a proactive and reactive response

... Trang 1Open AccessResearch Physical and in silico approaches identify DNA-PK in a Tax DNA-damage response interactome Emad Ramadan1, Michael Ward2,3, Xin Guo3, Sarah S Durkin3,7, Adam Sawyer3, ... University, West Lafayette IN, USA and 7 Department of Exploratory Biology, Pfizer Global Research and Development, La Jolla, CA, USA Email: Emad Ramadan - eramadan@cs.odu.edu; Michael Ward - wardmd@evms.edu; ... Our analysis identified DNA-PK as a top candidate protein for further analysis into the mechanism of action for Tax-induced defects in the cellular DNA damage repair response Results Assimilation

Ngày tải lên: 13/08/2014, 05:21

... on the variables age at exposure (agex) and age attained (agea): expo-modifying parameters geand ga for a Japanese population and for different sites are taken from Preston et al [1] and are listed ... of Doreset al [22] agex = 37 and agea = 45 EARorgagex = 30 and agea = 70 Patients were primarily treated for Hodgkin’s disease with radiotherapy The data for agex = 30 and agea = 70 years were ... compared to the original data The a- and R-values, anda- and b-values were fitted iteratively by minimizing c2 for carcinoma and sarcomainduction, respectively A fit was accepted as significant

Ngày tải lên: 13/08/2014, 16:20

... Trang 1R E S E A R C H Open AccessClinical aspects and cytokine response in severe H1N1 influenza A virus infection Natalia Hagau1*, Adriana Slavcovici2, Daniel N Gonganau1, Simona Oltean2, Dan ... critical and noncritical hospitalized patients with nvA(H1N1) from Cluj-Napoca, Romania, and to correlate them with the clinical aspects Materials and methods Patients and controls The study was ... G, Lapinsky SE, Macias AE, Pinto R, Espinoza-Perez L, de la Torre A, Poblano-Morales M, Baltazar-Torres JA, Bautista E, Martinez A, Martinez MA, Rivero E, Valdez R, Ruiz-Palacios G, Hernandez

Ngày tải lên: 13/08/2014, 21:21

... Gaussian and threshold characters, traits following a Poisson mixed model and survival traits Inge Riis KORSGAARDa ∗, Anders Holst ANDERSENb, Just JENSENa aDepartment of Animal Breeding and Genetics,Danish ... Var (a i |data)
(follows from Var (a i)= Var E (a i |data)
+ E Var (a i |data)
) and inserting in the expression for PEV, it follows that PEV = E Var (a i |data)
so that an unbiased estimate, ... Varv|data E (a i |v, data)
the first term Ev|data Var (a i |v, data)
= Ev|data Var (a i|v)
(because p (a i |v, data) = p (a i|v), which follows from the conditional inde-pendence of a i and

Ngày tải lên: 14/08/2014, 13:21

... prevalence and incidence in this population than in Australian Caucasians Both racial and genetic differences, and more complex social factors related to poverty and access to care are likely associated ... anticholesterol antibody aCL anticardiolipin antibodies ANA antinuclear autoantibody ANP atrial natriuretic peptide APS anti-phospholipid syndrome aPL anti-phospholipids antibodies ARA American Rheumatology ... non-white population of the USA, Europe, Canada and Australia (Danchenko et al 2006a) Trang 281.1.2 Pathogenesis of SLE The pathogenesis of SLE relates to abnormalities of both the innate and adaptive

Ngày tải lên: 14/09/2015, 12:42

... ameliorates diarrhea, urgency and faecal soiling, although it has no effect on other IBS-related symptoms such as pain and bloating (Jailwala et al, 2000& Read et al, 1982) Compared to codeine and ... sensation, physical intra-abdominal expansion and abdominal wall adaptation to content and deformation These mechanisms may play an independent role or may be interrelated Bloating, like many ... and constipation (Jailwala et al, 2000& Poynard et al, 2001) Antispasmodics, taken about 30 minutes before meals, can be effective in controlling postprandial cramps and diarrhea and they should

Ngày tải lên: 26/09/2015, 10:05

... Standard and Poor's Compustat Ball and Brown (1968) finds that there is a significant association between accounting return and share market return The useful information content of abnormal ... estimated relation between abnormal share returns and new information of accounting earnings announcements Beaver et al (1979) illustrate that the association between share prices and accounting earnings ... abnormal income can be essentially conveyed to the capital market and the share market typically has reacted in the same direction Based upon a sample of annual earnings announcement released by 143

Ngày tải lên: 16/01/2020, 17:06

... inchloroplasts CRM (chloroplast RNA splicing and ribosome matur-ation) domain-containing proteins were first found in ar-chaea and bacteria Based on their structural data and predicted domain structures, ... experimentally The Arabi-dopsis (ArabiArabi-dopsis thaliana) and rice (Oryza sativa) genomes harbor the genes encoding 16 and 14 CRM domain-containing proteins, respectively [13] Among the 16 Arabidopsis ... biosynthesis-related genes, ABA1, ABA2, ABA3, and NCED3, were measured in 26-day-old plants by real-time RT-PCR, and relative expression levels to wild-type value are shown The values are mean ± SE obtained

Ngày tải lên: 27/05/2020, 01:43

... orchards: two situated in Spain's Murcia region, “El Jimeneo” (EJ) and “Aguas Amargas” (AA), and another in Valencia, Spain at the IVIA EJ is located at an altitude of 80m at latitude: 37° 45' ... [12], and are usually as-sociated with unripe fruit Several studies have demon-strated that aroma formation in peach is a dynamic process, as volatiles change dramatically during matur-ity and ... the aroma of the fruit [10] Among these volatiles, lactones appear to be the main contributors to peach aroma [10,11], and in particular γ-decalactone, an intramolecular ester with an aroma described

Ngày tải lên: 27/05/2020, 01:59

... were analyzed using Zeiss Zen Blue software suite Statistical analysis Data are presented as mean ± standard deviation (SD) of n ≥ 3 and analyzed using GraphPad Prism 6 (USA) Ana-lysis of variance ... therapeutic agents and enhancing the therapeutic efficacy of antican-cer drugs carries substantial clinical value Autophagy is an evolutionarily conserved lysosomal degradation pathway that maintains ... MDA-MB-231(breast cancer cell lines), and Hela (cervical cancer cell line) and the associated mecha-nisms Our findings demonstrate that MASM induces apoptosis and autophagy in all cancer lines In addition,

Ngày tải lên: 17/06/2020, 18:35

... These data revealed that growth in 3D culture resulted in a significant loss of PI3K/AKT pathway activity and a gain in MAPK signal-ing in both cell lines Fig 2 Basal growth rate of BT474 and MDAMB361 ... Endocrine agents and trastuzumab augment MAPK activity in 3D culture Comparison of signaling pathway activation in 2D versus 3D culture in response to tamoxifen, fulvestrant and trastuzumab monotherapy ... Her2+/ER+ luminal breast cancer models, their therapeutic response to the Her2 targeting agent, trastuzumab, and also to anti-ER therapies (tamoxi-fen and fulvestrant) is attenuated in 3D matrix enriched

Ngày tải lên: 21/09/2020, 01:30

... studies was assessed with the Newcastle-Ottawa Scale (NOS) criteria for cohort studies [14] A funnel plot was used to assess publication bias Any disagreements on data extraction and quality assessment ... Trang 1R E S E A R C H A R T I C L E Open AccessRelationship between circulating tumor cells and tumor response in colorectal cancer patients treated with chemotherapy: a meta-analysis Xuanzhang ... http://www.biomedcentral.com/1471-2407/14/976 Trang 4Table 1 Baseline characteristics and design variables of the included studies(M/F) and after ST Age mean ± SD/ median (range) Methods Rate(+) Follow up mean ± SD/ median (range) Tumor

Ngày tải lên: 30/09/2020, 13:28

... standardCampbell diagram approach A fan inlet distortion is ana-lyzed with measured distortion, and the predicted responseagreed with the measured response Chiang and Turner [2]developed an analysis ... frequency and amplitudemagnitude The static state blade experimental approach uses a spectrum analyzer, a hammer for PCB model, an ICPaccelerometer, a notebook/PC, rubber bands, blades, and asetup ... components 4 Static State Blade Experimental Analysis For the experimental testing and analysis, we used the staticstate blade experimental approach to measure the midspanand tip-shrouded blade response

Ngày tải lên: 02/11/2022, 08:48

... search of deaths and births in the Northeast and Legal Amazonia regions: Estimation of SIM and SINASC coverage in Brazilian municipalities In Health Brazil 2010: An analysis of health status and selected ... data analysis and result interpretation WSA participated in data analysis OLMN participated in study design, discussion of results, and writing text All authors read and approved the final manuscript. ... Célia Landmann Szwarcwald1*, Paulo Germano de Frias2, Paulo Roberto Borges deSouza Júnior1, Wanessa da Silva de Almeida1and Otaliba Libânio de Morais Neto3 Abstract Background: In the last 20 years,

Ngày tải lên: 02/11/2022, 08:48

... bureaucracy and non -proactive are widespread in Vietnam (especially in state owned enterprises) 1.1 Real situation of bureaucracy and non -proactive in Vietnam 1.2 Why bureaucracy and non -proactive are ... them PART I :Why bureaucracy and non -proactive are widespread in Vietnam (especially in state owned ENTERPRISES) 1.1 Real situation of bureaucracy and non -proactive in Vietnam The bureaucracy and ... Vietnamese organizations to change to adapt to new situation Therefore, it is necessary for Vietnamese organizations to abandon backward management and apply new management styles For this reason,...

Ngày tải lên: 05/04/2013, 14:58

... in all IFA activities Invaluable organisation and administration support was provided by Phimphakan Lebel, Drinya Totrakool from USER, Thailand and Sergei Barkov, Marya Schaskolskaya, Galina Zukova ... Environmental Research, Chiang Mai University, Thailand supaporn@sea-user.org KUNAPHINUM Atiwan, Asian Disaster Preparedness Center, Thailand atiwan@adpc.net LE Nguyen Van, Dyke Management, Flood and ... Indonesia, the Philippines, Bangladesh, Iran, Thailand, Sri Lanka, Vietnam and Pakistan; floods are at the top of disaster reduction agenda in the Asian Russia as well 3.1.2 Who and what should be at...

Ngày tải lên: 22/10/2013, 10:15

... two languages In addition, qualitative and quantitative - Collecting and classifying data approaches are used to make the data analysis more reliable - Analyzing data Calculations, statistics and ... English and Vietnamese? What are pragmatic features of CRs in English and Vietnamese? What are similarities and differences in the syntactic and pragmatic features of CRs in English and Vietnamese? ... and English + Declarative Structures English Language Vietnamese; 3) Similarities and differences in syntactic and pragmatic features of CRs in the two languages; and 4) Summary 4.1 THE SYNTACTIC...

Ngày tải lên: 26/11/2013, 13:19

... spread ambiguous and perhaps explaining why Powers and Thompson and Lyon obtained small and opposite predicted effects Joint Application of Marketing Orders and Cooperatives The AMAA and the Capper-Volstead ... chance of success; stringent evidence; Sec 2(f) may not be applicable Same as for Sherman Act case Same as for Sherman Act case Same as for Sherman Act case Same as for Sherman Act case FTC Act, ... the average produce aisle were branded products (Kaufman et al., 2000) For a brand to have value, a consumer must be able to associate the name with a consistent, reliable standard of quality,...

Ngày tải lên: 07/03/2014, 13:20

... in Alaska, Hawaii, and the U.S Virgin Islands), but are otherwise standard; (iii) Alt -A mortgages not conform to the Fannie Mae and Freddie Mac definitions, perhaps because a mortgagee has a higher ... of accounting as much as regulation Since 1998 the Financial Accounting Standards Board (FASB) in the U.S Statement of Financial Accounting Standard (SFAS) No 133, has required fair value accounting ... necessary, and this was arranged through a shares purchase by JPMorgan Chase initially set at $2 per share, but later increased to $10 per share to placate shareholders and ensure the deal would...

Ngày tải lên: 15/03/2014, 07:20

... International and regional speakers included Drs Rosemary Tannock (Canada), Edmund Sonuga- Barke (UK), Jan Assheton (UK), John Fayyad (Lebanon) and Ahmad Al Ansari (Bahrain) Dr Omar Al Modayfer, ... Sociedad Uruguaya de Psiquiatr a de la Infancia y de la Adolescencia (SUPIA) • Canadian Academy of Child and Adolescent Psychiatry (CACAP) • Società Italiana di Neuropsichiatria dell’Infanzia e ... Icelandic Association for Child and Adolescent Psychiatry • Indian Association for Child and Adolescent Mental Health • Iranian Academy of Child and Adolescent Psychiatry (IACAP) • Iraqi Association...

Ngày tải lên: 31/03/2014, 15:20