a roadmap of cancer systems biology

... Trang 1S O F T W A R E Open AccessCRA toolbox: software package for conditional robustness analysis of cancer systems biology models in MATLAB Fortunato Bianconi1*, Chiara Antonini2†, ... Sensitivity Analysis (GSA) class of algorithms [8] They are similar to CRA and are involved in the analysis of the uncertainties in kinetic model parameters through the sampling of the parameter space ... Kitano in [10]: it is the quantitative measure of the ability of a system S to maintain a specific propertyτ against some pertur-bations of the parameter vector p of S The mathematical formulation

Ngày tải lên: 25/11/2020, 12:37

... sperrnatogenic stages antecedental to spermatozoa Spermatozoa dominate the remainder of the testis B, Partially spawned testis of male displaying Type I pattern, collected April 3, 1973 Dark areas contain ... low water temperature fluctuation for the Midas abalone Annual water temperature fluctuation in our areas may not be great enough to stimulate complete spawning Trang 988 CALIFORNIA FISH AND GAME ... Point Cabrillo and accepted for Van Damme The degree of human predation certainly has a significant effect on the age class structure of these two populations For years the red abalone at Van Damme

Ngày tải lên: 18/10/2019, 14:52

... (Prostate Gene DataBase; Li et al 2003), a curated database of genes related to prostate cancer One limitation of the approach is that, similar to the Molecular Triangulation approach (Krauthammer ... that are causally implicated in the growth of several cancer cell lines (Luo et al 2008) Trang 29as separate and linear pathways, a lot of cross-talk occurs among the signaling cascades, particularly ... Signaling NF–kappaB Activation by Viruses NGF Pathway OSM Pathway PDGF Pathway Prolactin Signaling RANK Pathway TGF–Beta Pathway Thrombopoietin Pathway TLR–TRIF Pathway TNF Signaling TNFR1 Pathway

Ngày tải lên: 21/01/2020, 18:29

... struc-ture of data into the database The database consists of four main data types: analysis,  Clinical datais associated to the clinical course of a patient’s disease, and meta data about these ... vast amount of data that has been generated, there are surprisingly few databases which facilitate access to these data and make them available for flexible analysis queries in the broad research ... queries and analysis of cancer-related data across multiple data types and multiple studies The CancerSysDB can be adopted by any center for the organization of their locally acquired data and its

Ngày tải lên: 25/11/2020, 15:45

... a nonzero proportional gain I C _is an integral gain and C I 0 II DIRECT ADAPTIVE DESIGN OF SLIDING PROPORTIONAL CONTROLLER Theorem 2: The following adaptive law with a nonzero bounded adaptive ... DESIGNS WITH INTERGRAL SLIDING SURFACE FOR A CLASSS OF NONLINEAR SYSTEMS Abstract: The Lyapunov stable theory and L2_gain control performance are employed to interpret a sliding controller ... update history of simulation 2 Trang 11P a g e 11 | 14 C Simulation 3 As mentioned above, in order to remove the system gain function (g) in the adaptive law design We replace the adaptive rate

Ngày tải lên: 22/07/2022, 22:19

... emancipatoryFrankfurt school and many have argued (e.g Howcroft and Trauth, 2004) that the relativedominance of the Habermassian approach is unnecessarily limiting and have suggestedthat other approaches ... technology as neutral, technical progress as natural, and to Trang 4view History1 as hagiography (success stories, e.g Peters and Waterman, success of IBM)rather than historiography.From a managerial ... reorientationist) to code each paper(see Appendices 1 and 2 for raw data and additional analysis) The results are presented in a succinct form in Tables 2 and 3 An extract of the full list of papers

Ngày tải lên: 18/10/2022, 11:56

... TOCSY NMR spectrum of a fecal extract acquired at 400 MHz Key: Ala, alanine; Arg, arginine; Asn, asparagine; Asp, aspartate; BAs, bile acids; But, butyrate; Eth, ethanol; Gal, galactose; Glc, glucose; ... and gluconeogenesis Correlation analysis of microbiotal variation and SCFAs A correlation analysis was applied to investigate the connec-tions between levels of fecal and jejunal microbiota and ... with L paracasei revealed that dietary oligosaccharide supplementation induced significant changes in the functional and lactobacilli, bifidobacteria, Bacteroides distasonis and PC PUFA TG L Ala Gln

Ngày tải lên: 19/03/2023, 15:05

... state variables, boundaries, etc.) Examples of open systems are: groundwater systems, social systems, as well as most of the natural systems Four types of variables characterize a model of a ... input variables, control variables and state variables Considering a system element with an input variable x(t), a state variable s(t), a control variable c(t) and an output variable y(t) as shown ... a coastal area These changes result in integrated coastal-zone management, integrated river basin management and/or ecosystem-based river basin management (Nakamura, 2003) Embedded in these approaches

Ngày tải lên: 06/11/2012, 10:35

... value of OFDM system capacity for Rayleigh fading channel and Ricean fading channel, by numerical method 165Fig 6.9: The variance of OFDM system capacity for Rayleigh fading channel and Ricean fading ... a standards-based technology enabling the delivery of last mile wireless broadband access as an alternative to cable and digital subscriber line (DSL) The basis of WiMAX is IEEE 802.16 standard ... propagation and the small scale propagation The signal variations due to path loss or shadowing occur over relatively large distances, this variation is referred to as the large scale propagation

Ngày tải lên: 20/11/2012, 11:28

... Anal Chem 74, 4725–4733 22 Kagebayashi C, Yamaguchi I, Akinaga A, Kitano H, Yokoyama K, Satomura M, Kurosawa T, Watanabe M, Kawabata T, Chang W et al (2009) Automated immunoassay system for AFP-L3% ... commercially available antibodies, and their glycan alteration was examined by a lectin microarray Finally, they were analyzed by multi-stage tandem MS Abbreviations AAL, Aleuria aurantia lectin; AFP, a-fetoprotein; ... determination of the glycan structure of a form of AFP [10] However, identification of the details of a glycan structural change on a glycoprotein is limited, as a comparatively large amount of a relatively

Ngày tải lên: 16/02/2014, 08:20

... farms adopting the organic approach because of access to high quality pastures and the ability to manage pasture as a dairy feed source These areas also have a long history of small dairy operations ... operators of conventional dairies that go through what can be a challenging and costly transition process Many changes in such areas as animal husbandry, land and crop management, sourcing new and ... research is limited in terms of the scope and the depth of data supporting the analyses This study addresses these limitations, taking advantage of a unique nationwide data set of organic and

Ngày tải lên: 22/02/2014, 05:20

... Nasopharynx 20 Non-Hodgkin’s Lymphoma 20 Ovarian Cancer 21 Pancreatic Cancer 21 Prostate Cancer 22 Rectal Cancer 22 Soft Tissue Sarcomas (STS) 23 Skin Cancer 23 Stomach Cancer 23 Testicular Cancer ... causes of cancer, but mortality data are crucial for understanding the burden of cancer in particular populations Heart disease was far and away the leading cause of death in the U.S for all ages ... suggests an excess risk of pancreatic cancer.73 Reactive chemicals have also been associated with pancreatic cancer A meta-analysis of formal-dehyde exposure and pancreatic cancer provide weak evidence

Ngày tải lên: 06/03/2014, 01:20

... may have intended his absurdly totalitarian cancer hospital to parallel the absurdly totalitarian state outside it, yet when I once asked a woman with invasive cervical cancer about the parallel, ... 1902, a new theory of cancer had slowly coalesced out of all these observations Cancer was a disease of pathological hyperplasia in which cells acquired an autonomous will to divide This aberrant, ... was assembled from universities and hospitals A state -of- the-art laboratory space, with gleaming halls and conference rooms, was built among leafy arcades and gardens in suburban Bethesda, a...

Ngày tải lên: 03/05/2014, 19:11

... elliptic systems, ” Bulletin of the Australian Mathematical Society, vol 50, no 3, pp 501–519, 1994 D G de Figueiredo, “Nonlinear elliptic systems, ” Anais da Academia Brasileira de Ciˆ ncias, vol ... nonlinearities in the critical growth range,” Calculus of Variations and Partial Differential Equations, vol 3, no 2, pp 139–153, 1995 Y Shen, Y Yao, and Z Chen, “On a class of nonlinear elliptic ... a nontrivial solution As the potential V x and the nonlinearity f x, t are asymptotically periodic at infinity, Alves et al 11 proved the existence of at least one positive weak solution Our aim...

Ngày tải lên: 21/06/2014, 22:20

... x -Laplacian problems on a bounded domain,” Journal of Mathematical Analysis and Applications, vol 306, no 2, pp 604–618, 2005 17 X.-L Fan, Q Zhang, and D Zhao, “Eigenvalues of p x -Laplacian ... of the calculus of variations and elasticity theory,” Izvestiya Akademii Nauk SSSR Seriya Matematicheskaya, vol 50, no 4, pp 675–710, 1986 Russian 14 C O Alves and M A Souto, “Existence of solutions ... Journal of Mathematical Analysis and Applications, vol 302, no 2, pp 306–317, 2005 18 X.-L Fan, “Solutions for p x -Laplacian Dirichlet problems with singular coefficients,” Journal of Mathematical...

Ngày tải lên: 22/06/2014, 03:20

... of Mathematics and Econometrics, Hunan University, Changsha, Hunan 410082, China E-mail address: lhhuang@hnu.net.cn Guang Zhang: Department of Mathematics, Qingdao Institute of Architecture and ... Equations: An Introduction with Applications, Academic Press, Massachusetts, 1991 [9] Y M Meng, L Huang, and K Y Liu, Asymptotic behavior of solutions for a class of neural network models of two ... thresholds, Acta Mathematicae Applicatae Sinica 26 (2003), no 1, 158–175 [10] Z Yuan, L Huang, and Y Chen, Convergence and periodicity of solutions for a discrete-time network model of two neurons, Mathematical...

Ngày tải lên: 22/06/2014, 22:20

... conventional electric motor (Boldea & Nasar, 1997) Linear actuators are classified types such as mechanical linear actuators, hydraulic and pneumatic linear actuators, piezoelectric linear actuators, ... Briefly a powerful user interface has features as summarized below:   Individual Functional 14    A Roadmap of Biomedical Engineers and Milestones Adaptation capability Easy-to-use and understandable ... classified as gear motor, gerotor motor, and radial piston motor Hydraulic actuators have great advantages like; have large lifting capacity, can used with servo control, have quick reaction capability,...

Ngày tải lên: 26/06/2014, 23:20

... These systems as a whole are called cyclical systems in the sense that the pattern of male exchange between groups changes cyclically (Rochambeau and Chevalet, 1982) Assuming a simple model of each ... but also much easier to practise than random mating of the whole population (Rochambeau and Chevalet, 1990) Maintenance in different locations has the additional merit of reducing the risk of accidental ... value c G as ) C (AF is c obtained, with A showing the largest eigen value of t’ Introducing OF and AF as the average rate of inbreeding per generation and inbreeding at generation t’ within a...

Ngày tải lên: 09/08/2014, 18:22

... University, May 2011 Acquired STAT4 deficiency as a consequence of cancer chemotherapy Major Professor: Hua-Chen Chang Signal Transducer and Activator of Transcription (STAT4) is an important transcription ... cause tumor death in a variety of murine models such as melanomas, sarcomas and mammary, colon and renal carcinomas (124) Its antitumor effects are the main consequence of activating the primary ... experimental autoimmune encephalomyelitis (EAE) (133) Lovastatin, a 16 member of a class of drugs called statins, was initially reported to have anti-inflammatory effects that ameliorate the symptoms of...

Ngày tải lên: 24/08/2014, 10:35