advanced head and neck cancer survival rate

... Yosuke Kito1, Keita Mori6and Hirofumi Yasui1 Abstract Background: Chemoradiotherapy (CRT) and bio-radiotherapy (BRT) are recognized as standard therapies for head and neck cancer (HNC) Aspiration ... ma-lignancies included multiple primary HNC, esophageal cancer, gastric cancer, prostate cancer, lung cancer, and renal cancer All of these cancers were found at an early stage by routine endoscopic ... HNC: Head and neck cancer; IMRT: Intensity-modulated radiation therapy; OS: Overall survival; PPIs: Proton pump inhibitors; RND: Radical neck dissection; RT: Radiotherapy; SND: Selective neck

Ngày tải lên: 20/09/2020, 01:10

... human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer: a systematic review and meta-analysis of trends by time and region Head Neck 2013;35:747 –55. 10 Fakhry C, Westra ... E6/E7 oncogene and p53 function within tumours were associated with the widely reported improved patient survival and prognosis in head and neck cancer Methods: HPV16 DNA, mRNA and p53 mRNA presence ... HPV-positive head and neck cancers increases, this may highlight the importance of under-standing the underlying mechanisms responsible for oncogenesis and the differences between HPV-related and HPV-unrelated

Ngày tải lên: 21/09/2020, 01:35

... diagnosis of head and neck cancer –a longitudinal study Head Neck 2001;23(2):113 –25. 6 Langius A, Bjorvell H, Lind MG Oral- and pharyngeal-cancer patients ’ perceived symptoms and health Cancer Nurs ... in patients with head and neck cancer Arch Otolaryngol Head Neck Surg. 2009;135(12):1209 –17. 23 Wildiers H, Mauer M, Pallis A, Hurria A, Mohile SG, Luciani A, et al End points and trial design ... LQ, Rao K, Malone J, Kandula P, Ronen O, Markwell SJ, et al Factors associated with quality of life in outpatients with head and neck cancer 6 months after diagnosis Head Neck 2009;31(9):1207

Ngày tải lên: 23/09/2020, 00:08

... AccessProteoglycan-based diversification of disease outcome in head and neck cancer patients identifies NG2/CSPG4 and syndecan-2 as unique relapse and overall survival predicting factors Anna Farnedi1†, Silvia ... Cocchi9,10, Andrea Ambrosini-Spaltro1, Maria Pia Foschini1and Roberto Perris2,5* Abstract Background: Tumour relapse is recognized to be the prime fatal burden in patients affected by head and neck ... PGs and a characteristic de novo transcription/translation of GPC2, GPC5 and NG2/ CSPG4 respectively in 36%, 72% and 71% on 119 cases Importantly, expression of NG2/CSPG4, on neoplastic cells and

Ngày tải lên: 29/09/2020, 16:16

... risk for relapse Keywords: Cancer stem cells, Head and neck cancer, Proteasome, Radiotherapy Background Radiotherapy is standard of care for advanced stage head and neck squamous cell carcinoma ... [33] and pancreatic cancer [34] Interest-ingly, in prostate cancer [35], breast cancer [16,36], and glioma [21,25] cells with low proteasome activity are radioresistant and patients with breast cancers ... tracking, and targeting of cancer stem cells J Natl Cancer Inst 2009, 101:350 –359. 22 Prince ME: Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous

Ngày tải lên: 05/11/2020, 01:29

... therapy for head and neck carcinoma The Oncologist 2007, 12:555-564. 2 Lee N, Puri D, Blanco AI, Chao KS: Intensity modulated radiathion therapy in head and neck cancers: an update Head and Neck 2007, ... radiation therapy of head and neck cancer Expert Rev Anticancer Ther 2008, 8:633-644. 4 Li Y, Ten Haken R, Eisbruch A: The impact of dose on parotid recovery in head and neck cancer patients treated ... advanced head and neck cancers is feasible and effective, with acceptable toxicities Introduction Radiotherapy (RT), with or without chemotherapy, is the primary treatment modality for head and

Ngày tải lên: 09/08/2014, 09:20

... accelerated radiotherapy in head and neck cancer: a meta-analysis Lancet 2006, 368:843-854. 7 Lee N, Puri DR, Blanco AI, Chao KS: Intensity-modulated radiation therapy in head and neck cancers: ... For the entire cohort of 151 patients the OS rates were 67.5% and 58.3%; the CSS rates were 75.1% and 66.8% and PFS rates were 72.5% and 67.2% at 2 and 3-years respectively Patterns of recurrence ... preliminary results of a European Organization for Research and Treatment of Cancer phase III trial EORTC Head and Neck Cancer Cooperative Group J Natl Cancer Inst 1996, 88:890-899. 3 Induction chemotherapy

Ngày tải lên: 09/08/2014, 09:20

... 5.5 months for time to progression The 1-year and 2-year local control and overall survival rates for all patients were 51.2% and 30.7%, and 48.5% and 16.1%, respectively Overall, the MST for ... remission rate was 97% The rates of 5-year local con-trol, relapse-free survival, disease-specific survival, over-all survival, and major complication were 85%, 68.3%, 74.8%, 61.3%, and 46.9%, ... cases of 12.5 Gy SRS and 43 cases of 34 Gy delivered in 2-6 fractions of SRT The 1- and 3-year local failure-free survival rates were 70% and 51% for the SRS group and 91% and 83% for the SRT

Ngày tải lên: 09/08/2014, 09:21

... Amsterdam, The Netherlands, 3 Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands, 4 Department of ... Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands and 5 Department of ORL, Academic Medical Center, Amsterdam, the Netherlands, Department of Head and Neck ... glands was removed in 53% of the cases, both submandibular glands in 12%, 6% had their superficial parotid gland removed another 6% had their superficial parotid gland and one submandibular gland

Ngày tải lên: 09/08/2014, 09:22

... with head and neck cancer Head Neck 2000, 22:474-82. 37 Stenson KM, MacCracken E, List M, Haraf DJ, Brockstein B, Weich-selbaum R, Vokes EE: Swallowing function in patients with head and neck cancer ... patients with head and neck cancer treated with radiotherapy J Clin Oncol 3776, 26:3770-2008. 32. Rosenthal DI, Trotti A: Strategies for managing radiation-induced mucositis in head and neck cancer ... for head and neck carcinoma Oncologist 2007, 12:565-8. 5. Rosenthal DI, Lewin JS, Eisbruch A: Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer

Ngày tải lên: 09/08/2014, 10:20

... IMRT using simultaneously integrated boost (SIB) in head and neck cancer patients Address: 1 Department of Radiation Oncology, University Hospital, Zurich, Switzerland and 2 Department of Radiation ... simultaneously integrated boost (SIB) application in the head and neck region in terms of normal tissue response As known from 3DCRT, dose, fractionation and treated volumes are the tumor control and normal ... year local, nodal, and distant disease free survival: 77 %, 87 %, and 78 %, respectively Figure 1 Actuarial 2 year local, nodal, and distant disease free survival: 77 %, 87 %, and 78 %, respectively

Ngày tải lên: 09/08/2014, 10:20

... angiogenesis, immune and proinflammatory responses, and therapeutic resistance in head and neck squa- mous cell carcinoma (HNSCC) and other cancers [3-5]. How- ever, nuclear activation of hetero- and homodimers ... expression, and contributes to the malignant heterogeneity of head and neck cancer, is not well understood. Results: To address this question, we used a newly developed computational strategy, COGRIM ... regulons in 1,265 genes differentially expressed in head and neck cancer cell lines differing in p53 status revealed a cross talk between NFkB and specific signaling pathways.</p> Abstract

Ngày tải lên: 14/08/2014, 08:20

... targeted therapeutics, head-and-neck cancer, RNA interference, drug delivery, ra-diosensitization, photothermal therapy Introduction Head-and-neck cancer is the sixth most common cancer worldwide, ... chemo- and radiosensitizers A phase III randomized trial of EGFR inhibitors (CET) as radiosensitizers for locoregionally advanced head-and-neck cancer reported significantly increased survival ... including, breast, prostate, head-and-neck, and colon cancers, and is regarded as a prognostic factor for a poor outcome and therapeutic resistance [154, 155] Aloy et al demonstrated the protective role

Ngày tải lên: 15/01/2020, 16:59

... cell head and neck cancer J Clin Oncol 2003;21:92 –8. 3 Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, et al Defining risk levels in locally advanced head and neck cancers: ... EORTC (#22931) and RTOG (# 9501) Head Neck 2005;27:843 –50. 4 Pignon JP, le Maître A, Maillard E, Bourhis J, MACH-NC Collaborative Group Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): ... patients with head and neck cancer receiving outpatient treatment with concurrent high-dose cisplatin and radiotherapy Am J Clin Oncol 2018;41: 432 –40. 23 Prasaja Y, Sutandyo N, Andrajati R Incidence

Ngày tải lên: 17/06/2020, 18:48

... mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer Sandhya Yadav1, Somnath D Bhagat2, Amit Gupta1, Atul Samaiya3, Aasheesh Srivastava2and Sanjeev Shukla1* ... head-and-neck cancer (HNC) Though both epigenetic alterations [40,41] and aberrant alternative splicing [42,43] are in-dividually associated with the development and pro-gression of various cancers ... approach can provide an effective way to modulate cancer-specific-splicing and thereby aid in the treatment of HNC Keywords: Curcumin, Head and neck cancer, PKM, Warburg effect, Alternative splicing

Ngày tải lên: 17/06/2020, 18:58

... Research and Treatment of Cancer – Head and Neck module; EORTC-QLQ: European Organization for Research and Treatment of Cancer- Quality of Life Questionnaire; HADS: Hospital Anxiety and Depression ... life, and swallowing function in head and neck cancer patients 1 year after definitive therapy Laryngoscope 2012;122(7):1518 –25. 5 Patterson JM, McColl E, Wilson J, Carding P, Rapley T Head and neck ... Background: Head and neck cancer squamous cell carcinoma (HNSSC) patients report substantial rates of clinically significant depression and/or anxiety, with dysphagia being a predictor of distress and

Ngày tải lên: 23/07/2020, 23:44

... treatment by radiotherapy and/or chemotherapy (hereinafter re-ferred to as “CRT”) for cancer in the head and neck region with severe oral stomatitis Radiotherapy for head and neck cancer has a nearly ... Medicine 2014;39:25 –9. 6 Katou K Nutrition support and oral Care for Head and Neck Cancer Patients Undergoing Chemoradiotherapy Head and Neck Cancer Frontier 2014;2: 48 –51. 7 Valente VB, Takamiya ... Genomic insights into head and neck cancer Cancers of the Head & Neck 2016;1(1) 2 Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, et al. Perspectives on cancer therapy-induced

Ngày tải lên: 24/07/2020, 01:55

... Denmark (protocol id: H-15003725) and registered retrospectively at ClinicalTrials.gov (NCT02557529) September 11th 2015 Keywords: Head and neck cancer, Head and neck squamous cell carcinoma, Chemoradiotherapy, ... Der Laan BFaM V, Pruim J, et al Changes in nutritional status and dietary intake during and after head and neck cancer treatment Head Neck 2011;33(6):863 –70. 15 Van Den Berg MG, Rasmussen-Conrad ... challenges must be addressed We designed a randomized trial on exercise for head and neck cancer patients undergoing concomi-tant CCRT and decided to describe the strategy in this article about the protocol

Ngày tải lên: 06/08/2020, 07:25

... activity and cancers of tonsil and tongue base and other pharyngeal cancers This supplementary table examines the association between regular recreational physical activity and head and neck cancer ... C, Talamini R, et al Recreational physical activity and risk of head and neck cancer: a pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium Eur J Epidemiol. ... carcinoma of the head and neck, including cancers of the oral cavity, oropharynx, hypopharynx, and larynx; 2) no history of any type of cancer diagnosis; and 3) between the age of 20 and 80 Controls

Ngày tải lên: 19/09/2020, 21:40

... behavioural strategies in swallowing interventions, and to explore any relationships between these strategies and intervention effects Randomised and quasi-randomised studies of head and neck cancer ... patients treated for head and neck cancer (HNC) [1], arise both from the presence of a tumour, and as a con-sequence of its treatment [2] Dysphagia is a major patient concern after cancer treatment ... [27] and Performance Status Scale (PSS) [28], patient-reported and QOL measures such as the MD Anderson Dysphagia Inventory (MDADI) [29] and European Organisation for Research and Treatment of Cancer

Ngày tải lên: 20/09/2020, 01:02