a bench utopia or a therapeutic approach

... systems as supportive medical care and for symptomatic treatment; they represent an important aid for patients and for improving survival in severe forms of disease Antiviral therapeutic strategies ... Compound Ki value (lM) Reference a- keto-amide Amide Ac-FAAGRR -a keto–SL-CONH2 Ac-FAAGRR-CONH2 Ac-RTSKKR-CONH2 Ac-KKR-CONH2 Ac-FAAGRR-CHO Bz-Nle-Lys-Arg-Arg-H Bz-Ala-Lys-Arg-Arg-H Bz-Phe-Lys-Arg-Arg-H ... The major pharmaceutical companies are currently developing a treatment against the disease A tetravalent live attenuated vaccine was developed at the Walter Reed Army Institute of Research,...

Ngày tải lên: 19/02/2014, 00:20

... supply additional hemodynamics data in addition to the morphological analysis Renal and extrarenal pathologies as well as other factors also alter renal hemodynamics Hemodynamic change can be ... differential diagnosis or management of renal diseases Despite major technological advances, gray-scale renal US has remained largely unchanged since the 1970s It provides only basic anatomical data, ... calculate an output variable from other input variables and parameters The structural analysis by ISM classifies variables and parameters in accordance with the hierarchical levels, which are obtained...

Ngày tải lên: 19/02/2014, 23:20

... fossa approach, while Dearmin [14] and Farrior [15] described an approach between the posterior semicircular canal and the jugular bulb All of these latter approaches attempted to preserve hearing ... proper antibiotic treatment dramatically changed the incidence of the disease and its dramatic course, but surgical drainage of the petrous apex was still Kantas et al Journal of Medical Case Reports ... the manuscript for important intellectual content NM performed the operation on our patient and critically reviewed the manuscript All authors read and approved the final manuscript Author Details...

Ngày tải lên: 11/08/2014, 12:20

... Pelham WE, et al: Behavioral versus behavioral and pharmacological treatment in ADHD children attending a summer treatment program J Abnorm Child Psychol 2000, 28(6):507-25 41 Yamashita Y, et al: ... ensure greater generalization of therapeutic effects Following the idea of Pelham’s summer treatment approach, also in Germany and Japan Intensive-Behavioural Treatment approaches have been developed ... 27 Patterson GR, et al: Variables that initiate and maintain an early-onset trajectory for juvenile offending Dev Psychopathol 1998, 10(3):531-47 28 Bandura A: Social learning theory of aggression...

Ngày tải lên: 13/08/2014, 18:21

... the target RNA forming a double-stranded RNA structure that either blocks translation or becomes a target for degradation in the cell Attractive targets for this type of therapy are gag and other ... by an intracellular anti-Rev single-chain antibody Proc Natl Acad Sci USA 1994, 91(11):5075-5079 Marasco WA, Haseltine WA, Chen SY: Design, intracellular expression, and activity of a human anti-human ... 7(5):552-564 Morgan RA, Walker R, Carter CS, Natarajan V, Tavel JA, Bechtel C, Herpin B, Muul L, Zheng Z, Jagannatha S, Bunnell BA, Fellowes V, Metcalf JA, Stevens R, Baseler M, Leitman SF, Read EJ, Blaese...

Ngày tải lên: 14/08/2014, 19:22

... hormone-refractory metastatic disease Prostate 1999, 38:73-8 Callegari-Jacques SM, Grattapaglia D, Salzano FM, Salamoni SP, Crossetti SG, Ferreira ME, Hutz MH: Historical genetics: spatiotemporal ... we compare two methods, electroporation and coincubation, for transfecting RNA into DCs The amount of RNA and the DC maturation stage for transfection were also analyzed The prostate tumor cell ... CR, Partin AW, Eisenberger MA, Chan DW, Pearson JD, Walsh PC: Natural history of progression after PSA elevation following radical prostatectomy JAMA 1999, 281(17):1642-5 Hadaschik BA, Gleave...

Ngày tải lên: 14/08/2014, 19:22

... Data Analysis The qualitative analysis is based on a phenomenographic approach; that is a qualitative method to use empiric data (e.g., interview) to describe the variation in and logical relations ... should clearly be improved before analysing the data on national level Causal analysis of cow-level and herd-level risk factors for metritis at the national level based on Danish central data base ... understanding provides insight into potential errors (bias and random error) related to data based on clinical examina- Page of 10 (page number not for citation purposes) Acta Veterinaria Scandinavica...

Ngày tải lên: 25/10/2012, 10:45

... international normalized ratio (INR), and a liver panel Although the serum aminotransferase level correlates poorly with liver histology, the ratio of aspartate aminotransferase (AST) to alanine aminotransferase ... further evaluated by a HCV RNA test HCV RNA can be measured either quantitatively or qualitatively, which can approach a low limit of detection of 50 IU/ml or 100 viral copies/ml as early as 1-2 ... hepatitis C virus infection Am J Gastroenterol 1998;93(1):44-8 29 Giannini E, Risso D, Botta F, et al Validity and clinical utility of the aspartate aminotransferase-alanine aminotransferase ratio...

Ngày tải lên: 02/11/2012, 09:51

... replication is now more achievable than before In addition, an active HBV replication has been associated with increased risk for HCC [21] Thus, it has become more accepted that a normal ALT level ... normal transaminases have historically not been considered as candidates for HBV treatment based on the assumption that these patients usually have a slow progression and evidence that these patients ... years, ALT has been used as a standard surrogate for the activity of CHB Thus, ALT level in combination with HBV DNA level and histological activity has been used as a determinant for HBV treatment...

Ngày tải lên: 03/11/2012, 09:41

... xn (a) and which leaves the action invariant (for example, the transformation may be a rotation) The transformation is to contain a parameter, a, and is to be a continuous function of a For a equal ... there was a great obstacle to this delayed action-at -a- distance theory: namely, if a radiating electron, say in an atom or an antenna, were not acted upon at all by the field that it radiated, then ... gives probably the most fundacorresponds to e mental quantum analogue for the classical Lagrangian function It is preferable for the sake of analogy to consider the classical Lagrangian as a function...

Ngày tải lên: 06/11/2012, 11:21

... now C .A plays an important role in learning a foreign language as a main subject at most language universals According to C James (1980;19), C .A is a form of inter-language study and a central concern ... features of contrastive analysis in learning a foreign language which has particular effect on analyzing a language and its equivalents in other languages and then the author would like to make ... as we have seen it also has syntactic implications 2.2.2 Gradable and non- gradable adjectives According to L G Alexander (1988, 108) adjectives can be also divided into gradable and non- gradable...

Ngày tải lên: 10/04/2013, 14:46

... structural or reclamation works was proposed to avoid impact to the corals CAFEO 28 Hanoi, Vietnam (18-22nd Dec 2010) Coastal Management - Beach Rehabilitation At Pulau Tioman, Malaysia Figure7 - Layout ... Coastal Management - Beach Rehabilitation At Pulau Tioman, Malaysia Figure - Cascaded Seawall Design Plate -Cascaded Granite Block Revetment Sg Tekek and Sg Sabut River Improvement Works: Approximately ... Department of Environment, Malaysia For Project Approval ACS (2009), “Detailed Environmental Impact Assessment For Beach Rehabilitation Project At Tekek, Tioman Island, Malaysia”, Reports Prepared...

Ngày tải lên: 25/04/2013, 08:20

... is an anomaly behavior or not As demonstrated in [11], a basic assumption of anomaly detection is that attacks differ from normal behavior But the definition of what’s normal and what’s abnormal ... a hybrid misuse-anomaly detection approach to take advantage of anomaly detection’s ability to detect new attacks, but without the approach s accompanying high rate of false positives There are ... for IdM, Privacy and Identity Management for Europe (PRIME), Windows CardSpace, and OpenID Also they propose an entity-centric approach for IdM in the cloud that based on active bundles and anonymous...

Ngày tải lên: 31/07/2013, 09:43

... minutes or more discussing a particular word, phrase, or metaphor, Mining the Data for Metaphors We have learned to pay particular attention to the metaphors participants use Metaphors compel attention ... be an adequate word for the radical transformations that must take place in our healing practices Learning about existential phenomenology can be profoundly transformational, as our students and ... and perhaps for comparisons or contrasts of these instances For example, a researcher asking men about their anger may initially hear stories about anger at malfunctioning cars, boats, or computers...

Ngày tải lên: 16/10/2013, 11:15

... computers or software), database management and revision (ensuring proper data storage and access), hardware and software upgrades (replacing or enhancing existing assets), and network infrastructure ... structure provides a framework for addressing organizational alignment and organizational learning An IT executive in the U.S government once remarked that creating organizational change while continuing ... Project managers usually employ a Responsibility Assignment Matrix (RAM) such as the sample in Table (PMI, 2000), and OD scholars have advocated similar approaches in teambuilding and organizational...

Ngày tải lên: 24/10/2013, 08:20

... military, which faced a series of major tasks that simply were not achievable by traditional organizations operating in traditional ways The United States Navy’s Polaris program, NASA’s Apollo space ... insisted that project management was primarily a quantitative science and those who maintained that it was a behavioral science It has become clear that one cannot adequately manage a project ... side, most organizations report that project management results in greater organizational complexity Many also report that project organization increases the likelihood that organizational policy...

Ngày tải lên: 06/12/2013, 17:34

... proper software can be used as a firewall just the same as a dedicated firewall Device Hardening:Taking a Layered Approach When it comes to securing your network, taking a layered approach offers ... operating system, application, or appliance By taking a metered approach, you ensure consistent installation and hardening of each system The following recommendations for a secure installation ... instead, terminates into a firewall device Caution: So as not to contradict anyone or any other publication that may have come before this one, I will simply say that I not place a VPN Concentrator...

Ngày tải lên: 10/12/2013, 14:15

... view each first paragraph or page as a throwaway The absolutely worst part of writing for me is starting, staring at a blank page or monitor If I can just get some words down, the task looks started, ... let each student draw an audience out of a hat Each now write a paragraph to the audience drawn making the information relevant to that particular audience (Results could be read and evaluated ... ideas are supportive of larger ideas (subordinate) In formal outlines, broad coordinate ideas are designated with Roman numerals, and related supportive ideas are clustered beneath larger ideas,...

Ngày tải lên: 18/12/2013, 17:33

... present value in May dollars By comparing this score among a set of customers a prioritization is arrived at for directing future marketing efforts Lifetime Value metrics (Net Present Value models) ... retention rate, so Rrt=survival rate for t periods • • LTV is a measure of a single customer’s worth to the firm Used for pedagogical and conceptual purposes LTV: Definition Accounting for Acquisition ... return later The contribution of a customer may be causally tied to churn and abandonment, making this trickier than it looks You need to understand NPV calculations LTV: Definition Accounting for...

Ngày tải lên: 22/12/2013, 14:16

... summation of = j =1 value of sales made by all the J firms that sell a category of products to a buyer Information source: Numerator: From internal records Denominator: From primary market research ... brand Information source: Numerator: From internal records Denominator: Through market and distribution panels, or primary market research (surveys) and extrapolated to the entire buyer Evaluation: ... =1 = summation of value of sales made by all the J firms that sell a category of products to the focal customer Information source: Primary market research Evaluation: Critical measure for customer-centric...

Ngày tải lên: 22/12/2013, 14:16