is that

Ngày tải lên: 13/08/2014, 16:20

... manuscript LDL: Animal preparation, performance of experimental work, analysis of the mechanical and morphometrical data CMD: Animal prepara-tion, performance of experimental work, analysis of ... GPO: Animal preparation, performance of experimental work, analysis of the mechanical and histological data, statistical analysis, writing of the manuscript MBGO: Animal prepara-tion, performance ... performance of experimental work, preliminary analysis of the data, helped to draft the manuscript RSS: Animal prepa-ration, performance of experimental work, analysis of the mechanical data,

Ngày tải lên: 13/08/2014, 16:20

... of the peroxynitrite-PARP pathway Rosanna Vaschetto*1,2,3,4, Jan W Kuiper2,4, René JP Musters4,5, Etto C Eringa4,5, Francesco Della Corte1, Kanneganti Murthy6, AB Johan Groeneveld3,4 and Frans ... (Harlan CPB, Zeist, The Netherlands) with a mean weight of 310 ± 10 g, were anesthetized with a bolus of 60 mg/kg pentobarbital sodium (Nembutal; CEVA Santa Animale BV, Maassluis, The Netherlands) ... Values represent median (interquartile range). Trang 7These observations may warrant a discussion of potentialcause-effect relations in a complex model of inter-organ crosstalk The model was characterized

Ngày tải lên: 13/08/2014, 20:21

... Transcription of the LHX3 gene produces two mRNA transcripts from which three protein isoforms are translated The LHX3a and Trang 35LHX3b isoforms result from alternate use of exons Ia and Ib and therefore ... development and expansion of Rathke’s pouch and the proper expression of HESX1 and PROP1 during pouch development These mice also reveal the importance of PITX2 for the appropriate differentiation of ... DISCUSSION AND CONCLUSIONS 71 BIBLIOGRAPHY 85 VITA 101 Trang 10LIST OF FIGURES 1.1 Development of the anterior pituitary gland within mammals 25 1.2 Transcriptional regulation of anterior pituitary

Ngày tải lên: 24/08/2014, 13:00

... Integrated Model of Internationalization 21 2 An Integrated Model of SMEs Internationalization 25 3 An Integrated Model of SMEs Internationalization 41 Trang 84 International Business Activities of Singapore ... Italian “SMEs Incentive Law” that measures the size of SMEs by number of employees and/or volume of Trang 13Wilson committee and the UK Companies Act define small firms in term of their annual ... to gain access and possibly direct and indirect control of resources The resources can be both tangible and intangible (Holmlund and Kock, 1995) They can be personnel resources, software resources,

Ngày tải lên: 28/09/2015, 13:38

... ratio and profitability and positive on tangibility and log of sales The effect of the financing deficit is significant but it does not have much effect on the magnitudes and significance of the ... Mr Nguyen Xuan Thanh and Mr Truong Dang Thuy for their guidance in conducting this thesis My special thanks go to Mr Nguyen Xuan Thanh for his valuable guidance, critical comments and warm support ... descriptions of variables in the studied model and data to conduct the analysis Chapter IV presents the overview of food processing industry and the results of the analysis including descriptive and

Ngày tải lên: 29/11/2018, 23:53

... Taiwan 4 School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan 5 Department of Cell Biology and Anatomy, National Cheng Kung University, Tainan 701, Taiwan 6 Department of ... including the cortex, basal ganglia, thalamus, hippocampus, cerebellum and brain stem 4.7 Statistical analysis All results were presented as mean ± standard error of the mean, and the Student t test ... Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1988; 8: 186-92 17 Huang NC, Wei J, Quast MJ A comparison of

Ngày tải lên: 15/01/2020, 21:52

... integrating quantity discounts and transportation costs Although these EOQ promotion models enhance the range of application of inventory management, and expand the application of inventory theory, they ... [15] Weng, Z K., “Channel coordination and quantity discounts”,Management Science, 41(9) (1995) 1509-1522 [16] Yang, W T., and Chu, L C., “Anintegratedplanning ofproduction anddistribution formultiple ... discontinuous transport cost model Jain and Saksena [9] discuss time minimize transportation problems Hoque and Goyal [8], Norden and Velde [12] considered the economic bulk model of transport cost

Ngày tải lên: 04/02/2020, 01:54

... Trang 3To give attention on the concept of variability of the holding cost of decaying item, Tyagi et al (2012) developed an inventory model for decaying item withpower demand pattern and managed ... the discrete change in the holding cost under considering environment of inventory set-ups Tripathi (2013) studied an inventory model for time varying demand and constant demand; and time dependent ... where demand is price reliant and partial backorder permitted is discussed Liao and Huang (2010) developed a deterministic inventory model for deteriorating items with trade credit financing and capacity

Ngày tải lên: 14/05/2020, 21:51

... impact of uncertainty of demands using analytics and optimization of supply chain system design One of the most popular methods for maintaining a competitive advantage is to enhance the value of ... competition in global manufacturing market and outsourcing suppliers, many supply chain systems have become more complex and faced with high risks and low performance Many financial losses and failures ... term of optimization, any improved model should be more accurate and sensitive in order to build an effective global supply chain Many challenges lead to better Trang 3  understanding the risks and

Ngày tải lên: 27/05/2020, 03:30

... fold change ± SD over the baseline apoptosis b Western blot analysis (left panel) of cleaved Caspase-3 and PARP in MICOL-14h-tertand MICOL-14tum cell lines non-transfected (NT) and transfected ... functional changes, transcript and gene expression profiling was performed on MICOL-14h-tertand MICOL-14tum24 h after treatment with anti-miR-182 or anti-miR-NC Four replicates for cell type and condition ... the Annexin-V-FLUOS staining kit (Roche, Mannheim, Germany) was used according to manufacturer’s instructions For cell cycle analysis, cells were fixed with cold ethanol, stained with anti-human

Ngày tải lên: 17/06/2020, 17:12

... resistance mechanism of a few cancer cells to sunitinib might act through an induction of their Trang 9cell-division cycle Moreover, two recent publicationsproved that one of the effects of this drug ... out the animal model set up, the therapy model monitoring, the histochemistry experiments, and the analyses led by digital microscopy and qRT-PCR He performed the statistical analyses and drafted ... agent and in combination with “standard of care” therapeutic agents for the treatment of breast cancer Mol Cancer Ther 2003;2:1011 –21. 16 Eades G Breast cancer MicroRNAs: signaling networks and

Ngày tải lên: 28/09/2020, 10:11