4—assess the response to therapy

... shown, the addition of stressors to the cultures inhibits growth without killing the cells The hybridizing band in the northern analysis showed the expected size of about 680 bp indicating that the ... ⁄ O2); in the presence of an electron donor, such as dithiothreitol (DTT), Fe3+ catalyses the reduction of O2 to H2O2, which is further converted to OH by the Fenton reaction [18] The MCO system ... examined the involvement of the peroxiredoxin Bcp2 in oxidative stress in the hyperthermophilic aerobic archaeon Sulfolobus solfataricus Furthermore, we report the cloning, the expression and the...

Ngày tải lên: 07/03/2014, 12:20

... Ovariectomy was performed using a dorsal midline incision and the entrance into the abdominal cavity was made with a small cut in to the muscle half to two-thirds of the way down the side of the ... Overall, there are a series of situations where CTXII behaves distinctly to other markers The present study adds to these series the unique response of CTX-II to oestrogen deficiency There are ... investigates whether these collagen degradation products may relate to the breakdown of newly synthesised collagen, because collagen synthesis is reported to be upregulated in OA [22-24] PIIANP, the fetal...

Ngày tải lên: 09/08/2014, 01:22

... Ovariectomy was performed using a dorsal midline incision and the entrance into the abdominal cavity was made with a small cut in to the muscle half to two-thirds of the way down the side of the ... Overall, there are a series of situations where CTXII behaves distinctly to other markers The present study adds to these series the unique response of CTX-II to oestrogen deficiency There are ... investigates whether these collagen degradation products may relate to the breakdown of newly synthesised collagen, because collagen synthesis is reported to be upregulated in OA [22-24] PIIANP, the fetal...

Ngày tải lên: 09/08/2014, 13:22

... population, and Ed (X ) the expectation of phenotypes among the offspring of the w-selected parents The numerator is the response R(w, X) to selection based on the fitness function w in the trait X of ... t The + ! rauav ) selection yo response to If genotypes is added to the are numerator, and is added to the denominator can be written correlated, as: an 4(l extra term V OUUV + n)r i.e as the ... or to consider its genetic value u, since the former is just equal to half the latter Breeding animals are ranked according to their estimated genetic value In the present context, due to the...

Ngày tải lên: 09/08/2014, 18:21

... interval = 0.42 to 3.26) predicted response to therapy, whereas a positive anti-CRP test did (relative risk = 2.16, 95% confidence interval = 1.20 to 3.89) Response to therapy in relation to anti-CRP, ... = 22) to therapy (analysed with Mann-Whitney U test) Response to therapy was defined as a renal British Isles Lupus Assessment Group improvement ≥ grades The limitations extend down from the lowest ... intravenously as induction therapy Five of these six patients did not respond to therapy as judged by renal histopathology; one patient switched from WHO class IVb to a IIa pattern, but the remaining five...

Ngày tải lên: 12/08/2014, 11:22

... considerations of cytoskeletal plasticity The cytoskeleton of ASM is continuously adapting to its dynamic microenvironment, and these cytoskeletal-remodeling events seem to play out over a wide ... reports The potent dilating response to a DI observed in normal individuals fails in asthmatics Bridge dynamics and plastic reorganization of the cytoskeleton are surely important factors, but how they ... dilating substance such as nitric oxide [11] Taken together, the weight of available evidence seems to support the idea that loss of the dilating response to a DI may indeed play a central role in airway...

Ngày tải lên: 12/08/2014, 18:20

... need to be mobile, the hospital telephone system was of limited use and on many occasions the coordinators had to meet face to face This was practical because the GICU, the ED and the operating theatre ... anyway given the size of the hospital) was not possible The blast occurred near to the local bus depot and a bus was mobilized (it is unclear with what authority) to take the injured to the TCH Unfortunately ... deal with clinical issues These are the province of the coordinators or may be addressed in departmental major incident response plans Due to its proximity to the blast and the communications blackout,...

Ngày tải lên: 12/08/2014, 22:21

... decided not to disconnect these patients from the ventilator to avoid de-recruitment, and also because measurements obtained off ventilatory support may not reflect the situation during respiratory ... Third, the respiratory rate may be higher in patients with spontaneous respiratory movements, so that the number of cardiac beats per respiratory cycle may be reduced, and hence the chance to detect ... (RAP) and the likelihood of Relationshipto fluid challenge responding to fluid challenge to generate a mmHg decrease in PAOP; removing these patients from the analysis did not improve the performance...

Ngày tải lên: 13/08/2014, 01:20

... in the DDR, showing that the response to uncapped telomeres is not identical to the response to DSBs at non-telomeric loci The response to telomerase deletion was also sufficiently different to ... yeast to the absence of telomerase [22], the DDR [27] and the ESR [24] Furthermore, the response to uncapped telomeres in cdc13-1 budding yeast strains has features in common with the responses to ... Whether uncapped telomeres elicit a different response to that to a DSB elsewhere in the genome remains unknown A genomewide analysis of the transcriptional response of yeast to deletion of the...

Ngày tải lên: 14/08/2014, 21:20

... These include cognitive-behavioral therapy, dynamic/interpersonal psychotherapy, hypnotherapy, and stress management training (Guthrie et al, 1993) The psychotherapeutic approach emphasizes the ... 1998, www.appi.org) In the central nervous system, 5-HT is synthesized within the nerve terminal The 5-HT produced in the EC cell of the gut is distributed to the rest of the body, except CNS, ... could improve bloating and intestine transit in these patients Therefore, the objective of this study is to investigate the symptomatology of bloating, the role of gastrointestinal transit and effect...

Ngày tải lên: 26/09/2015, 10:05

... scales17, is called the ‘understandability factor’ Similar to the first factor, the lay people is found to have a much smaller range (-1.18 to 1.00) compared to the experts (-2.03 to 2.24) Both groups ... concepts to meet preconceived demands” With the local people, the tone and response was very different even though similar lines of questioning were used The locals tend to support one another’s ... ‘tie-breaking’!!! Wish you all the best in Toronto study hard, play hard and train hard too… I’ll be awaiting you on-court… hopefully by then I’ll be able to live up to the rivalry!! Hey, Lloyd…...

Ngày tải lên: 05/10/2015, 21:24

... response to chemotherapy in these biopsies The correlation to response, if proven, would help clinicians to tailor chemotherapy to individual patients and may provide the opportunity to offer ... indirect evidence of the efficacy of the chemotherapy in these patients in eliminating the mitotic fraction It is intriguing to note that, as soon as 24 hours after chemotherapy, there was a rise ... apoptosis may respond poorly to chemotherapy We observed a significant inverse correlation between expression of Bcl-2 and response to the chemotherapy These results are in general line with the...

Ngày tải lên: 09/08/2014, 04:21

... at another week Evaluation of the response scores To evaluate categorical scores, we adapted the cut-off of the variable with the highest ranking (DAS28 at week 22) to the specificity of the categorical ... clinical trials) The aim of the present analyses was to evaluate whether the decision to increase the dose could be reflected by using single variables or composite indices, alone or together in a model ... to be less important than the momentary remaining disease activity at week 22, to discriminate the rheumatologist's decision After the prior selection of variables, based on the findings of the...

Ngày tải lên: 09/08/2014, 06:23

... identified 41 transcripts associated with response to therapy in baseline PBMC samples They confirmed the association of 20 of these transcripts with response to therapy in an additional set of 20 patients ... helped to acquire the data BJVdE, PD, and FAH helped to design the study and contributed to the writing of the manuscript BRL helped to design the study and to acquire, analyze, and interpret the ... selected synovial markers of response to adalimumab therapy Synovial samples of rheumatoid arthritis patients who therapy responded or who did not respond to adalimumab therapy were stained at baseline...

Ngày tải lên: 09/08/2014, 14:20

... in the management of chronic hepatitis C monoinfection Drugs 2008, 68:1273-1317 Shiratori Y, Kato N, Yokosuka O, Imazeki F, Hashimoto E, Hayashi N: Predictors of the efficacy of interferon therapy ... treatment response Hepatology 2000, 31(6):1360-1370 Lo S, Lin HH: Variations within hepatitis C virus E2 protein and response to interferon treatment Virus Res 2001, 75(2):107-112 Saito T, Ito T, tto ... Association of amino acid sequence in the PKR-eIF2 phosphorylation homology domain and response to interferon therapy Hepatology 2000, 32(5):1138-1144 Gerotto M, Dal Pero F, Pontisso P, Noventa...

Ngày tải lên: 11/08/2014, 21:21

... fight) The sum of the points assigned to the answer represents the total aggression and ranges from to 44 Procedure The first assessment in March 2010 was carried out by four of the authors They ... assesses the severity of symptoms based on the frequency of symptoms reported by the child The occurrence of each DSM-IV symptom within the last month is scored on a scale ranging from none of the ... six months allowed the caretakers to get used to the new strategies and the children to profit from the changes, but also to recover from PTSD A decline in reported violence in the orphanage as...

Ngày tải lên: 13/08/2014, 18:22

... factors, the role of biological factors affecting the drug absorption, distribution, metabolism or deletion has been investigated [1-9] Till now, the most significant biological factors known to ... is expressed, it may count for the 50% of the total hepatic CYP3A protein [5,14] Macphee et al were the first to detect the effect of a CYP3A5 polymorphism in the distribution of tacrolimus [11] ... be taken into account [7] The aim of the present study was to 95 determine the impact of CYP3A5*1 and CYP3A5*3 genotype on the kinetics of tacrolimus in renal transplant recipients The drug dose...

Ngày tải lên: 26/10/2012, 09:32

... however, the software of the system offers the possibility to examine the wave over the entire sampling time, or part of the wave as all information is stored in the computer memory The software ... application point for the test voltage is the line terminal of the phase winding which is to be tested The other terminal of this phase winding should be earthed For three-phase reactors, the requirement, ... capacitance, wider tolerances may have to be accepted The surge capacitance of the transformer under test being constant, the series resistance may have to be reduced in an attempt to obtain the correct...

Ngày tải lên: 25/12/2013, 10:35

... needs to be done to reduce the probability and the severity of future financial crises The Chancellor of the Exchequer asked me in October 2008 to review the causes of the current crisis, and to ... the mortgage market The combination of factors common with the US and global story, and factors specific to the UK, resulted in the evolution of the crisis in the UK having the following features: ... covered neither by the Icelandic scheme nor by the FSCS top up The UK government concluded that these deposits should be protected to underpin depositor confidence in the banking system The total...

Ngày tải lên: 16/02/2014, 11:20

... rates In the second sub-period, given the structural break in the mean, the convergence dummy9 as well as the constant are allowed to lie in the cointegration space until the middle of the month ... to the problem In order to reduce the number of parameters to be estimated, in the asymmetric model we then use the result αD3=αL3=αB1=αB2=0 which is valid in both sub-periods This helps us to ... tightening In the second period, the only asymmetry is detected in the response of the lending rate to a deviation in the long run relationship between the interest rate on deposits and the interbank...

Ngày tải lên: 17/02/2014, 03:20